Tumor microenvironment and therapeutic response

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Microenvironmental regulation of tumor progression and metastasis

Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994

Macrophage Diversity Enhances Tumor Progression and Metastasis

Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759

Coordinated regulation of myeloid cells by tumours

Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544

Immunogenic Cell Death in Cancer Therapy

Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384

Synthesis and anti-hepatocellular carcinoma evaluation of salicylic acid-modified indole trimethoxy flavonoid derivatives

Zou, Y., Lü, N., Yang, X., Xie, Z., Lei, X., Liu, X., Li, Y., Sheng, H., Tang, G., & Wang, Z. (2023) · RSC Medicinal Chemistry · doi:10.1039/d3md00128h · Cited by 10

The development of an anti-cancer peptide M1-21 targeting transcription factor FOXM1

Cheng, H., Yuan, J., Pei, C., Ouyang, M., Bu, H., Chen, Y., Huang, X., Zhang, Z., Li, Y., & Tan, Y. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01059-7 · Cited by 10

Extracellular matrix remodelling and stiffening contributes to tumorigenesis of salivary carcinoma ex pleomorphic adenoma——A study based on patient-derived organoids

Chen, W., Gu, T., Chen, Q., Qu, C., Zhang, C., Hu, Y., Xia, R., Zhang, Y., Wang, M., Huang, X., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01071-x · Cited by 10

Integrated analysis of FKBP1A/SLC3A2 axis in everolimus inducing ferroptosis of breast cancer and anti-proliferation of T lymphocyte

Chen, Z., Li, R., Fang, M., Wang, Y., Bi, A., Yang, L., Song, T., Li, Y., Li, Q., Lin, B., et al. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.84872 · Cited by 10

A role for platelets in metabolic reprogramming of tumor-associated macrophages

Kang, Y., Amoafo, E. B., Entsie, P., Beatty, G. L., & Liverani, E. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1250982 · Cited by 10

Integrated analysis of single-cell and bulk RNA-sequencing reveals a novel signature based on NK cell marker genes to predict prognosis and immunotherapy response in gastric cancer

Sun, J.-R., Kong, C., Ye, Y., Wang, Q., Qu, X.-K., Jia, L., & Wu, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-57714-7 · Cited by 12

PD-L2 drives resistance to EGFR-TKIs: dynamic changes of the tumor immune environment and targeted therapy

Wang, S., Su, D., Chen, H., Lai, J.-C., Tang, C., Yu, L., Wang, Y., Yang, Y., Qin, M., Jia, L., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01317-2 · Cited by 10

Smart Microenvironment-Responsive Organocopper(II) Supramolecular Polymers to Regulate the Stability and Anticancer Efficacy by Different Substituents

Lai, L., Xiong, Z., Ma, L., & Chen, T. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c09919 · Cited by 10

CTLA-4 immunotherapy exposes differences in immune response along with different tumor progression in colorectal cancer

Fu, X., Luo, H., Zheng, Y., Wang, S., Zhong, Z., Wang, Y., & Yang, Y. (2020) · Aging · doi:10.18632/aging.103765 · Cited by 10

Gene expression and DNA methylation analyses suggest that two immune related genes are prognostic factors of colorectal cancer

Xing, X., Yao, Z.-Y., Xing, C., Huang, Z., Peng, J., & Liu, Y. (2021) · BMC Medical Genomics · doi:10.1186/s12920-021-00966-3 · Cited by 10

Identification of biomarkers, pathways and potential therapeutic target for docetaxel resistant prostate cancer

Liu, R., Li, S., Liu, L.-Q., Xu, B., & Chen, M. (2021) · Bioengineered · doi:10.1080/21655979.2021.1936831 · Cited by 10

Prognostic and immunological significance of metastasis associated lung adenocarcinoma transcript 1 among different kinds of cancers

Guo, L., Zhang, X., Pan, H., Li, Y., Wang, J., Li, L., Dong, Y., Du, X., Chen, J., & Guo, F. (2021) · Bioengineered · doi:10.1080/21655979.2021.1955511 · Cited by 10

Tumor microenvironment is not an ‘innocent bystander’ in the resistance to treatment of head and neck cancers (Review)

Mazilu, L., Suceveanu, A., Stănculeanu, D. L., Gheorghe, A. D., Fricatel, G., & Negru, Ș.-M. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10562 · Cited by 10

Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma

Zheng, B., Xie, F., Cheng, F., Wang, J., Yao, Z., He, W., & Niu, Z. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.760031 · Cited by 10

Role of the CBX Molecular Family in Lung Adenocarcinoma Tumorigenesis and Immune Infiltration

Zhang, C., Chang, L., Yao, Y., Chao, C., Ge, Z., Fan, C., Yu, H., Wang, B., & Yang, J. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.771062 · Cited by 10

Development of a Prognostic Model Based on Pyroptosis-Related Genes in Pancreatic Adenocarcinoma

Su, K., Peng, Y., & Yu, H. (2022) · Disease Markers · doi:10.1155/2022/9141117 · Cited by 10

Promoting Best Practice in Cancer Care in Sub Saharan Africa

Sharma, K., Sayed, S., & Saleh, M. N. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.950309 · Cited by 10

G‐quadruplex‐enhanced circular single‐stranded DNA ( G4‐CSSD ) adsorption of miRNA to inhibit colon cancer progression

Wu, H., Zhong, W., Zhang, R., Ding, Y., Sun, B., Qu, C., Lai, K., Pang, Z., Yin, S., Sun, T., et al. (2023) · Cancer Medicine · doi:10.1002/cam4.5721 · Cited by 10

Renewed interests in carbonic anhydrase IX in relevance to breast cancer treatment

Dolatkhah, M., & Omidi, Y. (2019) · Bioimpacts · doi:10.15171/bi.2019.24 · Cited by 10

Identification of Immune Subtypes of Esophageal Adenocarcinoma to Predict Prognosis and Immunotherapy Response

Chen, L., Zhou, X., Gao, Y., & Sui, X. (2022) · Pharmaceuticals · doi:10.3390/ph15050605 · Cited by 9

Identification of an Immune-Related Prognostic Risk Model in Glioblastoma

Lin, Z., Wang, R., Huang, C., He, H., OuYang, C., Li, H., Zhong, Z., Guo, J., Chen, X., Yang, C., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.926122 · Cited by 9

Identification and Validation of Prognostic Related Hallmark ATP-Binding Cassette Transporters Associated With Immune Cell Infiltration Patterns in Thyroid Carcinoma

Wang, L., Sun, X.-D., He, J., & Liu, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.781686 · Cited by 9

High expression of RNF169 is associated with poor prognosis in pancreatic adenocarcinoma by regulating tumour immune infiltration

Wang, J., Chen, H., Deng, Q., Chen, Y., Wang, Z., Yan, Z., Wang, Y., Tang, H.-X., Liang, H., & Jiang, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.1022626 · Cited by 9

Role of Epiregulin in Lung Tumorigenesis and Therapeutic Resistance

Sunaga, N., Miura, Y., Masuda, T., & Sakurai, R. (2024) · Cancers · doi:10.3390/cancers16040710 · Cited by 9

Tumor Microenvironment Modulates Invadopodia Activity of Non-Selected and Acid-Selected Pancreatic Cancer Cells and Its Sensitivity to Gemcitabine and C18-Gemcitabine

Carvalho, T. M. A., Audero, M. M., Greco, M. R., Ardone, M., Maggi, T., Mallamaci, R., Rolando, B., Arpicco, S., Ruffinatti, F. A., Fiorio, A., et al. (2024) · Cells · doi:10.3390/cells13090730 · Cited by 9

Spatial proteomic profiling of tumor and stromal compartments in non‐small‐cell lung cancer identifies signatures associated with overall survival

Naei, V. Y., Monkman, J. H., Sadeghirad, H., Mehdi, A. M., Blick, T., Mullally, W. J., O'Byrne, K. J., Warkiani, M. E., & Kulasinghe, A. (2024) · Clinical & Translational Immunology · doi:10.1002/cti2.1522 · Cited by 9

Manganese-doped carbon dots with catalase-like activity enable MRI-guided enhanced photodynamic therapy

Wang, H., Chu, D., Zhang, M., Huang, X., Shi, Y., Zhao, Y. Y., Qu, H., Li, D., Xu, Z., Gao, L., et al. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114398 · Cited by 9

SLC2A3 promotes head and neck squamous cancer developing through negatively regulating CD8+ T cell in tumor microenvironment

Jiang, W., Xu, S. Y., Zhao, M., & Li, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-79417-9 · Cited by 9

Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction

Lyu, F., Zhong, Y., He, Q., Xiao, W., & Zhang, X. (2025) · BMC Cancer · doi:10.1186/s12885-025-13534-0 · Cited by 9

4D printed hydrogels for precision delivery of bioactive molecules in cancer

Gato-Diaz, U., Concheiro, Á., Alvarez‐Lorenzo, C., & Blanco‐Fernandez, B. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2539959 · Cited by 9

Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery

Zeng, T., Chen, L., Yoshitomi, T., Kawazoe, N., Yang, Y., & Chen, G. (2025) · Biomedicines · doi:10.3390/biomedicines13081899 · Cited by 10

Integrating Peritumoral and Intratumoral Radiomics with Deep Learning for Preoperative Prediction of Lymphovascular Invasion in Invasive Breast Cancer Using DCE-MRI

Zhao, Q., Zhang, H., & Xing, W. (2025) · Technology in Cancer Research & Treatment · doi:10.1177/15330338251374945 · Cited by 9

Human sperm-associated antigen 4 as a potential prognostic biomarker of lung squamous cell carcinoma

Wang, Y., Tang, Y., Li, J., Wang, D., & Li, W. (2021) · Journal of International Medical Research · doi:10.1177/03000605211032807 · Cited by 9

The Immune Subtype Contributes to Distinct Overall Survival for Ovarian Cancer Patients With Platinum-Based Adjuvant Therapy

Li, Y., Wang, H., Chen, M., & Ma, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.872991 · Cited by 9

Pan-Cancer Analysis and Experimental Validation Identify ACOT7 as a Novel Oncogene and Potential Therapeutic Target in Lung Adenocarcinoma

Zheng, C., Zhang, G., Xie, K., Diao, Y., Luo, C., Wang, Y., Shen, Y., & Xue, Q. (2022) · Cancers · doi:10.3390/cancers14184522 · Cited by 9

The Relationship between the Prognostic Marker LIMA1 in Head and Neck Squamous Cell Carcinoma and Immune Infiltration

Huang, H., Du, Y., Zhao, D., & Chen, K. (2022) · Journal of Oncology · doi:10.1155/2022/1040116 · Cited by 9

Anticancer Tetrahydrocarbazoles: A Wide Journey from 2000 Till Date

Kumar, N., & Gupta, P. (2022) · Letters in Drug Design & Discovery · doi:10.2174/1570180820666221028163319 · Cited by 9

SEVs-mediated miR-6750 transfer inhibits pre-metastatic niche formation in nasopharyngeal carcinoma by targeting M6PR

Zhang, C., Chen, W., Pan, S. Y., Zhang, S., Xie, H., Zhang, Z., Lei, W., Bao, L., & You, Y. (2023) · Cell Death Discovery · doi:10.1038/s41420-022-01262-4 · Cited by 9

Study on the effect and mechanisms of piperine against cervical cancer based on network pharmacology and experimental validation

Cheng, H. W., Li, Y., Cheng, J., Zhang, Y., & Zhang, B. (2023) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2023.2217611 · Cited by 9

Non-coding RNA therapeutics: Towards a new candidate for arsenic-induced liver disease

Sun, J., Wu, L., Wu, M., Liu, Q., & Cao, H. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110626 · Cited by 9

iPSC-Derived Glioblastoma Cells Have Enhanced Stemness Wnt/β-Catenin Activity Which Is Negatively Regulated by Wnt Antagonist sFRP4

Yasmin, I. A., Dharmarajan, A., & Warrier, S. R. (2023) · Cancers · doi:10.3390/cancers15143622 · Cited by 9

Deep pan-cancer analysis and multi-omics evidence reveal that ALG3 inhibits CD8+ T cell infiltration by suppressing chemokine secretion and is associated with 5-fluorouracil sensitivity

Wu, Z., Su, R., Dai, Y., Wu, X. F., Wu, H., Wang, X., Wang, Z., Bao, J., Chen, J., & Xia, E. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108666 · Cited by 9

Dissecting prostate Cancer: Single-Cell insight into Macrophage Diversity, molecular Prognosticators, and the role of Peptidylprolyl Isomerase F

Guan, B., Huang, C., Meng, L., Zhang, S., Liu, Q., Wang, X., Li, X., & Hao, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112599 · Cited by 9

Application value of CyTOF 2 mass cytometer technology at single-cell level in human gastric cancer cells

Han, S., Jiang, X., Sun, X., Zhang, H., Li, C., Zhao, Z., & Yu, W. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111568 · Cited by 9

