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A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production
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The findings are consistent with previous reports that RAB10 silencing affects Aβ levels.
“These findings are consistent with previous reports that RAB10 silencing affects Aβ levels [52]”
From Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience (2017) · cites this paper as [52]
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Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · cited 2×
“Identifies Rab11 as a Regulator of b-Amyloid Production”
BackgroundAlzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., et al. (2012) · Nature · doi:10.1038/nature11283 · Cited by 1,738
Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V., Bhamidipati, A., Punna, T., Ihmels, J., Andrews, B., Boone, C., Greenblatt, J. F., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.031 · Cited by 870 · cited 1×
“Rab GTPases regulate many aspects of membrane protein trafficking, acting as membrane organizers on cellular compartments that mediate vesicular trafficking and aid in vesicle fusion (Seabra et al., 2002).”
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
De Strooper, B. (2010) · Physiological Reviews · doi:10.1152/physrev.00023.2009 · Cited by 455
Morel, E., Chamoun, Z., Lasiecka, Z. M., Chan, R. B., Williamson, R. L., Vetanovetz, C., Dall’Armi, C., Simoes, S., Point Du Jour, K. S., McCabe, B. D., et al. (2013) · Nature Communications · doi:10.1038/ncomms3250 · Cited by 222
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Research works printed but not linked: 68
- Andersen, 2005, Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein, Proc. Natl. Acad. Sci. USA, 102, 13461, 10.1073/pnas.0503689102 · DOI · Paper page
- Annaert, 2002, A cell biological perspective on Alzheimer’s disease, Annu. Rev. Cell Dev. Biol., 18, 25, 10.1146/annurev.cellbio.18.020402.142302 · DOI · Paper page
- Barr, 2010, Rab GEFs and GAPs, Curr. Opin. Cell Biol., 22, 461, 10.1016/j.ceb.2010.04.007 · DOI
- Borchelt, 1996, Familial Alzheimer’s disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo, Neuron, 17, 1005, 10.1016/S0896-6273(00)80230-5 · DOI · Paper page
- Buggia-Prévot, 2013, A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer’s disease Aβ production, Cell Rep., 5, 1552, 10.1016/j.celrep.2013.12.006 · DOI · Paper page
- Cataldo, 2000, Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations, Am. J. Pathol., 157, 277, 10.1016/S0002-9440(10)64538-5 · DOI · Paper page
- Choudhury, 2002, Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells, J. Clin. Invest., 109, 1541, 10.1172/JCI0215420 · DOI
- Choy, 2012, Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network, Proc. Natl. Acad. Sci. USA, 109, E2077, 10.1073/pnas.1208635109 · DOI
- Chyung, 2003, Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface, J. Biol. Chem., 278, 51035, 10.1074/jbc.M304989200 · DOI · Paper page
- Das, 2013, Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway, Neuron, 79, 447, 10.1016/j.neuron.2013.05.035 · DOI
- Duff, 1996, Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1, Nature, 383, 710, 10.1038/383710a0 · DOI
- Dumanchin, 1999, Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport, Hum. Mol. Genet., 8, 1263, 10.1093/hmg/8.7.1263 · DOI · Paper page
- Ehehalt, 2003, Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts, J. Cell Biol., 160, 113, 10.1083/jcb.200207113 · DOI · Paper page
- Frasa, 2012, Illuminating the functional and structural repertoire of human TBC/RABGAPs, Nat. Rev. Mol. Cell Biol., 13, 67, 10.1038/nrm3267 · DOI
- Frisoni, 2011, Revised criteria for Alzheimer’s disease: what are the lessons for clinicians?, Lancet Neurol., 10, 598, 10.1016/S1474-4422(11)70126-0 · DOI
- Gagescu, 2000, The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components, Mol. Biol. Cell, 11, 2775, 10.1091/mbc.11.8.2775 · DOI
