A plasticity-based theory of the pathogenesis of Alzheimer's disease.
Abstract
Amyloid plaques (APs) and neurofibrillary tangles (NFTs) are the two diagnostic markers of Alzheimer's disease (AD). The neuropsychological features of AD are closely correlated with the distribution of the NFTs and therefore favor a disease process revolving around neurofibrillary degeneration. The genetics, however, favor a disease process revolving around the APs, principally because mutations in the amyloid precursor protein (A beta PP) are sufficient to cause AD. The inability to reconcile these two aspects of AD has prevented the formulation of a unified theory of pathogenesis. It is interesting to note that all genetic causes and risk factors of AD can increase the physiological burden of neuroplasticity. My hypothesis is that the resultant intensification of the plasticity burden leads to an initially adaptive upregulation of tau phosphorylation and A beta PP turnover, to the subsequent formation of NFTs and APs as independent consequences of excessive plasticity-related cellular activity, and to the eventual loss of neurons, dendrites, and synapses as the ultimate expression of plasticity failure. The two pathological markers of AD are therefore independent manifestations of a more fundamental process through which the many different genotypes of AD trigger an identical clinical and neuropathological phenotype.
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The observed medial wall deficit pattern is consistent with the hypothesis that Alzheimer's disease pathology spreads centrifugally from limbic/paralimbic to higher-order association cortices.
“This pattern is consistent with the hypothesis that AD pathology spreads centrifugally from limbic/paralimbic to higher-order association cortices (Mesulam, 2000).”
From Dynamics of Gray Matter Loss in Alzheimer's Disease (2003) · cites this paper as Mesulam, 2000
Cites
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works
Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590 · see citing works
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380 · see citing works
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370 · see citing works
Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
Mattson, M. P. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.1081 · Cited by 1,006 · see citing works
Mechanisms of Neuronal Degeneration in Alzheimer's Disease
Yankner, B. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80115-4 · Cited by 947 · see citing works
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
Chapman, P. F., White, G. L., Jones, M. W., Cooper-Blacketer, D., Marshall, V. J., Irizarry, M., Younkin, L., Good, M. A., Bliss, T. V. P., Hyman, B. T., et al. (1999) · Nature Neuroscience · doi:10.1038/6374 · Cited by 946 · see citing works
Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro
Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., & Pitas, R. E. (1994) · Science · doi:10.1126/science.8171342 · Cited by 795 · see citing works
Alzheimer's Disease: A Central Role for Amyloid
Selkoe, D. J. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00003 · Cited by 752 · see citing works
Evolution of the neuropathology of Alzheimer's disease
Braak, H., & Braak, E. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05866.x · Cited by 710 · see citing works
Water-soluble Aβ(N-40, N-42) oligomers in normal and Alzheimer disease brains
Kuo, Y.-M., Emmerling, M. R., Vigo-Pelfrey, C., Kasunic, T. C., Kirkpatrick, J. B., Murdoch, G. H., Ball, M. J., & Roher, A. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4077 · Cited by 618 · see citing works
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
Zhang, Z., Hartmann, H., Do, V. M., Abramowski, D., Sturchler, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H. C., Säftig, P., et al. (1998) · Nature · doi:10.1038/27208 · Cited by 511 · see citing works
Neuroplasticity Failure in Alzheimer's Disease
Mesulam, M.-M. (1999) · Neuron · doi:10.1016/s0896-6273(00)81109-5 · Cited by 449 · see citing works
Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons
Naruse, S., Thinakaran, G., Luo, J.-J., Kusiak, J. W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80637-6 · Cited by 355 · see citing works
Arendt, T., Schindler, C., Brückner, M. K., Eschrich, K., Bigl, V., Zedlick, D., & Marcova, L. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00516.1997 · Cited by 319 · see citing works
Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice
Capsoni, S., Ugolini, G., Comparini, A., Ruberti, F., Berardi, N., & Cattaneo, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6826 · Cited by 279 · see citing works
Lovestone, S., & Reynolds, C. H. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00577-5 · Cited by 278 · see citing works
Tau Is Enriched on Dynamic Microtubules in the Distal Region of Growing Axons
Black, M. M., Slaughter, T., Moshiach, S., Obrocka, M., & Fischer, I. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03601.1996 · Cited by 270 · see citing works
