The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Open accessAbstract
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. In order to identify miRNAs and to assess their expression patterns, we sequenced over 250 small RNA libraries from 26 different organ systems and cell types of human and rodents that were enriched in neuronal as well as normal and malignant hematopoietic cells and tissues. We present expression profiles derived from clone count data and provide computational tools for their analysis. Unexpectedly, a relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues. This broad survey also provides detailed and accurate information about mature sequences, precursors, genome locations, maturation processes, inferred transcriptional units, and conservation patterns. We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“miR-27a/b are expressed in SN of human midbrain (Additional file 2a) [34–36]”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [34]
In the citing paper
“Several previous studies showed that miR-27a/b are expressed in human midbrain [34–36].”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [34]
In the citing paper
“Previous studies have shown that only a small population of miRNAs accounts for a majority of miRNA pool in the brain (Shin et al. 2010, Hu et al. 2011, Landgraf et al. 2007, Berezikov et al. 2006).”
From miR‐186 is decreased in aged brain and suppresses BACE 1 expression (2016) · cites this paper as Landgraf et al. 2007
In the citing paper
“miRNAs often show strong cell typeand tissue-specific regulation of their targets (Landgraf et al., 2007;Jovic ˇic ´et al., 2013).”
From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Landgraf et al., 2007
In the citing paper
“Importantly, miRNAs quite often show cell-type, tissue, and species-specific regulation of their target genes due to the differences in their expression levels and the complexity of interaction with their targets in different cellular contexts (Landgraf et al., 2007;Jovic ˇic ´et al., 2013).”
From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Landgraf et al., 2007
In the citing paper
“Substantial data indicate that microRNA 21 (miR-21) is significantly elevated in glioblastoma (GBM) and in many other tumors of various origins.”
From MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008) · cites this paper as [33]
In the citing paper
“We also found 20 miRNAs that are up-regulated more than 2 fold during differentiation and some were previously identified from rat brain tissues: miR-21, miR-152, miR-142-5p and -3p, miR-338, miR-339 and miR-378 (Landgraf et al., 2007).”
From Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes (2008) · cites this paper as Landgraf et al., 2007
In the citing paper
“Notably, these included hsa-miR-219a and hsa-miR-338, both known to promote myelin repair 54 , and hsa-miR-23, which enhances oligodendrocyte differentiation and myelin synthesis 55 .”
From Human brain microRNAs exhibit cell-type specificity and age dependence (2026) · cites this paper as [54]
In the citing paper
“both known to promote myelin repair 54 , and hsa-miR-23, which enhances oligodendrocyte differentiation and myelin synthesis 55”
From Human brain microRNAs exhibit cell-type specificity and age dependence (2026) · cites this paper as [54]
In the citing paper
“miR-375, miR-141, and miR-200a in the pituitary (Landgraf et al. 2007);”
From MicroRNA expression in the adult mouse central nervous system (2008) · cites this paper as Landgraf et al. 2007
In the citing paper
“with some being shown to be expressed in a tissue- (16), cell type- (17), or even cell state-specific manner (18)”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [16]
In the citing paper
“Recent efforts in profiling of the most studied types of small ncRNA, miRNA, across cells and tissues demonstrated the existence of tissue- and cell type-specific short noncoding transcripts (16, 24, 25, 33).”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [16]
In the citing paper
“We identified both well-described brain-specific miRNAs, such as mir-9, mir-124, mir-219, mir-338 (16, 24, 33), as well as those which are missing from existing catalogs, such as mir-666, mir-878, mir-433, etc.”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [16]
In the citing paper
“Consistent with previous reports, we observed that a group of miRNAs known to be brain specific, such as miR-124, miR-29b and miR-9, were highly enriched in all the samples. (Bak et al., 2008, Landgraf et al., 2007).”
From Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain (2012) · cites this paper as Landgraf et al., 2007
In the citing paper
“The most thorough of these microRNA localization projects performed small RNA library sequencing (RNA-seq) on over 250 libraries from 26 organ systems. However, this nascent effort sequenced only ∼1200 reads per library (Landgraf et al. 2007).”
