Cited by 346Algal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionLipid metabolism and biosynthesis

Manipulating environmental stresses and stress tolerance of microalgae for enhanced production of lipids and value-added products–a review

Chen, Bailing, Wan, Chun, Mehmood, Muhammad Aamer, Chang, Jo-Shu, Bai, Fengwu, Zhao, Xinqing·2017·Bioresource Technology

Abstract

Microalgae have promising potential to produce lipids and a variety of high-value chemicals. Suitable stress conditions such as nitrogen starvation and high salinity could stimulate synthesis and accumulation of lipids and high-value products by microalgae, therefore, various stress-modification strategies were developed to manipulate and optimize cultivation processes to enhance bioproduction efficiency. On the other hand, advancements in omics-based technologies have boosted the research to globally understand microalgal gene regulation under stress conditions, which enable further improvement of production efficiency via genetic engineering. Moreover, integration of multi-omics data, synthetic biology design, and genetic engineering manipulations exhibits a tremendous potential in the betterment of microalgal biorefinery. This review discusses the process manipulation strategies and omics studies on understanding the regulation of metabolite biosynthesis under various stressful conditions, and proposes genetic engineering of microalgae to improve bioproduction via manipulating stress tolerance.

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Crossref · 10.1016/j.biortech.2017.05.170

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98 of 98 references verified0 citation errors · 0 not checkable

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  • Nutrient limitation increases carbohydrate and lipid content in microalgae.

    “Moreover, nutrient limitation have been shown to further increase the carbohydrate and lipid content in microalgae (Chen et al., 2017;Nagappan et al., 2019aNagappan et al., , 2019b)).”

    From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Chen et al., 2017

  • Both whole cell Haematococcus pluvialis and extracted astaxanthin are used as feed additives, at around 1.5%, in the aquaculture industry.

    “Both whole cell H. pluvialis and extracted astaxanthin are used as feed additives (1.5% in range) in the aquaculture industry (Chen et al., 2017).”

    From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Chen et al., 2017

  • Pigments like carotenoids, which give microalgal functional properties like antioxidant activity to fishes, are easily degraded.

    “Pigments like carotenoids, which give microalgal functional properties like antioxidant activity to fishes, are easily degraded (Chen et al., 2017).”

    From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Chen et al., 2017

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Authors
Chen, B., Wan, C., Mehmood, M. A., Chang, J.-S., Bai, F., & Zhao, X.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Dalian University of Technology (CN)
  • National Cheng Kung University (TW)
Corresponding author
Zhao, Xinqing
Venue
Bioresource Technology
Publisher
Elsevier BV
Published
2017-11
Volume
244
Issue
Pt 2
Pages
1198-1206
ISSN
0960-8524 (ISSN-L)
OpenAlex
W2620135990
Cited by
346
References
100
Citations by year
2026: 21 · 2025: 36 · 2024: 27 · 2023: 37 · 2022: 48 · 2021: 58 · 2020: 50 · 2019: 50 · 2018: 15 · 2017: 3
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Locations
  • Bioresource Technology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (21536006)
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
microalgae, lipid production, stress tolerance, nitrogen starvation, high salinity, microalgae biorefinery, genetic engineering of microalgae, multi-omics, synthetic biology, value-added products, metabolite synthesis
MeSH terms
Biotechnology, Lipids, Stress, Physiological, Biofuels, Microalgae

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