Cited by 243Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersFetal and Pediatric Neurological Disorders

Corpus callosum size in autism

Hardan, A.Y., Minshew, N.J., Keshavan, M.S.·2000·Neurology

Abstract

The size of the seven subregions of the corpus callosum was measured on MRI scans from 22 non-mentally retarded autistic subjects and 22 individually matched controls. Areas of the anterior subregions were smaller in the autistic group. In a subsample, measurements were adjusted for intracranial, total brain, and white matter volumes and the differences between groups remained significant. No differences were found in the other subregions. This observation is consistent with the frontal lobe dysfunction reported in autism.

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Crossref · 10.1212/wnl.55.7.1033

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9 of 9 references verified0 citation errors · 0 not checkable

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  • Anterior corpus callosum regions represent fibers from prefrontal cortices; mid/body regions contain fibers from premotor, motor, parietal, and superior temporal cortices; and the posterior region represents fibers from inferior temporal and occipital cortices.

    “Anterior CC regions represent fibers from pre-frontal cortices; mid/body regions are composed of fibers from pre-motor, motor, parietal, and superior temporal cortices; and the posterior region represents fibers from inferior temporal and occipital cortices (25).”

    From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [25]

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Authors
Hardan, A. Y., Minshew, N. J., & Keshavan, M. S.
Affiliations
University of Pittsburgh (US)
Venue
Neurology
Published
2000-10-10
Volume
55
Issue
7
Pages
1033-1036
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2067863368
Cited by
243
References
9
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 11 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 12 · 2014: 4 · 2013: 15 · 2012: 13
FWCI
2.82
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh040858-06)
  • National Institute of Mental Health (MH 40858)
  • National Institute of Neurological Disorders and Stroke (NS33355)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD35469)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
autism spectrum disorder, corpus callosum, brain size, frontal lobe dysfunction, white matter volume, intracranial volume
MeSH terms
Adult, Autistic Disorder, Corpus Callosum, Humans, Magnetic Resonance Imaging

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