Roch, J., Masliah, E., Roch‐Levecq, A., Sundsmo, M. P., Otero, D. A., Veinbergs, I., & Saitoh, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7450 · Cited by 255 · see citing works
Stone, D. J., Rozovsky, I., Morgan, T. E., Anderson, C. P., & Finch, C. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03180.1998 · Cited by 237 · see citing works
Estrogen-enhanced neurite growth: evidence for a selective induction of Tau and stable microtubules
Ferreira, A., & Cáceres, A. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00392.1991 · Cited by 203 · see citing works
Tokuda, T., Ikeda, S., Yanagisawa, N., Ihara, Y., & Glenner, G. G. (1991) · Acta Neuropathologica · doi:10.1007/bf00308813 · Cited by 197 · see citing works
Kang, D. E., Soriano, S., Frosch, M. P., Collins, T., Naruse, S., Sisodia, S. S., Leibowitz, G., Levine, F., & Koo, E. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04229.1999 · Cited by 193 · see citing works
Scheff, S. W., Benardo, L. S., & Cotman, C. W. (1980) · Brain Research · doi:10.1016/0006-8993(80)90227-9 · Cited by 186 · see citing works
Ishida, A., Furukawa, K., Keller, J. N., & Mattson, M. P. (1997) · Neuroreport · doi:10.1097/00001756-199707070-00009 · Cited by 178 · see citing works
Viereck, C., Tucker, R., & Matus, A. I. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03547.1989 · Cited by 176 · see citing works
Giannakopoulos, P., Hof, P. R., Michel, J., Guimón, J., & Bouras, C. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00023-4 · Cited by 173 · see citing works
Stress-induced activation of nitric oxide-producing neurons in the rat brain
Krukoff, T. L., & Khalili, P. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970127)377:4 · Cited by 167 · see citing works
Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons
Brion, J., Octave, J., & Couck, A. M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90533-9 · Cited by 141 · see citing works
Banati, R. B., Gehrmann, J., Czech, C., Mönning, U., Jones, L. L., König, G., Beyreuther, K. T., & Kreutzberg, G. W. (1993) · Glia · doi:10.1002/glia.440090305 · Cited by 132 · see citing works
Wallace, W., Ahlers, S. T., Gotlib, J. R., Bragin, V., Sugar, J., Gluck, R., SHEA, P. A., Davis, K. L., & Haroutunian, V. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8712 · Cited by 118 · see citing works
Neurofibrillary tangles, but not Alzheimer‐type pathology, in a young boxer
Geddes, J. F., Vowles, G. H., Robinson, S. F. D., & Sutcliffe, J. C. (1996) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1996.tb00840.x · Cited by 116 · see citing works
Soluble derivatives of the β amyloid protein precursor in cerebrospinal fluid
Palmert, M. R., Usiak, M., Mayeux, R. P., Raskind, M. A., Tourtellotte, W. W., & Younkin, S. G. (1990) · Neurology · doi:10.1212/wnl.40.7.1028 · Cited by 106 · see citing works
β-Amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons
Roher, A. E., Ball, M. J., Bhave, S. V., & Wakade, A. R. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91455-l · Cited by 102 · see citing works
Lanahan, A. A., Lyford, G. L., Stevenson, G. S., Worley, P. F., & Barnes, C. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02876.1997 · Cited by 89 · see citing works
Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures
Teter, B., Harris‐White, M. E., Frautschy, S. A., & Cole, G. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00630-7 · Cited by 71 · see citing works
Synaptic β-amyloid precursor proteins increase with learning capacity in rats
Huber, G., Bailly, Y. J. R., Martin, J. R., Mariani, J., & Brugg, B. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00120-6 · Cited by 59 · see citing works
Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain
Beeson, J. G., Shelton, E. R., Chan, H. W., & Gage, F. H. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903420108 · Cited by 49 · see citing works
van Gool, W. A., Schenk, D. B., & Bolhuis, P. A. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90677-7 · Cited by 42 · see citing works
Toward Understanding of the Molecular Basis of Loss of Neuronal Plasticity in Ageing
Mori, N. (1993) · Age and Ageing · doi:10.1093/ageing/22.suppl_1.s5 · Cited by 29 · see citing works
Busciglio, J. A., Ferreira, A., Steward, O., & Cáceres, A. (1987) · Brain Research · doi:10.1016/0006-8993(87)90590-7 · Cited by 28 · see citing works
Apolipoprotein E Role in Maintaining the Integrity of the Aging Central Nervous System
Masliah, E., Mallory, M. E., Alford, M. F., Veinbergs, I., & Roses, A. D. (1996) · Springer eBooks · doi:10.1007/978-3-642-80109-9_6 · Cited by 25 · see citing works
Structure, development, and maintenance of the nerve net of the body column in hydra
Sakaguchi, M., Mizusina, A., & Kobayakawa, Y. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960909)373:1 · Cited by 24 · see citing works
Bondareff, W., Matsuyama, S., & Dell'Albani, P. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980601)52:5 · Cited by 12 · see citing works
Christensen (1997) · doi:10.1002/(sici)1099-1166(199703)12:3
Flagged first, then by citations
2 of the 49 references couldn’t be matched to a known paper.
