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Regulatory T Cells and Immune Tolerance
Open accessAbstract
Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.
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Metadata
- Authors
- Sakaguchi, S., Yamaguchi, T., Nomura, T., & Ono, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 133
- Issue
- 5
- Pages
- 775-787
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2148226248
- Cited by
- 5,325
- References
- 14
- FWCI
- 102.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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