MicroRNAs expression profiling of eutopic proliferative endometrium in women with ovarian endometriosis
Open accessAbstract
BACKGROUND: The eutopic endometrium of women with endometriosis, compared with disease-free individuals, contains certain molecular alterations, including the differential expression of microRNA (miRNA). The aim of the study was to compare the expression of the most relevant miRNAs in the eutopic endometrium of women with and without ovarian endometriosis. METHODS: A total of 46 regularly menstruating patients, 21 patients with ovarian endometriosis and 25 controls, underwent surgery in the proliferative phase of the cycle. The eutopic endometrium was collected through aspirating biopsy prior to laparoscopy. Only patients with advanced (stage III and IV) histopathologically confirmed ovarian endometriosis were included. TaqMan MicroRNA Array Cards were applied to examine the expression of 667 human miRNAs in 10 patients with endometriosis and 10 controls. Custom-made, low-density real-time PCR arrays were used to confirm the expression of 15 selected molecules in 21 endometriosis patients and 25 disease-free individuals. RESULTS: Of 667 miRNAs, 2 were highly likely to be upregulated and 13 were downregulated in the eutopic endometrium of patients with endometriosis compared with the controls. Validation using real-time PCR showed that hsa-miR-483-5p (p = 0.012) and hsa-miR-629* (p = 0.02) are significantly downregulated in patients with endometriosis. CONCLUSIONS: Changes in the expression of select miRNAs might lead to or be a consequence of an early defect in the physiological activity of the proliferative endometrium, ultimately resulting in the overgrowth of this tissue outside the uterus.
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hsa-miR-483-5p and miR-629 are significantly reduced in expression in endometriosis patients.
“In addition, hsa-miR-483-5p and miR-629 have been shown to be significantly reduced in expression in endometriosis patients [163].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [163]
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1 retracted
Pan, Q., Luo, X., Toloubeydokhti, T., & Chegini, N. (2007) · Molecular Human Reproduction · doi:10.1093/molehr/gam063 · Cited by 261 · see citing works
RetractedBartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,497 · see citing works
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969 · see citing works
A microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697 · see citing works
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626 · see citing works
Revised American Society for Reproductive Medicine classification of endometriosis: 1996
American Society for Reproductive Medicine (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81391-x · Cited by 3,018 · see citing works
Rw, N., Hertig, A. T., & Rock, J. A. (1950) · Fertility and Sterility · doi:10.1016/s0015-0282(16)30062-0 · Cited by 2,854 · see citing works
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC
Fabian, M. R., & Sonenberg, N. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2296 · Cited by 1,021 · see citing works
Role of cytokines in endometriosis
Harada, T., Iwabe, T., & Terakawa, N. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01816-7 · Cited by 567 · see citing works
深井順也, & 西尾, 和. (2006) · Mebio oncology · Cited by 557 · see citing works
An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis
Hatziapostolou, M., Polytarchou, C., Aggelidou, E., Drakaki, A., Poultsides, G. A., Jaeger, S. A., Ogata, H., Karin, M., Struhl, K., Hadzopoulou‐Cladaras, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.043 · Cited by 445 · see citing works
MicroRNA-regulated pathways associated with endometriosis
Ohlsson Teague, E. M. C., Van der Hoek, K. H., Van der Hoek, M. B., Perry, N., Wagaarachchi, P., Robertson, S. A., Print, C. G., & Hull, L. M. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0387 · Cited by 357 · see citing works
The role of microRNAs in endometriosis and associated reproductive conditions
Ohlsson Teague, E. M. C., Print, C. G., & Hull, M. L. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp034 · Cited by 309 · see citing works
Reprint of: Dating the Endometrial Biopsy
Rw, N., Hertig, A. T., & Rock, J. A. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.08.079 · Cited by 301 · see citing works
Mayor-Lynn, K., Toloubeydokhti, T., Cruz, A. C., & Chegini, N. (2010) · Reproductive Sciences · doi:10.1177/1933719110374115 · Cited by 270 · see citing works
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancerPreprint
Olson, P., Lü, J., Zhang, H., Shai, A., Chun, M. G. H., Wang, Y., Libutti, S. K., Nakakura, E. K., Golub, T. R., & Hanahan, D. (2009) · Genes & Development · doi:10.1101/gad.1820109 · Cited by 259 · see citing works
Burney, R. O., Hamilton, A. E., Aghajanova, L., Vo, K. C., Nezhat, C. N., Lessey, B. A., & Giudice, L. C. (2009) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gap068 · Cited by 254 · see citing works
