Immunosenescence: Implications for response to infection and vaccination in older people

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503 · see citing works

The biology of human natural killer-cell subsets

Cooper, M. A., Fehniger, T. A., & Caligiuri, M. A. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)02060-9 · Cited by 2,975 · see citing works

Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003*

Dombrovskiy, V. Y., Martin, A. A., Sunderram, J., & Paz, H. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000261890.41311.e9 · Cited by 1,250 · see citing works

The effect of age on the development and outcome of adult sepsis*

Martin, G. S., Mannino, D. M., & Moss, M. M. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000194535.82812.ba · Cited by 1,044 · see citing works

Understanding immunosenescence to improve responses to vaccines

Goronzy, J. J., & Weyand, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2588 · Cited by 827 · see citing works

Expansion of a unique CD57 ⁺ NKG2C ^hi natural killer cell subset during acute human cytomegalovirus infection

Lopez-Vergès, S., Milush, J. M., Schwartz, B. S., Pando, M. J., Jarjoura, J., York, V. A., Houchins, J. P., Miller, S., Kang, S.-M., Norris, P. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110900108 · Cited by 822 · see citing works

Innate lymphoid cells — how did we miss them?

Walker, J. A., Barlow, J. L., & McKenzie, A. N. J. (2013) · Nature reviews. Immunology · doi:10.1038/nri3349 · Cited by 668 · see citing works

Aging, frailty and age-related diseases

Fülöp, T., Larbi, A., Witkowski, J. M., McElhaney, J. E., Loeb, M. B., Mitnitski, A., & Pawelec, G. (2010) · Biogerontology · doi:10.1007/s10522-010-9287-2 · Cited by 651 · see citing works

Effectiveness of Influenza Vaccine in the Community-Dwelling Elderly

Nichol, K. L., Nordin, J. D., Nelson, D. B., Mullooly, J. P., & Hak, E. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa070844 · Cited by 647 · see citing works

Sex Differences in Autoimmune Disease from a Pathological Perspective

Fairweather, D., Frisancho-Kiss, S., & Rose, N. R. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071008 · Cited by 629 · see citing works

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567 · see citing works

Characterization of CD56 – /CD16 + natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals

Mavilio, D., Lombardo, G., Benjamin, J., Kim, D. J., Follman, D., Marcenaro, E., O’Shea, M. A., Kinter, A. L., Kovacs, C. C., Moretta, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409872102 · Cited by 543 · see citing works

Influenza and the Winter Increase in Mortality in the United States, 1959-1999

Reichert, T. A. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh227 · Cited by 447 · see citing works

Inflammation, ageing and chronic disease

Pawelec, G., Goldeck, D., & Derhovanessian, E. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.03.007 · Cited by 420 · see citing works

Role of Inflammation in Atherosclerosis Associated with Rheumatoid Arthritis

Libby, P. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.06.014 · Cited by 413 · see citing works

An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans

Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407 · see citing works

Human immunosenescence: is it infectious?

Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00271.x · Cited by 405 · see citing works

Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United States

Simanek, A. M., Dowd, J. B., Pawelec, G., Melzer, D. R., Dutta, A., & Aiello, A. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016103 · Cited by 398 · see citing works

Immunosenescence: what does it mean to health outcomes in older adults?

McElhaney, J. E., & Effros, R. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.023 · Cited by 340 · see citing works

Human NK cells display major phenotypic and functional changes over the life span

Le Garff‐Tavernier, M., Béziat, V., Decocq, J., Siguret, V., Gandjbakhch, F., Pautas, E., Debré, P., Merle‐Beral, H., & Vieillard, V. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00584.x · Cited by 338 · see citing works

Estrogens and Autoimmune Diseases

Cutolo, M., Capellino, S., Sulli, A., SERIOLI, B., Secchi, M. E., Villaggio, B., & Straub, R. H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.043 · Cited by 311 · see citing works

Cohort Study of Cytomegalovirus Infection as a Risk Factor for Carotid Intimal-Medial Thickening, a Measure of Subclinical Atherosclerosis

Nieto, F. J., Adam, E., Sorlie, P. D., Farzadegan, H., Melnick, J. L., Comstock, G. W., & Szklo, M. (1996) · Circulation · doi:10.1161/01.cir.94.5.922 · Cited by 303 · see citing works

Menopause and aging: Changes in the immune system—A review

Gameiro, C., Romão, F., & Castelo‐Branco, C. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.08.003 · Cited by 303 · see citing works

NK phenotypic markers and IL2 response in NK cells from elderly people

Borrego, F., Alonso, M. C., Galiani, M. D., Carracedo, J., Ramı́rez, R., Ostos, B., Peña, J., & Solana, R. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00076-x · Cited by 278 · see citing works

Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?

