Cited by 286Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects

Dore, Celina Maria P. Guerra, Faustino Alves, Monique Gabriela das C., Pofírio Will, Luiza Sheyla E., Costa, Thiago G., Sabry, Diego A., de Souza Rêgo, Leonardo Augusto R., Accardo, Camila M., Rocha, Hugo Alexandre O. +2 more·2013·Carbohydrate Polymers

Abstract

Fucan (SV1) sulfated polysaccharides from the brown algae Sargassum vulgare were extracted, fractionated in acetone and examined with respect to chemical composition, anticoagulant, anti-inflammatory, antithrombotic effects and cellular proliferation. These polysaccharides contain low levels of protein, high level of carbohydrate and sulfate. Monosaccharides analysis revealed that SV1 was composed of fucose, galactose, xylose, glucuronic acid and mannose. SV1 polysaccharide prolonged activated partial thromboplastin time (aPTT) and exhibited high antithrombotic action in vivo, with a concentration ten times higher than heparin activity. PSV1, a purified form in gel filtration showed very low biological activities. SV1 stimulated the enzymatic activity of FXa. Its action on DPPH radical scavenging activity was 22%. This polymer has no cytotoxic action (hemolytic) on ABO and Rh blood types in different erythrocyte groups. It displays strong anti-inflammatory action at all concentrations tested in the carrageenan-induced paw edema model, demonstrated by reduced edema and cellular infiltration.

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Crossref · 10.1016/j.carbpol.2012.07.075

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Authors
Dore, C. M. P. G., Faustino Alves, M. G. D. C., Pofírio Will, L. S. E., Costa, T. G., Sabry, D. A., de Souza Rêgo, L. A. R., Accardo, C. M., Rocha, H. A. O., Filgueira, L. G. A., & Leite, E. L.
Affiliations
  • Universidade Federal do Rio Grande do Norte (BR)
  • Universidade Federal de São Paulo (BR)
Corresponding author
Leite, Edda Lisboa
Venue
Carbohydrate Polymers
Publisher
Elsevier BV
Published
2013-01
Volume
91
Issue
1
Pages
467-475
ISSN
0144-8617 (ISSN-L)
OpenAlex
W2021800696
Cited by
286
References
32
Citations by year
2026: 5 · 2025: 22 · 2024: 23 · 2023: 18 · 2022: 26 · 2021: 29 · 2020: 35 · 2019: 26 · 2018: 22 · 2017: 19 · 2016: 20 · 2015: 15 · 2014: 11 · 2013: 15
FWCI
19.28
Type
journal article
Language
en
Open access
closed
Locations
  • Carbohydrate Polymers (publishedVersion)
  • PubMed (publishedVersion)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders
  • CAPES
  • MCT
  • FAPERN/CNPq
  • CNPq/Brazil
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords
fucan, sulfated polysaccharides, Sargassum vulgare, brown algae, anticoagulant activity, antithrombotic activity, antioxidant activity, anti-inflammatory activity, activated partial thromboplastin time, factor Xa, DPPH radical scavenging, hemolytic activity, carrageenan-induced paw edema, polysaccharide purification
MeSH terms
ABO Blood-Group System, Animals, Anti-Inflammatory Agents, Non-Steroidal, Anticoagulants, Carrageenan, Cell Survival, Edema, Erythrocytes, Fibrinolytic Agents, Hemolysis, Male, Polysaccharides, Rh-Hr Blood-Group System, Thrombin, Factor Xa, Free Radical Scavengers, Rats, Wistar, Sargassum, Cell Line, Tumor, Mice, Rats

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