Cited by 231Autism Spectrum Disorder ResearchNeuroendocrine regulation and behaviorGenetics and Neurodevelopmental Disorders

A Mouse Model System for Genetic Analysis of Sociability: C57BL/6J Versus BALB/cJ Inbred Mouse Strains

Sankoorikal, Geena Mary V., Kaercher, Kristin A., Boon, Catherine J., Lee, Jin Kyoung, Brodkin, Edward S.·2006·Biological Psychiatry

Abstract

Background Impairments in social behaviors are highly disabling symptoms of autism, schizophrenia, and other psychiatric disorders. Mouse model systems are useful for identifying the many genes and environmental factors likely to affect complex behaviors, such as sociability (the tendency to seek social interaction). To progress toward developing such a model system, we tested the hypothesis that C57BL/6J inbred mice show higher levels of sociability than BALB/cJ inbred mice.Methods Mice tested for sociability were 4- and 9-week-old, male and female C57BL/6J and BALB/cJ mice. On 2 consecutive days, the sociability of each test mouse toward an unfamiliar 4-week-old DBA/2J stimulus mouse was assessed with a social choice paradigm conducted in a three-chambered apparatus. Measures of sociability included the time that the test mouse spent near versus far from the stimulus mouse, the time spent directly sniffing the stimulus mouse, and the time spent in contact between test and stimulus mice in a free interaction.Results C57BL/6J mice showed higher levels of sociability than BALB/cJ mice overall in each of these measures.Conclusions We propose that C57BL/6J and BALB/cJ mice will be a useful mouse model system for future genetic and neurobiological studies of sociability.

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Crossref · 10.1016/j.biopsych.2005.07.026

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Authors
Sankoorikal, G. M. V., Kaercher, K. A., Boon, C. J., Lee, J. K., & Brodkin, E. S.
Affiliations
University of Pennsylvania (US)
Corresponding author
Brodkin, Edward S.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2006-03
Volume
59
Issue
5
Pages
415-423
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2053588982
Cited by
231
References
43
Citations by year
2026: 5 · 2025: 9 · 2024: 6 · 2023: 4 · 2022: 10 · 2021: 10 · 2020: 19 · 2019: 12 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 9 · 2014: 17 · 2013: 21 · 2012: 12
FWCI
4.45
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (K08MH068586, KO8MH068586)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
sociability, inbred mouse strains, C57BL/6J mice, BALB/cJ mice, social behavior, autism spectrum disorder, schizophrenia
MeSH terms
Aggression, Animals, Choice Behavior, Female, Genotype, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Models, Genetic, Social Behavior, Social Environment, Mice

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