Cited by 114Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchDementia and Cognitive Impairment Research

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The dendritic hypothesis for Alzheimer's disease pathophysiology

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Cochran, J. Nicholas, Hall, Alicia M., Roberson, Erik D.·2014·Brain Research Bulletin

DOI 10.1016/j.brainresbull.2013.12.004PMC PMC3989444

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Abstract

Converging evidence indicates that processes occurring in and around neuronal dendrites are central to the pathogenesis of Alzheimer's disease. These data support the concept of a "dendritic hypothesis" of AD, closely related to the existing synaptic hypothesis. Here we detail dendritic neuropathology in the disease and examine how Aβ, tau, and AD genetic risk factors affect dendritic structure and function. Finally, we consider potential mechanisms by which these key drivers could affect dendritic integrity and disease progression. These dendritic mechanisms serve as a framework for therapeutic target identification and for efforts to develop disease-modifying therapeutics for Alzheimer's disease.

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2 retracted

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Authors: Cochran, J. N., Hall, A. M., & Roberson, E. D.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Roberson, Erik D.
ORCID: Cochran, J. Nicholas
Hall, Alicia M.
Roberson, Erik D.
Venue: Brain Research Bulletin
Publisher: Elsevier BV
Published: 2014-04
Volume: 103
Pages: 18-28
ISSN: 0361-9230 (ISSN-L)
DOI: 10.1016/j.brainresbull.2013.12.004
PMC: PMC3989444
OpenAlex: W2046296412
Cited by: 114
References: 225
Citations by year: 2026: 5 · 2025: 3 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 5 · 2018: 6 · 2017: 13 · 2016: 9 · 2015: 12 · 2014: 4
FWCI: 0.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Research Bulletin (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (T32GM008111)
National Institute of Neurological Disorders and Stroke (R01NS075487, T32NS061788)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, dendrites, amyloid-beta, tau protein, genetic risk factors, disease-modifying therapy, therapeutic target
MeSH terms: Alzheimer Disease, Animals, Dendrites, Humans, Amyloid beta-Peptides, Neurites, Tauopathies

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The dendritic hypothesis for Alzheimer's disease pathophysiology

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