LDOC1 as Negative Prognostic Marker for Vulvar Cancer Patients

Wanka, G., Schmoeckel, E., Mayr, D. C., Fuerst, S., Kühn, C., Mahner, S., Knabl, J., Karsten, M. M., Dannecker, C., Heidegger, H. H., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239287 · Cited by 9

Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment

Wei, T., Song, J., Liang, K., Li, L., Mo, X., Huang, Z., Chen, G., Mao, N., & Yang, J. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03489-z · Cited by 9

Multifunctional modification of Fe3O4 nanoparticles for diagnosis and treatment of diseases: A review

Qin, M., Xu, M., Niu, L., Cheng, Y., Niu, X., Kong, J., Zhang, X., Wei, Y., & Huang, D. (2021) · Frontiers of Materials Science · doi:10.1007/s11706-021-0543-y · Cited by 9

Characterization of Immune Infiltration and Construction of a Prediction Model for Overall Survival in Melanoma Patients

Li, G., Zhu, X., & Liu, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.639059 · Cited by 9

Tumor Margin Contains Prognostic Information: Radiomic Margin Characteristics Analysis in Lung Adenocarcinoma Patients

Lee, G., Park, H., Lee, H. Y., Ahn, J., Sohn, I., Lee, S.-H., & Kim, J. (2021) · Cancers · doi:10.3390/cancers13071676 · Cited by 9

T Cells Expressing Receptor Recombination/Revision Machinery Are Detected in the Tumor Microenvironment and Expanded in Genomically Over-unstable Models

Morello, G., Cancila, V., Rosa, M. L., Germano, G., Lecis, D., Amodio, V., Zanardi, F., Iannelli, F., Greco, D., Paglia, L. L., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0645 · Cited by 10

Genomic stratification based on microenvironment immune types and PD-L1 for tailoring therapeutic strategies in bladder cancer

Lyu, X., Wang, P., Qiao, Q., & Jiang, Y. (2021) · BMC Cancer · doi:10.1186/s12885-021-08350-1 · Cited by 9

Magnetite Fe3O4 Nanoparticles Enhance Mild Microwave Ablation of Tumor by Activating the IRE1-ASK1-JNK Pathway and Inducing Endoplasmic Reticulum Stress

Li, S., Liu, Y., Liu, X., Lan, B., Li, W., & Guo, F. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s312823 · Cited by 9

Pan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker

Zhao, C., Liu, Y., Ju, S., & Wang, X. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s331752 · Cited by 9

The Antitumoral Effect of Paris Saponin II on Head and Neck Squamous Cell Carcinomas Mediated via the Nitric Oxide Metabolic Pathway

Qi, W., Zhu, F., Wang, M., Teng, Z., Xu, R., Xi, Y., Meng, Q., Wu, X., Zhao, H., Ma, M., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.803981 · Cited by 9

A Prognostic Model of Colon Cancer Based on the Microenvironment Component ScoreviaSingle Cell Sequencing

Liu, Y., Liu, X., Xu, Q.-L., Gao, X., & Linghu, E. (2022) · In Vivo · doi:10.21873/invivo.12762 · Cited by 9

Tumor Microenvironment-Mediated Immune Profiles Characterized by Distinct Survival Outcome and Immunotherapeutic Efficacy in Breast Cancer

Xu, L., Hu, Y., & Liu, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.840348 · Cited by 9

Liquid biopsy for the assessment of adrenal cancer heterogeneity: where do we stand?

Perge, P., Nyírő, G., Vékony, B., & Igaz, P. (2022) · Endocrine · doi:10.1007/s12020-022-03066-z · Cited by 10

An Immune Signature for Risk Stratification and Therapeutic Prediction in Helicobacter pylori-Infected Gastric Cancer

Geng, H., Dong, Z., Zhang, L., Yang, C. G., Li, T., Lin, Y., Ke, S., Xia, X., Zhang, Z., Zhao, G., et al. (2022) · Cancers · doi:10.3390/cancers14133276 · Cited by 9

Inflammatory Microenvironment in Early Non-Small Cell Lung Cancer: Exploring the Predictive Value of Radiomics

Perrone, M., Raimondi, E., Costa, M., Rasetto, G., Rizzati, R., Lanza, G., Gafà, R., Cavallesco, G., Tamburini, N., Maniscalco, P., et al. (2022) · Cancers · doi:10.3390/cancers14143335 · Cited by 8

