Tumor microenvironment and therapeutic response

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Microenvironmental regulation of tumor progression and metastasis

Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994

Macrophage Diversity Enhances Tumor Progression and Metastasis

Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759

Coordinated regulation of myeloid cells by tumours

Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544

Immunogenic Cell Death in Cancer Therapy

Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384

Exosomes as a modulator of immune resistance in human cancers

Li, L., Wang, C., Li, Q., Guan, Y., Zhang, X., Kong, F., Feng, Z., Lu, Y., Wang, N., & Wang, N. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.07.007 · Cited by 25

Gene expression and DNA methylation analyses suggest that immune process‐related ADCY6 is a prognostic factor of luminal‐like breast cancer

Li, W., Sang, M., Hao, X., Li, J., Wang, Y., & Shan, B. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29633 · Cited by 25

Long non-coding RNA C5orf64 is a potential indicator for tumor microenvironment and mutation pattern remodeling in lung adenocarcinoma

Pang, Z., Chen, X., Wang, Y., Wang, Y., Yan, T., Wan, J., Wang, K., & Du, J. (2020) · Genomics · doi:10.1016/j.ygeno.2020.12.010 · Cited by 25

Association of tumor‐infiltrating lymphocytes before and after neoadjuvant chemotherapy with pathological complete response and prognosis in patients with breast cancer

Hong, J., Rui, W., Fei, X., Chen, X., & Shen, K. (2021) · Cancer Medicine · doi:10.1002/cam4.4302 · Cited by 24

WTAP‐induced N6 ‐methyladenosine of PD‐L1 blocked T‐cell‐mediated antitumor activity under hypoxia in colorectal cancer

Liu, Q., Zhang, N., Chen, J., Zhou, M., Zhou, D., Chen, Z., Huang, Z., xie, Y.-X., Qiao, G., & Tu, X. (2024) · Cancer Science · doi:10.1111/cas.16136 · Cited by 24

Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions

Sun, Y.-Q., Jiang, W., Liao, X., & Wang, D.-Q. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1421067 · Cited by 32

Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target

Sun, W.-D., Zhu, X., Li, J., Mei, Y.-Z., Li, W.-S., & Li, J.-H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113208 · Cited by 24

Senescent immune cells in the tumor microenvironment: emerging insights into cancer immunotherapy resistance

Gao, D., Kan, P., He, Y., Sun, S., Tang, L., & Yang, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1656733 · Cited by 25

A novel piperine analogue exerts in vivo antitumor effect by inducing oxidative, antiangiogenic and immunomodulatory actions

Ferreira, R. C., Batista, T. M., Duarte, S. S., Silva, D. K. F., Lisboa, T. M. H., Cavalcanti, R. F. P., Leite, F. C., Mangueira, V. M., de Sousa, T. K. G., de Abrantes, R. A., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110247 · Cited by 24

Contribution of the bone marrow stromal cells in mediating drug resistance in hematopoietic tumors

Chen, W.-C., Hu, G., & Hazlehurst, L. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.08.006 · Cited by 22

ANTXR1 Is a Prognostic Biomarker and Correlates With Stromal and Immune Cell Infiltration in Gastric Cancer

Huang, X., Zhang, J., & Zheng, Y. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.598221 · Cited by 24

Serum IL-6 as a vital predictor of severe lung cancer

An, J., Gu, Q., Cao, L., Yang, H., Deng, P., Hu, C., & Li, M. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-20-2229 · Cited by 24

Pan-Cancer Analysis of PIMREG as a Biomarker for the Prognostic and Immunological Role

Zhu, H., Hu, X., Ye, Y., Jian, Z., Zhong, Y., Gu, L., & Xiong, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.687778 · Cited by 24

A Paradoxical Effect of Interleukin-32 Isoforms on Cancer

Shim, S., Lee, S., Hisham, Y., Kim, S., Nguyen, T. T., Taitt, A. S., Hwang, J., Jhun, H., Park, H., Lee, Y.-M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.837590 · Cited by 24

Immunomodulatory effects of regorafenib: Enhancing the efficacy of anti-PD-1/PD-L1 therapy

Liu, J., Tao, H., Yuan, T., Li, J., Li, J., Liang, H., Huang, Z., & Zhang, E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.992611 · Cited by 27

Molecular mechanisms of resistance to tyrosine kinase inhibitor in clear cell renal cell carcinoma

Sekino, Y., Teishima, J., Liang, G., & Hinata, N. (2022) · International Journal of Urology · doi:10.1111/iju.15042 · Cited by 26

