Tumor microenvironment and therapeutic response

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Microenvironmental regulation of tumor progression and metastasis

Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994

Macrophage Diversity Enhances Tumor Progression and Metastasis

Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759

Coordinated regulation of myeloid cells by tumours

Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544

Immunogenic Cell Death in Cancer Therapy

Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384

Race as a Contributor to Stromal Modulation of Tumor Progression

Kakarla, M., ChallaSivaKanaka, S., Hayward, S. W., & Franco, O. E. (2021) · Cancers · doi:10.3390/cancers13112656 · Cited by 20

Identification of Immune-Related Subtypes and Characterization of Tumor Microenvironment Infiltration in Bladder Cancer

Huang, M., Liu, L., Zhu, J., Jin, T., Chen, Y., Xu, L., Cheng, W., Ruan, X., Su, L., Meng, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.723817 · Cited by 20

A Pan-Cancer Analysis Reveals the Prognostic and Immunotherapeutic Value of ALKBH7

Chen, K., Shen, D., Tan, L., Lai, D., Han, Y., Gu, Y., Lu, C., & Gu, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.822261 · Cited by 22

Systematic evaluation of the prognostic and immunological role of PDLIM2 across 33 cancer types

Zeng, Y., Lin, D., Gao, M., Du, G., & Cai, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-05987-1 · Cited by 20

Natural Alternatives in the Treatment of Colorectal Cancer: A Mechanisms Perspective

Fernandez-Muñoz, K. V., Sánchez-Barrera, C. Á., Meraz‐Ríos, M. A., Reyes, J. L., Pérez-Yépez, E.-A., Ortiz-Melo, M. T., Terrazas, L. I., & Mendoza-Rodríguez, M. (2025) · Biomolecules · doi:10.3390/biom15030326 · Cited by 19

Development and validation of the prognostic value of the immune-related genes in clear cell renal cell carcinoma

Liao, Z., Yao, H., Wei, J., Feng, Z., Chen, W., Luo, J., & Xu, C. (2021) · Translational Andrology and Urology · doi:10.21037/tau-20-1348 · Cited by 19

Osteosarcoma exocytosis of soluble LGALS3BP mediates macrophages toward a tumoricidal phenotype

Li, J., Zhao, C., Li, Y., Wen, J., Wang, S., Wang, D., Dong, H., Wang, D., Zhao, Y., Wang, X., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.12.023 · Cited by 19

Synthesis and Evaluation of 68Ga-NOTA-COG1410 Targeting to TREM2 of TAMs as a Specific PET Probe for Digestive Tumor Diagnosis

Shi, D., Si, Z., Xu, Z., Cheng, Y., Lin, Q., Fu, Z., Fu, W., Yang, T., Shi, H., & Cheng, D. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04701 · Cited by 19

Serum exosomal proteomics analysis of lung adenocarcinoma to discover new tumor markers

Liu, S., Tian, W., Ma, Y., Li, J., Yang, J. J., & Li, B. (2022) · BMC Cancer · doi:10.1186/s12885-022-09366-x · Cited by 19

Prognostic Significance and Immunological Role of FBXO5 in Human Cancers: A Systematic Pan-Cancer Analysis

Liu, P., Wang, X., Pan, L., Han, B., & He, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.901784 · Cited by 19

PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9

Sun, X., Li, K., Aryal, U. K., Li, B., & Yokota, H. (2022) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2022.08.003 · Cited by 19

Systematic pan‐cancer analysis identifies RBM39 as an immunological and prognostic biomarker

Zhang, R., Wang, W., Zhang, N., Chen, X., Liu, W., Zhang, L., & Liu, N. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17517 · Cited by 18

Stimulus-responsive inorganic semiconductor nanomaterials for tumor-specific theranostics

Hu, X., Ha, E., Ai, F., Huang, X., Yan, L., He, S., Ruan, S., & Hu, J. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214821 · Cited by 19

Screening for Biomarkers for Progression from Oral Leukoplakia to Oral Squamous Cell Carcinoma and Evaluation of Diagnostic Efficacy by Multiple Machine Learning Algorithms