From Toward the human cellular microRNAome (2017) · cites this paper as Landgraf et al. 2007
In the citing paper
“a previous study showed that miR-155 expression was highly specific to cells of hematopoietic origin 51 .”
From Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease (2023) · cites this paper as [51]
In the citing paper
“The first and as of now most comprehensive analysis of miRNA abundance in different tissues has been reported by Landgraf et al. in 2007 (3).”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“For canonical miRNAs they found a high concordance of tissue-specific expression in humans and rodents.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“This sequencing-based study reported 340 miRNAs in 26 organs.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“Amongst others, Landgraf et al. detected tissue-specific expression of miR-122 in liver, of miR-9, miR-124 and miR 128a/b in brain, of miR-7, miR-375, miR-141 and miR-200a in pituitary gland and of miR-142, miR-144, miR-150, miR-155 and miR-223 in hematopoietic cells.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“The, as of now, most comprehensive study on tissue-specific miRNAs in humans was published by Landgraf et al. in 2007 (3).”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“They identified 340 mature human miRNAs including 33 novel miRNAs not listed in the miRBase version 9.1, which was the current version at the time of the study (17).”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“MiR-124 (miR-124–3p) was identified as the third most specific miRNA in the nervous system by Landgraf et al.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“They sequenced 256 small RNA libraries from 26 different organ systems and cell types of humans and rodents, with ∼1000 clone each.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“MiR-514a-3p belongs to the miR-506 family; the mouse orthologue of miR-506, mmu-201, has been shown to be specifically expressed in reproductive tissues (3).”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“Loss-of-function of the abundant neuronal miRNAs let-7 and miR-124, and of the less abundant miR-125 and miR-132 (Landgraf et al., 2007), caused a marked pruning of the dendritic arbor, as quantified by Sholl analysis (Figure 4A, E).”
From Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 (2010) · cites this paper as Landgraf et al., 2007
In the citing paper
“The second is that early publications of general miRNA expression focused on tissues, which comprise numerous cell types, and the localization of miRNAs, whether cell specific or ubiquitous, has not been established [8, 9].”
From A curated human cellular microRNAome based on 196 primary cell types (2022) · cites this paper as [9]
In the citing paper
“Notably, five of the top 25 upregulated miRNAs in IS patients were brain-specific or enriched, including hsa-miR-9-3p, hsa-miR-124-3p, hsa-miR-143-3p, hsa-miR-98-5p, and hsa-miR-93-5p.”
From Acute Cerebral Ischemia Increases a Set of Brain-Specific miRNAs in Serum Small Extracellular Vesicles (2022) · cites this paper as Landgraf et al., 2007
In the citing paper
“Likewise, 9 out of the 20 upregulated miRNAs in tMCAO mice are brain-specific or preferentially expressed in brain tissues, including mmu-miR-124-3p, mmu-miR-9-3p, mmu-miR-9-5p, mmu-miR-323-3p, mmu-miR-219b-5p, mmu-miR-129b-3p, mmu-miR-129-5p, mmu-miR-433-3p, and mmu-miR-128-3p (Table 3).”