γδ T cells and their clinical application in colon cancer

Corsale, A. M., Simone, M. D., Presti, E. L., Dieli, F., & Meraviglia, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098847 · Cited by 24

Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity

Chen, Z., Zhao, Y., Tian, Y., Cao, R., & Shang, D. (2023) · Biomolecules · doi:10.3390/biom13020282 · Cited by 22

Fusion Radiomics-Based Prediction of Response to Neoadjuvant Chemotherapy for Osteosarcoma

Zheng, F., Yin, P., Liang, K., Wang, Y., Hao, W., Hao, Q., & Hong, N. (2023) · Academic Radiology · doi:10.1016/j.acra.2023.12.015 · Cited by 24

Human Serum Albumin-Based Dual-Agent Delivery Systems for Combination Therapy: Acting against Cancer Cells and Inhibiting Neovascularization in the Tumor Microenvironment

Zhang, Z., Zhang, J., Jiang, M., Zhao, L., Li, S., Sun, H., Yang, F., & Liang, H. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00133 · Cited by 24

Application of Immune Infiltration Signature and Machine Learning Model in the Differential Diagnosis and Prognosis of Bone-Related Malignancies

Li, G.-Q., Wang, Y.-K., Zhou, H., Jin, L.-G., Wang, C.-Y., Albahde, M., Wu, Y., Li, H.-Y., Zhang, W.-K., Li, B.-H., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.630355 · Cited by 24

Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma

Ren, P., Yu, X., Yue, H., Tang, Q., Wang, Y., & Xue, C. (2023) · Food & Function · doi:10.1039/d3fo02986g · Cited by 23

Targeting caspase-8: a new strategy for combating hepatocellular carcinoma

Chen, H., Lin, Y., Chen, J., Luo, X., Kan, Y., He, Y., Zhu, R., Jin, J., Li, D., Wang, Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1501659 · Cited by 23

Prediction and analysis of tumor infiltrating lymphocytes across 28 cancers by TILScout using deep learning

Zhang, H., Chen, L., Li, L., Liu, Y., Das, B., Zhai, S., Tan, J., Jiang, Y., Turco, S., Yao, Y., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00866-0 · Cited by 25

Screening the Cancer Genome Atlas Database for Genes of Prognostic Value in Acute Myeloid Leukemia

Ni, J., Wu, Y., Qi, F., Li, X., Yu, S., Liu, S., Feng, J., & Zheng, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01509 · Cited by 23

Identification of genes of prognostic value in the ccRCC microenvironment from TCGA database

Wan, B., Liu, B., Huang, Y., & Lv, C. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1159 · Cited by 23

Bioinformatic Profiling of Prognosis-Related Genes in Malignant Glioma Microenvironment

Li, Y., Deng, G., Qi, Y., Zhang, H., Gao, L., Jiang, H., Ye, Z., Liu, B., & Chen, Q. (2020) · Medical Science Monitor · doi:10.12659/msm.924054 · Cited by 23

A novel long noncoding RNA, TMEM92‐AS1, promotes gastric cancer progression by binding to YBX1 to mediate CCL5

Song, S., He, X., Wang, J., Song, H., Wang, Y., Liu, Y., Zhou, Z., Yu, Z., Miao, D., & Xue, Y. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12863 · Cited by 23

Boosting innate and adaptive antitumor immunity via a biocompatible and carrier-free nanovaccine engineered by the bisphosphonates-metal coordination

Qin, M., Li, M., Song, G., Yang, C., Wu, P., Dai, W., Zhang, H., Wang, X., Wang, Y., Zhou, D., et al. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101097 · Cited by 23

The Role of Bone Morphogenetic Protein 4 in Ovarian Function and Diseases

Yang, D., Yang, X., Dai, F., Wang, Y., Yang, Y., Hu, M. S., & Cheng, Y. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00600-8 · Cited by 24

Using Immune-Related lncRNA Signature for Prognosis and Response to Immunotherapy in Cutaneous Melanoma

Xue, L., Wu, P., Zhao, X., Jin, X., Wang, J., Shi, Y., Yang, X., She, Y., Li, Y., & Li, C. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s335266 · Cited by 21

KCNN4 may weaken anti-tumor immune response via raising Tregs and diminishing resting mast cells in clear cell renal cell carcinoma

Cui, Y., Shen, T., Xu, F., Zhang, J., Wang, Y., Wu, J., Bu, H., Fu, D., Fang, B., Lv, H., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02626-7 · Cited by 24