Jing, F., Zhang, J., Cai, X., Zhou, X., Bai, J., Zhang, H., & Li, T. (2022) · Cancers · doi:10.3390/cancers14235808 · Cited by 19

A pan-cancer analysis of the oncogenic role of zinc finger protein 419 in human cancer

Zhu, W., Feng, D., Shi, X., Li, D., Wei, Q., & Yang, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1042118 · Cited by 20

GBP2 promotes clear cell renal cell carcinoma progression through immune infiltration and regulation of PD‑L1 expression via STAT1 signaling

Ye, S., Li, S., Qin, L., Zheng, W., Liu, B., Li, X., Ren, Z., Zhao, H., Hu, X., Ye, N., et al. (2023) · Oncology Reports · doi:10.3892/or.2023.8486 · Cited by 19

The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach

Khan, A. U., Khan, A., Shal, B., Khan, S., Khan, M., Ahmad, R., & Riaz, M. (2023) · Phytotherapy Research · doi:10.1002/ptr.7755 · Cited by 20

Comprehensive analysis of cuproptosis-related genes in immune infiltration and prognosis in lung adenocarcinoma

Xiaona, X., Liu, Q., Zhou, X., Liang, R., Yang, S., Xu, M., Zhao, H., Li, C., Chen, Y., & Xueding, C. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106831 · Cited by 19

Multi-targeting liposomal codelivery of cisplatin and rapamycin inhibits pancreatic cancer growth and metastasis through stromal modulation

Zhu, W., Yu, H., Jia, M., Lin, C., Yuan, Z., Tan, X., & Yan, P. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123316 · Cited by 19

The Present and Future of Novel Protein Degradation Technology

Xia, L., Liu, W., Song, Y., Zhu, H., & Duan, Y. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666191011162955 · Cited by 19

Immunotherapy: A Potential Approach for High-Grade Spinal Cord Astrocytomas

Hu, J., Liu, T., Han, B. R., Tan, S., Guo, H., & Xin, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582828 · Cited by 19

Potential therapeutic applications of medical gases in cancer treatment

Bazzal, A. A., Hoteit, B. H., Chokor, M., Safawi, A., Zibara, Z., Rizk, F., Kawssan, A., Danaf, N., Msheik, L. B., & Hamdar, H. (2025) · Medical Gas Research · doi:10.4103/mgr.medgasres-d-24-00089 · Cited by 18

A CTLA-4 blocking strategy based on Nanobody in dendritic cell-stimulated cytokine-induced killer cells enhances their anti-tumor effects

Wang, W., Wang, X., Yang, W., Zhong, K., He, N. S. M., Li, X., Pang, Y., Lu, Z., Liu, A., & Lü, X. (2021) · BMC Cancer · doi:10.1186/s12885-021-08732-5 · Cited by 18

Identification of prognostic alternative splicing events related to the immune microenvironment of hepatocellular carcinoma

Yu, S., Cai, L., Liu, C., Gu, R., Cai, L., & Zhuo, L. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00294-3 · Cited by 18

Prognosis of Non-small-cell Lung Cancer Patients With Lipid Metabolism Pathway Alternations to Immunotherapy

Cheng, T., Zhang, J., Liu, D., Lai, G., & Wen, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.646362 · Cited by 18

Identification of CCL4 as an Immune-Related Prognostic Biomarker Associated With Tumor Proliferation and the Tumor Microenvironment in Clear Cell Renal Cell Carcinoma

Zhang, L., Zhang, M., Wang, L., Li, J., Yang, T., Shao, Q., Xiao, L., Ma, M., Zhang, N., Jing, M., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.694664 · Cited by 18

Chimeric antigen receptor T cells targeting CD147 for non-small cell lung cancer therapy

Chen, X.-H., Chen, R., Shi, M.-Y., Tian, R.-F., Zhang, H., Xin, Z., Chen, Z., & Wang, X. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101309 · Cited by 18

Chrysin enhances antitumour immunity response through the IL‐12‐STAT4 signal pathway in the B16F10 melanoma mouse model

Lu, R., Wang, S., Jiang, S., Li, C., Wang, Y., Li, L., Wang, Y., Ma, G., Qiao, H., Leng, Z., et al. (2022) · Scandinavian Journal of Immunology · doi:10.1111/sji.13177 · Cited by 17

Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases

Yang, L., Ma, X., Guo, K., Li, J., Zhang, C., & Wu, L. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114439 · Cited by 18

Identification of Ligand-Receptor Pairs Associated With Tumour Characteristics in Clear Cell Renal Cell Carcinoma

Liu, F., Wang, P., Sun, W., Jiang, Y., & Gong, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.874056 · Cited by 18

Photon- and Proton-Mediated Biological Effects: What Has Been Learned?

