Cholinergic signals in mouse barrel cortex during active whisker sensing
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Internal brain states affect sensory perception, cognition, and learning. Many neocortical areas exhibit changes in the pattern and synchrony of neuronal activity during quiet versus active behaviors. Active behaviors are typically associated with desynchronized cortical dynamics. Increased thalamic firing contributes importantly to desynchronize mouse barrel cortex during active whisker sensing. However, a whisking-related cortical state change persists after thalamic inactivation, which is mediated at least in part by acetylcholine, as we show here by using whole-cell recordings, local pharmacology, axonal calcium imaging, and optogenetic stimulation. During whisking, we find prominent cholinergic signals in the barrel cortex, which suppress spontaneous cortical activity. The desynchronized state of barrel cortex during whisking is therefore driven by at least two distinct signals with opposing functions: increased thalamic activity driving glutamatergic excitation of the cortex and increased cholinergic input suppressing spontaneous cortical activity.
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Both cholinergic and serotoninergic systems can activate kinetically fast excitatory postsynaptic potentials in postsynaptic targets through nicotinic and 5HT3A receptors, respectively, and the discharges of both cholinergic and serotonergic neurons are strongly modulated by movement.
“Both cholinergic and serotoninergic systems can activate kinetically fast excitatory postsynaptic potentials in postsynaptic targets through nicotinic and 5HT3A receptors, respectively, and the discharges of both cholinergic (e.g. Figure 9C) and serotonergic neurons are strongly modulated by movement (Eggermann et al., 2014; Jacobs and Fornal, 1993) (Reimer, McGinley, McCormick, Tolias, unpub”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Eggermann et al., 2014
Pharmacological block of both cholinergic and noradrenergic receptors locally in the cortex is associated with a strong reduction of the ability of locomotion to modulate cortical state.
“Pharmacological block of both cholinergic and noradrenergic receptors locally in the cortex is associated with a strong reduction of the ability of locomotion to modulate cortical state (Eggermann et al., 2014; Polack et al., 2013), suggesting that movement may reduce low frequency, and promote higher frequency, rhythms largely through its association with arousal.”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Eggermann et al., 2014
The high correlation between movement and basal forebrain cholinergic activity, and neurons in the region of the brainstem cholinergic nuclei, suggests that there may also be a high correlation between pupil diameter and the activity of these neurons.
“The high correlation between movement and basal forebrain cholinergic activity (Eggermann et al., 2014), and neurons in the region of the brainstem cholinergic nuclei (Lee et al., 2014) suggests that there may also be a high correlation between pupil diameter and the activity of these neurons.”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Eggermann et al., 2014
Both basal forebrain cholinergic and locus coeruleus noradrenergic neurons increase their discharge in relation to increased attention to external stimuli, arousal, and locomotion, in both a graded and transient manner.
“Both basal forebrain cholinergic and locus coeruleus noradrenergic neurons increase their discharge in relation to increased attention to external stimuli, arousal, and locomotion, in both a graded and transient manner (Figure 9) (Aston-Jones and Cohen, 2005; Eggermann et al., 2014; Steriade and McCarley, 2005).”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Eggermann et al., 2014
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- Authors
- Eggermann, E., Kremer, Y., Crochet, S., & Petersen, C. C. H.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Crochet, Sylvain
- Petersen, Carl C.H.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 9
- Issue
- 5
- Pages
- 1654-1660
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2090094004
- Cited by
- 234
- References
- 50
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 30 · 2023: 21 · 2022: 23 · 2021: 22 · 2020: 22 · 2019: 21 · 2018: 21 · 2017: 16 · 2016: 20 · 2015: 9
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- European Research Council
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cholinergic neurotransmission, acetylcholine, barrel cortex, active behavior, cortical desynchronization, spontaneous cortical activity, glutamatergic excitation
- MeSH terms
- Animals, Cerebral Cortex, Vibrissae, Mice, Touch Perception, Cholinergic Neurons
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