Development of a novel hypoxia-immune–related LncRNA risk signature for predicting the prognosis and immunotherapy response of colorectal cancer

Luan, L., Dai, Y., Shen, T., Yang, C., Chen, Z., Liu, S., Jia, J., Li, Z., Fang, S., Qiu, H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.951455 · Cited by 23

Tumor-Specific Monomethyl Auristatin E (MMAE) Prodrug Nanoparticles for Safe and Effective Chemotherapy

Cho, H., Shim, M. K., Moon, Y., Song, S., Kim, J., Choi, J., Kim, J., Lee, Y. J., Park, J. Y., Kim, Y., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102131 · Cited by 23

The benefits of propofol on cancer treatment: Decipher its modulation code to immunocytes

Gu, L., Pan, X., Wang, C., & Wang, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.919636 · Cited by 26

Towards a New 3Rs Era in the construction of 3D cell culture models simulating tumor microenvironment

Zhang, L., Liao, W., Chen, S., Chen, Y., Cheng, P., Lu, X., & Ma, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1146477 · Cited by 24

Identification and validation of PCSK9 as a prognostic and immune-related influencing factor in tumorigenesis: a pan-cancer analysis

Sun, C., Zhu, G., Shen, C., Huang, S., Li, R., Li, J., Ma, Z., & Wang, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1134063 · Cited by 22

Complement C7 (C7), a Potential Tumor Suppressor, Is an Immune-Related Prognostic Biomarker in Prostate Cancer (PC)

Chen, Z., Yan, X., Du, G.-W., Tuoheti, K., Bai, X., Wu, H., Zhang, R., Xiao, G.-F., & Liu, T.-Z. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01532 · Cited by 23

IGLL5 is correlated with tumor‐infiltrating immune cells in clear cell renal cell carcinoma

Xia, Z., Wang, X., Cai, L., Jian, W., & Zhang, C. L. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13085 · Cited by 23

Research progress in tumor targeted immunotherapy

Fang, Y., Yu, A., Ye, L., & Zhai, G. (2021) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1882992 · Cited by 23

Personalized models of heterogeneous 3D epithelial tumor microenvironments: Ovarian cancer as a model

Horst, E. N., Bregenzer, M. E., Mehta, P., Snyder, C. S., Repetto, T., Yang‐Hartwich, Y., & Mehta, G. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.041 · Cited by 25

In vitro study of cold atmospheric plasma-activated liquids inhibits malignant melanoma by affecting macrophage polarization through the ROS/JAK2/STAT1 pathway

Chen, C., Zhou, S., Yang, X., Ren, M., Qi, Y., Mao, Y., & Yang, C. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116657 · Cited by 27

Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery

Guo, Y., He, X., Williams, G. R., Zhou, Y., Liao, X., Xiao, Z., Yu, C., & Liu, Y. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101003 · Cited by 23

Stimuli-Responsive Nanomaterials for Tumor Immunotherapy

Li, X., Hou, D., Wu, J.-C., Zhang, P., Wang, Y.-Z., Lv, M.-Y., Yi, Y., & Xu, W. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00388 · Cited by 22

Towards precision medicine: design considerations for nanozymes in tumor treatment

Li, X., Hu, J., Zhao, Q., Yao, W., Jing, Z., & Jin, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05845-w · Cited by 24

The role of the tumor microenvironment in HNSCC resistance and targeted therapy

Guo, Z., Li, K., Ren, X., Wang, X., Yang, D., Ma, S., Zeng, X., & Zhang, P. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1554835 · Cited by 23

Expression of IL-17 with tumor budding as a prognostic marker in oral squamous cell carcinoma.

Zhang, S., Wang, X., Gupta, A., Fang, X. L., Wang, L., & Zhang, C. (2019) · Europe PMC (PubMed Central) · Cited by 22

Dissecting the molecular pathways involved in the effects of physical activity on breast cancers cells: A narrative review

Orlandella, F. M., Stefano, A. E. D., Iervolino, P. L. C., Buono, P., Soricelli, A., & Salvatore, G. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118790 · Cited by 23

Inhibitors of ADAM10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect

Pece, R., Tavella, S., Costa, D., Varesano, S., Camodeca, C., Cuffaro, D., Nuti, E., Rossello, A., Alfano, M., D’Arrigo, C., et al. (2021) · Haematologica · doi:10.3324/haematol.2021.278469 · Cited by 22

