Neuronal activity modifies the DNA methylation landscape in the adult brain
Open accessAbstract
DNA methylation has been traditionally viewed as a highly stable epigenetic mark in postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation changes, at least in a few identified CpG dinucleotides. How extensively the neuronal DNA methylome is regulated by neuronal activity is unknown. Using a next-generation sequencing-based method for genome-wide analysis at single-nucleotide resolution, we quantitatively compared the CpG methylation landscape of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation. About 1.4% of 219,991 CpGs measured showed rapid active demethylation or de novo methylation. Some modifications remained stable for at least 24 h. These activity-modified CpGs showed a broad genomic distribution with significant enrichment in low-CpG density regions, and were associated with brain-specific genes related to neuronal plasticity. Our study implicates modification of the neuronal DNA methylome as a previously underappreciated mechanism for activity-dependent epigenetic regulation in the adult nervous system.
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Extensive active demethylation following neuronal activity through the Tet-TDG pathway-associated base excision repair can be a source of DNA breaks.
“extensive active demethylation following neuronal activity through the Tet-TDG pathway-associated base excision repair can also be a source of DNA breaks”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [12]
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Moroz, L. L., & Kohn, A. B. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-556-9_21 · Cited by 42 · see citing works
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Retracted
- Authors
- Guo, J. U., Ma, D. K., Mo, H., Ball, M. P., Jang, M.-H., Bonaguidi, M. A., Balazer, J. A., Eaves, H. L., Xie, B., Ford, E., Zhang, K., Ming, G.-L., Gao, Y., & Song, H.
- Affiliations
- Johns Hopkins University (US)
- Virginia Commonwealth University (US)
- Proofpoint (United States) (US)
- Lieber Institute for Brain Development (US)
- University of California San Diego (US)
- Corresponding author
- Gao, Yuan
- Song, Hongjun
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2011-08-28
- Volume
- 14
- Issue
- 10
- Pages
- 1345-1351
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3183401
- OpenAlex
- W2064756496
- Cited by
- 669
- References
- 51
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 24 · 2023: 34 · 2022: 32 · 2021: 46 · 2020: 34 · 2019: 47 · 2018: 52 · 2017: 62 · 2016: 51 · 2015: 52 · 2014: 74 · 2013: 65 · 2012: 46
- FWCI
- 24.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health
- National Institute on Aging (AG 024984, R01AG024984)
- National Institute of Mental Health (R00MH090115, K99MH090115)
- National Institute on Drug Abuse (R01DA025779)
- National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R37NS047344, R56NS047344)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD069184, HD069184)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- DNA methylation, neuronal activity, dentate gyrus granule cells, CpG methylation, demethylation, de novo methylation, adult brain, neuroplasticity, brain-specific genes
- MeSH terms
- Animals, Chromosome Mapping, Gene Expression Regulation, Hippocampus, Molecular Sequence Data, Motor Activity, Neurons, Physical Conditioning, Animal, Statistics as Topic, CpG Islands, DNA Methylation, Genomics, Mice, Epigenomics
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