Chiesa, M. D., Falco, M., Podestà, M., Locatelli, F., Moretta, L., Frassoni, F., & Moretta, A. (2011) · Blood · doi:10.1182/blood-2011-08-372003 · Cited by 251 · see citing works

VZV T Cell-Mediated Immunity

Weinberg, A., & Levin, M. J. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_31 · Cited by 232 · see citing works

Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults

McElhaney, J. E., Ewen, C., Zhou, X., Kane, K. P., Xie, D., Hager, W. D., Barry, M. B., Kleppinger, A., Wang, Y., & Bleackley, R. C. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.01.136 · Cited by 219 · see citing works

Immunosenescence of Human Natural Killer Cells

Gayoso, I., Sánchez-Correa, B., Campos, C., Alonso, C., Pera, A., Casado, J. G., Morgado, S., Tarazona, R., & Solana, R. (2011) · Journal of Innate Immunity · doi:10.1159/000328005 · Cited by 210 · see citing works

Cytomegalovirus-induced immunopathology and its clinical consequences

Varani, S., & Landini, M. P. (2011) · Herpesviridae · doi:10.1186/2042-4280-2-6 · Cited by 206 · see citing works

CMV and Immunosenescence: from basics to clinics

Solana, R., Tarazona, R., Aiello, A. E., Akbar, A. N., Appay, V., Beswick, M., Bosch, J. A., Campos, C., Cantisán, S., Čičin‐Šain, L., et al. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-23 · Cited by 181 · see citing works

Shaping of NK cell subsets by aging

Solana, R., Campos, C., Pera, A., & Tarazona, R. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.04.002 · Cited by 167 · see citing works

Human regulatory T cells and autoimmunity

Costantino, C. M., Baecher‐Allan, C., & Hafler, D. A. (2008) · European Journal of Immunology · doi:10.1002/eji.200738104 · Cited by 158 · see citing works

Influenza vaccine responses in older adults

McElhaney, J. E. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.008 · Cited by 155 · see citing works

Sepsis in Old Age: Review of Human and Animal Studies

Starr, M. E. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500126 · Cited by 154 · see citing works

Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity

DelaRosa, O., Pawelec, G., Peralbo, E., Wikby, A., Mariani, E., Mocchegiani, E., Tarazona, R., & Solana, R. (2006) · Biogerontology · doi:10.1007/s10522-006-9062-6 · Cited by 150 · see citing works

Expansion of Functionally Skewed CD56-Negative NK Cells in Chronic Hepatitis C Virus Infection: Correlation with Outcome of Pegylated IFN-α and Ribavirin Treatment

Gonzalez, V. D., Falconer, K., Björkström, N. K., Blom, K. G., Weiland, O., Ljunggren, H., Alaeus, A., & Sandberg, J. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901437 · Cited by 147 · see citing works

Menopause, oestrogens and arthritis

Wluka, A. E., Cicuttini, F., & Spector, T. D. (2000) · Maturitas · doi:10.1016/s0378-5122(00)00118-3 · Cited by 141 · see citing works

Human Cytomegalovirus-Induced NKG2C hi CD57 hi Natural Killer Cells Are Effectors Dependent on Humoral Antiviral Immunity

Wu, Z., Sinzger, C., Frascaroli, G., Reichel, J. J., Bayer, C., Wang, L., Schirmbeck, R., & Mertens, T. (2013) · Journal of Virology · doi:10.1128/jvi.01096-13 · Cited by 139 · see citing works

Adaptive reconfiguration of the human NK‐cell compartment in response to cytomegalovirus: A different perspective of the host‐pathogen interaction

Muntasell, A., Vilches, C., Angulo, A., & López‐Botet, M. (2013) · European Journal of Immunology · doi:10.1002/eji.201243117 · Cited by 132 · see citing works

Effect of age and CMV on NK cell subpopulations

Campos, C., Pera, A., Sanchez-Correa, B., Alonso, C., Lopez-Fernandez, I., Morgado, S., Tarazona, R., & Solana, R. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.008 · Cited by 128 · see citing works

Selective Depletion of CD56dim NK Cell Subsets and Maintenance of CD56bright NK Cells in Treatment-Naive HIV-1-Seropositive Individuals

Tarazona, R., Casado, J. G., DelaRosa, O., Torre‐Cisneros, J., Villanueva, J. L., Sánchez, B., Galiani, M. D., Gonzalez, R., Solana, R., & Peña, J. (2002) · Journal of Clinical Immunology · doi:10.1023/a:1015476114409 · Cited by 124 · see citing works

CD56negCD16+NK cells are activated mature NK cells with impaired effector function during HIV-1 infection

Milush, J. M., López‐Vergès, S., York, V. A., Deeks, S. G., Martin, J. N., Hecht, F. M., Lanier, L. L., & Nixon, D. F. (2013) · Retrovirology · doi:10.1186/1742-4690-10-158 · Cited by 120 · see citing works

Menopause in patients with autoimmune diseases

Sammaritano, L. R. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.11.006 · Cited by 119 · see citing works

Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells

Brindley, S. M., Lanham, A. M., Karrer, F. M., Tucker, R. M., Fontenot, A. P., & Mack, C. L. (2011) · Hepatology · doi:10.1002/hep.24807 · Cited by 116 · see citing works