From Acute Cerebral Ischemia Increases a Set of Brain-Specific miRNAs in Serum Small Extracellular Vesicles (2022) · cites this paper as Landgraf et al., 2007
In the citing paper
“Previous reports have shown that miR-138-5p is highly expressed in the CNS, particularly among brain neurons [45,46,47].”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [45]
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Self-citationMicroarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
MicroRNA genes are transcribed by RNA polymerase II
Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,556
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
miRBase: microRNA sequences, targets and gene nomenclature
Griffiths-Jones, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj112 · Cited by 3,950
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 1,101–1,200 of 3,637
MicroRNA-Based Promotion of Human Neuronal Differentiation and Subtype Specification
Stappert, L., Borghese, L., Roese-Koerner, B., Weinhold, S., Koch, P., Terstegge, S., Uhrberg, M., Wernet, P., & Brüstle, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059011 · Cited by 71
Self-citationHu, R., Pan, W., Fedulov, A. V., Jester, W. F., Jones, M. R., Weiss, S. T., Panettieri, R. A., Tantisira, K. G., & Lu, Q. (2014) · The FASEB Journal · doi:10.1096/fj.13-247247 · Cited by 71
MicroRNA Expression Signatures in Solid Malignancies
Galasso, M., Sandhu, S. K., & Volinia, S. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318258b5f4 · Cited by 71
Primate-Specific Long Non-Coding RNAs and MicroRNAs
Awan, H. M., Shah, A., Rashid, F., & Shan, G. (2017) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2017.04.002 · Cited by 72
Transcriptional control of dendritic cell development and functions
Amon, L., Lehmann, C. H. K., Barańska, A., Schoen, J., Heger, L., & Dudziak, D. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.10.001 · Cited by 72
The Liver-Specific MicroRNA miR-122: Biology and Therapeutic Potential
Filipowicz, W., & Großhans, H. (2010) · Springer eBooks · doi:10.1007/978-3-7643-8989-5_11 · Cited by 72
Laudanski, P., Charkiewicz, R., Kuzmicki, M., Szamatowicz, J., Charkiewicz, A., & Niklinski, J. (2013) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-11-78 · Cited by 70
Yang, J., Cong, X., Ren, M., Sun, H., Liu, T., Chen, G., Wang, Q., Li, Z., Yu, S. L., & Yang, Q. (2019) · Journal of Oncology · doi:10.1155/2019/7630894 · Cited by 71
MicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation
Melton, C. A., & Blelloch, R. H. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7037-4_8 · Cited by 72
Fiumara, F., Rajasethupathy, P., Antonov, I., Kosmidis, S., Sossin, W. S., & Kandel, E. R. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.034 · Cited by 66
Aguado-Fraile, E., Ramos, E., Sáenz-Morales, D., Conde, E., Blanco-Sánchez, I., Stamatakis, K., del Peso, L., Cuppen, E. P. J. G., Brüne, B., & García‐Bermejo, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044305 · Cited by 70
Identification of Schistosoma mansoni microRNAs
Simões, M. C., Lee, J., Djikeng, A., Cerqueira, G., Zerlotini, A., da Silva-Pereira, R. A., Dalby, A., LoVerde, P. T., El-Sayed, N. M., & Oliveira, G. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-47 · Cited by 77
Computational identification and characterization of primate-specific microRNAs in human genome
Lin, S., Cheung, W. K. C., Chen, S., Lü, G., Wang, Z., Xie, D., Li, K., Lin, M. C. M., & Kung, H. (2010) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2010.08.001 · Cited by 70
Flexible and Versatile as a Chameleon—Sophisticated Functions of microRNA-199a
Gu, S., & Chan, W. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078449 · Cited by 73
microRNAs: fine tuning of erythropoiesis
