Corpus callosum size in autism
Abstract
The size of the seven subregions of the corpus callosum was measured on MRI scans from 22 non-mentally retarded autistic subjects and 22 individually matched controls. Areas of the anterior subregions were smaller in the autistic group. In a subsample, measurements were adjusted for intracranial, total brain, and white matter volumes and the differences between groups remained significant. No differences were found in the other subregions. This observation is consistent with the frontal lobe dysfunction reported in autism.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Anterior corpus callosum regions represent fibers from prefrontal cortices; mid/body regions contain fibers from premotor, motor, parietal, and superior temporal cortices; and the posterior region represents fibers from inferior temporal and occipital cortices.
“Anterior CC regions represent fibers from pre-frontal cortices; mid/body regions are composed of fibers from pre-motor, motor, parietal, and superior temporal cortices; and the posterior region represents fibers from inferior temporal and occipital cortices (25).”
From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [25]
Cites
WITELSON, S. F. (1989) · Brain · doi:10.1093/brain/112.3.799 · Cited by 1,424 · see citing works
Reduced Size of Corpus Callosum in Autism
Egaas, B., Courchesne, E., & Saitoh, O. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540320070014 · Cited by 361 · see citing works
Regional brain enlargement in autism: a magnetic resonance imaging study.
Piven, J., Arndt, S., Bailey, J., & Andreasen, N. (1996) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-199604000-00020 · Cited by 354 · see citing works
An MRI study of the corpus callosum in autism
Piven, J., Bailey, J. M., Ranson, B. J., & Arndt, S. V. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.8.1051 · Cited by 338 · see citing works
Delayed maturation of the frontal cortex in childhood autism
Zilbovicius, M., Garreau, B., Samson, Y., Rémy, P., Barthélémy, C., Syrota, A., & Lelord, G. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.2.248 · Cited by 275 · see citing works
Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism
Minshew, N. J., Luna, B., & Sweeney, J. A. (1999) · Neurology · doi:10.1212/wnl.52.5.917 · Cited by 267 · see citing works
Self-citationFrontostriatal Measurement in Treatment-Naive Children With Obsessive-Compulsive Disorder
Rosenberg, D. R. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830210068007 · Cited by 235 · see citing works
Testosterone is correlated with regional morphology of the human corpus callosum
Moffat, S. D., Hampson, E., Wickett, J. C., et al. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00614-8 · Cited by 53 · see citing works
Brief report: Brain mechanisms in autism: Functional and structural abnormalities
Minshew, N. J. (1996) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172013 · Cited by 52 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Just, M. A., Cherkassky, V. L., Keller, T. A., Kana, R. K., & Minshew, N. J. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl006 · Cited by 1,081 · see citing works
Self-citationMapping early brain development in autism
Courchesne, E., Pierce, K., Schumann, C. M., Redcay, E., Buckwalter, J. A., Kennedy, D. P., & Morgan, J. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.016 · Cited by 860 · see citing works
Agenesis of the corpus callosum: Genetic, developmental and functional aspects of connectivity
Paul, L. K., Brown, W. S., Adolphs, R., Tyszka, J. M., Richards, L. J., Mukherjee, P., & Sherr, E. H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2107 · Cited by 830 · see citing works
Autism and pervasive developmental disorders
Volkmar, F. R., Lord, C., Bailey, A., Schultz, R. T., & Klin, A. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1046/j.0021-9630.2003.00317.x · Cited by 616 · see citing works
Autism as a neural systems disorder: A theory of frontal-posterior underconnectivity
Just, M. A., Keller, T. A., Malave, V. L., Kana, R. K., & Varma, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.007 · Cited by 578 · see citing works
Sentence comprehension in autism: thinking in pictures with decreased functional connectivity
Kana, R. K. (2006) · Brain · doi:10.1093/brain/awl164 · Cited by 530 · see citing works
Stanfield, A. C., McIntosh, A. M., Spencer, M. D., Philip, R., Gaur, S., & Lawrie, S. M. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2007.05.006 · Cited by 524 · see citing works
Boddaert, N., Chabane, N., Gervais, H., Good, C. D., Bourgeois, M., Plumet, M.-H., Barthélémy, C., Mouren, M.-C., Artiges, E., Samson, Y., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.016 · Cited by 481 · see citing works
Decreased interhemispheric functional connectivity in autism
Anderson, J. S., Druzgal, T. J., Froehlich, A., DuBray, M. B., Lange, N., Alexander, A. L., Abildskov, T., Nielsen, J. A., Cariello, A. N., Cooperrider, J. R., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq190 · Cited by 438 · see citing works
Brain anatomy and development in autism: review of structural MRI studies
Brambilla, P., Hardan, A., di Nemi, S. U., Perez, J., Soares, J. C., & Barale, F. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.06.001 · Cited by 418 · see citing works
Self-citationKana, R. K., Keller, T. A., Cherkassky, V. L., Minshew, N. J., & Just, M. A. (2009) · Social Neuroscience · doi:10.1080/17470910802198510 · Cited by 319 · see citing works