- Galvez, 2012, SnapShot: mammalian Rab proteins in endocytic trafficking, Cell, 151, 234, 10.1016/j.cell.2012.09.013 · DOI · Paper page
- Haass, 1992, Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments, Nature, 357, 500, 10.1038/357500a0 · DOI
- He, 2005, GGA proteins mediate the recycling pathway of memapsin 2 (BACE), J. Biol. Chem., 280, 11696, 10.1074/jbc.M411296200 · DOI
- Hsu, 2010, Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C, J. Cell Biol., 189, 223, 10.1083/jcb.200911018 · DOI
- Kaether, 2006, Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface, Traffic, 7, 408, 10.1111/j.1600-0854.2006.00396.x · DOI
- Kalvodova, 2005, Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro, J. Biol. Chem., 280, 36815, 10.1074/jbc.M504484200 · DOI
- Kametani, 2004, Mutant presenilin (A260V) affects Rab8 in PC12D cell, Neurochem. Int., 44, 313, 10.1016/S0197-0186(03)00176-1 · DOI
- Kinoshita, 2003, Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes, J. Cell Sci., 116, 3339, 10.1242/jcs.00643 · DOI · Paper page
- Koo, 1994, Evidence that production and release of amyloid beta-protein involves the endocytic pathway, J. Biol. Chem., 269, 17386, 10.1016/S0021-9258(17)32449-3 · DOI · Paper page
- Laflamme, 2012, Evi5 promotes collective cell migration through its Rab-GAP activity, J. Cell Biol., 198, 57, 10.1083/jcb.201112114 · DOI
- Lichtenthaler, 2011, α-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential, J. Neurochem., 116, 10, 10.1111/j.1471-4159.2010.07081.x · DOI
- Lindsay, 2002, Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain, J. Biol. Chem., 277, 27193, 10.1074/jbc.M200757200 · DOI
- Longatti, 2012, TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes, J. Cell Biol., 197, 659, 10.1083/jcb.201111079 · DOI
- Maxfield, 1987, Endosome acidification and the pathways of receptor-mediated endocytosis, Adv. Exp. Med. Biol., 225, 189, 10.1007/978-1-4684-5442-0_16 · DOI
- Nitsch, 1993, Receptor-coupled amyloid precursor protein processing, Ann. N Y Acad. Sci., 695, 122, 10.1111/j.1749-6632.1993.tb23039.x · DOI
- Onodera, 2012, Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion, J. Cell Biol., 197, 983, 10.1083/jcb.201201065 · DOI
- Ostrowski, 2010, Rab27a and Rab27b control different steps of the exosome secretion pathway, Nat. Cell Biol., 12, 19, 10.1038/ncb2000 · DOI
- Perez, 1999, Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42, J. Biol. Chem., 274, 18851, 10.1074/jbc.274.27.18851 · DOI
- Pfeffer, 2004, Targeting Rab GTPases to distinct membrane compartments, Nat. Rev. Mol. Cell Biol., 5, 886, 10.1038/nrm1500 · DOI
- Prabhu, 2012, Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing, Mol. Biol. Cell, 23, 2339, 10.1091/mbc.e11-11-0944 · DOI · Paper page
- Rajendran, 2012, Membrane trafficking pathways in Alzheimer’s disease, Traffic, 13, 759, 10.1111/j.1600-0854.2012.01332.x · DOI · Paper page
- Rajendran, 2006, Alzheimer’s disease beta-amyloid peptides are released in association with exosomes, Proc. Natl. Acad. Sci. USA, 103, 11172, 10.1073/pnas.0603838103 · DOI · Paper page
- Rajendran, 2008, Efficient inhibition of the Alzheimer’s disease beta-secretase by membrane targeting, Science, 320, 520, 10.1126/science.1156609 · DOI
- Ren, 1998, Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes, Proc. Natl. Acad. Sci. USA, 95, 6187, 10.1073/pnas.95.11.6187 · DOI · Paper page
- Rogaeva, 2007, The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease, Nat. Genet., 39, 168, 10.1038/ng1943 · DOI · Paper page
- Sannerud, 2011, ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1, Proc. Natl. Acad. Sci. USA, 108, E559, 10.1073/pnas.1100745108 · DOI
- Schlüter, 2004, A complete genetic analysis of neuronal Rab3 function, J. Neurosci., 24, 6629, 10.1523/JNEUROSCI.1610-04.2004 · DOI
- Schmidt, 2007, Recycling endosomes in neuronal membrane traffic, Biol. Cell, 99, 333, 10.1042/BC20070007 · DOI
- Schneider, 2008, Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons, J. Neurosci., 28, 2874, 10.1523/JNEUROSCI.5345-07.2008 · DOI
