Circulating Levels of Inflammatory Cytokines and Risk of Colorectal Adenomas
Open accessAbstract
The association between obesity and colorectal neoplasia may be mediated by inflammation. Circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) are elevated in the obese. Adipose tissue can produce and release the inflammatory cytokines that are potentially procarcinogenic. We examined circulating levels of CRP, IL-6, and TNF-α in relation to risk factors and the prevalence of colorectal adenomas. Plasma levels of CRP, IL-6, and TNF-α were quantified in 873 participants (242 colorectal adenoma cases and 631 controls) in a colonoscopy-based cross-sectional study conducted between 1998 and 2002. Multivariable logistic regression was used to estimate associations between known risk factors for colorectal neoplasia and circulating levels of inflammatory cytokines and associations between inflammatory cytokines and colorectal adenomas. Several known risk factors for colorectal neoplasia were associated with higher levels of inflammatory cytokines, including older age, current smoking, and increasing adiposity. The prevalence of colorectal adenomas was associated with higher concentrations of IL-6 and TNF-α and, to a lesser degree, with CRP. For IL-6, adjusted odds ratios (OR) for colorectal adenomas were 1.79 [95% confidence interval (CI), 1.19–2.69] for the second highest plasma level and 1.85 (95% CI, 1.24–2.75) for the highest level compared with the reference level. A similar association was found with TNF-α, with adjusted ORs of 1.56 (95% CI, 1.03–2.36) and 1.66 (95% CI, 1.10–2.52), respectively. Our findings indicate that systemic inflammation might be involved in the early development of colorectal neoplasia. [Cancer Res 2008;68(1):323–8]
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Several pro-inflammatory cytokines, including TNF, PGE2, IL-1, and IL-6, have been demonstrated to exert a direct influence on the levels and function of GPX4 within cancer cells.
“Several pro-inflammatory cytokines, including TNF, PGE2, IL-1, and IL-6, have been demonstrated to exert a direct influence on the levels and function of GPX4 within cancer cells;251”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [251]
The Discussion describes effects of IL-6 and TNF-α on cell growth and apoptosis, while the Results address circulating cytokines and colorectal adenomas. Searches for GPX4 and for PGE2 in connection with the claimed direct effect found no passage about cytokines changing GPX4 levels or function in cancer cells. The indexed passages provide no page numbers. (LLM, conf=0.76)
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- Authors
- Kim, S., Keku, T. O., Martin, C., Galanko, J., Woosley, J. T., Schroeder, J. C., Satia, J. A., Halabi, S., & Sandler, R. S.
- Affiliations
- 1Department of Epidemiology, School of Public Health,
- 2Center for Gastrointestinal Biology and Disease, and
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
- ORCID
- Venue
- Cancer Research
- Published
- 2008-01-01
- Volume
- 68
- Issue
- 1
- Pages
- 323-328
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC2675825
- OpenAlex
- W2105702970
- Cited by
- 298
- References
- 44
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 10 · 2023: 18 · 2022: 25 · 2021: 20 · 2020: 17 · 2019: 12 · 2018: 13 · 2017: 19 · 2016: 12 · 2015: 20 · 2014: 16 · 2013: 18 · 2012: 27
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- AstraZeneca
- National Institutes of Health (DK-34987)
- National Cancer Institute (R01CA044684)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034987)
- Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- colorectal adenoma, inflammatory cytokines, C-reactive protein, interleukin-6, TNF-α, systemic inflammation, obesity, adiposity, colorectal neoplasia risk, smoking, colonoscopy
- MeSH terms
- Adenoma, Adult, Aged, Female, Humans, Inflammation, Male, Middle Aged, Risk, Tumor Necrosis Factor-alpha, Colorectal Neoplasms, Interleukin-6, Prevalence, Cytokines
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