Jumaniyazova, E. D., Смык, Д., Vishnyakova, P., Fatkhudinov, T., & Gordon, K. B. (2022) · Life · doi:10.3390/life13010030 · Cited by 18

Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy

Zhao, P., Xie, L.-Y., Yu, L., & Wang, P. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.12.008 · Cited by 22

Maternal embryonic leucine zipper kinase in tumor cells and tumor microenvironment: An emerging player and promising therapeutic opportunity

Tang, B., Yan, R., Wang, S., Zeng, Z., & Du, S. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216126 · Cited by 18

A pan-cancer analysis of the oncogenic role of YKT6 in human tumors

Zhang, X., Dapar, M. L. G., Zhang, X., & Chen, Y. (2023) · Medicine · doi:10.1097/md.0000000000033546 · Cited by 18

Reconstruction of tumor microenvironment via in vitro three-dimensional models

Zhou, Z., He, J., Pang, Y., & Sun, W. Y. (2023) · Biofabrication · doi:10.1088/1758-5090/acd1b8 · Cited by 18

Polysaccharide‑platinum complexes for cancer theranostics

Yang, Y., Wang, P., Ji, Z., Xu, X., Zhang, H., & Wang, Y. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120997 · Cited by 19

Bioprinted cancer-stromal in-vitro models in a decellularized ECM-based bioink exhibit progressive remodeling and maturation

Kort-Mascort, J., Shen, M. L., Martin, E. M., Flores-Torres, S., Pardo, L. A., Siegel, P. M., Tran, S. D., & Kinsella, J. M. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acd830 · Cited by 20

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Zhang, J., Tang, K., Liu, Z., Zhang, Z., Duan, S., Wang, H., Yang, H. Y., Yang, D., & Fan, W. (2023) · Nanoscale Horizons · doi:10.1039/d3nh00388d · Cited by 18

Systemic platelet inhibition with localized chemotherapy by an injectable ROS-scavenging gel against postsurgical breast cancer recurrence and metastasis

Gui, J., Zhu, Y., Chen, X., Gong, T., Zhang, Z., Yu, R., & Fu, Y. S. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.01.037 · Cited by 18

Optimizing cancer therapy: a review of the multifaceted effects of metronomic chemotherapy

Basar, O. Y., Mohammed, S. G. A. A., Qoronfleh, M. W., & Acar, A. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1369597 · Cited by 18

Current advances on the role of ferroptosis in tumor immune evasion

Gao, C., Zhang, H., & Wang, X. (2024) · Discover Oncology · doi:10.1007/s12672-024-01573-1 · Cited by 18

Distribution and prognostic impact of M1 macrophage on esophageal squamous cell carcinoma

Jiang, C. H., Liang, W. H., Li, F. P., Xie, Y., Yuan, X., Zhang, H. J., Li, M., Li, J. F., Zhang, A. Z., Yang, L., et al. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa128 · Cited by 18

Establishment of Immune-related Gene Pair Signature to Predict Lung Adenocarcinoma Prognosis

Jiang, X., Gao, Y., Zhang, N., Yuan, C., Luo, Y., Sun, W., Zhang, J., Ren, J., Gong, Y. Q., & Xie, C. (2020) · Cell Transplantation · doi:10.1177/0963689720977131 · Cited by 18

The Emerging Role of Extracellular Vesicles in Endocrine Resistant Breast Cancer

Camera, G. L., Gelsomino, L., Caruso, A., Panza, S., Barone, I., Bonofiglio, D., Andò, S., Giordano, C., & Catalano, S. (2021) · Cancers · doi:10.3390/cancers13051160 · Cited by 18

