Manipulating environmental stresses and stress tolerance of microalgae for enhanced production of lipids and value-added products–a review
Abstract
Microalgae have promising potential to produce lipids and a variety of high-value chemicals. Suitable stress conditions such as nitrogen starvation and high salinity could stimulate synthesis and accumulation of lipids and high-value products by microalgae, therefore, various stress-modification strategies were developed to manipulate and optimize cultivation processes to enhance bioproduction efficiency. On the other hand, advancements in omics-based technologies have boosted the research to globally understand microalgal gene regulation under stress conditions, which enable further improvement of production efficiency via genetic engineering. Moreover, integration of multi-omics data, synthetic biology design, and genetic engineering manipulations exhibits a tremendous potential in the betterment of microalgal biorefinery. This review discusses the process manipulation strategies and omics studies on understanding the regulation of metabolite biosynthesis under various stressful conditions, and proposes genetic engineering of microalgae to improve bioproduction via manipulating stress tolerance.
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Nutrient limitation increases carbohydrate and lipid content in microalgae.
“Moreover, nutrient limitation have been shown to further increase the carbohydrate and lipid content in microalgae (Chen et al., 2017;Nagappan et al., 2019aNagappan et al., , 2019b)).”
From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Chen et al., 2017
Both whole cell Haematococcus pluvialis and extracted astaxanthin are used as feed additives, at around 1.5%, in the aquaculture industry.
“Both whole cell H. pluvialis and extracted astaxanthin are used as feed additives (1.5% in range) in the aquaculture industry (Chen et al., 2017).”
From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Chen et al., 2017
Pigments like carotenoids, which give microalgal functional properties like antioxidant activity to fishes, are easily degraded.
“Pigments like carotenoids, which give microalgal functional properties like antioxidant activity to fishes, are easily degraded (Chen et al., 2017).”
From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Chen et al., 2017
Cites
Chisti, Y. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2007.02.001 · Cited by 9,524 · see citing works
Brennan, L., & Owende, P. (2010) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2009.10.009 · Cited by 4,894 · see citing works
Rodolfi, L., Chini Zittelli, G., Bassi, N., Padovani, G., Biondi, N., Bonini, G., & Tredici, M. R. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22033 · Cited by 2,879 · see citing works
Microalgae biorefinery: High value products perspectives
Chew, K. W., Yap, J. Y., Show, P. L., Suan, N. H., Juan, J. C., Ling, T. C., Lee, D.-J., & Chang, J.-S. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.01.006 · Cited by 1,336 · see citing works
Rubio, V., Linhares, F. S., Solano, R., Martin, A. C. B. M., Iglesias, J., Leyva, A., & Paz‐Ares, J. (2001) · Genes & Development · doi:10.1101/gad.204401 · Cited by 1,328 · see citing works
Microalgae biofuels: A critical review of issues, problems and the way forward
Lam, M. K., & Lee, K. T. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.11.008 · Cited by 938 · see citing works
Juneja, A., Ceballos, R., & Murthy, G. (2013) · Energies · doi:10.3390/en6094607 · Cited by 835 · see citing works
Lipid accumulation and CO2 utilization of Nannochloropsis oculata in response to CO2 aeration
Chiu, S.-Y., Kao, C.-Y., Tsai, M.-T., Ong, S.-C., Chen, C.-H., & Lin, C.-S. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2008.06.061 · Cited by 825 · see citing works
Markou, G., & Nerantzis, E. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.07.011 · Cited by 815 · see citing works
Carotenoids from microalgae: A review of recent developments
Gong, M., & Bassi, A. S. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.10.005 · Cited by 727 · see citing works
Takagi, M., Karseno, & Yoshida, T. (2006) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.101.223 · Cited by 629 · see citing works
Perspectives on Microalgal CO2-Emission Mitigation Systems—A Review
Ho, S.-H., Chen, C.-Y., Lee, D.-J., & Chang, J.-S. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.11.001 · Cited by 580 · see citing works
The effect of light, salinity, and nitrogen availability on lipid production by Nannochloropsis sp.