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<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works
Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2177-05.2005 · Cited by 2,140 · see citing works
Dynamics of Gray Matter Loss in Alzheimer's Disease
Thompson, P. M., Hayashi, K. M., de Zubicaray, G., Janke, A. L., Rose, S. E., Semple, J., Herman, D., Hong, M. S., Dittmer, S. S., Doddrell, D. M., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00994.2003 · Cited by 1,132 · see citing works
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works
Toga, A. W., Thompson, P. M., & Sowell, E. R. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.01.007 · Cited by 872 · see citing works
Turner, P. R., O’Connor, K., Tate, W. P., & Abraham, W. C. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00089-3 · Cited by 751 · see citing works
ApoE genotype accounts for the vast majority of AD risk and AD pathology
Raber, J., Huang, Y., & Ashford, J. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.023 · Cited by 599 · see citing works
Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
Morris, G. P., Clark, I. A., & Vissel, B. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0135-5 · Cited by 522 · see citing works
Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia
Thompson, P. M., Hayashi, K. M., Sowell, E. R., Gogtay, N., Giedd, J. N., Rapoport, J. L., de Zubicaray, G. I., Janke, A. L., Rose, S., Semple, J. M., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.071 · Cited by 396 · see citing works
Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease
de Haan, W., Mott, K. K., van Straaten, E. C. W., Scheltens, P., & Stam, C. J. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002582 · Cited by 389 · see citing works
Brain development and aging: Overlapping and unique patterns of change
Tamnes, C. K., Walhovd, K. B., Dale, A. M., Østby, Y., Grydeland, H., Richardson, G., Westlye, L. T., Roddey, J. C., Hagler, D. J., Due-Tønnessen, P., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.039 · Cited by 287 · see citing works
Thompson, P. M., Hayashi, K. M., Dutton, R. A., Chiang, M., Leow, A., Sowell, E. R., de Zubicaray, G. I., Becker, J. T., López, O. L., Aizenstein, H. J., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.017 · Cited by 250 · see citing works
Maestú, F., de Haan, W., Busche, M. A., & DeFelipe, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101372 · Cited by 235 · see citing works
Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders?
Demirtas-Tatlidede, A., Vahabzadeh-Hagh, A. M., & Pascual-Leone, A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.020 · Cited by 236 · see citing works
Sterniczuk, R., Antle, M. C., LaFerla, F. M., & Dyck, R. H. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.011 · Cited by 228 · see citing works
Hippocampal hyperperfusion in Alzheimer's disease
Alsop, D. C., Casement, M. D., de BAZELAIRE, C., Fong, T. G., & Press, D. Z. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.006 · Cited by 200 · see citing works
Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes
Sterniczuk, R., Dyck, R. H., LaFerla, F. M., & Antle, M. C. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.013 · Cited by 198 · see citing works
Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 188 · see citing works
Neuroplasticity in Alzheimer's disease
Teter, B., & Ashford, J. W. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10441 · Cited by 170 · see citing works
Non-familial Alzheimer's disease is mainly due to genetic factors
Ashford, J. W., & Mortimer, J. A. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4307 · Cited by 153 · see citing works
Amyloid-β Antibody Treatment Leads to Rapid Normalization of Plaque-Induced Neuritic Alterations
Lombardo, J. A., Stern, E. A., McLellan, M. E., Kajdasz, S. T., Hickey, G. A., Bacskai, B. J., & Hyman, B. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10879.2003 · Cited by 149 · see citing works
Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease
Das, R., & Chinnathambi, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03132-2 · Cited by 147 · see citing works
Gardini, S., Venneri, A., Sambataro, F., Cuetos, F., Fasano, F., MARCHI, M. D., Crisi, G., & Caffarra, P. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142547 · Cited by 143 · see citing works
Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia
Collins, J. A., Montal, V., Hochberg, D., Quimby, M., Mandelli, M. L., Makris, N., Seeley, W. W., Gorno‐Tempini, M. L., & Dickerson, B. C. (2016) · Brain · doi:10.1093/brain/aww313 · Cited by 139 · see citing works
Cortical hypermetabolism in MCI subjects: a compensatory mechanism?