Wentilactone A Reverses the NF-κB/ECM1 Signaling-Induced Cisplatin Resistance through Inhibition of IKK/IκB in Ovarian Cancer Cells

Lv, C., Ren, C., Yu, Y., Yin, H., Huang, C., Yang, G. S., & Hong, Y. (2022) · Nutrients · doi:10.3390/nu14183790 · Cited by 18

Discovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages

Pei, H., Qin, J., Wang, F., Tan, B., Zhao, Z., Peng, Y., Yu, F., Li, E., Liu, M., Zhang, R., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111741 · Cited by 18

MiR-769-5p of macrophage exosomes induced by GRP78 promotes stemness and chemoresistance in colorectal cancer

Tian, J., Zhang, L., La, X., Fan, X., & Li, Z. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07466-7 · Cited by 17

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

Cai, W., Fan, T. T., Xiao, C., Deng, Z., Liu, Y., Li, C., & He, J. (2025) · 癌症：英文版 · doi:10.1002/cac2.70027 · Cited by 17

Circulating Myeloid-derived Suppressor Cells Facilitate Invasion of Thyroid Cancer Cells by Repressing miR-486-3p

Chen, L., Xiong, L., Hong, S., Li, J., Huo, Z., Li, Y., Chen, S., Zhang, Q., Zhao, R., Gingold, J. A., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa344 · Cited by 17

Overexpression of NREP Promotes Migration and Invasion in Gastric Cancer Through Facilitating Epithelial-Mesenchymal Transition

Liu, Y., Zeng, S., Hu, Y.-D., Zhang, Y., & Li, J.-P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.746194 · Cited by 17

SDHB and SDHD silenced pheochromocytoma spheroids respond differently to tumour microenvironment and their aggressiveness is inhibited by impairing stroma metabolism

Martinelli, S., Riverso, M., Mello, T., Amore, F., Parri, M., Simeone, I., Mannelli, M., Maggi, M., & Rapizzi, E. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111594 · Cited by 17

OIP5 Is a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates

Gong, M., Li, Y., Song, E., Li, M., Qiu, S., Dong, W., & Yuan, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.805552 · Cited by 17

Evaluation of Galanin Expression in Colorectal Cancer: An Immunohistochemical and Transcriptomic Study

Talaat, I. M., Yakout, N. M. S., Soliman, A. S. A., Venkatachalam, T., Vinod, A., Eldohaji, L., Nair, V., Hareedy, A. A., Kandil, A., Abdel‐Rahman, W. M., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.877147 · Cited by 17

Analysis of Pan-Cancer Revealed the Immunological and Prognostic Potential of CBX3 in Human Tumors

Xu, H., Jiang, C., Chen, D., Wu, Y., Lu, J., Zhong, L., & Yao, F. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.869994 · Cited by 17

Tumor-Associated Lymphatics Upregulate MHC-II to Suppress Tumor-Infiltrating Lymphocytes

Li, C. Y., Park, H. J., Shin, J., Baik, J. E., Mehrara, B. J., & Kataru, R. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113470 · Cited by 17

Natural small molecule self-assembled hydrogel inhibited tumor growth and lung metastasis of 4T1 breast cancer by regulating the CXCL1/2-S100A8/9 axis

Yang, Y., Cai, D., Shu, Y., Yuan, Z., Pi, W., Zhang, Y., Lu, J., Jiao, J., Cheng, X., Li, F., et al. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.111435 · Cited by 17

Extracellular vesicles in the treatment and diagnosis of breast cancer: a status update

Zhang, X., Wang, C., Yu, J., Bu, J., Ai, F., Wang, Y., Lin, J., & Zhu, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1202493 · Cited by 18

Genome-scale modeling predicts metabolic differences between macrophage subtypes in colorectal cancer

Gelbach, P. E., & Finley, S. D. (2023) · iScience · doi:10.1016/j.isci.2023.107569 · Cited by 16

Neutrophil extracellular traps−related signature predicts the prognosis and immune infiltration in gastric cancer

Li, M., Zhao, Z., Mak, T. K., Wang, X., Chen, J., Ren, H., Yu, Z., & Zhang, C. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1174764 · Cited by 17