Pal, D., Khozin-Goldberg, I., Cohen, Z., & Boussiba, S. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3170-1 · Cited by 575 · see citing works
Biorefinery of microalgae for food and fuel
Vanthoor-Koopmans, M., Wijffels, R. H., Barbosa, M. J., & Eppink, M. H. M. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.135 · Cited by 502 · see citing works
Minhas, A. K., Hodgson, P., Barrow, C. J., & Adholeya, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00546 · Cited by 451 · see citing works
Trentacoste, E. M., Shrestha, R. P., Smith, S. R., Glé, C., Hartmann, A. C., Hildebrand, M., & Gerwick, W. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309299110 · Cited by 430 · see citing works
He, Q., Yang, H., Wu, L., & Hu, C. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.05.021 · Cited by 367 · see citing works
Mishra, A., & Jha, B. (2009) · Bioresource Technology · doi:10.1016/j.biortech.2009.02.006 · Cited by 352 · see citing works
Yang, J., Cao, J., Xing, G., & Yuan, H. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.10.124 · Cited by 331 · see citing works
Ho, S., Ye, X., Hasunuma, T., Chang, J., & Kondo, A. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.09.002 · Cited by 310 · see citing works
Carotenoid and fatty acid metabolism in light‐stressed Dunaliella salina
Lamers, P. P., van de Laak, C. C. W., Kaasenbrood, P. S., Lorier, J., Janssen, M. G. J., de Vos, R. C. H., Bino, R. J., & Wijffels, R. H. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22725 · Cited by 277 · see citing works
Breuer, G., Lamers, P. P., Martens, D. E., Draaisma, R. B., & Wijffels, R. H. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.05.105 · Cited by 270 · see citing works
Mechanisms of yeast stress tolerance and its manipulation for efficient fuel ethanol production
Zhao, X., & Bai, F. (2009) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2009.05.001 · Cited by 244 · see citing works
Chokshi, K., Pancha, I., Ghosh, A., & Mishra, S. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0747-7 · Cited by 238 · see citing works
Progress of microalgae biofuel’s commercialization
Su, Y., Song, K., Zhang, P., Su, Y., Cheng, J. Q., & Chen, X. (2017) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2016.12.078 · Cited by 229 · see citing works
Çakmak, T., Angün, P., Demiray, Y. E., Özkan, A. D., Elibol, Z., & Tekinay, T. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24474 · Cited by 228 · see citing works
Sun, X. L., Cao, Y., Xu, H., Liu, Y., Sun, J., Qiao, D., & Cao, Y. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2013.12.109 · Cited by 223 · see citing works
Factors affecting lipid accumulation by Nannochloropsis oculata in a two-stage cultivation process
Su, C., Chien, L., Gomes, J., Lin, Y., Yu, Y.-K., Liou, J.-S., & Syu, R.-J. (2010) · Journal of Applied Phycology · doi:10.1007/s10811-010-9609-4 · Cited by 214 · see citing works
Gonçalves, E., Wilkie, A. C., Kirst, M., & Rathinasabapathi, B. (2016) · Plant Biotechnology Journal · doi:10.1111/pbi.12523 · Cited by 212 · see citing works
Chu, F., Chu, P.-N., Cai, P.-J., Li, W., Lam, P. K. S., & Zeng, R. J. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.01.131 · Cited by 211 · see citing works
An updated comprehensive techno-economic analysis of algae biodiesel
Nagarajan, S., Chou, S. K., Cao, S., Wu, C., & Zhou, Z. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.11.108 · Cited by 211 · see citing works
Shi, X., & Chen, F. (2002) · Biotechnology Progress · doi:10.1021/bp0101987 · Cited by 193 · see citing works
Xu, P., Qiao, K., & Stephanopoulos, G. N. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26285 · Cited by 187 · see citing works
Iwai, M., Ikeda, K., Shimojima, M., & Ohta, H. (2014) · Plant Biotechnology Journal · doi:10.1111/pbi.12210 · Cited by 182 · see citing works
Mohan, S. V., & Devi, M. P. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.02.103 · Cited by 165 · see citing works
Gardner, R., Peters, P., Peyton, B., & Cooksey, K. E. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9633-4 · Cited by 159 · see citing works
Ho, S., Nakanishi, A., Kato, Y., Yamasaki, H., Chang, J., Misawa, N., Hirose, Y., Minagawa, J., Hasunuma, T., & Kondo, A. (2017) · Scientific Reports · doi:10.1038/srep45471 · Cited by 159 · see citing works
Chi, Z., Liu, Y., Frear, C. S., & Chen, S. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1740-7 · Cited by 151 · see citing works
Xie, Y., Ho, S.-H., Chen, C.-N. N., Chen, C.-Y., Ng, I.-S., Jing, K.-J., Chang, J.-S., & Lu, Y. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.06.064 · Cited by 151 · see citing works
Self-citationKang, N. K., Jeon, S., Kwon, S., Koh, H. G., Shin, S.-E., Lee, B., Choi, G., Yang, J.-W., Jeong, B., & Chang, Y. K. (2015) · Biotechnology for Biofuels · doi:10.1186/s13068-015-0386-9 · Cited by 150 · see citing works
Martin, G. J. O., Hill, D. R., Olmstead, I. L. D., Amanda, B., Shears, M. J., Dias, D. A., Kentish, S. E., Scales, P. J., Botté, C. Y., & Callahan, D. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103389 · Cited by 149 · see citing works
Liu, J., Mao, X., Zhou, W., & Guarnieri, M. T. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.04.112 · Cited by 146 · see citing works
Campenni’, L., Nobre, B. P., Santos, C. A., Oliveira, A. C., Aires-Barros, M. R., Palavra, A. M. F., & Gouveia, L. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4570-6 · Cited by 141 · see citing works
