Cited by 145Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking

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Kim, Christina K., Ye, Li, Jennings, Joshua H., Pichamoorthy, Nandini, Tang, Daniel D., Yoo, Ai-Chi W., Ramakrishnan, Charu, Deisseroth, Karl·2017·Cell

Abstract

Reward-seeking behavior is fundamental to survival, but suppression of this behavior can be essential as well, even for rewards of high value. In humans and rodents, the medial prefrontal cortex (mPFC) has been implicated in suppressing reward seeking; however, despite vital significance in health and disease, the neural circuitry through which mPFC regulates reward seeking remains incompletely understood. Here, we show that a specific subset of superficial mPFC projections to a subfield of nucleus accumbens (NAc) neurons naturally encodes the decision to initiate or suppress reward seeking when faced with risk of punishment. A highly resolved subpopulation of these top-down projecting neurons, identified by 2-photon Ca 2+ imaging and activity-dependent labeling to recruit the relevant neurons, was found capable of suppressing reward seeking. This natural activity-resolved mPFC-to-NAc projection displayed unique molecular-genetic and microcircuit-level features concordant with a conserved role in the regulation of reward-seeking behavior, providing cellular and anatomical identifiers of behavioral and possible therapeutic significance.

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Authors
Kim, C. K., Ye, L., Jennings, J. H., Pichamoorthy, N., Tang, D. D., Yoo, A.-C. W., Ramakrishnan, C., & Deisseroth, K.
Affiliations
  • Stanford University (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Deisseroth, Karl
Venue
Cell
Publisher
Elsevier BV
Published
2017-08
Volume
170
Issue
5
Pages
1013-1027.e14
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2750035077
Cited by
145
References
69
Citations by year
2026: 10 · 2025: 12 · 2024: 19 · 2023: 15 · 2022: 12 · 2021: 24 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 3
FWCI
7.09
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIDA (F31DA041795, R01DA03537701)
  • NIDDK (K01DK114165)
  • HHWF
  • NIMH (R01MH075957, R01MH086373)
  • DARPA/ARL Neuro-FAST program (W911NF-14-2-0013)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
reward seeking, top-down control, medial prefrontal cortex, nucleus accumbens
MeSH terms
Animals, Behavior, Animal, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Neural Pathways, Punishment, Reward, Prefrontal Cortex, Mice, Neuroimaging

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