Cited by 140Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionCholinesterase and Neurodegenerative Diseases

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Can herbs provide a new generation of drugs for treating Alzheimer’s disease?

Anekonda, Thimmappa S., Reddy, P. Hemachandra·2005·Brain Research Reviews

DOI 10.1016/j.brainresrev.2005.09.001

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Abstract

The overall aim of this review is to discuss cellular mechanisms at work in the progression of AD and current therapeutic strategies for treating AD, with a focus on the potential efficacy of herbal treatments. Recent advances in molecular, cellular, and animal model studies have revealed that formation of the 4-kDa amyloid beta peptide is a key factor in the development and progression of AD. Several cellular changes have been identified that are related to amyloid beta plaques and neurofibrillary tangles found in the autopsied brains of AD patients and in AD animal models. Several therapeutic strategies have been developed to treat AD, including anti-inflammatory, anti-oxidant, and anti-amyloid approaches. Recently, herbal treatments have been tested in animal and cellular models of AD and in clinical trials with AD subjects. In AD animal models and cell models, herbal extracts appear to have fewer adverse effects than beneficial effects on A beta and cognitive functions. These extracts have multi-functional properties (pro-cholinergic, anti-oxidant, anti-amyloid, and anti-inflammatory), and their use in the treatment of AD patients looks promising. The chemical compositions of herbs and their potential for alleviating or reducing symptoms of AD or for affecting the disease mechanism need to be further studied.

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Authors: Anekonda, T. S., & Reddy, P. H.
Affiliations: Oregon Health & Science University (US)
Corresponding author: Reddy, P. Hemachandra
ORCID: Reddy, P. Hemachandra
Venue: Brain Research Reviews
Publisher: Elsevier BV
Published: 2005-12
Volume: 50
Issue: 2
Pages: 361-376
ISSN: 0165-0173 (ISSN-L)
DOI: 10.1016/j.brainresrev.2005.09.001
OpenAlex: W1991124307
Cited by: 140
References: 176
Citations by year: 2026: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 10 · 2013: 10 · 2012: 6
FWCI: 0.75
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r03ag022643-01)
National Institute on Aging (AG 22643)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: Alzheimer's disease, herbal medicine, amyloid-beta, amyloid plaques, neurofibrillary tangles, anti-amyloid therapy, anti-inflammatory therapy, antioxidant therapy, cognitive function, plant extracts, animal models of Alzheimer's disease
MeSH terms: Alzheimer Disease, Animals, Antioxidants, Disease Models, Animal, Humans, Plant Extracts, Herbal Medicine

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