Listowski, M. A., Heger, E., Bogusławska, D. M., Machnicka, B., Kuliczkowski, K., Leluk, J., & Sikorski, A. F. (2012) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-012-0038-z · Cited by 70
IsomiRage: From Functional Classification to Differential Expression of miRNA Isoforms
Müller, H., Marzi, M. J., & Nicassio, F. (2014) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00038 · Cited by 71
Targeting miRNAs in osteoblast differentiation and bone formation
Hu, R., Li, H., Liu, W., Yang, L., Tan, Y., & Luo, X. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.512916 · Cited by 71
Evolution of an X-linked primate-specific micro RNA cluster
Li, J., Liu, Y., Dong, D., & Zhang, Z. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msp284 · Cited by 70
Langlois, R. A., Varble, A., Chua, M. A., García‐Sastre, A., & tenOever, B. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206039109 · Cited by 70
MicroRNAs and drug-induced kidney injury
Pavkovic, M., & Vaidya, V. S. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.03.016 · Cited by 70
Lamontagne, J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i24.7375 · Cited by 70
RNA on the brain: emerging layers of post‐transcriptional regulation in cerebral cortex development
Lennox, A. L., Mao, H., & Silver, D. L. (2017) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.290 · Cited by 73
SPENCER: a comprehensive database for small peptides encoded by noncoding RNAs in cancer patients
Luo, X., Huang, Y., Li, H., Luo, Y., Zuo, Z., Ren, J. M., & Xie, Y. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab822 · Cited by 70
Lu, K., Wang, J., Song, Y., Zhao, S., Liu, H., Tang, D., PAN, B., Zhao, H., & Zhang, Q. (2015) · Oncology Reports · doi:10.3892/or.2015.4025 · Cited by 69
Computational analysis of small RNA cloning data
Berninger, P., Gaidatzis, D., van Nimwegen, E., & Zavolan, M. (2007) · Methods · doi:10.1016/j.ymeth.2007.10.002 · Cited by 70
Self-citationWu, C., Lin, J., Hong, M., Choudhury, Y., Balani, P., Leung, D., Dang, L. H., Zhao, Y., Zeng, J., & Wang, S. (2009) · Molecular Therapy · doi:10.1038/mt.2009.225 · Cited by 61
MicroRNAs grow up in the immune system
Hoefig, K. P., & Heissmeyer, V. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.05.005 · Cited by 69
microRNA Response to Listeria monocytogenes Infection in Epithelial Cells
Izar, B., Mannala, G. K., Mraheil, M. A., Chakraborty, T., & Hain, T. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13011173 · Cited by 71
Chatterjee, A., Leichter, A. L., Fan, V., Tsai, P., Purcell, R. V., Sullivan, M. J., & Eccles, M. R. (2015) · Scientific Reports · doi:10.1038/srep10438 · Cited by 70
microRNA-guided diagnostics in clinical samples
Gustafson, D., Tyryshkin, K., & Renwick, N. M. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.07.002 · Cited by 72
The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity
Koenig, E. M., Fisher, C. D., Bernard, H., Wolenski, F. S., Gerrein, J., Carsillo, M., Gallacher, M., Tse, A., Peters, R., Smith, A. T., et al. (2016) · BMC Genomics · doi:10.1186/s12864-016-2958-x · Cited by 69
Tosar, J. P., Cayota, A., Eitan, E., Halushka, M. K., & Witwer, K. W. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2016.1272832 · Cited by 71
Wang, L., Yu, P., Li, B., Guo, Y., Liang, Z., Zheng, L., Yang, J., Xu, H. M., Liu, S., Zheng, L., et al. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12376 · Cited by 69
Molecular medicine of microRNAs: structure, function and implications for diabetes
Hennessy, E., & O’Driscoll, L. (2008) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399408000781 · Cited by 69
Borel, C., Deutsch, S., Letourneau, A., Migliavacca, E., Montgomery, S. B., Dimas, A. S., Vejnar, C. E., Attar, H., Gagnebin, M., Gehrig, C., et al. (2010) · Genome Research · doi:10.1101/gr.109371.110 · Cited by 74
