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Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System

Redding, Sy, Sternberg, Samuel H., Marshall, Myles, Gibb, Bryan, Bhat, Prashant, Guegler, Chantal K., Wiedenheft, Blake, Doudna, Jennifer A., Greene, Eric C.·2015·Cell
DOI 10.1016/j.cell.2015.10.003PMC PMC4636941
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  • Although degradation by Cas3 handicaps the invader, it might not lead to full destruction of the target; complete degradation might be induced by other cellular nucleases or by Cascade-independent Cas3 nuclease activity.

    “Although this degradation handicaps the invader, it might not lead to the full destruction of the target. Complete degradation might be induced by other cellular nucleases or by Cascade-independent Cas3 nuclease activity, which has been previously documented [44,45,46].”

    From CRISPR-Cas: Converting A Bacterial Defence Mechanism into A State-of-the-Art Genetic Manipulation Tool (2019) · cites this paper as [44]

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Research works printed but not linked: 38

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  17. Mulepati, 2013, In vitro reconstitution of an Escherichia coli RNA-guided immune system reveals unidirectional, ATP-dependent degradation of DNA target, J. Biol. Chem., 288, 22184, 10.1074/jbc.M113.472233 · DOI · Paper page
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Metadata

Authors
Redding, S., Sternberg, S. H., Marshall, M., Gibb, B., Bhat, P., Guegler, C. K., Wiedenheft, B., Doudna, J. A., & Greene, E. C.
Venue
Cell
Publisher
Elsevier BV
Published
2015-11
Volume
163
Issue
4
Pages
854-865
ISSN
0092-8674
DOI
10.1016/j.cell.2015.10.003
PMC
PMC4636941
Cited by
198
References
0
Language
en
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