Prognostic Value of Immune-Related Multi-IncRNA Signatures Associated With Tumor Microenvironment in Esophageal Cancer

Pang, J., He, P., Yang, C., Meng, P., Xie, W. Q., Li, J., Li, Y., & Xiao, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.722601 · Cited by 22

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study

Chen, W., Cao, H., Cao, J., Zuo, L., Qu, F., Xu, D., Zhang, H., Gong, H., Chen, J., Ye, J., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04501-9 · Cited by 22

Calculated Tumor-Associated Neutrophils Are Associated with the Tumor—Stroma Ratio and Predict a Poor Prognosis in Advanced Gastric Cancer

Kim, E. Y., Abdul‐Ghafar, J., Chong, Y., & Yim, K. (2022) · Biomedicines · doi:10.3390/biomedicines10030708 · Cited by 22

5-fluorouracil treatment of patient-derived scaffolds from colorectal cancer reveal clinically critical information

Salerno, S., Ståhlberg, A., Holdfeldt, A., Lindskog, E. B., & Landberg, G. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03423-6 · Cited by 22

Survival-related indicators ALOX12B and SPRR1A are associated with DNA damage repair and tumor microenvironment status in HPV 16-negative head and neck squamous cell carcinoma patients

Li, J., Tang, L., & Ma, J. (2022) · BMC Cancer · doi:10.1186/s12885-022-09722-x · Cited by 22

A comprehensive pan-cancer analysis on the immunological role and prognostic value of TYMP in human cancers

Yang, Y., Jiang, L., Wang, S., Chen, H., Yi, M., Wu, Y., Li, Z., & Fang, X. (2022) · Translational Cancer Research · doi:10.21037/tcr-22-502 · Cited by 21

CC Chemokine Ligand-2: A Promising Target for Overcoming Anticancer Drug Resistance

Shi, Z., Tu, J., Ying, Y., Diao, Y., Zhang, P., Liao, S., Xiong, Z., & Huang, S. (2022) · Cancers · doi:10.3390/cancers14174251 · Cited by 21

Combined inhibition of PARP and EZH2 for cancer treatment: Current status, opportunities, and challenges

Zhang, X., Huo, X., Guo, H., & Xue, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.965244 · Cited by 23

Vesicle-mediated transport-related genes are prognostic predictors and are associated with tumor immunity in lung adenocarcinoma

Qian, C., Jiang, Z., Zhou, T., Wu, T., Zhang, Y., Huang, J. W., Ouyang, J., Dong, Z., Wu, G. J., & Cao, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1034992 · Cited by 22

The role of ligands on synthesis, functional control, and biomedical applications of near-infrared light-responsive metal-based nanoparticles

Hu, X., Wang, P., Huang, C., Fang, C., Li, F., & Ling, D. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215632 · Cited by 24

Exercise potentially prevents colorectal cancer liver metastases by suppressing tumor epithelial cell stemness via RPS4X downregulation

Wan, R., Chen, Y., Feng, X., Luo, Z., Peng, Z., Qi, B., Qin, H., Lin, J., Chen, S., Xu, L., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26604 · Cited by 22

Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis

Yimin, E., Lü, Q., Zhu, K., Li, W., Sun, J., Ji, P., Meng, M., Liu, Z., & Yu, C. (2024) · iScience · doi:10.1016/j.isci.2024.109350 · Cited by 23

Spatial omics techniques and data analysis for cancer immunotherapy applications

Zhang, Y., Lee, R. Y., Tan, C. W., Guo, X., Yim, W. W., Lim, J., Wee, F. Y. T., Wu, Y., Kharbanda, M., Lee, J.-Y. J., et al. (2024) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2024.103111 · Cited by 23

Secretome profiling of heterotypic spheroids suggests a role of fibroblasts in HIF-1 pathway modulation and colorectal cancer photodynamic resistance

Lamberti, M. J., Rettel, M., Krijgsveld, J., Rivarola, V. A., & Vittar, N. B. R. (2019) · Cellular Oncology · doi:10.1007/s13402-018-00418-8 · Cited by 22

Have Cells Harboring the HIV Reservoir Been Immunoedited?