Comparative characteristics of small cell lung cancer and Ewing’s sarcoma: a narrative review

Hamilton, G. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-22-58 · Cited by 9

Prostate Cancer Secretome and Membrane Proteome from Pten Conditional Knockout Mice Identify Potential Biomarkers for Disease Progression

dos Santos, N. J., Camargo, A. C. L., Carvalho, H. F., Justulin, L. A., & Felisbino, S. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169224 · Cited by 9

Characterization of the Tumor Microenvironment in Osteosarcoma Identifies Prognostic- and Immunotherapy-Relevant Gene Signatures

Tan, J., Xuhui, F., Wu, H., Yang, B., Shi, M., Xie, C. L., Su, Z., Li, L., Luo, M., Zuo, Z., et al. (2022) · Journal of Immunology Research · doi:10.1155/2022/6568278 · Cited by 9

An evaluation of KIF20A as a prognostic factor and therapeutic target for lung adenocarcinoma using integrated bioinformatics analysis

Sun, D., Zhang, H., Zhang, C., & Wang, L. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.993820 · Cited by 9

Identification and Analysis of Crucial Genes in H. pylori-Associated Gastric Cancer Using an Integrated Bioinformatics Approach

Ding, W., Jiang, H., Ye, N., Zhuang, L., Yuan, Z., Tan, Y., Xue, W., & Xu, X. (2023) · Journal of Oncology · doi:10.1155/2023/8538240 · Cited by 9

Sterol regulatory element binding transcription factor 1 promotes proliferation and migration in head and neck squamous cell carcinoma

Tan, M., Li, X., Chen, H., Ye, W., Yi, J., Li, C., Liu, J., & Su, J. (2023) · PeerJ · doi:10.7717/peerj.15203 · Cited by 9

The ratiometric fluorescence nanoparticle based on SiRB for pH detection of tumor

Wang, Q., Ding, X., Wang, Y., Du, Q., Xu, T., Du, B., & Yao, H. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.03.015 · Cited by 9

Amplification of 7p12 Is Associated with Pathologic Nonresponse to Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer

Pichler, R., Lindner, A. K., Compérat, É., Obrist, P., Schäfer, G., Todenhöfer, T., Horninger, W., Čulig, Z., & Untergasser, G. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.10.018 · Cited by 9

Reactive oxygen species-sensitive nanophotosensitizers of aminophenyl boronic acid pinacol ester conjugated chitosan- g -methoxy poly(ethylene glycol) copolymer for photodynamic treatment of cancer

Jeong, Y., Kim, T., Hwang, E. J., Kim, S., Sonntag, K., Kim, D. H., & Koh, J. W. (2020) · Biomedical Materials · doi:10.1088/1748-605x/ab9bb2 · Cited by 9

Identification of Immune-Related Cells and Genes in Tumor Microenvironment of Clear Cell Renal Cell Carcinoma

Du, B., Zhou, Y., Yi, X., Zhao, T., Tang, C., Shen, T., Zhou, K., Wei, H., Xu, S. H., Dong, J., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01770 · Cited by 9

A Rapid and Specific HPLC Method to Determine Chemical and Radiochemical Purity of [68>Ga]Ga-DOTA-Pentixafor (PET) Tracer: Development and Validation

Migliari, S., Sammartano, A., Scarlattei, M., Baldari, G., Silva, C., & Ruffini, L. (2020) · Current Radiopharmaceuticals · doi:10.2174/1874471013666200929125102 · Cited by 9

Hierarchical Clustering of Cutaneous Melanoma Based on Immunogenomic Profiling

Yu, J., Xie, M., Ge, S., Chai, P., Zhou, Y., & Ruan, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.580029 · Cited by 9

An Immune Cell Signature Is Associated With Disease-Free Survival and Adjuvant Chemosensitivity of Patients With Resectable Gastric Cancer

Yan, H., Chen, Y., Yang, Z., Li, Z., Che, X., Xiao, J., Liu, Y., & Qu, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.621623 · Cited by 9

Development of a lncRNA‐based prognostic signature for oral squamous cell carcinoma

Xu, Z., Li, X., Pan, L., Tan, R., Ji, P., & Tang, H. (2022) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.13281 · Cited by 9

Real‐world effectiveness of regorafenib in the treatment of patients with metastatic colorectal cancer: A retrospective, observational study