Abe, M., Naqvi, A., Hendriks, G.-J., Feltzin, V., Zhu, Y., Grigoriev, A., & Bonini, N. M. (2014) · Genes & Development · doi:10.1101/gad.226654.113 · Cited by 68
Sirey, T., Roberts, K., Haerty, W., Bedoya-Reina, O. C., Rogatti, S., Tan, J. Y., Li, N., Heather, L. C., Carter, R. N., Cooper, S., et al. (2019) · eLife · doi:10.7554/elife.45051 · Cited by 70
Zhang, L., Liu, J., Liu, F., Liu, W., Wang, Y., Zhu, B., & Yu, B. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.092 · Cited by 68
Internal translation initiation of picornaviruses and hepatitis C virus
Niepmann, M. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.05.002 · Cited by 68
TargetingmiR-205in breast cancer
Wu, H., & Mo, Y. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903338777 · Cited by 68
A Concise Review on Epigenetic Regulation: Insight into Molecular Mechanisms
Golbabapour, S., Abdulla, M. A., & Hajrezaei, M. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12128661 · Cited by 72
Lewis, H. B., Lance, R. A., Troyer, D. A., Beydoun, H. A., Hadley, M. M., Orians, J., Benzine, T., Madric, K., Semmes, O. J., Drake, R. R., et al. (2013) · Cell Cycle · doi:10.4161/cc.26984 · Cited by 68
Xiao, Y., Wang, J., Chen, Y., Zhou, K., Wen, J., Wang, Y., Zhou, Y., Pan, W., & Cai, W. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.01.003 · Cited by 69
Conserved microRNA editing in mammalian evolution, development and disease
Warnefors, M., Liechti, A., Halbert, J., Valloton, D., & Kaessmann, H. (2014) · Genome biology · doi:10.1186/gb-2014-15-6-r83 · Cited by 68
Wu, Z., Wu, Y., Tian, Y., Sun, X., Liu, J., Ren, H., Liang, C., Song, L., Hu, H., WANG, L., et al. (2013) · Oncology Letters · doi:10.3892/ol.2013.1579 · Cited by 70
MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases
Saraiva, C., Esteves, M., & Bernardino, L. I. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.008 · Cited by 68
MicroRNA-196a/b Mitigate Renal Fibrosis by Targeting TGF-β Receptor 2
Meng, J., Li, L., Zhao, Y., Zhou, Z., Zhang, M., Li, D., Zhang, C., Zen, K., & Liu, Z. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015040422 · Cited by 67
Nixon, B., Stanger, S. J., Mihalas, B. P., Reilly, J. N., Anderson, A. L., Dun, M. D., Tyagi, S., Holt, J. E., & McLaughlin, E. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135605 · Cited by 67
Song, Z., & Li, G. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9163-0 · Cited by 68
Kawahigashi, Y., Mishima, T., Mizuguchi, Y., Arima, Y., Yokomuro, S., Kanda, T., Ishibashi, O., Yoshida, H., Tajiri, T., & Takizawa, T. (2009) · Journal of Nippon Medical School · doi:10.1272/jnms.76.188 · Cited by 67
Li, L., Meng, T., Jia, Z., Zhu, G., & Shi, B. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33236 · Cited by 67
miR-200s Contribute to Interleukin-6 (IL-6)-induced Insulin Resistance in Hepatocytes
Dou, L., Zhao, T., Wang, L., Huang, X., Jiao, J., Gao, D., Zhang, H., Shen, T., Man, Y., Wang, S., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.423145 · Cited by 67
miR-708-5p: a microRNA with emerging roles in cancer
Monteleone, N. J., & Lutz, C. S. (2017) · Oncotarget · doi:10.18632/oncotarget.19772 · Cited by 69
Rehfeld, F., Maticzka, D., Grosser, S., Knauff, P., Eravci, M., Vida, I., Backofen, R., & Wulczyn, F. G. (2018) · Nature Communications · doi:10.1038/s41467-018-03681-3 · Cited by 74
Linnstaedt, S. D., Riker, K. D., Rueckeis, C. A., Kutchko, K. M., Lackey, L., McCarthy, K. R., Tsai, Y.-H., Parker, J. S., Kurz, M. C., Hendry, P. L., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.3458-17.2018 · Cited by 66
MicroRNA-124: A Key Player in Microglia-Mediated Inflammation in Neurological Diseases
Zhao, J., He, Z., & Wang, J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.771898 · Cited by 66
Online resources for miRNA analysis
Vlachos, I. S., & Hatzigeorgiou, A. G. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.03.006 · Cited by 66