Moussa, I. D., Chtourou, H., Rezgui, F., Sayadi, S., & Dhouib, A. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.07.022 · Cited by 139 · see citing works
Ge, F., Huang, W., Chen, Z., Zhang, C., Xiong, Q., Bowler, C., Yang, J., Xu, J. H., & Hu, H. (2014) · The Plant Cell · doi:10.1105/tpc.114.124982 · Cited by 130 · see citing works
Ho, S., Nakanishi, A., Ye, X., Chang, J., Hara, K. Y., Hasunuma, T., & Kondo, A. (2014) · Biotechnology for Biofuels · doi:10.1186/1754-6834-7-97 · Cited by 128 · see citing works
Wang, T., Ge, H., Liu, T., Tian, X., Wang, Z., Guo, M., Chu, J., & Zhuang, Y. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.04.025 · Cited by 128 · see citing works
Yoshioka, S., Taniguchi, F., Miura, K., Inoue, T., Yamano, T., & Fukuzawa, H. (2004) · The Plant Cell · doi:10.1105/tpc.021162 · Cited by 127 · see citing works
Longworth, J., Wu, D., Huete-Ortega, M., Wright, P. C., & Vaidyanathan, S. (2016) · Algal Research · doi:10.1016/j.algal.2016.06.015 · Cited by 127 · see citing works
Growth of oil accumulating microalga Neochloris oleoabundans under alkaline–saline conditions
Santos, A. M., Janssen, M. G. J., Lamers, P. P., Evers, W. A. C., & Wijffels, R. H. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2011.10.084 · Cited by 123 · see citing works
NaCl as an effective inducer for lipid accumulation in freshwater microalgae Desmodesmus abundans
Xia, L., Rong, J., Yang, H., He, Q., Zhang, D., & Hu, C. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.03.063 · Cited by 123 · see citing works
Impact of temperature and light intensity on triacylglycerol accumulation in marine microalgae
Kurpan Nogueira, D. P., Silva, A. F., Araújo, O. Q. F., & Chaloub, R. M. (2015) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2014.10.017 · Cited by 122 · see citing works
Zhang, J., Hao, Q., Bai, L., Xu, J., Yin, W.-B., Song, L., Xu, L., Guo, X., Fan, C., Chen, Y., et al. (2014) · Biotechnology for Biofuels · doi:10.1186/s13068-014-0128-4 · Cited by 122 · see citing works
Ibáñez-Salazar, A., Rosales‐Mendoza, S., Rocha‐Uribe, A., Ramírez-Alonso, J. I., Lara-Hernández, I., Hernández-Torres, A., Paz-Maldonado, L. M. T., Silva‐Ramírez, A. S., Bañuelos-Hernández, B., Martínez-Salgado, J. L., et al. (2014) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2014.05.003 · Cited by 119 · see citing works
Ra, C.-H., Kang, C.-H., Jung, J.-H., Jeong, G., & Kim, S.-K. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.04.059 · Cited by 116 · see citing works
Transcriptional Engineering of Microalgae: Prospects for High-Value Chemicals
Bajhaiya, A. K., Moreira, J. Z., & Pittman, J. K. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.06.001 · Cited by 116 · see citing works
Metabolic Engineering of Microalgal Based Biofuel Production: Prospects and Challenges
Banerjee, C., Dubey, K. K., & Shukla, P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00432 · Cited by 110 · see citing works
Impacts of nitrogen and phosphorus starvation on the physiology of Chlamydomonas reinhardtii
Kamalanathan, M., Pierangelini, M., Shearman, L. A., Gleadow, R. M., & Beardall, J. (2015) · Journal of Applied Phycology · doi:10.1007/s10811-015-0726-y · Cited by 109 · see citing works
Subhash, G. V., Rohit, M. V., Devi, M. P., Swamy, Y. V., & Mohan, S. V. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.07.019 · Cited by 108 · see citing works
Assessment of Environmental Stresses for Enhanced Microalgal Biofuel Production – An Overview
Cheng, D., & He, Q. (2014) · Frontiers in Energy Research · doi:10.3389/fenrg.2014.00026 · Cited by 106 · see citing works
Remmers, I. M., Martens, D. E., Wijffels, R. H., & Lamers, P. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175630 · Cited by 102 · see citing works
Shen, X., Chu, F., Lam, P. K. S., & Zeng, R. J. (2015) · Water Research · doi:10.1016/j.watres.2015.06.003 · Cited by 99 · see citing works
Algal omics: unlocking bioproduct diversity in algae cell factories
Guarnieri, M. T., & Pienkos, P. T. (2015) · Photosynthesis Research · doi:10.1007/s11120-014-9989-4 · Cited by 97 · see citing works
Cheng, J., Lu, H., Huang, Y., Li, K., Huang, R., Zhou, J., & Cen, K. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2015.12.032 · Cited by 91 · see citing works
Guihéneuf, F., Khan, A. A., & Tran, L. P. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00400 · Cited by 89 · see citing works
Wan, C., Bai, F., & Zhao, X. (2013) · Biochemical Engineering Journal · doi:10.1016/j.bej.2013.04.014 · Cited by 88 · see citing works
Krzemińska, I., Piasecka, A., Nosalewicz, A., Simionato, D., & Wawrzykowski, J. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.07.043 · Cited by 86 · see citing works
Rapid Induction of Lipid Droplets in Chlamydomonas reinhardtii and Chlorella vulgaris by Brefeldin A
Kim, S., Kim, H., Ko, D., Yamaoka, Y., Otsuru, M., Kawai‐Yamada, M., Ishikawa, T., Oh, H., Nishida, I., Li‐Beisson, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081978 · Cited by 81 · see citing works
Improving Cell Growth and Lipid Accumulation in Green Microalgae Chlorella sp. via UV Irradiation
Liu, S., Zhao, Y., Liu, L., Ao, X., Ma, L., Wu, M., & Ma, F. (2015) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-015-1521-6 · Cited by 80 · see citing works
Ho, S., Nakanishi, A., Ye, X., Chang, J., Chen, C., Hasunuma, T., & Kondo, A. (2015) · Biotechnology for Biofuels · doi:10.1186/s13068-015-0226-y · Cited by 78 · see citing works
