SEARCH for Diabetes in Youth: a multicenter study of the prevalence, incidence and classification of diabetes mellitus in youth
Abstract
SEARCH for Diabetes in Youth is an observational, multicenter study focusing on physician-diagnosed diabetes in individuals <20 years old. The study will estimate the population prevalence and incidence of diabetes by type, age, gender, and ethnicity and develop practical approaches to diabetes classification in 5 million children ( approximately 6% of the <20 U.S. population) with wide ethnic and socioeconomic representation from four geographically defined populations and two health plans. An estimated 6000 prevalent and 800 incident diabetes cases per year will be identified with annual follow-up. Cases will be ascertained through clinical and nonclinical resources or partnerships at each site. Data collection involves patient interviews, physical examinations, laboratory measurements (diabetes autoantibodies, fasting/stimulating C-peptide, hemoglobin A1c, blood glucose, lipids, urine albumin, creatinine), medical records reviews, and documentation of risk factors for complications and processes of care.
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Atypical diabetes is becoming increasingly difficult to precisely define in the absence of a definitive set of tests for either type 1 or type 2 diabetes.
“although admittedly, atypical diabetes is becoming increasingly dif fi cult to precisely de fi ne in the absence of a de fi nitive set of tests for either type of diabetes (158 -160,163 -169)”
From 2. Diagnosis and Classification of Diabetes: <i>Standards of Care in Diabetes—2024</i> (2024) · cites this paper as [166]
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Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes
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Diabetic retinopathy in the SEARCH for Diabetes in Youth Cohort: a pilot study
Mayer‐Davis, E. J., Davis, C., SAADDINE, J. B., D’Agostino, R. B., Dabelea, D., Dolan, L. M., Garg, S., Lawrence, J. M., Pihoker, C., Rodríguez, B. L., et al. (2012) · Diabetic Medicine · doi:10.1111/j.1464-5491.2012.03591.x · Cited by 80 · see citing works
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Breast-Feeding and Type 2 Diabetes in the Youth of Three Ethnic Groups
Mayer‐Davis, E. J., Dabelea, D., Lamichhane, A. P., D'Agostino, R. B., Liese, A. D., Thomas, J. M., McKeown, R. E., & Hamman, R. F. (2008) · Diabetes Care · doi:10.2337/dc07-1321 · Cited by 77 · see citing works
Type 2 Diabetes in Youth: New Lessons from the SEARCH Study
Jensen, E. T., & Dabelea, D. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-0997-1 · Cited by 78 · see citing works
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Lindner, L. M. E., Rathmann, W., & Rosenbauer, J. (2018) · Diabetic Medicine · doi:10.1111/dme.13519 · Cited by 73 · see citing works
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Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes
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Insulin Regimens and Clinical Outcomes in a Type 1 Diabetes Cohort
Pihoker, C., Badaru, A., Anderson, A., Morgan, T. M., Dolan, L. M., Dabelea, D., Imperatore, G., Linder, B. L., Marcovina, S. M., Mayer‐Davis, E. J., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0720 · Cited by 69 · see citing works
Urbina, E. M., Isom, S. P., Bell, R. A., Bowlby, D., D'Agostino, R., Daniels, S. R., Dolan, L. M., Imperatore, G., Marcovina, S. M., Merchant, A. T., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010150 · Cited by 69 · see citing works
Registry of Youth Onset Diabetes in India (YDR)
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Naughton, M. J., Yi‐Frazier, J. P., Morgan, T. M., Seid, M., Lawrence, J. M., KLINGENSMITH, G. J., Waitzfelder, B., Standiford, D. A., & Loots, B. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.01.027 · Cited by 67 · see citing works
Liese, A. D., Ma, X., Maahs, D. M., & Trilk, J. L. (2012) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2012.10.005 · Cited by 67 · see citing works
Cardiovascular Risk Factors Among Youth With and Without Type 2 Diabetes
West, N. A., Hamman, R. F., Mayer‐Davis, E. J., D'Agostino, R. B., Marcovina, S. M., Liese, A. D., Zeitler, P. S., Daniels, S. R., & Dabelea, D. (2008) · Diabetes Care · doi:10.2337/dc08-1442 · Cited by 65 · see citing works
Weight-Loss Practices and Weight-Related Issues Among Youth With Type 1 or Type 2 Diabetes
Lawrence, J. M., Liese, A. D., Liu, L. L., Dabelea, D., Anderson, A., Imperatore, G., & Bell, R. A. (2008) · Diabetes Care · doi:10.2337/dc08-0719 · Cited by 64 · see citing works
Barnes, T. L., Crandell, J., Bell, R. A., Mayer‐Davis, E. J., Dabelea, D., Liese, A. D., & for the SEARCH for Diabetes in Youth Study Group (2013) · Nutrition and Diabetes · doi:10.1038/nutd.2013.32 · Cited by 61 · see citing works
Zhong, V. W., Pfaff, E., Beavers, D. P., Thomas, J. M., Jaacks, L. M., Bowlby, D., Carey, T. S., Lawrence, J. M., Dabelea, D., Hamman, R. F., et al. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12152 · Cited by 58 · see citing works
Self-management in Type 2 Diabetes
Mulvaney, S. A., Mudasiru, E., Schlundt, D. G., Baughman, C. L., Fleming, M., VanderWoude, A., Russell, W. E., Elasy, T. A., & Rothman, R. L. (2008) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721708320902 · Cited by 58 · see citing works
Self-Care and Self-Management Among Adolescent T2DM Patients: A Review
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Adherence to Guidelines for Youths With Diabetes Mellitus
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Physical Activity and Electronic Media Use in the SEARCH for Diabetes in Youth Case-Control Study
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Noise History and Auditory Function in Young Adults With and Without Type 1 Diabetes Mellitus
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Prevalence of Asthma and Its Association With Glycemic Control Among Youth With Diabetes
Black, M. H., Anderson, A., Bell, R. A., Dabelea, D., Pihoker, C., Saydah, S., Seid, M., Standiford, D. A., Waitzfelder, B., Marcovina, S. M., et al. (2011) · PEDIATRICS · doi:10.1542/peds.2010-3636 · Cited by 47 · see citing works
- Authors
- The SEARCH Study Group
- Corresponding author
- The SEARCH Study Group
- Venue
- Controlled Clinical Trials
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 25
- Issue
- 5
- Pages
- 458-471
- ISSN
- 0197-2456 (ISSN-L)
- OpenAlex
- W4229611233
- Cited by
- 268
- References
- 20
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 12 · 2023: 16 · 2022: 13 · 2021: 7 · 2020: 15 · 2019: 11 · 2018: 11 · 2017: 11 · 2016: 12 · 2015: 13 · 2014: 24 · 2013: 22 · 2012: 20
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Controlled Clinical Trials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kaiser Permanente
- U.S. Public Health Service (PA 00097)
- NIH Clinical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes mellitus, youth, children, prevalence, incidence, diabetes classification, type 1 diabetes, type 2 diabetes, diabetes autoantibodies, C-peptide, HbA1c, diabetes complications, risk factors, health plans
- MeSH terms
- Adolescent, Carrier Proteins, Child, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Male, Mass Screening, Multicenter Studies as Topic, Incidence, Prevalence
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