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A Corticostriatal Path Targeting Striosomes Controls Decision-Making under Conflict
Open accessAbstract
A striking neurochemical form of compartmentalization has been found in the striatum of humans and other species, dividing it into striosomes and matrix. The function of this organization has been unclear, but the anatomical connections of striosomes indicate their relation to emotion-related brain regions, including the medial prefrontal cortex. We capitalized on this fact by combining pathway-specific optogenetics and electrophysiology in behaving rats to search for selective functions of striosomes. We demonstrate that a medial prefronto-striosomal circuit is selectively active in and causally necessary for cost-benefit decision-making under approach-avoidance conflict conditions known to evoke anxiety in humans. We show that this circuit has unique dynamic properties likely reflecting striatal interneuron function. These findings demonstrate that cognitive and emotion-related functions are, like sensory-motor processing, subject to encoding within compartmentally organized representations in the forebrain and suggest that striosome-targeting corticostriatal circuits can underlie neural processing of decisions fundamental for survival.
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“Using an analogous task in rats, a similar pathway projecting from PLc to the striatal striosomes has been implicated in approach-avoidance decision making, with its inactivation increasing approach [203].”
From Prefrontal cortex and depression (2022) · cites this paper as [203]
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Cites
Kahneman, D., & Tversky, A. (1984) · American Psychologist · doi:10.1037/0003-066x.39.4.341 · Cited by 6,544
Kahneman, D. J., & Tversky, A. (2013) · World Scientific handbook in financial economic series · doi:10.1142/9789814417358_0016 · Cited by 5,379
Neurotransmitters and neuromodulators in the basal ganglia
Graybiel, A. M. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90104-i · Cited by 1,576
Self-citationThe mysterious motivational functions of mesolimbic dopamine
Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418
Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., & Hirsch, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.029 · Cited by 1,360
Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons
Watabe‐Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A., & Uchida, N. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.017 · Cited by 1,277
Frontal cortex and reward-guided learning and decision-making
Rushworth, M. F. S., Noonan, M. P., Boorman, E. D., Walton, M. E., & Behrens, T. E. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.014 · Cited by 1,111
Neuroeconomics: decision making and the brain
(2014) · Choice Reviews Online · doi:10.5860/choice.51-5702 · Cited by 1,020
Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
Pizzagalli, D. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.166 · Cited by 945
Inhibitory control of neostriatal projection neurons by GABAergic interneurons
Koós, T. Z., & Tepper, J. M. (1999) · Nature Neuroscience · doi:10.1038/8138 · Cited by 863
A simple and reliable conflict procedure for testing anti-anxiety agents
Vogel, J. R., Beer, B., & Clody, D. E. (1971) · Psychopharmacology · doi:10.1007/bf00403989 · Cited by 851
Gerfen, C. R. (1984) · Nature · doi:10.1038/311461a0 · Cited by 842
Graybiel, A. M., & Ragsdale, C. W. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.11.5723 · Cited by 784
Self-citationThe involvement of nucleus accumbens dopamine in appetitive and aversive motivation
Salamone, J. D. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90153-8 · Cited by 584
Separate neural pathways process different decision costs
Rudebeck, P. H., Walton, M. E., Smyth, A. N., Bannerman, D. M., & Rushworth, M. F. S. (2006) · Nature Neuroscience · doi:10.1038/nn1756 · Cited by 580
Neural computations associated with goal-directed choice
Rangel, A., & Hare, T. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.03.001 · Cited by 532
A Role for the Human Dorsal Anterior Cingulate Cortex in Fear Expression
Milad, M. R., Quirk, G. J., Pitman, R. K., Orr, S. P., Fischl, B., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.032 · Cited by 485
Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments
Crittenden, J. R., & Graybiel, A. M. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00059 · Cited by 470
Self-citationOptogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors
Burguière, E., Monteiro, P., Feng, G., & Graybiel, A. M. (2013) · Science · doi:10.1126/science.1232380 · Cited by 457
Self-citationA measure of striatal function predicts motor stereotypy
Canales, J. J., & Graybiel, A. M. (2000) · Nature Neuroscience · doi:10.1038/73949 · Cited by 423
Self-citationDonoghue, J. P., & Herkenham, M. A. (1986) · Brain Research · doi:10.1016/0006-8993(86)91658-6 · Cited by 418
Highly restricted origin of prefrontal cortical inputs to striosomes in the macaque monkey
Eblen, F., & Graybiel, A. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-05999.1995 · Cited by 389
Self-citationError-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder
Fitzgerald, K. D., Welsh, R. C., Gehring, W. J., Abelson, J. L., Himle, J. A., Liberzon, I., & Taylor, S. F. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.038 · Cited by 378
Kasai, K., Yamasue, H., Gilbertson, M. W., Shenton, M. E., Rauch, S. L., & Pitman, R. K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.022 · Cited by 377
Seamans, J. K., Floresco, S., & Phillips, A. G. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.6.1063 · Cited by 370
Kita, H., & Kitai, S. T. (1988) · Brain Research · doi:10.1016/0006-8993(88)91138-9 · Cited by 367
The role of rat medial frontal cortex in effort-based decision making
Walton, M. E., Bannerman, D. M., & Rushworth, M. F. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10996.2002 · Cited by 364
Parthasarathy, H. B., Schall, J. D., & Graybiel, A. M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04468.1992 · Cited by 353
Self-citationFlaherty, A. W., & Graybiel, A. M. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.4.1249 · Cited by 344
Self-citationSeamans, J. K., Floresco, S., & Phillips, A. G. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.6.1063 · Cited by 324
Fujiyama, F., Sohn, J., Nakano, T., Furuta, T., Nakamura, K., Matsuda, W., & Kaneko, T. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07564.x · Cited by 294
Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making
Amemori, K.-I., & Graybiel, A. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3088 · Cited by 262
Self-citationDopamine prediction error responses integrate subjective value from different reward dimensions
Lak, A., Stauffer, W. R., & Schultz, W. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321596111 · Cited by 257
Prefrontal Cortical Contribution to Risk-Based Decision Making
Onge, J. R. S., & Floresco, S. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp250 · Cited by 241
Prensa, L., & Parent, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07247.2001 · Cited by 238
Decision-making cognition in neurodegenerative diseases
Gleichgerrcht, E. L., Ibáñez, A. M., Roca, M., Torralva, T., & Manes, F. F. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.148 · Cited by 231
Neural systems underlying approach and avoidance in anxiety disorders
Robin L., A., & Martin, P. P. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.4/raupperle · Cited by 227 · cited 2×
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript function remain largely unknown (Aupperle and Paulus, 2010).”
