Cited by 1,802Cancer Cells and MetastasisCancer Immunotherapy and BiomarkersCancer, Hypoxia, and Metabolism

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Tumor microenvironment and therapeutic response

Wu, Ting, Dai, Yun·2017·Cancer Letters

DOI 10.1016/j.canlet.2016.01.043

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Abstract

The tumor microenvironment significantly influences therapeutic response and clinical outcome. Microenvironment-mediated drug resistance can be induced by soluble factors secreted by tumor or stromal cells. The adhesion of tumor cells to stromal fibroblasts or to components of the extracellular matrix can also blunt therapeutic response. Microenvironment-targeted therapy strategies include inhibition of the extracellular ligand-receptor interactions and downstream pathways. Immune cells can both improve and obstruct therapeutic efficacy and may vary in their activation status within the tumor microenvironment; thus, re-programme of the immune response would be substantially more beneficial. The development of rational drug combinations that can simultaneously target tumor cells and the microenvironment may represent a solution to overcome therapeutic resistance.

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Authors: Wu, T., & Dai, Y.
Affiliations: Peking University First Hospital (CN)
Corresponding author: Dai, Yun
ORCID: Wu, Ting
Dai, Yun
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2017-02
Volume: 387
Pages: 61-68
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2016.01.043
OpenAlex: W2265419075
Cited by: 1,802
References: 124
Citations by year: 2026: 76 · 2025: 179 · 2024: 238 · 2023: 344 · 2022: 382 · 2021: 316 · 2020: 191 · 2019: 48 · 2018: 20 · 2017: 5
FWCI: 2.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: tumor microenvironment, treatment resistance, drug resistance, stromal fibroblasts, extracellular matrix, cell adhesion, immune cells, immune reprogramming, combination therapy, soluble factors
MeSH terms: Animals, Antineoplastic Agents, Humans, Neoplasms, Molecular Targeted Therapy, Tumor Microenvironment

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