An AMPK agonist suppresses the progress of colorectal cancer by regulating the polarization of TAM to M1 through inhibition of HIF-1α and mTOR signal pathway

Cao, Y., Wo, M., Xu, C., Fei, X., Jin, J., & Shan, Z. (2023) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_2670_22 · Cited by 17

Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer

Liang, S., & Heß, J. (2024) · Cells · doi:10.3390/cells13030256 · Cited by 17

Insights into lenvatinib resistance: mechanisms, potential biomarkers, and strategies to enhance sensitivity

You, Q., Li, R., Yao, J., Zhang, Y., Sui, X. Y., Xiao, C., Zhang, J.-B., Xiao, J., Chen, H., Li, H., et al. (2024) · Medical Oncology · doi:10.1007/s12032-023-02295-0 · Cited by 18

Nanomedicine for combination of chemodynamic therapy and immunotherapy of cancers

Ahmad, W., Sajjad, W., Zhou, Q., & Ge, Z. (2024) · Biomaterials Science · doi:10.1039/d3bm02133e · Cited by 18

The role of ANXA1 in the tumor microenvironment

Li, L., Wang, B., Zhao, S., Xiong, Q., & Cheng, A. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111854 · Cited by 18

Drug-Resistance Biomarkers in Patient-Derived Colorectal Cancer Organoid and Fibroblast Co-Culture System

Ryu, K., Seo, J.-A., Lee, K., Choi, J., Yoo, G., Ha, J.-H., & Ahn, M. R. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46060346 · Cited by 17

Targeting tumor-associated macrophages with nanocarrier-based treatment for breast cancer: A step toward developing innovative anti-cancer therapeutics

Muteeb, G., Khafaga, D. S. R., El-Morsy, M. T., Farhan, M., Aatif, M., & Hosney, M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37217 · Cited by 17

TCGA and ESTIMATE data mining to identify potential prognostic biomarkers in HCC patients

He, G., Fu, S., Yang, L., Li, T., Mei, P., Feng, L., Cai, L., Cheng, Y., Zhou, C., Tang, Y., et al. (2020) · Aging · doi:10.18632/aging.103943 · Cited by 17

Identification of an Individualized Immune-Related Prognostic Risk Score in Lung Squamous Cell Cancer

Zhuang, Y., Li, S., Liu, C., & Li, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.546455 · Cited by 17

Prognostic Utility of Systemic Immune-Inflammation Index After Resection of Extrahepatic Cholangiocarcinoma: Results from the U.S. Extrahepatic Biliary Malignancy Consortium

Toyoda, J., Sahara, K., Maithel, S. K., Abbott, D. E., Poultsides, G. A., Wolfgang, C. L., Fields, R. C., He, J. P., Scoggins, C. R., Idrees, K., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12058-2 · Cited by 17

The role and pharmacological properties of P2Y12 receptor in cancer and cancer pain

Hu, J., & Zhang, W. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113927 · Cited by 17

Cabozantinib Reverses Topotecan Resistance in Human Non-Small Cell Lung Cancer NCI-H460/TPT10 Cell Line and Tumor Xenograft Model

Lei, Z., Teng, Q., Gupta, P., Zhang, W., Narayanan, S., Yang, D., Wurpel, J. N. D., Fan, Y., & Chen, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.640957 · Cited by 17

Targeting the Tumor Microenvironment in EGFR-Mutant Lung Cancer: Opportunities and Challenges

Lim, J. U., Jung, J., Kim, Y. W., Kim, C. Y., Lee, S. H., Park, D. W., Choi, S. I., Ji, W., Yeo, C. D., & Lee, S. H. (2025) · Biomedicines · doi:10.3390/biomedicines13020470 · Cited by 20

Immune cell-based therapies for solid tumors, current challenges and therapeutic advances

Torabi, S., Yekzaman, E., Taherkhani, S., Talachi, N., Khoshravesh, R., Khosravi, A., Salehi, M., Zarrabi, A., & Vosough, M. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02632-y · Cited by 18

