Identification of a Spinal Circuit for Light Touch and Fine Motor Control
Open accessAbstract
Sensory circuits in the dorsal spinal cord integrate and transmit multiple cutaneous sensory modalities including the sense of light touch. Here, we identify a population of excitatory interneurons (INs) in the dorsal horn that are important for transmitting innocuous light touch sensation. These neurons express the ROR alpha (RORα) nuclear orphan receptor and are selectively innervated by cutaneous low threshold mechanoreceptors (LTMs). Targeted removal of RORα INs in the dorsal spinal cord leads to a marked reduction in behavioral responsiveness to light touch without affecting responses to noxious and itch stimuli. RORα IN-deficient mice also display a selective deficit in corrective foot movements. This phenotype, together with our demonstration that the RORα INs are innervated by corticospinal and vestibulospinal projection neurons, argues that the RORα INs direct corrective reflex movements by integrating touch information with descending motor commands from the cortex and cerebellum.
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The Prkcg dorsal excitatory family comprised Excit-3 and Excit-4 and likely corresponded to neurons involved in light static touch and allodynic pain in pathological situations.
“The Prkcg dorsal, excitatory family was comprised of Excit-3 and Excit-4 and likely corresponded to neurons involved in light static touch and allodynic pain in pathological situations46,48–56.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [50]
The Maf dorsal excitatory family comprised Excit-5, Excit-6, and Excit-7, which expressed markers of neurons involved in light touch.
“The Maf dorsal, the excitatory family was comprised of Excit-5, Excit-6, and Excit-7 which expressed markers of neurons involved in light touch46,48,50,56,57.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [50]
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- Authors
- Bourane, S., Grossmann, K. S., Britz, O., Dalet, A., Del Barrio, M. G., Stam, F. J., Garcia-Campmany, L., Koch, S., & Goulding, M.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Goulding, Martyn
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 160
- Issue
- 3
- Pages
- 503-515
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4431637
- OpenAlex
- W2026910668
- Cited by
- 215
- References
- 82
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 17 · 2023: 23 · 2022: 16 · 2021: 22 · 2020: 25 · 2019: 18 · 2018: 20 · 2017: 17 · 2016: 14 · 2015: 10
- FWCI
- 14.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS086372, NS080586, P30NS072031, NS072031, R01NS080586, NS086372)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- light touch, dorsal horn interneurons, low-threshold mechanoreceptors, dorsal spinal cord, descending motor control, nociception, pruritus, sensorimotor integration
- MeSH terms
- Animals, Interneurons, Motor Activity, Motor Neurons, Neural Pathways, Synapses, Touch, Mechanotransduction, Cellular, Mice, Nuclear Receptor Subfamily 1, Group F, Member 1, Spinal Cord Dorsal Horn
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