Wang, H., Liu, W., Zhao, Y., Hu, H., Zhang, B., & Yang, S. (2022) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13909 · Cited by 8

Construction and validation of a bladder cancer risk model based on autophagy-related genes

Shen, C., Yan, Y., Yang, S., Wang, Z., Wu, Z., Li, Z., Zhang, Z., Lin, Y., Li, P., & Hu, H. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-022-00957-2 · Cited by 8

Lactate oxidase/vSIRPα conjugates efficiently consume tumor-produced lactates and locally produce tumor-necrotic H2O2 to suppress tumor growth

Kang, Y., Yeo, M., Choi, H., Jun, H., Eom, S., Park, S. G., Yoon, H., Kim, E., & Kang, S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123577 · Cited by 8

Immune infiltration related CENPI associates with the malignant features and drug resistance of lung adenocarcinoma

Feng, Z., Cui, G., Tan, J., Liu, P., Chen, Y., Jiang, Z., Han, Y., Zeng, S., Shen, H., & Cai, C. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167017 · Cited by 8

Therapy-naïve malignancy causes cardiovascular disease: a state-of-the-art cardio-oncology perspective

Ogilvie, L. M., Coyle‐Asbil, B., Brunt, K. R., Petrik, J., & Simpson, J. A. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00795.2023 · Cited by 9

CAF ‐secreted COL5A2 activates the PI3K / AKT pathway to mediate erlotinib resistance in head and neck squamous cell carcinoma

Guo, Y., Chen, M., Yang, J., Zhou, W., Feng, G., Wang, Y., Ji, T., Zhang, Y., & Liu, Z. (2024) · Oral Diseases · doi:10.1111/odi.15130 · Cited by 8

Fructose-1,6-bisphosphatase 1 in cancer: Dual roles, mechanistic insights, and therapeutic potential – A comprehensive review

Song, Q., Sui, J., Yang, Y., Zhang, H., Li, Y., & Yang, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139273 · Cited by 9

Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment

Feng, Y., Qiu, D., He, Y., Jin, H., Chen, L., Xi, F., Hu, Z., Xie, Y., Li, Y., Lin, H.-T., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1502349 · Cited by 8

A comprehensive pan-cancer examination of transcription factor MAFF: Oncogenic potential, prognostic relevance, and immune landscape dynamics

Cai, F., Mao, S., Peng, S., Wang, Z., Li, W., Zhang, R., Zhang, S., Sun, A., & Zhang, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114105 · Cited by 8

Erianin inhibits cell migration and induces apoptosis by inhibiting VEGF-α/PI3K/AKT signaling pathway in malignant melanoma

Sun, H., Wang, G., Ren, C., Zhang, X., Zhao, P., & Guo, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-99383-0 · Cited by 8

Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer

Hartner, S., Abolfathi, H., Rezanejad, M., Liu, B., Karimi, E., Rogers, D., Sorin, M., Doré, S., Desharnais, L., Orain, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63465-4 · Cited by 10

Esophageal cancer: from pathogenesis to precision therapies

Zhang, S., Shen, Y., Zhu, L., Lai, Y., Zhu, L. C., Xiao, X., Li, J., Tan, W., Lin, D., & Wu, C. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02614-7 · Cited by 12

Novel tumour–infiltrating lymphocyte-related risk stratification based by flow cytometry for patients with de novo angioimmunoblastic T cell lymphoma

Zhu, Q., Deng, X., Yao, W., Chen, Z., Ye, Y., Gao, L., Zhang, W., Liu, W., & Zhao, S. (2021) · Annals of Hematology · doi:10.1007/s00277-020-04389-5 · Cited by 8

ALK is frequently phosphorylated in Merkel cell carcinoma and associates with longer survival

Jaatinen, J., Veija, T., Salmikangas, M., Böhling, T., Sihto, H. J., & Koljonen, V. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252099 · Cited by 8

Tumor Cell Secretomes in Response to Anti- and Pro-Tumorigenic Agents

Liu, S., Sun, X., Li, K., Lin, C., Na, S., Li, B., & Yokota, H. (2021) · Onco · doi:10.3390/onco1020009 · Cited by 8

Pyroptosis patterns of colon cancer could aid to estimate prognosis, microenvironment and immunotherapy: evidence from multi-omics analysis