Ashraf, A., Fan, Z., Brooks, D. J., & Edison, P. (2014) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2919-z · Cited by 136 · see citing works
Ikonomovic, M., Mufson, E., Wuu, J., Cochran, E., Bennett, D., & DeKosky, S. (2003) · Journal of Alzheimer's Disease · doi:10.3233/jad-2003-5106 · Cited by 145 · see citing works
Changes in Plasticity Across the Lifespan
Oberman, L. M., & Pascual‐Leone, Á. (2013) · Progress in brain research · doi:10.1016/b978-0-444-63327-9.00016-3 · Cited by 125 · see citing works
Loewenstein, D., Acevedo, A., Luis, C. A., Crum, T. A., Barker, W., & Duara, R. (2004) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617704101112 · Cited by 122 · see citing works
Structural MRI and Brain Development
Thompson, P. M., Sowell, E. R., Gogtay, N., Giedd, J. N., Vidal, C. N., Hayashi, K. M., Leow, A., Nicolson, R., Rapoport, J. L., & Toga, A. W. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)67009-2 · Cited by 112 · see citing works
Quadratic trajectories of brain myelin content: unifying construct for neuropsychiatric disorders
Bartzokis, G. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.001 · Cited by 92 · see citing works
Noninvasive brain stimulation to modulate neuroplasticity in traumatic brain injury
Villamar, M. F., Santos Portilla, A., Fregni, F., & Zafonte, R. (2012) · Neuromodulation: Technology at the Neural Interface · doi:10.1111/j.1525-1403.2012.00474.x · Cited by 119 · see citing works
Structural networks in Alzheimer's disease
Reid, A., & Evans, A. C. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.11.010 · Cited by 90 · see citing works
Synaptic dysfunction and oxidative stress in Alzheimer's disease: Emerging mechanisms
Forero, D. A., Casadesús, G., Perry, G. L., & Arboleda, H. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00439.x · Cited by 87 · see citing works
Mapstone, M. E., Lin, F. V., Nalls, M. A., Cheema, A. K., Singleton, A., Fiandaca, M. S., & Federoff, H. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.11.007 · Cited by 84 · see citing works
Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.
Pietropaolo, S., Feldon, J., & Yee, B. K. (2008) · Behavioral Neuroscience · doi:10.1037/a0012520 · Cited by 84 · see citing works
Bigio, E. H., Hynan, L. S., Sontag, E., Satumtira, S., & White, C. L. (2002) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2002.00385.x · Cited by 81 · see citing works
Scherr, M., Utz, L., Tahmasian, M., Pasquini, L., Grothe, M. J., Rauschecker, J. P., Grimmer, T., Drzezga, A. E., Sorg, C., & Riedl, V. (2019) · Human Brain Mapping · doi:10.1002/hbm.24517 · Cited by 73 · see citing works
Bedse, G., Romano, A., Cianci, S., Lavecchia, A. M., Pace, L., Elphick, M. R., LaFerla, F. M., Vendemiale, G., Grillo, C., Fabio Altieri, F., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131910 · Cited by 68 · see citing works
Protective effects of different exercise modalities in an Alzheimer’s disease-like model
Özbeyli, D., Sarı, G., Özkan, N., Karademir-Yilmaz, B., Yüksel, M., Çilingir‐Kaya, Ö. T., & ÇAKIR, Ö. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.044 · Cited by 68 · see citing works
Bellanti, F., Iannelli, G., Blonda, M., Tamborra, R., Villani, R., Romano, A., Calcagnini, S., Mazzoccoli, G., Vinciguerra, M., Gaetani, S., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160942 · Cited by 70 · see citing works
Arsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer’s Disease Model
