Unearthing the phylogenetic roots of sleep

Allada, Ravi; Siegel, Jerome M.

doi:10.1016/j.cub.2008.06.033

Cited by 280Sleep and Wakefulness ResearchNeurobiology and Insect Physiology ResearchCircadian rhythm and melatonin

Unearthing the phylogenetic roots of sleep

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Allada, Ravi, Siegel, Jerome M.·2008·Current Biology

DOI 10.1016/j.cub.2008.06.033PMC PMC2899675

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Abstract

Why we sleep remains one of the enduring unanswered questions in biology. At its core, sleep can be defined behaviorally as a homeostatically regulated state of reduced movement and sensory responsiveness. The cornerstone of sleep studies in terrestrial mammals, including humans, has been the measurement of coordinated changes in brain activity during sleep measured using the electroencephalogram (EEG). Yet among a diverse set of animals, these EEG sleep traits can vary widely and, in some cases, are absent, raising questions as to whether they define a universal, or even essential, feature of sleep. Over the past decade, behaviorally defined sleep-like states have been identified in a series of genetic model organisms, including fish, flies and worms. Genetic analyses in these systems are revealing a remarkable conservation in the underlying mechanisms controlling sleep behavior. Taken together, these studies suggest an ancient origin for sleep and raise the possibility that model organism genetics may reveal the molecular mechanisms that guide sleep and wake.

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The observation of behaviorally and mechanistically conserved sleep-like states across animals strongly supports an early rooted sleep state rather than many instances of convergent evolution.
“The observation of behaviorally and mechanistically conserved sleep-like states across the animal kingdom [6,7] strongly supports the possibility for an early rooted sleep state rather than many instances of convergent evolution.”
From The Jellyfish Cassiopea Exhibits a Sleep-like State (2017) · cites this paper as [6]

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Authors: Allada, R., & Siegel, J. M.
Affiliations: Northwestern University (US)
University of California, Los Angeles (US)
Corresponding author: Allada, Ravi
Siegel, Jerome M.
ORCID: Allada, Ravi
Siegel, Jerome M.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2008-08
Volume: 18
Issue: 15
Pages: R670-R679
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2008.06.033
PMC: PMC2899675
OpenAlex: W2021185182
Cited by: 280
References: 149
Citations by year: 2026: 13 · 2025: 21 · 2024: 22 · 2023: 15 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 18 · 2016: 16 · 2015: 16 · 2014: 23 · 2013: 14 · 2012: 13
FWCI: 0.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1847 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH064109, R01MH067870, R01MH64109)
National Institute of Neurological Disorders and Stroke (R01NS042947, R01NS052903, 1R01-NS42947, R01NS059042)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep evolution, sleep-like state, sleep homeostasis, sleep-wake regulation, genetic model organisms, fish, Drosophila, Caenorhabditis elegans
MeSH terms: Animals, Behavior, Animal, Circadian Rhythm, Homeostasis, Humans, Phylogeny, Sleep, Species Specificity, Time Factors, Signal Transduction, Models, Animal

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