Roles of Non-Coding RNA in Alzheimer’s Disease Pathophysiology
Olufunmilayo, E. O., & Holsinger, R. M. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512498 · Cited by 68
Cancer therapy via modulation of micro RNA levels: a promising future
Kota, S. K., & Balasubramanian, S. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.07.003 · Cited by 67
Ultra-Deep Sequencing Reveals the microRNA Expression Pattern of the Human Stomach
Ribeiro‐dos‐Santos, Â., Khayat, A. S., Silva, A., Alencar, D. O., Lobato, J., Luz, L., Pinheiro, D. G., Varuzza, L., Assumpção, M. B., de Assumpção, P. P., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013205 · Cited by 66
Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of DICER1
Ravi, A., Gurtan, A. M., Kumar, M. S., Bhutkar, A. J., Chin, C., Lu, V., Lees, J. A., Jacks, T., & Sharp, P. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.037 · Cited by 66
MYC Protein Inhibits Transcription of the MicroRNA Cluster MC-let-7a-1∼let-7d via Noncanonical E-box
Wang, Z., Lin, S., Li, J. J., Xu, Z., Yao, H., Zhu, X., Xie, D., Shen, Z., Sze, J., Li, K., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.293126 · Cited by 69
MicroRNAs and vascular (dys)function
Hartmann, D., & Thum, T. (2011) · Vascular Pharmacology · doi:10.1016/j.vph.2011.07.005 · Cited by 67
MicroRNA Profiling: From Dark Matter to White Matter, or Identifying New Players in Neurobiology
Krichevsky, A. M. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.201 · Cited by 66
Dicer-Dependent MicroRNAs Control Maturation, Function, and Maintenance of Langerhans Cells In Vivo
Kuipers, H., Schnorfeil, F. M., Fehling, H. J., Bartels, H., & Brocker, T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903912 · Cited by 66
Electrochemical determination of microRNA-21 based on bio bar code and hemin/G-quadruplet DNAenzyme
Meng, X., Zhou, Y., Liang, Q., Qu, X., Yang, Q., Yin, H., & Ai, S. (2013) · The Analyst · doi:10.1039/c3an36788f · Cited by 66
Eriksson, A. L., Perry, J. R. B., Coviello, A. D., Delgado, G. E., Ferrucci, L., Hoffman, A. R., Huhtaniemi, I. T., Ikram, M. A., Karlsson, M. K., Kleber, M. E., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02060 · Cited by 68
A critical appraisal of the use of microRNA data in phylogenetics
Thomson, R. C., Plachetzki, D. C., Mahler, D. L., & Moore, B. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407207111 · Cited by 67
miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4
Liu, Y., Ur-Rehman, U., Guo, Y., Liang, H., Cheng, R., Yang, F., Hong, Y., Zhao, C., Liu, M., Yu, M., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0313-2 · Cited by 65
Yang, H., Rao, J. N., & Wang, J. (2014) · Tissue Barriers · doi:10.4161/tisb.28320 · Cited by 65
Bali, P., & Kenny, P. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00043 · Cited by 67
Outside the coding genome, mammalian microRNAs confer structural and functional complexity
Olive, V., Minella, A. C., & He, L. (2015) · Science Signaling · doi:10.1126/scisignal.2005813 · Cited by 67
Sun, J., Li, M., Li, Z., Xue, J., Lan, X., Zhang, C., Lei, C., & Chen, H. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-42 · Cited by 66
Copy number variation of microRNA genes in the human genome
Marcinkowska, M., Szymański, M., Krzyżosiak, W. J., & Kozłowski, P. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-183 · Cited by 67
The Blood-Brain Barrier in Multiple Sclerosis: microRNAs as Key Regulators
Kamphuis, W. W., Troletti, C. D., Reijerkerk, A., Romero, I. A., & de Vries, H. E. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150116125246 · Cited by 65
Role of circulating microRNAs in liver diseases
Loosen, S. H., Schueller, F., Trautwein, C., Roy, S., & Roderburg, C. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i12.586 · Cited by 65