Niño, S. A., Morales-Martínez, A., Chi-Ahumada, É., Carrizales, L., Salgado‐Delgado, R., Pérez‐Severiano, F., Díaz-Cintra, S. Y., Jiménez-Capdeville, M. E., & Zarazúa, S. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00278 · Cited by 64 · see citing works
Belviranlı, M., & Okudan, N. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.030 · Cited by 60 · see citing works
Shao, Y., Mang, J., Li, P.-L., Wang, J., Deng, T., & Xu, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130831 · Cited by 54 · see citing works
Ally, B. A. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0310-7 · Cited by 57 · see citing works
ApoE-Dependent Plasticity in Alzheimer's Disease
Teter, B. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:167 · Cited by 57 · see citing works
The Neuroprotective Role of Creatine
Klein, A., & Ferrante, R. J. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6486-9_11 · Cited by 56 · see citing works
GAP-43 gene expression regulates information storagePreprint
Holahan, M. R., Honegger, K. S., Tabatadze, N., & Routtenberg, A. (2007) · Learning & Memory · doi:10.1101/lm.581907 · Cited by 56 · see citing works
Adamczuk, K., Weer, A. D., Nelissen, N., Chen, K., Sleegers, K., Bettens, K., Broeckhoven, C. V., Vandenbulcke, M., Thiyyagura, P., Dupont, P. J., et al. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.04.001 · Cited by 55 · see citing works
Traumatic brain injury and its effects on synaptic plasticity
Albensi, B. C., & Janigro, D. (2003) · Brain Injury · doi:10.1080/0269905031000107142 · Cited by 51 · see citing works
Subfield-specific increase in brain growth protein in postmortem hippocampus of Alzheimer's patients
Rekart, J. L., Quinn, B., Mesulam, M. M., & Routtenberg, A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.060 · Cited by 51 · see citing works
Flaherty, L. T. (2013) · Routledge eBooks · doi:10.4324/9780203780589-9 · Cited by 49 · see citing works
The role of synaptic activity in the regulation of amyloid beta levels in Alzheimer's disease
Cheng, X., Wu, J., Geng, M., & Xiong, J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.021 · Cited by 48 · see citing works
Stefanovski, L., Meier, J. M., Pai, R. K., Triebkorn, P., Lett, T. A. P., Martin, L., Bülau, K., Hofmann‐Apitius, M., Solodkin, A., McIntosh, A. R., et al. (2021) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2021.630172 · Cited by 46 · see citing works
The neuritic plaque in Alzheimer's disease: perivascular degeneration of neuronal processes
Hansra, G. K., Popov, G., Banaczek, P. O., Vogiatzis, M., Jegathees, T., Goldsbury, C. S., & Cullen, K. M. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.06.009 · Cited by 47 · see citing works
Neuronal Activity and Amyloid Plaque Pathology: An Update
Ovsepian, S. V., & O’Leary, V. B. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150544 · Cited by 42 · see citing works
Cantanelli, P., Sperduti, S., Ciavardelli, D., Stuppia, L., Gatta, V., & Sensi, S. L. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00200 · Cited by 42 · see citing works
Ross, E. K., Kim, J. P., Settell, M. L., Han, S. R., Blaha, C. D., Min, H.-K. P., & Lee, K. H. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.12.056 · Cited by 42 · see citing works
Toga, A. W., Thompson, P. M., & Sowell, E. R. (2006) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.4.3.378 · Cited by 42 · see citing works
Neurotrophin secretory pathways and synaptic plasticity
Lim, K. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.003 · Cited by 41 · see citing works
Champagne, D. L., Rochford, J. M., & Poirier, J. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.01.016 · Cited by 39 · see citing works