Co‐culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques

Shannon, A. E., Boos, C. E., & Hummon, A. B. (2021) · PROTEOMICS · doi:10.1002/pmic.202000103 · Cited by 16

Development of an Oncogenic Driver Alteration Associated Immune-Related Prognostic Model for Stage I-II Lung Adenocarcinoma

Xu, J., Chen, G., Xie, Z.-F., & Zhao, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.593022 · Cited by 16

Identification of a Five-Gene Prognostic Signature Related to B Cells Infiltration in Pancreatic Adenocarcinoma

Tang, S., Huang, X., Jiang, H., & Qin, S. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s324432 · Cited by 16

Identification of Potential Novel Prognosis-Related Genes Through Transcriptome Sequencing, Bioinformatics Analysis, and Clinical Validation in Acute Myeloid Leukemia

Wang, J., Uddin, M. N., Jian-ping, H., Chen, R., Xiang, Y.-X., Xiong, D.-Q., & Wu, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.723001 · Cited by 16

Development of immune gene pair-based signature predictive of prognosis and immunotherapy in esophageal cancer

Cao, K., Ma, T., Ling, X., Liu, M., Jiang, X., Ma, K., Zhu, J., & Ma, J. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-5217 · Cited by 16

Metastasis Related Epithelial-Mesenchymal Transition Signature Predicts Prognosis and Response to Immunotherapy in Gastric Cancer

Song, J., Wei, R., Huo, S., Gao, J., & Liu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.920512 · Cited by 16

Vimentin and tumor–stroma ratio for neoadjuvant chemoradiotherapy response prediction in locally advanced rectal cancer

Tian, W., Yang, Y., Qin, Q., Zhang, L., Wang, Z., Su, L., Lirong, Z., Chen, H., Hu, L., Hong, J., et al. (2022) · Cancer Science · doi:10.1111/cas.15610 · Cited by 16

The promise of targeting heme and mitochondrial respiration in normalizing tumor microenvironment and potentiating immunotherapy

Akter, Z., Salamat, N., Ali, M. Y., & Li, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1072739 · Cited by 17

LRRC superfamily expression in stromal cells predicts the clinical prognosis and platinum resistance of ovarian cancer

Zhu, X., Shijing, Y. O. U., Du, X., Song, K., Lv, T., Zhao, H., & Yao, Q. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01435-9 · Cited by 20

In Vitro Interaction of Melanoma-Derived Extracellular Vesicles with Collagen

Palmulli, R., Bresteau, E., Raposo, G., Montagnac, G., & van Niel, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043703 · Cited by 23

Comprehensive multi-omics analysis reveals m7G-related signature for evaluating prognosis and immunotherapy efficacy in osteosarcoma

Zhang, Y., Gan, W., Ru, N., Xue, Z., Chen, W., Chen, Z., Wang, H., & Zheng, X. (2023) · Journal of bone oncology · doi:10.1016/j.jbo.2023.100481 · Cited by 16

Identifying the oncogenic roles of FAP in human cancers based on systematic analysis

Ma, C., Xi, S., Sun, H., Zhang, M., & Pei, Y. (2023) · Aging · doi:10.18632/aging.204892 · Cited by 16

ROS impairs tumor vasculature normalization through an endocytosis effect of caveolae on extracellular SPARC

Zhao, Y., Yu, J., Huang, A., Yang, Q., Li, G., Yang, Y., & Chen, Y. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03003-8 · Cited by 16

An Overview of Systemic Targeted Therapy in Renal Cell Carcinoma, with a Focus on Metastatic Renal Cell Carcinoma and Brain Metastases

Semenescu, L. E., Kamel, A., Ciubotaru, V. G., Rodriguez, S. M. B., Fürtös, A. M., Costachi, A., Dricu, A., & Tătăranu, L. G. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45090485 · Cited by 18

Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms

Shi, Y., Adu‐Amankwaah, J., Zhao, Q., Li, X., Yu, Q., Bushi, A., Yuan, J., & Tan, R. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27207 · Cited by 17

Apolipoprotein E is a Potential Biomarker for Predicting Cancer Prognosis and is Correlated with Immune Infiltration