miR-29 family: A potential therapeutic target for cardiovascular disease
Liu, M., Luo, G., Gao, W., Yang, S., & Zhou, H. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105510 · Cited by 64
Characterisation and Comparison of Lactating Mouse and Bovine Mammary Gland miRNomes
Guillou, S. L., Marthey, S., Laloë, D., Laubier, J., Mobuchon, L., Leroux, C., & Provost, F. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091938 · Cited by 65
Omrani, M., Hashemi, M. M., Eskandari‐Nasab, E., Hasani, S., Mashhadi, M. A., Arbabi, F., & Taheri, M. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.13.118 · Cited by 64
Large-scale analysis of microRNA evolution
Guerra‐Assunção, J. A., & Enright, A. J. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-218 · Cited by 64
Li, J., Liu, Y., Xin, X., Kim, T. S., Cabeza, E. A., Ren, J., Nielsen, R., Wrana, J. L., & Zhang, Z. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002578 · Cited by 66
MicroRNAs in pluripotency, reprogramming and cell fate induction
Lüningschrör, P., Hauser, S., Kaltschmidt, B., & Kaltschmidt, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.03.025 · Cited by 64
Liu, Y., Zhang, Y., Wen, J., Liu, L., Zhai, X., Liu, J., Pan, S., Chen, J., Shen, H., & Hu, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032230 · Cited by 64
Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells
Huang, X., Gschweng, E. H., Handel, B. V., Cheng, D., Mikkola, H. K. A., & Witte, O. N. (2010) · Blood · doi:10.1182/blood-2010-08-302711 · Cited by 67
MicroRNAs: Promising New Antiangiogenic Targets in Cancer
Gallach, S., Fariñas, S. C., Lewintre, E. J., & Camps, C. (2014) · BioMed Research International · doi:10.1155/2014/878450 · Cited by 64
Differential expression of microRNAs in Marek's disease virus-transformed T-lymphoma cell lines
Yao, Y., Zhao, Y., Smith, L. P., Lawrie, C. H., Saunders, N. J. S. G., Watson, M., & Nair, V. (2009) · Journal of General Virology · doi:10.1099/vir.0.009902-0 · Cited by 64
Micro RNA function in NK ‐cell biology
Beaulieu, A. M., Bezman, N., Lee, J., Matloubian, M., Sun, J. C.-Y., & Lanier, L. L. (2013) · Immunological Reviews · doi:10.1111/imr.12045 · Cited by 66
Marques, A. C., Tan, J. Y., Lee, S., Kong, L., Heger, A., & Ponting, C. P. (2012) · Genome biology · doi:10.1186/gb-2012-13-11-r102 · Cited by 65
MicroRNA and Male Infertility: A Potential for Diagnosis.
Khazaie, Y., & Nasr‐Esfahani, M. H. (2014) · PubMed Central · Cited by 64
Precise tuning of gene expression levels in mammalian cells
Michaels, Y. S., Barnkob, M. B., Barbosa, H., Baeumler, T. A., Thompson, M. K., André, V., Colin‐York, H., Fritzsche, M., Gileadi, U., Sheppard, H. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08777-y · Cited by 64
Chu, H., Wang, M., Shi, D., Ma, L., Zhang, Z., Tong, N., Huo, X., Wang, W., Luo, D., Gao, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018108 · Cited by 63
Khamina, K., Diendorfer, A. B., Skalicky, S., Weigl, M., Pultar, M., Krammer, T. L., Aquino, C., Schofield, A. L., Otto, C., Smith, A. T., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031226 · Cited by 64
Jiang, Y., Chen, J., Wu, J., Hu, Z., Qin, Z., Liu, X., Guan, X., Wang, Y., Han, J., Jiang, T., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28237 · Cited by 63
Increased levels of microRNA-424 are associated with the pathogenesis of fetal growth restriction
Huang, L., Shen, Z., Xu, Q., Huang, X., Chen, Q., & Li, D. (2013) · Placenta · doi:10.1016/j.placenta.2013.04.009 · Cited by 63
MapMi: automated mapping of microRNA loci
Guerra‐Assunção, J. A., & Enright, A. J. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-133 · Cited by 63
Mattis, A. N., Song, G., Hitchner, K., Kim, R. Y., Lee, A. Y., Sharma, A. D., Malato, Y., McManus, M. T., Esau, C., Koller, E., et al. (2014) · Hepatology · doi:10.1002/hep.27379 · Cited by 63