Zhou, J., Guo, H., Liu, L., Feng, M.-L., Yang, X., & Hao, S. (2022) · Aging · doi:10.18632/aging.204302 · Cited by 8

Prediction of prognosis, immune infiltration and immunotherapy response with N6-methyladenosine-related lncRNA clustering patterns in cervical cancer

Jia, H., Cao, M., Hao, S., Wang, J., & Wang, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-20162-2 · Cited by 8

Immune and non-immune cell subtypes identify novel targets for prognostic and therapeutic strategy: A study based on intratumoral heterogenicity analysis of multicenter scRNA-seq datasets in lung adenocarcinoma

Fan, T., Lü, J., Niu, D., Zhang, Y., Wang, B., Zhang, B., Zhang, Z., He, X., Peng, N., Li, B., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1046121 · Cited by 8

Cancer-Associated Fibroblasts Affect Tumor Metabolism and Immune Microenvironment in Gastric Cancer and Identification of Its Characteristic Genes

Gao, C., Liu, F., Ye, Q., & Guo, A. (2023) · Journal of Oncology · doi:10.1155/2023/1424589 · Cited by 8

TIPE2 acts as a tumor suppressor and correlates with tumor microenvironment immunity in epithelial ovarian cancer

Xu, S., Gao, X., Qiu, J., Hong, F., Gao, F., Wang, X., & Zhang, S. (2023) · Aging · doi:10.18632/aging.204529 · Cited by 8

A large-scale screening and functional sorting of tumour microenvironment prognostic genes for breast cancer patients

Xiao, B., Li, M., Cui, M., Yin, C., & Zhang, B. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1131525 · Cited by 8

A pH‑responsive hyaluronic acid nano‑vehicle co‑encapsulating doxorubicin and all‑trans retinoic acid for the inhibition of hepatic stellate cell‑induced tumor growth and metastasis

Qiao, L., Gong, X., Jia, G., Wu, J., Liu, S., Song, K., & Tian, G. (2023) · Molecular Medicine Reports · doi:10.3892/mmr.2023.13029 · Cited by 8

TME-targeting nano-theranostic agent for NIR fluorescence diagnosis and O2-economized PDT-based multimodal synergistic therapy

Meng, C., Xie, X., Qian, J., Tao, W., Wu, H., Ji, D., Gao, G., Wang, R., Ling, C., Zhang, Y., et al. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.112251 · Cited by 8

Tumorigenic effects of human mesenchymal stromal cells and fibroblasts on bladder cancer cells

Frerichs, L. M., Frerichs, B., Petzsch, P., Köhrer, K., Windolf, J., Bittersohl, B., Hoffmann, M. J., & Grotheer, V. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1228185 · Cited by 9

Identification and validation of a ferroptosis-related signature for prediction of the prognosis and tumor microenvironment in patients with chromophobe renal cell carcinoma

Liu, S., Yao, Y., Hou, M., Mei, J., Sun, L., & Zhang, G. (2023) · BMC Cancer · doi:10.1186/s12885-023-11589-5 · Cited by 8

Identification of a Novel Oxidative Stress- and Anoikis-Related Prognostic Signature and Its Immune Landscape Analysis in Non-Small Cell Lung Cancer

Zhao, H., Huang, Y., Tong, G., Wu, W., & Ren, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216188 · Cited by 8

Exploring the Immune Landscape of ccRCC : Prognostic Signatures and Therapeutic Implications

Pan, M., Xu, X., Zhang, D., & Cao, W. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70212 · Cited by 8

Microenvironmental regulation of therapeutic response in cancer

Klemm, F., & Joyce, J. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.006 · Cited by 795

Tumor microenvironment as a therapeutic target in cancer

Xiao, Y. Q., & Yu, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107753 · Cited by 2,026

From immune exclusion to exhaustion: tumor microenvironment drives therapy response

Maletin, N. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1785587 · Cited by 16

Tumor Microenvironment and Drug Response: A Pathology–pharmacology Perspective on Mechanisms of Therapeutic Resistance

Ravichandran, S., & Vilvanathan, S. (2026) · doi:10.9734/ajmpcp/2026/v9i1402

Potential Strategies to Improve the Effectiveness of Drug Therapy by Changing Factors Related to Tumor Microenvironment

Cao, D., Naiyila, X., Li, J., Huang, Y. C., Chen, Z., Chen, B., Li, J., Guo, J., Dong, Q., Ai, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.705280 · Cited by 7