Alzheimer’s Disease: Genes, Pathogenesis and Risk Prediction
Sleegers, K., & van Duijn, C. M. (2001) · Public Health Genomics · doi:10.1159/000064193 · Cited by 39 · see citing works
Hanseeuw, B. J., Dricot, L., Kavec, M., Grandin, C. B. G., Seron, X., & Ivanoiu, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.03.034 · Cited by 38 · see citing works
Klucken, J., McLean, P. J., Gómez‐Tortosa, E., Ingelsson, M., & Hyman, B. T. (2003) · Neurochemical Research · doi:10.1023/a:1026061021946 · Cited by 38 · see citing works
Probing neural circuit mechanisms in Alzheimer’s disease using novel technologies
Grieco, S. F., Holmes, T. C., & Xu, X. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02018-x · Cited by 34 · see citing works
Dubelaar, E. J. G., Mufson, E. J., ter Meulen, W. G., van Heerikhuize, J. J., Verwer, R. W. H., & Swaab, D. F. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000205143.16339.cd · Cited by 33 · see citing works
Baazaoui, N., Flory, M. J., & Iqbal, K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160845 · Cited by 29 · see citing works
Alzheimer’s Disease and Neuronal Network Activity
Gleichmann, M., & Mattson, M. P. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8100-3 · Cited by 28 · see citing works
Lin, X., Chen, L., Baglietto‐Vargas, D., Kamalipour, P., Ye, Q., LaFerla, F. M., Nitz, D. A., Holmes, T. C., & Xu, X. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105562 · Cited by 27 · see citing works
Williams, J. H., Wilcock, G. K., Seeburger, J. L., Dallob, A. L., Laterza, O., Potter, W. Z., & Smith, A. D. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt64 · Cited by 26 · see citing works
Differential expression of LMO4 protein in Alzheimer's disease
Leuba, G., Vernay, A., Vu, D., Walzer, C., Belloir, B., Kraftsik, R., Bouras, C., & Savioz, A. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2003.00511.x · Cited by 23 · see citing works
Cortical Changes in Incipient Alzheimer's Disease
Prestia, A., Drago, V., Rasser, P. E., Bonetti, M., Thompson, P. M., & Frisoni, G. B. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101191 · Cited by 24 · see citing works
Ye, M., Chung, H., An, Y. H., Lim, S.-J., Choi, W., Yu, A., Kim, J. S., Kang, M., Cho, S., Shim, I., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9458-x · Cited by 22 · see citing works
Clinical heterogeneity in familial Alzheimer’s disease
van der Flier, W. M. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30275-7 · Cited by 23 · see citing works
Neill, D. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.06.004 · Cited by 21 · see citing works
Pooler, A. M., Polydoro, M., Wegmann, S., Pitstick, R., Kay, K. R., Sanchez, L., Carlson, G. A., Gómez‐Isla, T., Albers, M. W., Spires‐Jones, T. L., et al. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23411 · Cited by 20 · see citing works
A Scoping Review of Alzheimers Disease Hypotheses: An Array of Uni- and Multi-Factorial Theories
Duchesne, S., Rousseau, L., Belzile, F., Welch, L., Cournoyer, B., Arseneau, M., Lapierre, V., Poulin, S., Potvin, O., & Hudon, C. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230772 · Cited by 19 · see citing works
Haubold, A., Peterson, B. S., & Bansal, R. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02539.x · Cited by 19 · see citing works
Cognitive neural plasticity during learning and recovery from brain damage
Raymont, V., & Grafman, J. H. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)57013-x · Cited by 18 · see citing works
Conducta simbólica y neuroplasticidad: ¿un ejemplo de coevolución gen-cultura?