Reciprocal age related change in natural killer cell receptors for MHC class I

Lutz, C. T., Moore, M. B., Bradley, S., Shelton, B. J., & Lutgendorf, S. K. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.01.004 · Cited by 114 · see citing works

Shades of grey — the blurring view of innate and adaptive immunity

Lanier, L. L. (2013) · Nature reviews. Immunology · doi:10.1038/nri3389 · Cited by 103 · see citing works

Decreased natural killer cell activity is associated with atherosclerosis in elderly humans

Brüünsgaard, H. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00162-0 · Cited by 100 · see citing works

Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction

Yu, H. T., Youn, J., Lee, J., Park, S., Chi, H.-S., Lee, J., Choi, C., Park, S., Choi, D., Ha, J., et al. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.74 · Cited by 98 · see citing works

CMV Latent Infection Improves CD8+ T Response to SEB Due to Expansion of Polyfunctional CD57+ Cells in Young Individuals

Pera, A., Campos, C., Corona, A., Sánchez-Correa, B., Tarazona, R., Larbi, A., & Solana, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088538 · Cited by 90 · see citing works

Predictors of Long-term Mortality After Severe Sepsis in the Elderly

Lemay, A., Anzueto, A., Restrepo, M. I., & Mortensen, E. M. (2013) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318295a147 · Cited by 74 · see citing works

Vaccination of adults 65 years of age and older with tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Boostrix®): Results of two randomized trials

Weston, W. M., Friedland, L. R., Wu, X., & Howe, B. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.12.055 · Cited by 62 · see citing works

Association of anticytomegalovirus seropositivity with more severe joint destruction and more frequent joint surgery in rheumatoid arthritis

Pierer, M., Rothe, K., Quandt, D., Schulz, A., Rossol, M., Scholz, R., Baerwald, C., & Wagner, U. G. (2011) · Arthritis & Rheumatism · doi:10.1002/art.34346 · Cited by 62 · see citing works

Expansion of peripheral CD8+ T cells in patients with coronary artery disease: relation to cytomegalovirus infection

Jonasson, L., Tompa, A., & Wikby, A. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01217.x · Cited by 50 · see citing works

A Novel Cytomegalovirus-Induced Regulatory-Type T-Cell Subset Increases in Size During Older Life and Links Virus-Specific Immunity to Vascular Pathology

Terrazzini, N., Bajwa, M., Vita, S., Cheek, E., Thomas, D. W., Seddiki, N., Smith, H. E., & Kern, F. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit576 · Cited by 45 · see citing works

Cytomegalovirus Infection Accelerates Inflammation in Vascular Tissue Overexpressing Monocyte Chemoattractant Protein-1

Froberg, M. K., Adams, A., Seacotte, N., Parker‐Thornburg, J., & Kolattukudy, P. E. (2001) · Circulation Research · doi:10.1161/hh2401.100601 · Cited by 42 · see citing works

T-cell immunity in the aging human

Pawelec, G. (2014) · Haematologica · doi:10.3324/haematol.2013.094383 · Cited by 36 · see citing works

Epidemiología y pronóstico tardío de la sepsis en ancianos

Carbajal-Guerrero, J., Cayuela, A., Fernández-García, E., Aldabó-Pallás, T., Márquez-Vácaro, J. A., Ortíz-Leyba, C., & Garnacho‐Montero, J. (2013) · Medicina Intensiva · doi:10.1016/j.medin.2012.12.006 · Cited by 33 · see citing works

Alterations of T cell activation signalling and cytokine production by postmenopausal estrogen levels

Ku, L. T., Gerçel-Taylor, Ç., Nakajima, S. T., & Taylor, D. D. (2009) · Immunity & Ageing · doi:10.1186/1742-4933-6-1 · Cited by 33 · see citing works

Menopause and Aging

Løbo, R. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00014-7 · Cited by 32 · see citing works

Impact of Cytomegalovirus on Early Immunosenescence of CD8+ T Lymphocytes After Solid Organ Transplantation

Cantisán, S., Torre‐Cisneros, J., Lara, R., Zárraga, S., Montejo, M., & Solana, R. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls130 · Cited by 27 · see citing works

New Concepts on the Pathogenesis of Autoimmune Diseases: A Role for Immune Homeostasis, Immunoregulation, and Immunosenescence

Thewissen, M. M., & Stinissen, P. (2008) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v28.i5.10 · Cited by 25 · see citing works

The role of T cells in the pathogenesis of primary hypertension

Quiroz, Y., Johnson, R. J., & Rodríguez‐Iturbe, B. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs421 · Cited by 25 · see citing works

Invited Commentary: Human Cytomegalovirus, Inflammation, Cardiovascular Disease, and Mortality

Crumpacker, C. S. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq174 · Cited by 18 · see citing works

Bioavailable estradiol in man: Relationship with age and testosterone

Dolomie-Fagour, L., Gatta‐Cherifi, B., Nguyen, T. D. T., & Corcuff, J. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.09.005 · