Tumor microenvironment and therapeutic response

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Microenvironmental regulation of tumor progression and metastasis

Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994

Macrophage Diversity Enhances Tumor Progression and Metastasis

Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759

Coordinated regulation of myeloid cells by tumours

Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544

Immunogenic Cell Death in Cancer Therapy

Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Jing, X., Yang, F., Shao, C., Wei, K., Xie, M., Shen, H., & Shu, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1089-9 · Cited by 2,054

The rediscovery of platinum-based cancer therapy

Rottenberg, S., Disler, C., & Perego, P. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00308-y · Cited by 993

Radiotherapy combined with immunotherapy: the dawn of cancer treatment

Zhang, Z., Liu, X., Chen, D., & Yu, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01102-y · Cited by 736

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

Yang, M., Li, J., Gu, P., & Fan, X. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.010 · Cited by 688

Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy

Gao, J., Liang, Y., & Wang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.888713 · Cited by 586

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Ding, B., Zheng, P., Ma, P., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.201905823 · Cited by 527

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

Pinto, B., Henriques, A. C., Silva, P. M. A., & Bousbaa, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121186 · Cited by 440

Comprehensive analysis of spatial architecture in primary liver cancer

Wu, R. T., Guo, W., Qiu, X., Wang, S., Sui, C., Lian, Q., Wu, J., Shan, Y., Zhao, Y., Yang, S., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg3750 · Cited by 383

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Lu, Q., Kou, D., Lou, S., Ashrafizadeh, M., Aref, A. R., Canadas, I., Tian, Y., Niu, X., Wang, Y., Torabian, P., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01535-8 · Cited by 373

Cancer associated-fibroblast-derived exosomes in cancer progression

Li, C., Teixeira, A. F., Zhu, H., & ten Dijke, P. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01463-y · Cited by 352

Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics

Ji, X., Ge, L., Chuang, L. I. U., Tang, Z., Xiao, Y., Chen, W., Lei, Z., Gao, W. M., Blake, S., De, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21436-5 · Cited by 323

The Promise of Nanotechnology in Personalized Medicine

Alghamdi, M. A., Fallica, A. N., Virzì, N. F., Kesharwani, P., Pittalà, V., & Greish, K. F. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12050673 · Cited by 324

Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights

Patel, S., Alam, A., Pant, R., & Chattopadhyay, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02872 · Cited by 293

3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer Drugs

Barbosa, M. A. G., Xavier, C. P. R., Pereira, R. F., Petrikaitė, V., & Vasconcelos, M. H. (2021) · Cancers · doi:10.3390/cancers14010190 · Cited by 285

Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations

Letai, A. G., Bhola, P. D., & Welm, A. L. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.12.004 · Cited by 282

Current therapy and drug resistance in metastatic castration-resistant prostate cancer

Cai, M., Song, X., Li, X., Chen, M., Guo, J., Yang, D., Chen, Z., & Zhao, S. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100962 · Cited by 278

Carbon‐Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment

Saleem, J., Wang, L., & Chen, C. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800525 · Cited by 263

PD-L1, TMB, MSI, and Other Predictors of Response to Immune Checkpoint Inhibitors in Biliary Tract Cancer

Rizzo, A., Ricci, A. D., & Brandi, G. (2021) · Cancers · doi:10.3390/cancers13030558 · Cited by 261

Single‐cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy

Ding, S., Chen, X., & Shen, K. (2020) · 癌症：英文版 · doi:10.1002/cac2.12078 · Cited by 275

Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer

Liu, S., Zhang, X., Wang, W., Li, X., Sun, X., Zhao, Y., Wang, Q., Li, Y., Hu, F., & Ren, H. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02165-x · Cited by 300

A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma

Wu, J., Li, L., Zhang, H., Zhao, Y., Zhang, H., Wu, S., & Xu, B. (2021) · Oncogene · doi:10.1038/s41388-021-01853-y · Cited by 255

An Overview: The Diversified Role of Mitochondria in Cancer Metabolism

Liu, Y., Sun, Y., Guo, Y., Shi, X., Chen, X., Feng, W., Wu, L., Zhang, J., Yu, S., Wang, Y., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81609 · Cited by 275

Advances of medical nanorobots for future cancer treatments

Kong, X., Gao, P., Wang, J., Fang, Y., & Hwang, K. C. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01463-z · Cited by 260

Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28

Chen, B., Sang, Y., Song, X., Zhang, D., Wang, L., Zhao, W., Liang, Y., Zhang, N., & Yang, Q. (2021) · Theranostics · doi:10.7150/thno.53412 · Cited by 231

Enhancement of EPR Effect for Passive Tumor Targeting: Current Status and Future Perspectives

Vagena, I.-A., Malapani, C., Gatou, Μ.-A., Lаgopati, N., & Pavlatou, E. A. (2025) · Applied Sciences · doi:10.3390/app15063189 · Cited by 252

Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment

López de Andrés, J., Griñán-Lisón, C., Jiménez, G., & Marchal, J. A. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00966-3 · Cited by 207

Targeted xCT‐mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti‐PD‐1/L1 Response

Tang, B., Zhu, J., Wang, Y., Chen, W., Fang, S., Mao, W., Xu, Z., Yang, Y., Weng, Q., Zhao, Z., et al. (2022) · Advanced Science · doi:10.1002/advs.202203973 · Cited by 224

Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications

Fang, J., Lu, Y., Zheng, J., Jiang, X., Shen, H., Xi, S., Lu, Y., & Fu, P. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06119-x · Cited by 220

Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis

Li, X., & Wang, J. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.44943 · Cited by 220

Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases

Wang, S., Liang, B., Wang, W., Li, L., Feng, N., Zhao, Y., Wang, T., Yan, F., Yang, S., & Xia, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01408-5 · Cited by 230

Cancer Stem Cells and Targeting Strategies

Barbato, L., Bocchetti, M., Biase, A. D., & Regad, T. (2019) · Cells · doi:10.3390/cells8080926 · Cited by 218

Single-cell transcriptome analysis reveals tumor immune microenvironment heterogenicity and granulocytes enrichment in colorectal cancer liver metastases

Zhang, Y., Song, J., Zhao, Z., Yang, M., Chen, M., Liu, C., Ji, J., & Zhu, D. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.10.016 · Cited by 215

Tumor‐derived exosomal miR‐19b‐3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway

Chen, J., Zhang, K., Zhi, Y., Wu, Y., Chen, B., Bai, J., & Wang, X. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.478 · Cited by 214

Exosomes and breast cancer drug resistance

Dong, X., Bai, X., Ni, J., Zhang, H., Duan, W., Graham, P., & Li, Y. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03189-z · Cited by 205

Metabolism in tumor microenvironment: Implications for cancer immunotherapy

Shi, R., Tang, Y., & Miao, H. (2020) · MedComm · doi:10.1002/mco2.6 · Cited by 210

Chlorin e6: A Promising Photosensitizer in Photo-Based Cancer Nanomedicine

Hak, A., Ali, M. S., Sankaranarayanan, S. A., Shinde, V. R., & Rengan, A. K. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00891 · Cited by 186

Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient

Lee, H. W., Chung, W., Lee, H., Jeong, D. E., Jo, A., Lim, J. E., Hong, J. H., Nam, D., Jeong, B. C., Park, S. H., et al. (2020) · Genome Medicine · doi:10.1186/s13073-020-00741-6 · Cited by 192

Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review

Li, J., Zhao, J., Tan, T., Liu, M., Zeng, Z., Zeng, Y., Zhang, L., Fu, C., Chen, D., & Xie, T. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s243223 · Cited by 182

METTL3 restrains papillary thyroid cancer progression via m6A/c-Rel/IL-8-mediated neutrophil infiltration

He, J., Zhou, M., Yin, J., Wan, J., Chu, J., Jia, J., Sheng, J., Wang, C., Yin, H., & He, F. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.01.019 · Cited by 182

Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes

Hu, J., Chen, Z., Bao, L., Zhou, L., Hou, Y., Liu, L., Xiong, M., Zhang, Y., Wang, B., Tao, Z., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.04.023 · Cited by 183

3D Tumor Models and Their Use for the Testing of Immunotherapies

Boucherit, N., Gorvel, L., & Olive, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.603640 · Cited by 188

TLR 7/8 agonist reverses oxaliplatin resistance in colorectal cancer via directing the myeloid-derived suppressor cells to tumoricidal M1-macrophages

Liu, Z., Xie, Y., Xiong, Y., Liu, S., Qiu, C., Zhu, Z., Mao, H., Yu, M., & Wang, X. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.10.020 · Cited by 165

Patient-derived organoids in precision cancer medicine

Tong, L., Cui, W., Zhang, B., Fonseca, P., Zhao, Q. C., Zhang, P., Xu, B., Zhang, Q., Li, Z., Seashore-Ludlow, B. A., et al. (2024) · Med · doi:10.1016/j.medj.2024.08.010 · Cited by 192

Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

Kang, Y., Mao, Z., Wang, Y., Pan, C., Ou, M., Zhang, H., Zeng, W., & Ji, X. (2022) · Nature Communications · doi:10.1038/s41467-022-30166-1 · Cited by 160

Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

Bhat, A. A., Yousuf, P., Wani, N. A., Rizwan, A., Chauhan, S. S., Siddiqi, M. A., Bedognetti, D., El-Rifai, W. M., Frenneaux, M. P., Batra, S. K., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00419-w · Cited by 157

Reactive Oxygen Species and Antitumor Immunity—From Surveillance to Evasion

Kotsafti, A., Scarpa, M., Castagliuolo, I., & Scarpa, M. (2020) · Cancers · doi:10.3390/cancers12071748 · Cited by 161

Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression

Liang, M., Chen, X., Wang, L., Qin, L., Wang, H., Sun, Z., Zhao, W., & Geng, B. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01688-7 · Cited by 159

Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies

Davalli, P., Marverti, G., Lauriola, A., & D’Arca, D. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2389523 · Cited by 156

CD63 + Cancer‐Associated Fibroblasts Confer Tamoxifen Resistance to Breast Cancer Cells through Exosomal miR‐22

Gao, Y., Li, X., Zeng, C., Liu, C., Hao, Q., Li, W., Zhang, K., Zhang, W., Wang, S., Zhao, H., et al. (2020) · Advanced Science · doi:10.1002/advs.202002518 · Cited by 147

Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy

Zhang, J., Yang, J., Zuo, T., Ma, S., Xokrat, N., Hu, Z., Wang, Z., Xu, R., Wei, Y., & Shen, Q. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120429 · Cited by 143

Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies

Li, Y.-R., Fang, Y., Lyu, Z., Zhu, Y., & Yang, L. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04575-9 · Cited by 168

The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited

Dzobo, K., Senthebane, D. A., & Dandara, C. (2023) · Cancers · doi:10.3390/cancers15020376 · Cited by 146

Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

Vasconcelos, M. H., Caires, H. R., Ābols, A., Xavier, C. P. R., & Linē, A. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100647 · Cited by 150

Tumor Microenvironment: Implications in Melanoma Resistance to Targeted Therapy and Immunotherapy

Falcone, I., Conciatori, F., Bazzichetto, C., Ferretti, G., Cognetti, F., Ciuffreda, L., & Milella, M. (2020) · Cancers · doi:10.3390/cancers12102870 · Cited by 151

Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy

Peng, X., He, Y., Huang, J. X., Tao, Y., & Liu, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.613492 · Cited by 146

Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis

Yu, J., Han, Q., Zhao, H., & Zhang, J. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01808-3 · Cited by 143

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

Kitaeva, K. V., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00322 · Cited by 142

M2 macrophage-derived exosomes promote lung adenocarcinoma progression by delivering miR-942

Wei, K., Ma, Z., Yang, F., Zhao, X., Jiang, W., Pan, C., Li, Z., Pan, X., He, Z., Xu, J., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.045 · Cited by 139

Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities

Liu, Y., Zhou, X., & Wang, X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01134-x · Cited by 142

The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review

Li, L., Chen, C., Chiang, C., Xiao, T., Chen, Y., Zhao, Y., & Zheng, D. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59918 · Cited by 137

Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer

Peng, Z., Ye, M., Ding, H., Feng, Z., & Hu, K. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03510-8 · Cited by 133

Cancer Spheroids and Organoids as Novel Tools for Research and Therapy: State of the Art and Challenges to Guide Precision Medicine

Harane, S. E., Zidi, B., Harane, N. E., Krause, K., Matthes, T., & Preynat‐Seauve, O. (2023) · Cells · doi:10.3390/cells12071001 · Cited by 135

Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment

Ruan, R., Li, L., Li, X., Huang, C., Zhanmin, Z., Zhong, H., Zeng, S., Shi, Q., Yang, X., Zeng, Q., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01761-7 · Cited by 135

Low tumor purity is associated with poor prognosis, heavy mutation burden, and intense immune phenotype in colon cancer

Mao, Y., Feng, Q., Zheng, P., Yang, L., Liu, T., Xu, Y., Zhu, D., Chang, W., Ji, M., Ren, L., et al. (2018) · Cancer Management and Research · doi:10.2147/cmar.s171855 · Cited by 128

Cisplatin-activated PAI-1 secretion in the cancer-associated fibroblasts with paracrine effects promoting esophageal squamous cell carcinoma progression and causing chemoresistance