Iwai, M., Hori, K., Sasaki‐Sekimoto, Y., Shimojima, M., & Ohta, H. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00912 · Cited by 76 · see citing works
Lv, J., Guo, J., Feng, J., Liu, Q., & Xie, S. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.03.061 · Cited by 75 · see citing works
Ra, C. H., Kang, C.-H., Kim, N. K., Lee, C., & Kim, S.-K. (2015) · Renewable Energy · doi:10.1016/j.renene.2015.02.002 · Cited by 74 · see citing works
Peng, H., Wei, D., Chen, G., & Chen, F. (2016) · Biotechnology for Biofuels · doi:10.1186/s13068-016-0571-5 · Cited by 73 · see citing works
Kim, S., Liu, K., Lee, S.-Y., Hong, S.-J., Cho, B., Lee, H., Lee, C., & Choi, H.-K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072415 · Cited by 70 · see citing works
Gao, Z., Li, Y., Wu, G., Li, G., Sun, H., Deng, S., Shen, Y., Chen, G., Zhang, R., Meng, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140609 · Cited by 70 · see citing works
An, M., Mou, S., Zhang, X., Ye, N., Zheng, Z., Cao, S., Xu, D., Fan, X., Wang, Y., & Miao, J. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.01.142 · Cited by 69 · see citing works
Silva, C. E. D. F., & Sforza, E. (2016) · Process Biochemistry · doi:10.1016/j.procbio.2016.09.015 · Cited by 69 · see citing works
Cheng, R., Feng, J., Zhang, B., Huang, Y. Y., Cheng, J., & Zhang, C. (2013) · BioEnergy Research · doi:10.1007/s12155-013-9360-1 · Cited by 67 · see citing works
Han, F., Pei, H., Hu, W., Jiang, L., Cheng, J., & Zhang, L. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.02.103 · Cited by 64 · see citing works
Ettlia sp. YC001 showing high growth rate and lipid content under high CO2
Yoo, C., Choi, G., Kim, S., & Oh, H. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.09.046 · Cited by 60 · see citing works
López‐Rosales, L., García-Camacho, F., Sánchez‐Mirón, A., Contreras‐Gómez, A., & Grima, E. M. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.08.087 · Cited by 54 · see citing works
Lipidomic analysis of the extremophilic red alga Galdieria sulphuraria in response to changes in pH
Vítová, M., Goecke, F., Sigler, K., & Řezanka, T. (2015) · Algal Research · doi:10.1016/j.algal.2015.12.005 · Cited by 53 · see citing works
Matthijs, M., Fabris, M., Broos, S., Vyverman, W., & Goossens, A. (2015) · PLANT PHYSIOLOGY · doi:10.1104/pp.15.01300 · Cited by 50 · see citing works
Bajhaiya, A. K., Dean, A. P., Driver, T., Trivedi, D. K., Rattray, N. J. W., Allwood, J. W., Goodacre, R., & Pittman, J. K. (2016) · Metabolomics · doi:10.1007/s11306-015-0878-4 · Cited by 49 · see citing works
Liang, M., & Jiang, J. (2017) · Scientific Reports · doi:10.1038/srep37025 · Cited by 46 · see citing works
Potential biomass yield per phosphorus and lipid accumulation property of seven microalgal species
Wu, Y.-H., Yin, Y., & Hu, H. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.12.116 · Cited by 45 · see citing works
Zhang, P., Li, Z., Lu, L., Xiao, Y., Liu, J., Guo, J., & Fang, F. (2017) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2017.03.022 · Cited by 45 · see citing works
Inhibition of nitrate reductase by azide in microalgae results in triglycerides accumulation
Zalogin, T. R., & Pick, U. (2013) · Algal Research · doi:10.1016/j.algal.2013.11.018 · Cited by 41 · see citing works
Concurrent production of carotenoids and lipid by a filamentous microalga Trentepohlia arborum
Chen, L., Zhang, L., & Liu, T. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.05.017 · Cited by 41 · see citing works
Ji, M.-K., Yun, H.-S., Hwang, J.-H., Salama, E., Jeon, B., & Choi, J. (2016) · Environmental Technology · doi:10.1080/09593330.2016.1246145 · Cited by 40 · see citing works
Yoo, C., La, H., Kim, S., & Oh, H. (2014) · Biotechnology and Bioengineering · doi:10.1002/bit.25362 · Cited by 36 · see citing works
Skrupski, B. P., Wilson, K. E., Goff, K. L., & Zou, J. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-012-9930-1 · Cited by 33 · see citing works
Mild pressure induces rapid accumulation of neutral lipid (triacylglycerol) in Chlorella spp.
Praveenkumar, R., Kim, B., Lee, J., Vijayan, D., Lee, K., Nam, B., Jeon, S. G., Kim, D., & Oh, Y. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.09.025 · Cited by 25 · see citing works
Wang, T., Tian, X., Liu, T., Wang, Z., Guan, W., Guo, M., Chu, J., & Zhuang, Y. (2016) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2016.10.010 · Cited by 22 · see citing works
Saeki, K., Aburai, N., Aratani, S., Miyashita, H., & Abe, K. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0911-7 · Cited by 20 · see citing works
N., O. G. C., & Rorrer, G. L. (2017) · Biotechnology Progress · doi:10.1002/btpr.2445 · Cited by 20 · see citing works
Galarza, J. I., Delgado, N., & Henríquez, V. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7948-z · Cited by 12 · see citing works
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Shahid, A., Malik, S., Zhu, H., Xu, J., Nawaz, M. Z., Nawaz, S., Alam, M. A., & Mehmood, M. A. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135303 · Cited by 457 · see citing works
Sustainability of direct biodiesel synthesis from microalgae biomass: A critical review
Goh, B. H. H., Ong, H. C., Cheah, M. Y., Chen, W., Yu, K. L., & Mahlia, T. M. I. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.02.012 · Cited by 406 · see citing works
Potential of microalgae as a sustainable feed ingredient for aquaculture