Neural substrates of approach‐avoidance conflict decision‐making
Aupperle, R. L., Melrose, A. J., Francisco, A. J., Paulus, M. P., & Stein, M. B. (2014) · Human Brain Mapping · doi:10.1002/hbm.22639 · Cited by 209
Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction
Goldstein, R. Z., Alia‐Klein, N., Tomasi, D. G., Honorio, J., Maloney, T., Woicik, P. A., Wang, R., Telang, F., & Volkow, N. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900491106 · Cited by 200
Approach and Avoidance Goals and Plans: Their Relationship to Anxiety and Depression
Dickson, J. M., & MacLeod, A. K. (2004) · Cognitive Therapy and Research · doi:10.1023/b:cotr.0000031809.20488.ee · Cited by 171
Striosomes and mood dysfunction in Huntington's disease
Tippett, L. J., Waldvogel, H. J., Thomas, S. J., Hogg, V. M., van Roon‐Mom, W., Synek, B. J., Graybiel, A. M., & Faull, R. L. M. (2006) · Brain · doi:10.1093/brain/awl243 · Cited by 162
Self-citationIndependent circuits in the basal ganglia for the evaluation and selection of actions
Stephenson‐Jones, M., Kardamakis, A. A., Robertson, B., & Grillner, S. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314815110 · Cited by 141
Functional Properties of Striatal Fast-Spiking Interneurons
Berke, J. D. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00045 · Cited by 140
Overriding Phasic Dopamine Signals Redirects Action Selection during Risk/Reward Decision Making
Stopper, C. M., Tse, M. T. L., Montes, D. R., Wiedman, C. R., & Floresco, S. B. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.033 · Cited by 136
Sangha, S., Robinson, P. D., Greba, Q., Davies, D. A., & Howland, J. G. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.89 · Cited by 135
A reverse translational approach to quantify approach-avoidance conflict in humans
Aupperle, R. L., Sullivan, S., Melrose, A. J., Paulus, M. P., & Stein, M. B. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.003 · Cited by 134
Output architecture of the primate putamen
Flaherty, A. W., & Graybiel, A. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03222.1993 · Cited by 126
Self-citationCompartmental origin of the striato‐entopeduncular projection in the rat
Rajakumar, N., Elisevich, K. V., & Flumerfelt, B. A. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903310210 · Cited by 98
Hong, S., & Hikosaka, O. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00778 · Cited by 70
Newman, H., Liu, F., & Graybiel, A. M. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23725 · Cited by 28
Self-citationDwyer, D. M., Dunn, M. J., Rhodes, S. E. V., & Killcross, S. (2009) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470210903411049 · Cited by 15
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Kalueff, A. V., Stewart, A. M., Song, C., Berridge, K. C., Graybiel, A. M., & Fentress, J. C. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.8 · Cited by 852
Self-citationPrefrontal cortex and depression
Pizzagalli, D. A., & Roberts, A. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01101-7 · Cited by 667
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Cox, J., & Witten, I. B. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0189-2 · Cited by 584
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Metadata
- Authors
- Friedman, A., Homma, D., Gibb, L. G., Amemori, K.-I., Rubin, S. J., Hood, A. S., Riad, M. H., & Graybiel, A. M.
- Affiliations
- McGovern Institute for Brain Research (US)
- Corresponding author
- Graybiel, Ann M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 6
- Pages
- 1320-1333
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4477966
- OpenAlex
- W1554715089
- Cited by
- 309
- References
- 50
- Citations by year
- 2026: 36 · 2025: 19 · 2024: 19 · 2023: 18 · 2022: 18 · 2021: 39 · 2020: 34 · 2019: 27 · 2018: 32 · 2017: 26 · 2016: 33 · 2015: 8
- FWCI
- 19.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH060379)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- striosomes, striatum, corticostriatal circuits, medial prefrontal cortex, decision-making, approach-avoidance conflict, anxiety, striatal interneurons, emotion and cognition
- MeSH terms
- Animals, Caudate Nucleus, Choice Behavior, Conflict, Psychological, Decision Making, Environment, Gyrus Cinguli, Prefrontal Cortex, Maze Learning, Rats
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