The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas
Wu, Z. B., Cai, L., Lin, S., Lu, J. L., Yao, Y., & Zhou, L. F. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.031 · Cited by 63
Testosterone-induced upregulation of miRNAs in the female mouse liver
Delić, D., Großer, C., Dkhil, M. A., Al‐Quraishy, S., & Wunderlich, F. T. (2010) · Steroids · doi:10.1016/j.steroids.2010.06.010 · Cited by 63
Molecular, Cellular, and Structural Mechanisms of Cocaine Addiction: A Key Role for MicroRNAs
Jonkman, S., & Kenny, P. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.120 · Cited by 63
MicroRNAs in early vertebrate development
Rosa, A., & Brivanlou, A. H. (2009) · Cell Cycle · doi:10.4161/cc.8.21.9847 · Cited by 63
Metadata
- Authors
- Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., Lin, C., Socci, N. D., Hermida, L., Fulci, V., Chiaretti, S., Foà, R., Schliwka, J., Fuchs, U., Novosel, A., Müller, R.-U., Schermer, B., Bissels, U., Inman, J., Phan, Q., Chien, M., Weir, D. B., Choksi, R., De Vita, G., Frezzetti, D., Trompeter, H.-I., Hornung, V., Teng, G., Hartmann, G., Palkovits, M., Di Lauro, R., Wernet, P., Macino, G., Rogler, C. E., Nagle, J. W., Ju, J., Papavasiliou, F. N., Benzing, T., Lichter, P., Tam, W., Brownstein, M. J., Bosio, A., Borkhardt, A., Russo, J. J., Sander, C., Zavolan, M., & Tuschl, T.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Basel (CH)
- Memorial Sloan Kettering Cancer Center (US)
- SIB Swiss Institute of Bioinformatics (CH)
- Sapienza University of Rome (IT)
- German Cancer Research Center (DE)
- Ludwig-Maximilians-Universität München (DE)
- University Medical Center Freiburg (DE)
- Miltenyi Biotec (Germany) (DE)
- J. Craig Venter Institute (US)
- Columbia University (US)
- University of Naples Federico II (IT)
- Düsseldorf University Hospital (DE)
- Rockefeller University (US)
- University of Bonn (DE)
- Albert Einstein College of Medicine (US)
- National Institutes of Health (US)
- Cornell University (US)
- Corresponding author
- Zavolan, Mihaela
- Tuschl, Thomas
- ORCID
- Landgraf, Pablo
- Rusu, Mirabela
- Iovino, Nicola
- Aravin, Alexei
- Pfeffer, Sébastien
- Kamphorst, Alice O.
- Landthaler, Markus
- Lin, Carolina
- Socci, Nicholas D.
- Hermida, Leandro
- Fulci, Valerio
- Chiaretti, Sabina
- Foà, Robin
- Müller, Roman-Ulrich
- Schermer, Bernhard
- Inman, Jason
- Frezzetti, Daniela
- Trompeter, Hans-Ingo
- Hornung, Veit
- Hartmann, Gunther
- Papavasiliou, F. Nina
- Benzing, Thomas
- Tam, Wayne
- Bosio, Andreas
- Borkhardt, Arndt
- Russo, James J.
- Sander, Chris
- Zavolan, Mihaela
- Tuschl, Thomas
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 129
- Issue
- 7
- Pages
- 1401-1414
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2681231
- OpenAlex
- W2149146453
- Cited by
- 3,626
- References
- 70
- Citations by year
- 2026: 42 · 2025: 73 · 2024: 87 · 2023: 104 · 2022: 131 · 2021: 160 · 2020: 152 · 2019: 167 · 2018: 205 · 2017: 185 · 2016: 221 · 2015: 238 · 2014: 275 · 2013: 310 · 2012: 283
- FWCI
- 84.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2274 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- HAL (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (105945, 205321)
- National Institute of General Medical Sciences (P01GM073047)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, small RNA sequencing, microRNA precursors, microRNA maturation, miRNA conservation, microRNA target regulation, hematopoietic cells, neurons, cell lineage, miRNA expression profiling
- MeSH terms
- Animals, Base Sequence, Gene Expression Regulation, Hematopoietic Stem Cells, Humans, Molecular Sequence Data, Phylogeny, RNA, Messenger, Sequence Homology, Nucleic Acid, Gene Library, Conserved Sequence, Cell Lineage, Hematologic Neoplasms, Gene Expression Profiling, MicroRNAs, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