Nagappan, S., Das, P., AbdulQuadir, M., Thaher, M., Khan, S., Mahata, C., Al-Jabri, H., Vatland, A. K., & Kumar, G. (2021) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2021.09.003 · Cited by 364 · see citing works
Minimizing carbon footprint via microalgae as a biological capture
Onyeaka, H. N., Miri, T., Obileke, K. C., Hart, A., Anumudu, C. K., & Al-Sharify, Z. T. (2021) · Carbon Capture Science & Technology · doi:10.1016/j.ccst.2021.100007 · Cited by 345 · see citing works
Recent developments and key barriers to advanced biofuels: A short review
Oh, Y., Hwang, K.-R., Kim, C., Kim, J. R., & Lee, J. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.02.089 · Cited by 318 · see citing works
Microalgae for high-value products: A way towards green nutraceutical and pharmaceutical compounds
Mehariya, S., Goswami, R. K., Karthikeysan, O. P., & Verma, P. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130553 · Cited by 291 · see citing works
Antioxidant Compounds from Microalgae: A Review
Coulombier, N., Jauffrais, T., & Lebouvier, N. (2021) · Marine Drugs · doi:10.3390/md19100549 · Cited by 277 · see citing works
Overview of Carbon Capture Technology: Microalgal Biorefinery Concept and State-of-the-Art
Singh, J. P., & Dhar, D. W. (2019) · Frontiers in Marine Science · doi:10.3389/fmars.2019.00029 · Cited by 271 · see citing works
Zhao, Y., Wang, H., Han, B., & Yu, X. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.12.030 · Cited by 251 · see citing works
Ahmad, A., Hassan, S. W., & BANAT, F. A. (2022) · Bioengineered · doi:10.1080/21655979.2022.2061148 · Cited by 257 · see citing works
Two-stage cultivation of microalgae for production of high-value compounds and biofuels: A review
Liyanaarachchi, V. C., Premaratne, M., Ariyadasa, T. U., Nimarshana, P. H. V., & Malik, A. (2021) · Algal Research · doi:10.1016/j.algal.2021.102353 · Cited by 225 · see citing works
Storage of starch and lipids in microalgae: Biosynthesis and manipulation by nutrients
Ran, W., Wang, H., Liu, Y., Qi, M., Xiang, Q., Yao, C., Zhang, Y., & Lan, X. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121894 · Cited by 224 · see citing works
Algal cellulose, production and potential use in plastics: Challenges and opportunities
Zanchetta, E., Damergi, E., Patel, B., Borgmeyer, T., Pick, H. M., Pulgarin, A., & Ludwig, C. D. R. (2021) · Algal Research · doi:10.1016/j.algal.2021.102288 · Cited by 222 · see citing works
Microalgae as source of polyhydroxyalkanoates (PHAs) — A review
Costa, S. S., Miranda, A. L., de Morais, M. G., Costa, J. A. V., & Druzian, J. I. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.099 · Cited by 218 · see citing works
Growth and lipid accumulation by different nutrients in the microalga Chlamydomonas reinhardtii
Yang, L., Chen, J., Qin, S., Zeng, M., Jiang, Y., Hu, L., Xiao, P., Hao, W., Hu, Z., Lei, A., et al. (2018) · Biotechnology for Biofuels · doi:10.1186/s13068-018-1041-z · Cited by 209 · see citing works
Vasistha, S., Khanra, A., Clifford, M., & Rai, M. P. (2021) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2020.110498 · Cited by 208 · see citing works
Microalgae under environmental stress as a source of antioxidants
Gauthier, M. R., Senhorinho, G. N. A., & Scott, J. A. (2020) · Algal Research · doi:10.1016/j.algal.2020.102104 · Cited by 202 · see citing works
Algal-based system for removal of emerging pollutants from wastewater: A review
Gondi, R., Kavitha, S. K., Kannah, R. Y., Karthikeyan, O. P., Kumar, G., Tyagi, V. K., & Banu, J. R. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126245 · Cited by 198 · see citing works
Zhang, S., He, Y., Sen, B., & Wang, G. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123234 · Cited by 188 · see citing works
Regulatory mechanisms of lipid biosynthesis in microalgae
Chen, H., & Wang, Q. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12759 · Cited by 181 · see citing works
Enhancement of lipid accumulation in microalgae by metabolic engineering
Sun, X., Ren, L., Zhao, Q., Ji, X., & Huang, H. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.10.004 · Cited by 181 · see citing works
Microalgae as feed sources and feed additives for sustainable aquaculture: Prospects and challenges
Ma, M., & Hu, Q. (2023) · Reviews in Aquaculture · doi:10.1111/raq.12869 · Cited by 177 · see citing works
Ferreira, G. F., Ríos Pinto, L. F., Maciel Filho, R., & Fregolente, L. V. (2019) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2019.04.052 · Cited by 176 · see citing works
Chong, J. W. R., Khoo, K. S., Yew, G. Y., Leong, W. H., Lim, J. W., Lam, M. K., Ho, Y.-C., Ng, H. S., Munawaroh, H. S. H., & Show, P. L. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125947 · Cited by 163 · see citing works
Mutanda, T., Naidoo, D., Bwapwa, J. K., & Anandraj, A. (2020) · Frontiers in Energy Research · doi:10.3389/fenrg.2020.598803 · Cited by 160 · see citing works
Ren, Y., Deng, J., Huang, J., Wu, Z., Yi, L., Bi, Y., & Chen, F. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125736 · Cited by 155 · see citing works
Biodiesel production from microalgae using lipase-based catalysts: Current challenges and prospects
Mota, G. F., de Sousa, I. G., de Oliveira, A. L. B., Cavalcante, A. L. G., Moreira, K. D. S., Cavalcante, F. T. T., Souza, J. E. D. S., Falcão, Í. R. D. A., Rocha, T. G., Valério, R. B. R., et al. (2022) · Algal Research · doi:10.1016/j.algal.2021.102616 · Cited by 157 · see citing works
