The DOI matches its Crossref record; 122 of the 124 references it cites were found in a registry or an index.
Tumor microenvironment and therapeutic response
Abstract
The tumor microenvironment significantly influences therapeutic response and clinical outcome. Microenvironment-mediated drug resistance can be induced by soluble factors secreted by tumor or stromal cells. The adhesion of tumor cells to stromal fibroblasts or to components of the extracellular matrix can also blunt therapeutic response. Microenvironment-targeted therapy strategies include inhibition of the extracellular ligand-receptor interactions and downstream pathways. Immune cells can both improve and obstruct therapeutic efficacy and may vary in their activation status within the tumor microenvironment; thus, re-programme of the immune response would be substantially more beneficial. The development of rational drug combinations that can simultaneously target tumor cells and the microenvironment may represent a solution to overcome therapeutic resistance.
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“Recent studies reported that alteration of tumour immune microenvironment in gastric cancer is a pivotal strategy for predicting the immunotherapeutic responses and prognosis, which might provide new treatment strategies for patients [26, 27].”
From Phosphoserine phosphatase as a prognostic biomarker in patients with gastric cancer and its potential association with immune cells (2022) · cites this paper as [26]
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759
Coordinated regulation of myeloid cells by tumours
Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544
Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463
Macrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384
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Items 301–400 of 1,000
Tumor microenvironment-responsive thermoelectric scaffold for on-demand antitumor therapy
Gao, X., Deng, W., Tan, J., Shuai, X., Zan, J., Ye, T., Luo, K.-W., Qi, F., Wei, Y., & Shuai, C. (2024) · Materials Today Chemistry · doi:10.1016/j.mtchem.2024.102455 · Cited by 40
Gong, Q., Song, X., Tong, Y., Huo, L., Zhao, X., Han, Y., Shen, W., Ru, J., Shen, X., & Liang, C. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03134-2 · Cited by 47
Interactions between cancer cells and tumor-associated macrophages in tumor microenvironment
Liu, L., Li, Y., & Li, B. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189344 · Cited by 44
The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer
Bessone, M. I. D., Gattas, M. J., Laporte, T., Tanaka, M., & Simian, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00547 · Cited by 40
Past, Present, and Future of Anticancer Nanomedicine
Kim, K., & Khang, D. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s254774 · Cited by 39
Ringquist, R., Ghoshal, D., Jain, R., & Roy, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114003 · Cited by 39
Patient Derived Xenografts for Genome-Driven Therapy of Osteosarcoma
Landuzzi, L., Manara, M. C., Lollini, P.-L., & Scotlandi, K. (2021) · Cells · doi:10.3390/cells10020416 · Cited by 39
Pan, S., Niu, B., Tao, Y., Xia, G., Huang, L., Xu, J., Zhu, L., & Cao, H. (2021) · Materials Express · doi:10.1166/mex.2021.2063 · Cited by 39
Shi, Y., He, X., Wang, H., Dai, J., Fang, J., He, Y., Chen, X., Hong, Z., & Chai, Y. (2022) · Talanta · doi:10.1016/j.talanta.2022.123971 · Cited by 40
Knipper, K., Lyu, S. I., Quaas, A., Bruns, C. J., & Schmidt, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713482 · Cited by 41
Najafi, S., & Mortezaee, K. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122387 · Cited by 39
Metal–Organic Framework Nanocomposites in Conquering Hypoxia for Tumor Therapy
Zhou, S., Jia, F., Wei, Y., Du, J., Liu, J., Dong, W., Sui, J., Xue, W., Yang, Y., Chen, L., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202314012 · Cited by 40
Influence of the gut microbiota on immune cell interactions and cancer treatment
Liu, C., Fu, L., Wang, Y., & Yang, W. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05709-3 · Cited by 47
Kang, Y., Hu, W., Bai, E., Zheng, H., Liu, Z., Wu, J., Jin, R., Zhao, C., & Liang, G. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s118272 · Cited by 39
