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Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex

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Monoselective Histone Deacetylase 6 PROTAC Degrader Shows In Vivo Tractability

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Crbn-based molecular Glues: Breakthroughs and perspectives

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Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes

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Ubiquiton—An inducible, linkage-specific polyubiquitylation tool

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Function, mechanism and drug discovery of ubiquitin and ubiquitin-like modification with multiomics profiling for cancer therapy

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Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective

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Development of Potent and Selective CK1α Molecular Glue Degraders

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Benchmarking Cofolding Methods for Molecular Glue Ternary Structure Prediction

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Ubiquitin‐specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling

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Discovery of Monovalent Direct Degraders of BRD4 that Act via the Recruitment of DCAF11

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Allostery in Disease: Anticancer Drugs, Pockets, and the Tumor Heterogeneity Challenge

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Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders

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Molecular glue degrader for tumor treatment

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Cross‐Linking Profiling of Molecular Glue Degrader‐Induced E3 Ligase Interactome to Expand Target Space

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Development of PROTACS degrading KRAS and SOS1

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Degraders: The Ultimate Weapon Against Amplified Driver Kinases in Cancer

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EFMC: Trends in Medicinal Chemistry and Chemical Biology

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Salinization Dramatically Enhance the Anti-Prostate Cancer Efficacies of AR/AR-V7 and Mnk1/2 Molecular Glue Degraders, Galeterone and VNPP433-3β Which Outperform Docetaxel and Enzalutamide in CRPC CWR22Rv1 Xenograft Mouse Model

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It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease

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Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-Resistant Prostate Cancer

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Targeted protein degradation might present a novel therapeutic approach in the fight against African trypanosomiasis

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Emerging mechanisms of targeted protein degradation by molecular glues

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C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies

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Strategies for Conditional Regulation of Proteins

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Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules

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Discovery of molecular glues by modeling ternary complex conformational ensembles and thermodynamic stabilityPreprint

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Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment

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Nondegradative Synthetic Molecular Glues Enter the Clinic

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Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies

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The genetic architecture of an allosteric hormone receptor

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Opportunities in proximity modulation: Bridging academia and industry

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MGTbind: a comprehensive database of molecular glue ternary interactome

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Research progress on covalent inhibitors targeting alkaline amino acids

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Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers

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Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma

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Short circuit: Transcription factor addiction as a growing vulnerability in cancer

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COVID-19 Therapies: Protease Inhibitions and Novel Degrader Strategies

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Cooperative Free Energy: Induced Protein–Protein Interactions and Cooperative Solvation in Ternary Complexes

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A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation

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Rational design of molecular glue degraders via computational prediction of E3 ligase interactions

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Molecular Glue Degraders and the Expanding Design Space of Drug Discovery

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Abstract A054: Molecular glue discovery enabled by targeted degron display

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Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic

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Molecular Glue Degraders in Early Development for Cancer Therapy

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