Endometriosis: its association with retrograde menstruation, dysmenorrhoea and tubal pathology
LIU, D. T. Y., & HITCHCOCK, A. (1986) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1986.tb07995.x · Cited by 230 · see citing works
Heterotopic or misplaced endometrial tissue
Sampson, J. A. (1925) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(25)90629-1 · Cited by 229 · see citing works
MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy
Patterson, E. E., Holloway, A. K., Weng, J., Fojo, T., & Kebebew, E. (2011) · Cancer · doi:10.1002/cncr.25724 · Cited by 171 · see citing works
Molecular Evidence for Differences in Endometrium in Severe Versus Mild Endometriosis
Aghajanova, L., & Giudice, L. C. (2011) · Reproductive Sciences · doi:10.1177/1933719110386241 · Cited by 146 · see citing works
microRNAs expression in endometriosis and their relation to angiogenic factors
Ramon, L. A., Braza-Boils, A., Gilabert-Estelles, J., Gilabert, J., Espana, F., Chirivella, M., & Estelles, A. (2011) · Human Reproduction · doi:10.1093/humrep/der025 · Cited by 117 · see citing works
Ma, N., Wang, X., Qiao, Y., Li, F., Hui, Y., Zou, C., Jin, J., Lv, G., Peng, Y., & Wang, L. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.027 · Cited by 85 · see citing works
MiR‐483–5p suppresses the proliferation of glioma cells via directly targeting ERK1
Wang, L., Shi, M., Hou, S., Ding, B., Liu, L., Ji, X., Zhang, J., & Deng, Y. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.035 · Cited by 77 · see citing works
MiR-483-5p controls angiogenesis in vitro and targets serum response factor
Qiao, Y., Ma, N., Wang, X., Hui, Y., Li, F., Xiang, Y., Zhou, J., Zou, C., Jin, J., Lv, G., et al. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.039 · Cited by 77 · see citing works
Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis
Laudański, P., Szamatowicz, J., Kowalczuk, O., Kuźmicki, M., Grabowicz, M., & Chyczewski, L. (2009) · Human Reproduction · doi:10.1093/humrep/dep175 · Cited by 66 · see citing works
Self-citationLaudański, P., Szamatowicz, J., & Ramel, P. (2005) · Gynecological Endocrinology · doi:10.1080/09513590500154043 · Cited by 40 · see citing works
Self-citationChemokine growth-regulated-α: a possible role in the pathogenesis of endometriosis
Szamatowicz, J., Laudański, P., Tomaszewska, I. M., & Szamatowicz, M. (2002) · Gynecological Endocrinology · doi:10.1080/gye.16.2.137.141 · Cited by 40 · see citing works
Self-citationCalpain and the Glutamatergic Synapse
Doshi, S. (2009) · Frontiers in Bioscience-Elite · doi:10.2741/e38 · Cited by 38 · see citing works
Endometriosis: Its association with retrograde menstruation, dysmenorrhoea and tubal pathology
Liu, D., & Hitchcock, A. (1987) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(87)90386-9 · Cited by 32 · see citing works
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Smolarz, B., Szyłło, K., & Romanowicz, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910554 · Cited by 560 · see citing works
MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors
Braza-Boïls, A., Marí-Alexandre, J., Gilabert, J., Sánchez-Izquierdo, D., España, F., Estellés, A., & Gilabert-Estellés, J. (2014) · Human Reproduction · doi:10.1093/humrep/deu019 · Cited by 164 · see citing works
Sofo, V., Götte, M., Laganà, A. S., Salmeri, F. M., Triolo, O., Sturlese, E., Retto, G., Alfa, M., Granese, R., & Abrão, M. S. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3739-5 · Cited by 88 · see citing works
Laudanski, P., Charkiewicz, R., Tolwinska, A., Szamatowicz, J., Charkiewicz, A., & Niklinski, J. (2015) · BioMed Research International · doi:10.1155/2015/760698 · Cited by 48 · see citing works
Self-citationMonnaka, V. U., Hernandes, C., Heller, D., & Podgaec, S. (2021) · Einstein (São Paulo) · doi:10.31744/einstein_journal/2021rw5704 · Cited by 33 · see citing works
- Authors
- Laudanski, P., Charkiewicz, R., Kuzmicki, M., Szamatowicz, J., Charkiewicz, A., & Niklinski, J.
- Affiliations
- Medical University of Białystok (PL)
- ORCID
- Szamatowicz, Jacek
- Venue
- Reproductive Biology and Endocrinology
- Published
- 2013
- Volume
- 11
- Issue
- 1
- Pages
- 78
- ISSN
- 1477-7827 (ISSN-L)
- PMC
- PMC3766175
- OpenAlex
- W2130359564
- Cited by
- 70
- References
- 31
- Citations by year
- 2026: 2 · 2023: 8 · 2022: 2 · 2021: 6 · 2020: 12 · 2019: 5 · 2018: 10 · 2017: 8 · 2016: 7 · 2015: 7 · 2014: 3
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Update notices
- correction (2015-05-27)
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Reproductive Biology and Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometrioma, eutopic endometrium, proliferative endometrium, miRNA expression profiling, microRNA downregulation, endometriosis pathogenesis
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Follicular Phase, Humans, Down-Regulation, Up-Regulation, MicroRNAs, Real-Time Polymerase Chain Reaction
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