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Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling
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Cites
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Araki, N., Johnson, M. T., & Swanson, J. A. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.5.1249 · Cited by 949 · cited 1×
“Macrophages do not typically have a leading edge, but instead have membrane ruffles, which are discrete regions of the plasma membrane that are biochemically similar to the leading edge of fibroblasts (Allen et al., 1998; Araki et al., 1996).”
PIP2and Proteins: Interactions, Organization, and Information Flow
McLaughlin, S., Wang, J., Gambhir, A., & Murray, D. (2002) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.31.082901.134259 · Cited by 837
Raucher, D., Stauffer, T., Chen, W., Shen, K., Guo, S., York, J. D., Sheetz, M. P., & Meyer, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81560-3 · Cited by 675
Cited by
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
LPS/TLR4 signal transduction pathway
Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
O'Neill, L. A. J., & Bowie, A. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2079 · Cited by 2,667
Toll-like Receptors and the Control of Immunity
Fitzgerald, K. A., & Kagan, J. C. (2020) · Cell · doi:10.1016/j.cell.2020.02.041 · Cited by 2,168
Self-citationThe history of toll-like receptors - redefining innate immunity
O'Neill, L. A. J., Golenbock, D., & Bowie, A. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3446 · Cited by 1,765
Innate Immune Pattern Recognition: A Cell Biological Perspective
Brubaker, S. W., Bonham, K. S., Zanoni, I., & Kagan, J. C. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112240 · Cited by 1,475
Self-citationTLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
Ciesielska, A., Matyjek, M., & Kwiatkowska, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03656-y · Cited by 1,420
Hayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178
CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
Zanoni, I., Ostuni, R., Marek, L. R., Barresi, S., Barbalat, R., Barton, G. M., Granucci, F., & Kagan, J. C. (2011) · Cell · doi:10.1016/j.cell.2011.09.051 · Cited by 997
Self-citationAssembly and localization of Toll-like receptor signalling complexes
Gay, N. J., Symmons, M. F., Gangloff, M., & Bryant, C. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3713 · Cited by 832
MyD88: a central player in innate immune signaling
Deguine, J., & Barton, G. M. (2014) · F1000Prime Reports · doi:10.12703/p6-97 · Cited by 692
Characterization of Heme as Activator of Toll-like Receptor 4
Figueiredo, R. T., Fernandez, P. L., Mourao-Sa, D. S., Porto, B. N., Dutra, F. F., Alves, L. S., Oliveira, M. F., Oliveira, P. L., Graça-Souza, A. V., & Bozza, M. T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610737200 · Cited by 576
Dissecting negative regulation of Toll-like receptor signaling
Kondo, T., Kawai, T., & Akira, S. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.05.002 · Cited by 419
The molecular basis of the host response to lipopolysaccharide
Bryant, C. E., Spring, D. R., Gangloff, M., & Gay, N. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2266 · Cited by 391
Critical role of TLR4 response in the activation of microglia induced by ethanol
Fernandez-Lizarbe, S., Pascual, M., & Guerri, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803590 · Cited by 373
TLR4/MyD88/PI3K interactions regulate TLR4 signaling.
Laird, M. H. W., Rhee, S. H., Perkins, D. J., Medvedev, A. E., Piao, W., Fenton, M. J., & Vogel, S. N. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1208763 · Cited by 342
Activating and inhibitory functions of DAP12
Turnbull, I. R., & Colonna, M. (2007) · Nature Reviews Immunology · doi:10.1038/nri2014 · Cited by 273
Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling
Norris, P. C., & Dennis, E. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200189109 · Cited by 193
Chinenov, Y., & Rogatsky, I. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.04.014 · Cited by 133
Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12
Paradowska-Gorycka, A., & Jurkowska, M. (2013) · Human Immunology · doi:10.1016/j.humimm.2013.02.003 · Cited by 103
Grohmann, A., Tanneberger, K., Alzner, A., Schneikert, J., & Behrens, J. (2007) · Journal of Cell Science · doi:10.1242/jcs.011320 · Cited by 85
TIRAP in the Mechanism of Inflammation
Rajpoot, S., Wary, K. K., Ibbott, R., Liu, D., Saqib, U., Thurston, T. L. M., & Baig, M. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.697588 · Cited by 79
Gulshan, K., Brubaker, G., Conger, H., Wang, S., Zhang, R., Hazen, S. L., & Smith, J. D. (2016) · Circulation Research · doi:10.1161/circresaha.116.308856 · Cited by 66
Structural and Functional Characterization of the Wnt Inhibitor APC Membrane Recruitment 1 (Amer1)
Tanneberger, K., Pfister, A. S., Kriz, V., Bryja, V., Schambony, A., & Behrens, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.224881 · Cited by 62
New insights into lipopolysaccharide inactivation mechanisms in sepsis
Pérez-Hernández, E. G., Delgado-Coello, B., Luna-Reyes, I., & Mas-Oliva, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111890 · Cited by 56
Toll-like receptor 4 plays significant roles during allergic rhinitis
Radman, M., Golshiri, A., Shamsizadeh, A., Zainodini, N., Bagheri, V., Arababadi, M. K., & Kennedy, D. (2015) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2014.04.006 · Cited by 39
Phospholipase Cγ in Toll-like receptor-mediated inflammation and innate immunity
Bae, Y.-S., Lee, H. Y., Jung, Y. S., Lee, M., & Suh, P.-G. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2016.09.006 · Cited by 34
Ernest James Phillips, T., & Maguire, E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.652593 · Cited by 33
Shi, M., Zhu, Y., Yan, J., Rouby, J., Summah, H., Monsel, A., & Qu, J. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.287 · Cited by 30
Li, K., Ran, B., Wang, Y., Liu, L., & Li, W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999061 · Cited by 18
Prothrombin Kringle-2: a potential inflammatory pathogen in the parkinsonian dopaminergic system
Leem, E., Jeong, K. H., Won, S.-Y., Shin, W.-H., & Kim, S. R. (2016) · Experimental Neurobiology · doi:10.5607/en.2016.25.4.147 · Cited by 16
Lagos Magallanes, S., Beasley Lomazzi, A., Zamarreño, F., Carrión, F., Fló, M., Dutto, J., Julve, J., Costabel, M., Maccioni, M., Folle, A. M., et al. (2026) · Infection and Immunity · doi:10.1128/iai.00361-25
Metadata
- Authors
- Kagan, J. C., & Medzhitov, R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 125
- Issue
- 5
- Pages
- 943-955
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2043823247
- Cited by
- 847
- References
- 5
- FWCI
- 16.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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