Soler, E. B., & Carbonell, E. (2004) · Revista de Neurología · doi:10.33588/rn.3901.2004314 · Cited by 16 · see citing works
Roe, J. M., Dídac Vidal-piñeiro, A., Sørensen, Ø., Grydeland, H., Leonardsen, E. H., Iakunchykova, O. P., Pan, M., Mowinckel, A. M., Strømstad, M., Nawijn, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53548-z · Cited by 15 · see citing works
Gürel, B., Cansev, M., Koç, C., Öcalan, B., Çakır, A., Aydın, S., Kahveci, N., Ulus, İ. H., Şahin, B., Karayel‐Basar, M., et al. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190730155926 · Cited by 16 · see citing works
Gardner, M. R., Baruah, V., Vargas, G., Motamedi, M., Milner, T. E., & Rylander, H. G. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.5.18 · Cited by 16 · see citing works
Liang, X., Xue, C., Zheng, D., Yuan, Q., Qi, W., Ruan, Y., chen, S., Song, Y., Wu, H., Lu, X., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1343926 · Cited by 15 · see citing works
Guo, Z., Liu, X., Hou, H., Wei, F., Chen, X., Shen, Y., & Chen, W. (2016) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2016.06.001 · Cited by 15 · see citing works
Fornix Stimulation Induces Metabolic Activity and Dopaminergic Response in the Nucleus Accumbens
Shin, H., Lee, S., Cho, H., Oh, Y., Kim, I. Y., Lee, K. H., Jang, D. P., & Min, H.-K. P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01109 · Cited by 14 · see citing works
Alzheimer's disease approaches - Focusing on pathology, biomarkers and clinical trial candidates
Hroudová, J., & Fišar, Z. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111069 · Cited by 13 · see citing works
Neural network plasticity, BDNF and behavioral interventions in Alzheimer's disease
Hubka, P. (2006) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03656858 · Cited by 12 · see citing works
Cognitive Stimulation: The Evidence Base for its Application in Neurodegenerative Disease
Marco, M. D., Shanks, M. F., & Venneri, A. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140505120145 · Cited by 12 · see citing works
Human Brain Myelination Trajectories Across the Life Span
Sherin, J. E., & Bartzokis, G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00015-4 · Cited by 11 · see citing works
Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex
Liao, K., Liu, D., & Zhu, L. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.11.040 · Cited by 11 · see citing works
Coconut oil ameliorates behavioral and biochemical alterations induced by D-GAL/AlCl3 in rats
Belviranlı, M., & Okudan, N. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148704 · Cited by 8 · see citing works
Reply to Biskup et al. and Tu et al.: Sex differences in metabolic brain aging
Goyal, M. S., Vlassenko, A. G., & Raichle, M. E. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904673116 · Cited by 8 · see citing works
Malignant Synaptic Growth and Alzheimer‘s Disease
Newman, E. L., Shay, C. F., & Hasselmo, M. E. (2012) · Future Neurology · doi:10.2217/fnl.12.47 · Cited by 6 · see citing works
Legrand, D., Roberge, P., Vanasse, A., Carrier, N., & Bocti, C. (2025) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2025.123746 · Cited by 5 · see citing works
PET Imaging of Epigenetic Influences on Alzheimer’s Disease
Couto, P. J., & Millis, R. M. (2015) · International Journal of Alzheimer's Disease · doi:10.1155/2015/575078 · Cited by 19 · see citing works
L’exploration en IRM des démences de type Alzheimer. Que peut-on voir sur un examen de routine ?
Salamon, G., Salamon, N., Johnson, N., Mongkolwat, P., Gitelman, D. R., Weıntraub, S., Mesulam, M. M., & Russell, E. (2004) · Revue Neurologique · doi:10.1016/s0035-3787(04)70848-6 · Cited by 4 · see citing works
Dynamic Mapping of Alzheimer’s Disease
Thompson, P. M., Hayashi, K. M., de Zubicaray, G. I., Janke, A. L., Sowell, E. R., Rose, S., Semple, J. M., Herman, D. H., Hong, M., Dittmer, S. S., et al. (2004) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-59300-0_8 · Cited by 4 · see citing works
National dementia research and development project
Park, S.-H., & Lee, J. (2018) · Journal of Korean Medical Association · doi:10.5124/jkma.2018.61.5.304 · Cited by 3 · see citing works
Alzheimer disease and neuroplasticity: New approaches and new targets in pharmacotherapy
Uzbay, T. I. (2012) · MARMARA PHARMACEUTCAL JOURNAL · doi:10.12991/201216404 · Cited by 3 · see citing works
- Authors
- MESULAM, M. ‐.
- Affiliations
- Northwestern University (US)
- Corresponding author
- MESULAM, M.‐MARSEL
- ORCID
- MESULAM, M.‐MARSEL
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2000-12
- Volume
- 924
- Issue
- 1
- Pages
- 42-52
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2061837100
- Cited by
- 130
- References
- 49
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 7 · 2021: 6 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 10
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns020285-15)
- National Institute on Aging (AG13854, P30AG013854)
- National Institute of Neurological Disorders and Stroke (NS 20285)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease pathogenesis, neuroplasticity, amyloid plaques, neurofibrillary tangles, tau phosphorylation, amyloid precursor protein, synaptic loss, neurodegeneration, genotype-phenotype correlation
- MeSH terms
- Alzheimer Disease, Brain, Humans, Neuronal Plasticity
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