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Cited by 69Circadian rhythm and melatoninStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Effect of lesioning the suprachiasmatic nuclei on behavioral despair in rats

Tataroğlu, Özgür, Aksoy, Ayla, Yılmaz, Ajda, Canbeyli, Resit·2004·Brain Research
DOI 10.1016/j.brainres.2003.11.063
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Abstract

The suprachiasmatic nucleus (SCN) is involved in regulating many biological rhythms. Several lines of research implicate the SCN in affective behavior. The SCN is directly involved in regulating the daily rhythms of the hypothalamo-pituitary-adrenal (HPA) axis hormones involved in stress. Bilateral lesions of the SCN disrupt both the rhythms and the basal levels of the HPA axis hormones involved in coping with stress. Moreover, stress can affect the biological rhythms regulated by the SCN, and disruption of biological rhythms in turn can cause stress. The present study assessed the effect of bilateral destruction of the SCN on behavioral despair, an animal model of depression sensitive to antidepressant treatment. The results indicate that bilateral destruction of the SCN results in reduced immobility in the second forced swimming test (FST) compared to sham controls and animals with incomplete lesions. These results indicate that bilateral destruction of the SCN has a protective effect in the induction of behavioral despair which may arise out of disruption of the secretion of the HPA axis hormones and/or of the neural connections between the SCN and the limbic structures that modulate the response to swim stress.

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Crossref · 10.1016/j.brainres.2003.11.063

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  • Bilateral SCN lesions in rats reduce immobility in the forced swim test, indicating a protective effect in the induction of behavioral despair.

    “Rats that received bilateral SCN lesions demonstrated reduced immobility. Thus, the authors concluded that SCN lesions have a protective effect in the induction of behavioral despair88.”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [88]

  • Bilateral SCN lesions in rats had an antidepressant-like effect in the forced swim test, with less immobility time and more swimming.

    “A study by Tataroglu et al found that bilateral SCN lesions in rats had an antidepressant-like effect in the forced swim test in that the animals showed less immobility time and more swimming (Tataroglu et al., 2004).”

    From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Tataroglu et al., 2004

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Authors
Tataroğlu, Ö., Aksoy, A., Yılmaz, A., & Canbeyli, R.
Affiliations
Boğaziçi University (TR)
Corresponding author
Canbeyli, Resit
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2004-03
Volume
1001
Issue
1-2
Pages
118-124
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2003.11.063
OpenAlex
W2046308679
Cited by
69
References
78
Citations by year
2024: 1 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 4
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
suprachiasmatic nucleus, lesioning, behavioral despair, depression, forced swim test, immobility, hypothalamic-pituitary-adrenal axis, stress hormones, biological rhythms, limbic system, antidepressant sensitivity
MeSH terms
Animals, Behavior, Animal, Brain Diseases, Depression, Disease Models, Animal, Immobilization, Male, Motor Activity, Suprachiasmatic Nucleus, Swimming, Rats, Wistar, Rats

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