Self-citationReview of neuroimaging in autism spectrum disorders: what have we learned and where we go from here
Anagnostou, E., & Taylor, M. J. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-4 · Cited by 321 · see citing works
Neurodevelopment and executive function in autism
O'Hearn, K., Asato, M., Ordaz, S., & Luna, B. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000527 · Cited by 274 · see citing works
A Meta-Analysis of the Corpus Callosum in Autism
Frazier, T. W., & Hardan, A. Y. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.022 · Cited by 267 · see citing works
Self-citationPostural Stability in Children with Autism Spectrum Disorder
Molloy, C. A., Dietrich, K. N., & Bhattacharya, A. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000006001.00667.4c · Cited by 265 · see citing works
Assessing autism-like behavior in mice: Variations in social interactions among inbred strains
BOLIVAR, V, WALTERS, S., & PHOENIX, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.007 · Cited by 264 · see citing works
Bohland, J. W., Wu, C., Barbas, H., Bokil, H., Bota, M., Breiter, H. C., Cline, H. T., Doyle, J. C., Freed, P. J., Greenspan, R. J., et al. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000334 · Cited by 261 · see citing works
Mapping corpus callosum deficits in autism: An index of aberrant cortical connectivity
Vidal, C. N., Nicolson, R., DeVito, T. J., Hayashi, K. M., Geaga, J. A., Drost, D. J., Williamson, P. C., Rajakumar, N., Sui, Y., Dutton, R. A., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.011 · Cited by 244 · see citing works
Structural and functional magnetic resonance imaging of autism spectrum disorders
Stigler, K. A., McDonald, B. C., Anand, A., Saykin, A. J., & McDougle, C. J. (2011) · Brain Research · doi:10.1016/j.brainres.2010.11.076 · Cited by 197 · see citing works
Stephenson, D. T., O'Neill, S. M., Narayan, S., Tiwari, A., Arnold, E., Samaroo, H. D., Du, F., Ring, R. H., Campbell, B., Pletcher, M., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-7 · Cited by 180 · see citing works
Hardan, A. Y., Libove, R. A., Keshavan, M. S., Melhem, N. M., & Minshew, N. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.024 · Cited by 173 · see citing works
Self-citationSocial and behavioral problems of children with agenesis of the corpus callosum
Badaruddin, D. H., Andrews, G. L., Bölte, S., Schilmoeller, K. J., Schilmoeller, G., Paul, L. K., & Brown, W. S. (2007) · Child Psychiatry and Human Development · doi:10.1007/s10578-007-0065-6 · Cited by 150 · see citing works
The BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers
Meyza, K. Z., Defensor, E. B., Jensen, A. L., Corley, M. J., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.021 · Cited by 147 · see citing works
Mukaetova‐Ladinska, E. B., Arnold, H., Jaros, E., Perry, R., & Perry, E. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00574.x · Cited by 115 · see citing works
Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
Yang, M., Clarke, A. M., & Crawley, J. N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06714.x · Cited by 117 · see citing works
Dougherty, C. C., Evans, D. W., Myers, S. M., Moore, G. J., & Michael, A. M. (2016) · Neuropsychology Review · doi:10.1007/s11065-015-9300-2 · Cited by 104 · see citing works
Review: Cortical construction in autism spectrum disorder: columns, connectivity and the subplate
Hutsler, J. J., & Casanova, M. F. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12227 · Cited by 94 · see citing works
Solomon, M., Yoon, J. H., Ragland, J. D., Niendam, T. A., Lesh, T. A., Fairbrother, W., & Carter, C. S. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.036 · Cited by 78 · see citing works
Fairless, A. H., Dow, H. C., Toledo, M. M., Malkus, K. A., Edelmann, M., Li, H., Talbot, K., Arnold, S. E., Abel, T., & Brodkin, E. S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.025 · Cited by 69 · see citing works
Reduced long-range functional connectivity in young children with autism spectrum disorder
Kikuchi, M., Yoshimura, Y., Hiraishi, H., Munesue, T., Hashimoto, T., Tsubokawa, T., Takahashi, T., Suzuki, M., Higashida, H., & Minabe, Y. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu049 · Cited by 64 · see citing works
Kinast, K., Peeters, D., Kolk, S. M., Schubert, D., & Homberg, J. R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00072 · Cited by 57 · see citing works
- Authors
- Hardan, A. Y., Minshew, N. J., & Keshavan, M. S.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Neurology
- Published
- 2000-10-10
- Volume
- 55
- Issue
- 7
- Pages
- 1033-1036
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2067863368
- Cited by
- 243
- References
- 9
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 11 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 12 · 2014: 4 · 2013: 15 · 2012: 13
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh040858-06)
- National Institute of Mental Health (MH 40858)
- National Institute of Neurological Disorders and Stroke (NS33355)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD35469)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- autism spectrum disorder, corpus callosum, brain size, frontal lobe dysfunction, white matter volume, intracranial volume
- MeSH terms
- Adult, Autistic Disorder, Corpus Callosum, Humans, Magnetic Resonance Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review