Chen, J., Zhu, H., Chen, S., & Mi, H. (2024) · OncoTargets and Therapy · doi:10.2147/ott.s447319 · Cited by 17

Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis

Yan, P., Zhou, B., Ma, Y., Wang, A., Hu, X., Luo, Y., Yuan, Y., Wei, Y., Pang, P., & Mao, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.11235 · Cited by 16

Mining the potential prognostic value of synaptosomal-associated protein 25 (SNAP25) in colon cancer based on stromal-immune score

Zou, J., Duan, D., Yu, C., Pan, J., Xia, J., Yang, Z., & Cai, S. (2020) · PeerJ · doi:10.7717/peerj.10142 · Cited by 16

Prognostic value of immune-related cells and genes in the tumor microenvironment of ovarian cancer, especially CST4

Wang, S., Wang, C., Liu, O., Hu, Y., Li, X., & Lin, B. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119461 · Cited by 16

Targeted delivery by pH-responsive mPEG-S-PBLG micelles significantly enhances the anti-tumor efficacy of doxorubicin with reduced cardiotoxicity

Feng, Q., Xu, J., Liu, X., Wang, H., Xiong, J., & Xiao, K. (2021) · Drug Delivery · doi:10.1080/10717544.2021.2008052 · Cited by 16

Genetically diverse mouse platform to xenograft cancer cells

Sargent, J. K., Warner, M. A. A., Low, B. E., Schott, W. H., Hoffert, T. A., Coleman, D., Woo, X. Y., Sheridan, T., Erattupuzha, S., Henrich, P. P., et al. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049457 · Cited by 16

Evolution of precision oncology‐guided treatment paradigms

DasGupta, R., Yap, A., Yong, E. Y., & Chia, S. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1585 · Cited by 17

Identification of B cell marker genes based on single-cell sequencing to establish a prognostic model and identify immune infiltration in osteosarcoma

Zhang, Z., Zhang, J., Duan, Y., Li, X., Pan, J., Wang, G., & Shen, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026701 · Cited by 16

Defining oligometastatic non-small cell lung cancer: concept versus biology, a literature review

Mentink, J. F., Paats, M. S., Dumoulin, D. W., Cornelissen, R., Elbers, J. B. W., Maat, A. P. W. M., von der Thüsen, J. H., & Dingemans, A. C. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-265 · Cited by 17

Phosphoserine phosphatase as a prognostic biomarker in patients with gastric cancer and its potential association with immune cells

Huang, M.-Y., Liu, X.-Y., Shao, Q., Zhang, X., Miao, L., Wu, X.-Y., Xu, Y.-X., Wang, F., Wang, H.-Y., Zeng, L., et al. (2022) · BMC Gastroenterology · doi:10.1186/s12876-021-02073-0 · Cited by 15

Intercellular communication between FAP+ fibroblasts and SPP1+ macrophages in prostate cancer via multi-omics

Wu, T., Li, X., Zheng, F., Liu, H., & Yu, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1560998 · Cited by 16

Gut microbiome and gastric cancer: microbial interactions and therapeutic potential

El-Ghannam, M., Hassanien, M. H., Ameen, Y. A., Turky, E. A., ELattar, G. M., Ray, A. A. E., & Eltalkawy, M. D. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00729-w · Cited by 16

Microenvironmental regulation of therapeutic response in cancer

Klemm, F., & Joyce, J. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.006 · Cited by 795

Tumor microenvironment as a therapeutic target in cancer

Xiao, Y. Q., & Yu, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107753 · Cited by 2,026

From immune exclusion to exhaustion: tumor microenvironment drives therapy response

Maletin, N. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1785587 · Cited by 16

Tumor Microenvironment and Drug Response: A Pathology–pharmacology Perspective on Mechanisms of Therapeutic Resistance

Ravichandran, S., & Vilvanathan, S. (2026) · doi:10.9734/ajmpcp/2026/v9i1402

Potential Strategies to Improve the Effectiveness of Drug Therapy by Changing Factors Related to Tumor Microenvironment

Cao, D., Naiyila, X., Li, J., Huang, Y. C., Chen, Z., Chen, B., Li, J., Guo, J., Dong, Q., Ai, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.705280 · Cited by 7