- Seabra, 2002, Rab GTPases, intracellular traffic and disease, Trends Mol. Med., 8, 23, 10.1016/S1471-4914(01)02227-4 · DOI
- Selkoe, 2011, Alzheimer’s disease, Cold Spring Harb. Perspect. Biol., 3, a004457, 10.1101/cshperspect.a004457 · DOI
- Selkoe, 2011, Resolving controversies on the path to Alzheimer’s therapeutics, Nat. Med., 17, 1060, 10.1038/nm.2460 · DOI · Paper page
- Selkoe, 2007, Presenilin: running with scissors in the membrane, Cell, 131, 215, 10.1016/j.cell.2007.10.012 · DOI
- Shiba, 2006, Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1, Proc. Natl. Acad. Sci. USA, 103, 15416, 10.1073/pnas.0605357103 · DOI
- Siegenthaler, 2012, Retromers in Alzheimer’s disease, Neurodegener. Dis., 10, 116, 10.1159/000335910 · DOI
- Small, 2006, Sorting through the cell biology of Alzheimer’s disease: intracellular pathways to pathogenesis, Neuron, 52, 15, 10.1016/j.neuron.2006.09.001 · DOI
- Small, 2005, Model-guided microarray implicates the retromer complex in Alzheimer’s disease, Ann. Neurol., 58, 909, 10.1002/ana.20667 · DOI · Paper page
- Sönnichsen, 2000, Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11, J. Cell Biol., 149, 901, 10.1083/jcb.149.4.901 · DOI · Paper page
- Spasic, 2008, Building gamma-secretase: the bits and pieces, J. Cell Sci., 121, 413, 10.1242/jcs.015255 · DOI
- Stenmark, 2001, The Rab GTPase family, Genome Biol., 2, 10.1186/gb-2001-2-5-reviews3007 · DOI
- Szodorai, 2009, APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle, J. Neurosci., 29, 14534, 10.1523/JNEUROSCI.1546-09.2009 · DOI
- Tesco, 2007, Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity, Neuron, 54, 721, 10.1016/j.neuron.2007.05.012 · DOI · Paper page
- Thinakaran, 2008, Amyloid precursor protein trafficking, processing, and function, J. Biol. Chem., 283, 29615, 10.1074/jbc.R800019200 · DOI · Paper page
- Tisdale, 2003, Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation, J. Biol. Chem., 278, 52524, 10.1074/jbc.M309343200 · DOI
- Vassar, 2009, The beta-secretase enzyme BACE in health and Alzheimer’s disease: regulation, cell biology, function, and therapeutic potential, J. Neurosci., 29, 12787, 10.1523/JNEUROSCI.3657-09.2009 · DOI · Paper page
- von Arnim, 2006, GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing, J. Neurosci., 26, 9913, 10.1523/JNEUROSCI.2290-06.2006 · DOI
- Wakabayashi, 2009, Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains, Nat. Cell Biol., 11, 1340, 10.1038/ncb1978 · DOI · Paper page
- Wilcke, 2000, Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-golgi network, J. Cell Biol., 151, 1207, 10.1083/jcb.151.6.1207 · DOI · Paper page
- Willem, 2009, Function, regulation and therapeutic properties of beta-secretase (BACE1), Semin. Cell Dev. Biol., 20, 175, 10.1016/j.semcdb.2009.01.003 · DOI
- Yang, 2003, Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease, Nat. Med., 9, 3, 10.1038/nm0103-3 · DOI · Paper page
- Yoshimura, 2007, Functional dissection of Rab GTPases involved in primary cilium formation, J. Cell Biol., 178, 363, 10.1083/jcb.200703047 · DOI
- Zerial, 2001, Rab proteins as membrane organizers, Nat. Rev. Mol. Cell Biol., 2, 107, 10.1038/35052055 · DOI · Paper page
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Self-citationRAB10: an Alzheimer’s disease resilience locus and potential drug target
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Metadata
- Authors
- Udayar, V., Buggia-Prévot, V., Guerreiro, R. L., Siegel, G., Rambabu, N., Soohoo, A. L., Ponnusamy, M., Siegenthaler, B., Bali, J., Guerreiro, R., Brás, J., Sassi, C., Gibbs, J. R., Hernandez, D., Lupton, M. K., Brown, K., Morgan, K., Powell, J., Singleton, A., Hardy, J., Simons, M., Ries, J., Puthenveedu, M. A., Hardy, J., Thinakaran, G., & Rajendran, L.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 5
- Issue
- 6
- Pages
- 1536-1551
- ISSN
- 2211-1247
- PMC
- PMC4004174
- Cited by
- 147
- References
- 6
- Language
- en
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