Guan, Y., Du, Y., Wang, G., Gou, H., Xue, Y., Xu, J., Li, E., Chan, D. W., Wu, D., Xu, P., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.673295 · Cited by 38
Chen, S., Tsuneyama, K., Yen, M., Lee, J., Chen, J.-L., & Huang, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-91454-2 · Cited by 39
Li, Z., Ning, F., Wang, C., Yu, H., Ma, Q., & Sun, Y. (2021) · Nanoscale · doi:10.1039/d1nr03387e · Cited by 39
Shimizu, M., Koma, Y., Sakamoto, H., Tsukamoto, S., Kitamura, Y., Urakami, S., Tanigawa, K., Kodama, T., Higashino, N., Nishio, M., et al. (2021) · Cancers · doi:10.3390/cancers13184552 · Cited by 41
Yadav, D. K., Singh, D., Singh, M. R., & Pradhan, M. (2022) · OpenNano · doi:10.1016/j.onano.2022.100107 · Cited by 39
Lan, M., Lü, W., Zou, T., Li, L., Liu, F., Cai, T., & Cai, Y. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03696-4 · Cited by 39
Hu, X., Zhu, H., Zhang, X., He, X., & Xu, X. (2021) · Cancer Medicine · doi:10.1002/cam4.4203 · Cited by 41
AMPK: An odyssey of a metabolic regulator, a tumor suppressor, and now a contextual oncogene
Penugurti, V., Mishra, Y. G., & Manavathi, B. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188785 · Cited by 39
Park, Y., Lee, D., Lee, J. E., Park, H. S., Jung, S. S., Park, D., Kang, D. H., Lee, S., Woo, S., & Chung, C. (2024) · Cancers · doi:10.3390/cancers16030598 · Cited by 42
Dhas, N. L., Parekh, K., Pandey, A. P., Kudarha, R. R., Mutalik, S., & Mehta, T. A. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.07.016 · Cited by 38
Colorectal Cancer Stem Cells in the Progression to Liver Metastasis
González-Villarreal, C. A., Quiroz-Reyes, A. G., Islas, J. F., & Garza-Treviño, E. N. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01511 · Cited by 42
Li, S., Liu, M., Ma, H., Jin, Q., Ma, Y., Wang, C., Ren, J., Liu, G., & Dai, Y. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-020-00763-z · Cited by 38
Self-citationWang, J., Shen, S., Li, J., Cao, Z., & Yang, X. (2021) · ACS Nano · doi:10.1021/acsnano.0c08996 · Cited by 38
Guan, Z., Lan, H., Cai, X., Zhang, Y., Liang, A., & Li, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.722917 · Cited by 39
Zhu, H., Hu, X., Feng, S., Jian, Z., Xu, X., Gu, L., & Xiong, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6419695 · Cited by 44
Exploiting E3 ubiquitin ligases to reeducate the tumor microenvironment for cancer therapy
Li, X.-M., Zhao, Z., Xiao, Y., Xia, Q., Zhou, P., Wang, S., Wu, H., & Hu, J. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00394-2 · Cited by 40
Cancer cell states and emergent properties of the dynamic tumor systemPreprint
Barkley, D., Rao, A. N., Pour, M., França, G. S., & Yanai, I. (2021) · Genome Research · doi:10.1101/gr.275308.121 · Cited by 39
The Redox Protein High-Mobility Group Box 1 in Cell Death and Cancer
Chen, R., Zou, J., Kang, R., & Tang, D. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0236 · Cited by 39
The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma
Lu, Y., Lin, B., & Li, M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1363695 · Cited by 41
Pan, L., Fang, J., Chen, M., Zhai, S., Zhang, B., Jiang, Z., Juengpanich, S., Wang, Y., & Cai, X. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i8.789 · Cited by 37
Wnt signalling pathway in bladder cancer
Wu, G., Weng, W., Xia, P., Yan, S., Zhong, C., Xie, L., Xie, Y., & Fan, G. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109886 · Cited by 36
Lawal, B., Lin, L.-C., Lee, J., Chen, J.-H., Bekaii‐Saab, T., Wu, A. T. H., & Ho, C. (2021) · Cancers · doi:10.3390/cancers13050954 · Cited by 38
Liao, Y., He, D., & Wen, F. (2021) · Immunogenetics · doi:10.1007/s00251-021-01223-8 · Cited by 36
Zhao, M., Zhuang, A., & Fang, Y. (2022) · Journal of Oncology · doi:10.1155/2022/9514697 · Cited by 37
RetractedYang, T., Zhang, Z., Zhang, J., Li, Y., Li, W., Liang, H., & Yang, F. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01684 · Cited by 37
Strategies for the development of stimuli-responsive small molecule prodrugs for cancer treatment
Tu, Y., Gong, J., Mou, J., Jiang, H., Zhao, H., & Gao, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1434137 · Cited by 36
Screening TCGA database for prognostic genes in lower grade glioma microenvironment
Ni, J., Liu, S., Qi, F., Xiao, L., Yu, S., Feng, J., & Zheng, Y. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.01.73 · Cited by 35
