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A Corticostriatal Path Targeting Striosomes Controls Decision-Making under Conflict

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Friedman, Alexander, Homma, Daigo, Gibb, Leif G., Amemori, Ken-ichi, Rubin, Samuel J., Hood, Adam S., Riad, Michael H., Graybiel, Ann M.·2015·Cell

DOI 10.1016/j.cell.2015.04.049PMC PMC4477966

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Abstract

A striking neurochemical form of compartmentalization has been found in the striatum of humans and other species, dividing it into striosomes and matrix. The function of this organization has been unclear, but the anatomical connections of striosomes indicate their relation to emotion-related brain regions, including the medial prefrontal cortex. We capitalized on this fact by combining pathway-specific optogenetics and electrophysiology in behaving rats to search for selective functions of striosomes. We demonstrate that a medial prefronto-striosomal circuit is selectively active in and causally necessary for cost-benefit decision-making under approach-avoidance conflict conditions known to evoke anxiety in humans. We show that this circuit has unique dynamic properties likely reflecting striatal interneuron function. These findings demonstrate that cognitive and emotion-related functions are, like sensory-motor processing, subject to encoding within compartmentally organized representations in the forebrain and suggest that striosome-targeting corticostriatal circuits can underlie neural processing of decisions fundamental for survival.

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Authors: Friedman, A., Homma, D., Gibb, L. G., Amemori, K.-I., Rubin, S. J., Hood, A. S., Riad, M. H., & Graybiel, A. M.
Affiliations: McGovern Institute for Brain Research (US)
Corresponding author: Graybiel, Ann M.
ORCID: Friedman, Alexander
Amemori, Ken-ichi
Graybiel, Ann M.
Venue: Cell
Publisher: Elsevier BV
Published: 2015-06
Volume: 161
Issue: 6
Pages: 1320-1333
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2015.04.049
PMC: PMC4477966
OpenAlex: W1554715089
Cited by: 309
References: 50
Citations by year: 2026: 36 · 2025: 19 · 2024: 19 · 2023: 18 · 2022: 18 · 2021: 39 · 2020: 34 · 2019: 27 · 2018: 32 · 2017: 26 · 2016: 33 · 2015: 8
FWCI: 19.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 369 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH060379)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: striosomes, striatum, corticostriatal circuits, medial prefrontal cortex, decision-making, approach-avoidance conflict, anxiety, striatal interneurons, emotion and cognition
MeSH terms: Animals, Caudate Nucleus, Choice Behavior, Conflict, Psychological, Decision Making, Environment, Gyrus Cinguli, Prefrontal Cortex, Maze Learning, Rats

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A Corticostriatal Path Targeting Striosomes Controls Decision-Making under Conflict

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