The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Genetics of Sleep and Sleep Disorders
Open accessAbstract
Sleep remains one of the least understood phenomena in biology – even its role in synaptic plasticity remains debatable. Since sleep was recognized to be regulated genetically, intense research has launched on two fronts: the development of model organisms for deciphering the molecular mechanisms of sleep and attempts to identify genetic underpinnings of human sleep disorders. In this Review, we describe how unbiased, high-throughput screens in model organisms are uncovering sleep regulatory mechanisms and how pathways, such as the circadian clock network and specific neurotransmitter signals, have conserved effects on sleep from Drosophila to humans. At the same time, genome-wide association (GWA) studies have uncovered ~14 loci increasing susceptibility to sleep disorders, such as narcolepsy and restless leg syndrome. To conclude, we discuss how these different strategies will be critical to unambiguously defining the function of sleep.
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Cited by
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Control of sleep and wakefulness
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Metadata
- Authors
- Sehgal, A., & Mignot, E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 146
- Issue
- 2
- Pages
- 194-207
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2034261913
- Cited by
- 410
- References
- 16
- FWCI
- 14.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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