Pan, H., Wang, X., Huang, W., Dai, Y., Yang, M. Y., Liang, H., Wu, X., Zhang, L., Huang, W., Lü, Y., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.557157 · Cited by 36
Self-citationYu, D., Yang, X. N., Lin, J., Cao, Z., Lu, C., Yang, Z., Zheng, M., Pan, R., & Cai, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.724655 · Cited by 38
Cui, X., Wang, Q., Zhou, J., Wang, Y., Xu, C., Tong, F., Wang, H., & Kang, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.710695 · Cited by 38
Pu, Y., Zhu, J., Xu, J., Zhang, S., & Bao, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.111 · Cited by 36
Cao, Y., Xie, J., Liang, C., Hu, Y., Zhai, L., Yuan, J., Suo, L., Shen, Y., Ye, R., Li, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.761350 · Cited by 35
Targeting redox regulation and autophagy systems in cancer stem cells
Khan, S. U., Rayees, S., Sharma, P., & Malik, F. A. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00955-5 · Cited by 36
EZH2: The roles in targeted therapy and mechanisms of resistance in breast cancer
Chen, Y., Zhu, H., Luo, Y., Tong, S., & Liu, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116624 · Cited by 36
Zhai, R., Gong, Z., Wang, M., Ni, Z., Zhang, J., Wang, M., Zhang, Y., Zeng, F., Gu, Z., Chen, X., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01982-9 · Cited by 38
Matsusaka, K., Fujiwara, Y., Pan, C., Esumi, S., Saito, Y., Bi, J., Nakamura, Y., Mukunoki, A., Takeo, T., Nakagata, N., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3471 · Cited by 34
A pan-cancer analysis revealed the role of the SLC16 family in cancer
Li, J., Xie, J., Wu, D., Chen, L., Gong, Z., Wu, R., Hu, Y., Zhao, J., & Xu, Y. (2021) · Channels · doi:10.1080/19336950.2021.1965422 · Cited by 35
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Ren, X., Chen, X., Zhang, X., Jiang, S., Zhang, T., Li, G., Lü, Z., Zhang, D., Wang, S., & Qin, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686809 · Cited by 35
Guo, J., Wang, X., Guo, Q., Zhu, S., Li, P., Zhang, S., & Min, L. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.69405 · Cited by 34
Song, Q., Ye, Y., Jiang, D., Qin, Z., Xu, C., Wang, H., Huang, J., Chen, L., Luo, R., Zhang, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31719-0 · Cited by 35
Li, Y., Han, S., Wu, B., Zhong, C., Shi, Y., Lv, C., Fu, L., Zhang, Y., Lang, Q., Liang, Z., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.951247 · Cited by 35
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Zhu, Y., Lin, X., Zhou, X., Prochownik, E. V., Wang, X., & Li, Y. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01340-1 · Cited by 39
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Wen, Z., Wang, S., Yang, D. M., Xie, Y., Chen, M., Bishop, J., & Xiao, G. (2023) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2023.02.003 · Cited by 34
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Teng, Q., Lei, Z., Wang, J., Yang, Y., Wu, Z., Acharekar, N., Zhang, W., Yoganathan, S., Pan, Y., Wurpel, J. N. D., et al. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.101028 · Cited by 34
Restrepo, J. C., Guevara, D. M., López, A. P., Palacios, J. F. M., & Liscano, Y. (2024) · Cancers · doi:10.3390/cancers16132338 · Cited by 35
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Chen, W., Jiang, M., Zou, X., Chen, Z., Shen, L., Hu, J., Kong, M., Huang, J., Ni, C., & Xia, W. (2025) · Oncogene · doi:10.1038/s41388-025-03359-3 · Cited by 34
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Ning, L., Wang, L., Zhang, H., Jiao, X., & Chen, D. (2020) · Oncology Letters · doi:10.3892/ol.2020.11942 · Cited by 38
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Lu, J.-J., Abudukeyoumu, A., Zhang, X. Y., Liu, L., Li, M., & Xie, F. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.61073 · Cited by 34
Liu, G., Liu, R., Shan, Y., & Sun, C. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101133 · Cited by 36
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Mirzaei, N. M., Su, S., Sofia, D., Hegarty, M., Abdel‐Rahman, M. H., Asadpoure, A., Cebulla, C. M., Chang, Y. H., Hao, W., Jackson, P., et al. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11101031 · Cited by 37
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Sun, Y., Chen, S., Lu, Y., Xu, Z., Fu, W., & Yan, W. (2024) · Communications Biology · doi:10.1038/s42003-024-05765-x · Cited by 33