Chen, Y.-D., Ho, S., Nagarajan, D., Ren, N., & Chang, J. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.11.017 · Cited by 148 · see citing works
Strategies to control biological contaminants during microalgal cultivation in open ponds
Lam, T. P., Lee, T., Chen, C., & Chang, J. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.12.088 · Cited by 150 · see citing works
High-value bioproducts from microalgae: Strategies and progress
Liang, M., Wang, L., Wang, Q., Zhu, J., & Jiang, J. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1455030 · Cited by 137 · see citing works
Bioethanol and biodiesel: Bibliometric mapping, policies and future needs
Osman, A. I., Qasim, U., Jamil, F., Al-Muhtaseb, A. H., Abu-Jrai, A., Al-Riyami, M. B., Al-Maawali, S., Al‐Haj, L., Al‐Hinai, A., Al-Abri, M. Z., et al. (2021) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2021.111677 · Cited by 139 · see citing works
Tailoring Microalgae for Efficient Biofuel Production
Sharma, P. K., Saharia, M., Srivstava, R., Kumar, S., & Sahoo, L. (2018) · Frontiers in Marine Science · doi:10.3389/fmars.2018.00382 · Cited by 134 · see citing works
Multilateral Approach on Enhancing Economic Viability of Lipid Production from Microalgae: A Review
Shin, Y. S., Choi, H. I., Choi, J. W., Lee, J. S., Sung, Y. J., & Sim, S. J. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.03.002 · Cited by 122 · see citing works
Park, S., Nguyen, T., & Jin, E. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121953 · Cited by 121 · see citing works
Biodiesel from microalgae: Recent progress and key challenges
Kim, J. Y., Jung, J., Jung, S., Park, Y., Tsang, Y. F., Lin, K. A., Choi, Y.-E., & Kwon, E. E. (2022) · Progress in Energy and Combustion Science · doi:10.1016/j.pecs.2022.101020 · Cited by 120 · see citing works
Yun, H.-S., Kim, Y.-S., & Yoon, H. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.774143 · Cited by 120 · see citing works
Li, S., Zhao, S., Yan, S., Qiu, Y., Song, C., Li, Y., & Kitamura, Y. (2019) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2019.03.028 · Cited by 115 · see citing works
Advancements on process regulation for microalgae-based carbon neutrality and biodiesel production
Wu, W., Ling, T., Chang, H., Zhang, C., Tan, X., Liao, Q., Zhong, N., Zhang, X., Zhang, Y., & Ho, S. (2022) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2022.112969 · Cited by 111 · see citing works
Shahid, A., Ishfaq, M. K., Ahmad, M. S., Malik, S., Farooq, M. U., Hui, Z., Batawi, A. H., Shafi, M. E., Aloqbi, A. A., Gull, M., et al. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121701 · Cited by 110 · see citing works
Lin, W., Tan, S., Hsiang, C., Sung, P.-K., & Ng, I. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121932 · Cited by 108 · see citing works
Ibrahim, T. N. B. T., Feisal, N. A. S., Kamaludin, N. H., Cheah, W. Y., How, V., Bhatnagar, A., Ma, Z., & Show, P. L. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.128661 · Cited by 111 · see citing works
(Bio)Technological Aspects of Microalgae Pigments for Cosmetics
Morocho-Jácome, A. L., Ruscinc, N., Martinez, R. M., de Carvalho, J. C. M., Santos de Almeida, T., Rosado, C., Costa, J. G., Velasco, M. V. R., & Baby, A. R. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10936-x · Cited by 104 · see citing works
Nayak, M., Suh, W. I., Chang, Y. K., & Lee, B. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.12.111 · Cited by 104 · see citing works
Kothri, M., Mavrommati, M., Elazzazy, A. M., Baeshen, M. N., Moussa, T. A. A., & Aggelis, G. (2020) · FEMS Microbiology Letters · doi:10.1093/femsle/fnaa028 · Cited by 103 · see citing works
The effect of stress environment towards lipid accumulation in microalgae after harvesting
Poh, Z. L., Kadir, W. N. A., Lam, M. K., Uemura, Y., Suparmaniam, U., Lim, J. W., Show, P. L., & Lee, K. T. (2020) · Renewable Energy · doi:10.1016/j.renene.2020.03.081 · Cited by 100 · see citing works
A New Network for the Advancement of Marine Biotechnology in Europe and Beyond
Rotter, A., Bacu, A., Barbier, M., Bertoni, F., Bones, A. M., Cancela, M. L., Carlsson, J., Carvalho, M. F., Cegłowska, M., Dalay, M. C., et al. (2020) · Frontiers in Marine Science · doi:10.3389/fmars.2020.00278 · Cited by 100 · see citing works
Shokravi, Z., Shokravi, H., Ong, H. C., Lau, W. J., Koloor, S. S. R., Petrů, M., & Ismail, A. F. (2020) · Sustainability · doi:10.3390/su12219083 · Cited by 99 · see citing works
Influence of environmental stress on microalgae growth and lipid profile: a systematic review
Suparmaniam, U., Lam, M. K., Lim, J. W., Yusup, S. B., Tan, I. S., Lau, S. Y., Kodgire, P. V., & Kachhwaha, S. S. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-022-09810-7 · Cited by 95 · see citing works
Zhao, X., Tan, X., Yang, L., Liao, J.-Y., & Li, X. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.03.117 · Cited by 85 · see citing works
Zhang, S., Zheng, W. H., & Wang, H. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121530 · Cited by 79 · see citing works
Impact of abiotic factors on biodiesel production by microalgae
Ananthi, V., Brindhadevi, K., Pugazhendhi, A., & Arun, A. (2020) · Fuel · doi:10.1016/j.fuel.2020.118962 · Cited by 79 · see citing works
Zhao, Y., Wang, Q., Gu, D., Huang, F., Liu, J., Yu, L., & Yu, X. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.130093 · Cited by 78 · see citing works