Che, Y., Wang, J., Li, Y., Lu, Z., Huang, J., Sun, S., Mao, S., Lei, Y., Zang, R., Sun, N., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0808-2 · Cited by 135

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining

Vougas, K. N., Sakellaropoulos, T., Kotsinas, A., Foukas, G.-R. P., Ntargaras, A., Koinis, F., Polyzos, A., Myrianthopoulos, V., Zhou, H., Narang, S., et al. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107395 · Cited by 129

Radiotherapy induced immunogenic cell death by remodeling tumor immune microenvironment

Zhu, S., Wang, Y., Tang, J., & Cao, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1074477 · Cited by 137

LncRNA-encoded peptides in cancer

Zhang, Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01591-0 · Cited by 131

Role of the mechanical microenvironment in cancer development and progression

Liu, Q., Luo, Q., Ju, Y., & Song, G. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0437 · Cited by 123

Targeting tumor-associated macrophages for cancer immunotherapy

Shu, Y., & Cheng, P. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188434 · Cited by 122

Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment

Xiang, X., Niu, Y., Wang, Z.-H., Ye, L., Peng, W., & Zhou, Q. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.006 · Cited by 123

Immune-checkpoint inhibitor resistance in cancer treatment: Current progress and future directions

Zhang, C., Zhang, C., & Wang, H. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216182 · Cited by 125

Microbiota and prostate cancer

Rizzo, A., Santoni, M., Mollica, V., Fiorentino, M., Brandi, G., & Massari, F. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.09.007 · Cited by 120

Therapeutic resistance of pancreatic cancer: Roadmap to its reversal

Yu, S., Zhang, C., & Xie, K. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188461 · Cited by 119

Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches

Wang, Y., Zhong, X., He, X., Hu, Z., Huang, H., Chen, J., Chen, K., Zhao, S., Wei, P., & Li, D. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02729-7 · Cited by 131

Comprehensive analysis of the association between tumor glycolysis and immune/inflammation function in breast cancer

Li, W., Xu, M. L., Li, Y., Huang, Z., Zhou, J., Zhao, Q., Le, K., Dong, F., Wan, C., & Yi, P. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02267-2 · Cited by 116

Hyperthermia Targeting the Tumor Microenvironment Facilitates Immune Checkpoint Inhibitors

Li, Z., Deng, J., Sun, J., & Ma, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.595207 · Cited by 118

Combination therapy based on nano codelivery for overcoming cancer drug resistance

Wang, H., & Huang, Y. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100024 · Cited by 115

Ferroptosis‐related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma

Lei, T., Hu, Q., Lei, P., & Hu, Y. (2021) · Cancer Science · doi:10.1111/cas.15131 · Cited by 114

M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway

Pu, J., Xu, Z., Nian, J., Fang, Q., Yang, M., Huang, Y., Li, W., Ge, B., Wang, J., & Wei, H. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00556-3 · Cited by 114

Role of Exosomal miRNAs and the Tumor Microenvironment in Drug Resistance

dos Santos, P. W. D. S., & Almeida, F. B. D. R. (2020) · Cells · doi:10.3390/cells9061450 · Cited by 114

Prognostic Significance and Tumor Immune Microenvironment Heterogenicity of m5C RNA Methylation Regulators in Triple-Negative Breast Cancer

Huang, Z., Pan, J., Wang, H., Du, X., Xu, Y., Wang, Z., & Chen, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.657547 · Cited by 113

TNFSF14: LIGHTing the Way for Effective Cancer Immunotherapy

Skeate, J. G., Otsmaa, M., Prins, R., Fernandez, D. J., Silva, D. M. D., & Kast, W. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00922 · Cited by 113

Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker

Cheng, X. M., Wang, X., Nie, K., Cheng, L., Zhang, Z., Hu, Y., & Peng, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.646523 · Cited by 114

Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer

Li, Y., Chen, Z.-K., Duan, X., Zhang, H., Xiao, B.-L., Wang, K.-M., & Chen, G. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00856-3 · Cited by 114

Tumour Heterogeneity of Breast Cancer: From Morphology to Personalised Medicine

Aleskandarany, M. A., Vandenberghe, M. E., Marchiò, C., Ellis, I. O., Sapino, A., & Rakha, E. A. (2018) · Pathobiology · doi:10.1159/000477851 · Cited by 114

Prognostic value of inflammatory markers NLR, PLR, and LMR in gastric cancer patients treated with immune checkpoint inhibitors: a meta-analysis and systematic review

Tan, S., Zheng, Q., Zhang, W., Zhou, M., Xia, C., & Feng, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1408700 · Cited by 108

Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models

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