Cheng, Q., Shi, X., Chen, Y., Li, Q., Wang, J., Li, H., Wang, L., & Wang, Z. (2024) · ACS Nano · doi:10.1021/acsnano.3c12745 · Cited by 33
Wei, T., Cong, X., Wang, X., Xu, X.-J., Min, S., Ye, P., Peng, X., Wu, L., & Yu, G. (2016) · Oncotarget · doi:10.18632/oncotarget.14255 · Cited by 34
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Lee, G., Park, H., Sohn, I., Lee, S.-H., Song, S. H., Kim, H. S., Lee, K. S., Shim, Y. M., & Lee, H. Y. (2018) · The Oncologist · doi:10.1634/theoncologist.2017-0538 · Cited by 33
Li, G., & Zhao, L. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1642418 · Cited by 33
Han, L., Shi, H., Luo, Y., Sun, W., Li, S., Zhang, N., Jiang, X., Gong, Y. Q., & Xie, C. (2020) · Cancer Medicine · doi:10.1002/cam4.3561 · Cited by 33
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Ruan, Y., Ogana, H. A. N., Gang, E., Kim, H. N., & Kim, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-47189-7_7 · Cited by 35
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Rincón‐Riveros, A., López, L., Villegas, V. E., & Rodrı́guez, J. A. (2021) · Cancers · doi:10.3390/cancers13040847 · Cited by 33
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da Silva, S. P., Caires, H. R., Bergantim, R., Guimarães, J. E., & Vasconcelos, M. H. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.014 · Cited by 36
Cao, R., Ma, B., Wang, G., Xiong, Y., Tian, Y., & Yuan, L. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.06.011 · Cited by 33
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Rong, X., Jin-yu, L., Liu, Y., Wang, Z., Zeng, D., Li, Y., Li, S., Wu, J., Shen, Z., Shi, M., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.802257 · Cited by 34
Li, X., Zeng, L., Gu, S., & Zhao, X. (2022) · BMC Bioinformatics · doi:10.1186/s12859-022-04951-0 · Cited by 33
Zhou, Y., Li, X., Long, G., Tao, Y., Zhou, L., & Tang, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.994259 · Cited by 35
Wei, F., Fang, R., Lyu, K., Liao, J., Long, Y., Yang, J., Wen, W., & Sun, W. (2023) · Oral Oncology · doi:10.1016/j.oraloncology.2023.106532 · Cited by 34
Zhao, H., Yin, X., Wang, L., Liu, K., Liu, W., Bo, L., & Wang, L. (2023) · Scientific Data · doi:10.1038/s41597-023-02032-2 · Cited by 38
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Zou, Q., Lei, X., Xu, A., Li, Z., He, Q., Huang, X., Xu, G., Tian, F., Ding, Y., & Zhu, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.724139 · Cited by 33
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Duan, X., Zou, H., Yang, J.-Z., Liu, S., Xu, T., & Ding, J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.08.047 · Cited by 35
Identification prognosis-associated immune genes in colon adenocarcinoma
Miao, Y., Wang, J., Ma, X., Yang, Y., & Mi, D. (2020) · Bioscience Reports · doi:10.1042/bsr20201734 · Cited by 32
Xin, F., Wu, M., Cai, Z., Zhang, X., Wei, Z., Liu, X., & Liu, J. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002036 · Cited by 32
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Samadian, H., Jafari, S., Sepand, M. R., Alaei, L., Malvajerd, S. S., Jaymand, M., Ghobadinezhad, F., Jahanshahi, F., Hamblin, M. R., Derakhshankhah, H., et al. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100160 · Cited by 33
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Han, J., Yun, J., Quan, M., Kang, W., Jung, J. G., Heo, W., Li, S., Lee, K. J., Son, H., Kim, J. H., et al. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02138-3 · Cited by 32
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Metadata
- Authors
- Wu, T., & Dai, Y.
- Affiliations
- Peking University First Hospital (CN)
- Corresponding author
- Dai, Yun
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 387
- Pages
- 61-68
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2265419075
- Cited by
- 1,802
- References
- 124
- Citations by year
- 2026: 76 · 2025: 179 · 2024: 238 · 2023: 344 · 2022: 382 · 2021: 316 · 2020: 191 · 2019: 48 · 2018: 20 · 2017: 5
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- tumor microenvironment, treatment resistance, drug resistance, stromal fibroblasts, extracellular matrix, cell adhesion, immune cells, immune reprogramming, combination therapy, soluble factors
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Neoplasms, Molecular Targeted Therapy, Tumor Microenvironment
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