Perdana, B. A., Chaidir, Z., Kusnanda, A. J., Dharma, A., Zakaria, I. J., Syafrizayanti, S., Bayu, A., & Putra, M. Y. (2021) · Algal Research · doi:10.1016/j.algal.2021.102542 · Cited by 76 · see citing works
Пилигаев, А. В., Sorokina, K. N., Шашков, М. В., & Parmon, V. N. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.11.063 · Cited by 75 · see citing works
Peng, H., de‐Bashan, L. E., Yoav Bashan, A., & Higgins, B. T. (2020) · Algal Research · doi:10.1016/j.algal.2020.101845 · Cited by 76 · see citing works
Impact of Light Intensity on Antioxidant Activity of Tropical Microalgae
Coulombier, N., Nicolau, É., Déan, L. L., Antheaume, C., Jauffrais, T., & Lebouvier, N. (2020) · Marine Drugs · doi:10.3390/md18020122 · Cited by 76 · see citing works
Godbole, V., Pal, M. K., & Gautam, P. (2021) · Algal Research · doi:10.1016/j.algal.2021.102436 · Cited by 74 · see citing works
Behera, B., Unpaprom, Y., Ramaraj, R., Maniam, G. P., Govindan, N., & Balasubramanian, P. (2021) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2021.111270 · Cited by 72 · see citing works
Microalgal metabolic engineering strategies for the production of fuels and chemicals
Kang, N. K., Baek, K., Koh, H. G., Atkinson, C., Ort, D. R., & Jin, Y. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126529 · Cited by 71 · see citing works
Jakhwal, P., Biswas, J. K., Tiwari, A., Kwon, E. E., & Bhatnagar, A. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126250 · Cited by 70 · see citing works
Morales-Sánchez, D., Schulze, P. S. C., Kiron, V., & Wijffels, R. H. (2020) · Algal Research · doi:10.1016/j.algal.2020.102016 · Cited by 63 · see citing works
Ferreira, G. F., Pinto, L. F. R., Carvalho, P. D. O., Coelho, M. B., Eberlin, M. N., Filho, R. M., & Fregolente, L. V. (2019) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-019-00566-3 · Cited by 68 · see citing works
Recent advances in biotechnology and bioengineering for efficient microalgal biofuel production
Zhang, C., Singh, R. P., Yadav, P., Kumar, I., Kaushik, A., Roychowdhury, R., Mubeen, M., Singh, S. K., Kumar, A., & Wang, J. (2025) · Fuel Processing Technology · doi:10.1016/j.fuproc.2025.108199 · Cited by 71 · see citing works
Versatile Applications of Cyanobacteria in Biotechnology
Żymańczyk-Duda, E., Samson, S. O., Brzezińska-Rodak, M., & Klimek-Ochab, M. (2022) · Microorganisms · doi:10.3390/microorganisms10122318 · Cited by 64 · see citing works
Diversity and Distribution of Carotenogenic Algae in Europe: A Review
Александрович, Ч. К. (2023) · Marine Drugs · doi:10.3390/md21020108 · Cited by 63 · see citing works
Polat, E., Yüksel, E., & Altınbaş, M. (2019) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2019.105441 · Cited by 62 · see citing works
Kafil, M., Berninger, F. A., Koutra, E., & Kornaros, M. E. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126665 · Cited by 61 · see citing works
Chen, C., & Liu, C.-C. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.04.024 · Cited by 60 · see citing works
Harnessing genetic engineering to drive economic bioproduct production in algae
Gupta, A., Kang, K., Pathania, R., Saxton, L., Saucedo, B., Malik, A., Torres-Tiji, Y., Diaz, C. J., Dutra Molino, J. V., & Mayfield, S. P. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1350722 · Cited by 60 · see citing works
Yang, Y., Ge, S., Pan, Y., Qian, W., Wang, S., Zhang, J., & Zhuang, L.-L. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159281 · Cited by 57 · see citing works
Recent advances in enhancing the production of long chain omega-3 fatty acids in microalgae
Kumari, A., Pabbi, S., & Tyagi, A. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2226720 · Cited by 59 · see citing works
Emerging algal nanotechnology for high-value compounds: A direction to future food production
Koyande, A. K., Chew, K. W., Manickam, S., Chang, J., & Show, P.-L. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.07.026 · Cited by 58 · see citing works
Shahid, A., Rehman, A. U., Usman, M., Ashraf, M. U., Javed, M. R., Khan, A. Z., Gill, S. S., & Mehmood, M. A. (2019) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1812 · Cited by 56 · see citing works
Almutairi, A. W. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08531-8 · Cited by 54 · see citing works
Couto, D., Melo, T., Conde, T. A., Costa, M., Silva, J., Domingues, M. R. M., & Domingues, P. (2021) · Algal Research · doi:10.1016/j.algal.2020.102128 · Cited by 53 · see citing works
Microalgae Biomass as a New Potential Source of Sustainable Green Lubricants
Cabrera, L. I. F., Franco‐Morgado, M., Sánchez, A. G., Pérez‐González, J., & Marín‐Santibáñez, B. M. (2022) · Molecules · doi:10.3390/molecules27041205 · Cited by 56 · see citing works
Integration of sludge digestion and microalgae cultivation for enhancing bioenergy and biorefinery
Chen, Y.-D., Li, S., Ho, S., Wang, C., Lin, Y.-C., Nagarajan, D., Chang, J., & Ren, N. (2018) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2018.07.028 · Cited by 51 · see citing works
Jeon, S., Koh, H. G., Cho, J. M., Kang, N. K., & Chang, Y. K. (2021) · Algal Research · doi:10.1016/j.algal.2021.102218 · Cited by 50 · see citing works
Removal of nitrate and phosphate from simulated agricultural runoff water by Chlorella vulgaris
Vazirzadeh, A., Jafarifard, K., Ajdari, A., & Yusuf Chisti, B. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.149988 · Cited by 51 · see citing works