Huang, S.-H., McCann, C. D., Mota, T. M., Wang, C., Lipkin, S. M., & Jones, R. B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01842 · Cited by 23

The immune‐related biomarker TEK inhibits the development of clear cell renal cell carcinoma (ccRCC) by regulating AKT phosphorylation

Chen, S., Yu, M., Ju, L., Wang, G., Qian, K., Xiao, Y., & Wang, X. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01830-1 · Cited by 22

SOD1-high fibroblasts derived exosomal miR-3960 promotes cisplatin resistance in triple-negative breast cancer by suppressing BRSK2-mediated phosphorylation of PIMREG

Li, K., Lin, H., Liu, A., Qiu, C., Rao, Z., Wang, Z., Chen, S., She, X., Zhu, S., Liu, L., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216842 · Cited by 21

Glioblastoma Tumor Microenvironment: An Important Modulator for Tumoral Progression and Therapy Resistance

Tătăranu, L. G., Turliuc, Ș., Kamel, A., Rizea, R. E., Dricu, A., Staicu, G.-A., Baloi, C., Rodriguez, S. M. B., & Manole, A. I. M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46090588 · Cited by 21

Drug resistance in TKI therapy for hepatocellular carcinoma: Mechanisms and strategies

Jiang, X., Ge, X., Huang, Y., Xie, F., Chen, C., Wang, Z., Tao, W., Zeng, S., Lv, L., Zhan, Y., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217472 · Cited by 24

Precision Tumor Medicine and Drug Targets

Liu, W., Wang, X., Zhu, H., & Duan, Y. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/156802661917190828111130 · Cited by 21

Anti-hypoxia nanosized drug delivery systems improving cancer therapy

Yan, W., Lang, T., Zhu, R., Zhu, X. G., Yu, H., Wu, T., Yin, Q., & Li, Y. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101376 · Cited by 21

Identify the immune characteristics and immunotherapy value of CD93 in the pan-cancer based on the public data sets

Guo, A., Zhang, J., Tian, Y., Peng, Y., Luo, P., Zhang, J., Liu, Z., Wu, W., Zhang, H., & Cheng, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907182 · Cited by 21

Single-Cell RNA Sequencing Reveals Heterogeneity in the Tumor Microenvironment between Young-Onset and Old-Onset Colorectal Cancer

Li, G., Xiao, G.-Z., Qin, P., Wan, X., Fu, Y., Zheng, Y., Luo, M., Ren, D., Liu, S., Chen, H., et al. (2022) · Biomolecules · doi:10.3390/biom12121860 · Cited by 21

The redox protein HMGB1 in cell death and cancer

Chen, R., Zou, J., Kang, R., & Tang, D. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0007 · Cited by 22

Engineered macrophages acting as a trigger to induce inflammation only in tumor tissues

Tanito, K., Nii, T., Yokoyama, Y., Oishi, H., Shibata, M., Hijii, S., Kaneko, R., Tateishi, C., Ito, S., Kishimura, A., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.04.010 · Cited by 21

A novel CTLA-4 blocking strategy based on nanobody enhances the activity of dendritic cell vaccine-stimulated antitumor cytotoxic T lymphocytes

Yang, W., Pang, Y., Wang, X., Lai, Z., Lu, Y., Zheng, S., & Wang, W. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05914-w · Cited by 23

Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance

Fakhri, S., Moradi, S. Z., Faraji, F., Farhadi, T., Hesami, O., Iranpanah, A., Webber, K. J., & Bishayee, A. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10119-w · Cited by 24

Porphyromonas gingivalis suppresses oral squamous cell carcinoma progression by inhibiting MUC1 expression and remodeling the tumor microenvironment

Lan, Z., Zou, K., Cui, H., Zhao, Y., & Yu, G. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13517 · Cited by 21

Identification of Key Genes in Thyroid Cancer Microenvironment

Zhao, K., Yang, H., Kang, H., & Wu, A. (2019) · Medical Science Monitor · doi:10.12659/msm.918519 · Cited by 21

Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection

Vito, A. D., Orecchia, P., Balza, E., Reverberi, D., Scaldaferri, D., Taramelli, R., Noonan, D. M., Acquati, F., & Mortara, L. (2020) · Cancers · doi:10.3390/cancers12030717 · Cited by 21

Fibrinogen‑like protein 2 promotes the accumulation of myeloid‑derived suppressor cells in the hepatocellular carcinoma tumor microenvironment

Liu, B.-Q., Bao, Z., Zhu, J.-Y., & Liu, H. (2020) · Oncology Letters · doi:10.3892/ol.2020.12308 · Cited by 20

High expression of regulator of G‑protein signalling 1 is associated with the poor differentiation and prognosis of gastric cancer

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