Kim, S. H., Sunwoo, I. Y., Hong, H. J., Awah, C. C., Jeong, G.-T., & Kim, S.-K. (2019) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-019-02149-y · Cited by 50 · see citing works
Combined effect of salinity and pH on lipid content and fatty acid composition of Tisochrysis lutea
Almutairi, A. W., El-Sayed, A. E.-K. B., & Reda, M. M. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.07.027 · Cited by 49 · see citing works
Temperature-Dependent Lipid Accumulation in the Polar Marine Microalga Chlamydomonas malina RCC2488
Morales‐Sánchez, D., Schulze, P. S. C., Kiron, V., & Wijffels, R. H. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.619064 · Cited by 47 · see citing works
Metabolic Responses of a Model Green Microalga Euglena gracilis to Different Environmental Stresses
He, J., Liu, C., Du, M., Zhou, X.-Y., Hu, Z., Lei, A., & Wang, J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.662655 · Cited by 50 · see citing works
Regueiras, A., Huguet, Á., Conde, T., Couto, D., Domingues, P. M., Domingues, M. R., Costa, A. M., Silva, J., Vasconcelos, V. M., & Urbatzka, R. (2021) · Marine Drugs · doi:10.3390/md20010009 · Cited by 50 · see citing works
Application of chemicals for enhancing lipid production in microalgae-a short review
Sun, X., Ren, L., Zhao, Q., Zhang, L., & Huang, H. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122135 · Cited by 51 · see citing works
Cheah, M. Y., Ong, H. C., Zulkifli, N. W. M., Masjuki, H. H., & Salleh, A. (2019) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2019.11.020 · Cited by 50 · see citing works
Cyanobacteria as cell factories for the photosynthetic production of sucrose
Santos‐Merino, M., Yun, L., & Ducat, D. C. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1126032 · Cited by 48 · see citing works
Insights about sustainable biodiesel production from microalgae biomass: A review
Soosai, M. R., Sundaramahalingam, M. A., Shivamthi, C. S., Rajaram, S. K., Varalakshmi, P., Sankar, K., Jeyaram, K., Raja, V. K., Shanmugam, S., Moorthy, I. G., et al. (2020) · International Journal of Energy Research · doi:10.1002/er.6138 · Cited by 48 · see citing works
Zhang, Y., Wu, H., Yuan, C., Li, T., & Li, A. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-019-01783-z · Cited by 47 · see citing works
Enhancement of lipid accumulation in Monoraphidium sp. QLY-1 by induction of strigolactone
Song, X., Zhao, Y., Li, T., Han, B., Zhao, P., Xu, J., & Yu, X. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121607 · Cited by 47 · see citing works
Zhao, Y., Song, X., Zhao, P., Li, T., Xu, J., & Yu, X. (2021) · Algal Research · doi:10.1016/j.algal.2021.102196 · Cited by 46 · see citing works
Yang, L., & Lu, Q. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157470 · Cited by 46 · see citing works
Lu, H., Chen, H., Tang, X., Yang, Q., Zhang, H., Chen, Y. Q., & Chen, W. (2020) · Biotechnology for Biofuels · doi:10.1186/s13068-020-01757-1 · Cited by 46 · see citing works
Wu, P., Chen, Z., Zhang, Y., Wang, Y., Zhu, F., Cao, B., Wu, Y., & Li, N. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2018.11.087 · Cited by 44 · see citing works
Growth and LC-PUFA production of the cold-adapted microalga Koliella antarctica in photobioreactors
Suzuki, H., Hulatt, C. J., Wijffels, R. H., & Kiron, V. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1606-z · Cited by 44 · see citing works
Nagappan, S., & Kumar, G. (2021) · Environmental Technology & Innovation · doi:10.1016/j.eti.2021.101572 · Cited by 43 · see citing works
De Bhowmick, G., Sen, R., & Sarmah, A. K. (2019) · Journal of Environmental Management · doi:10.1016/j.jenvman.2019.109696 · Cited by 42 · see citing works
Panaite, T. D., Cornescu, G. M., Predescu, N. C., Cismileanu, A., Turcu, R. P., Saracila, M., & Soica, C. (2023) · Applied Sciences · doi:10.3390/app131810451 · Cited by 42 · see citing works
Established and Emerging Producers of PHA: Redefining the Possibility
Bhola, S., Arora, K., Kulshrestha, S., Mehariya, S., Bhatia, R. K., Kaur, P., & Kumar, P. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03626-5 · Cited by 44 · see citing works
Martinez-Villarreal, S., Breitenstein, A., Nimmegeers, P., Saura, P. P., Hai, B., Asomaning, J., Eslami, A. A., Billen, P., Passel, S. V., Bressler, D. C., et al. (2022) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2022.106555 · Cited by 42 · see citing works
- Authors
- Chen, B., Wan, C., Mehmood, M. A., Chang, J.-S., Bai, F., & Zhao, X.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Dalian University of Technology (CN)
- National Cheng Kung University (TW)
- Corresponding author
- Zhao, Xinqing
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 244
- Issue
- Pt 2
- Pages
- 1198-1206
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2620135990
- Cited by
- 346
- References
- 100
- Citations by year
- 2026: 21 · 2025: 36 · 2024: 27 · 2023: 37 · 2022: 48 · 2021: 58 · 2020: 50 · 2019: 50 · 2018: 15 · 2017: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21536006)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- microalgae, lipid production, stress tolerance, nitrogen starvation, high salinity, microalgae biorefinery, genetic engineering of microalgae, multi-omics, synthetic biology, value-added products, metabolite synthesis
- MeSH terms
- Biotechnology, Lipids, Stress, Physiological, Biofuels, Microalgae
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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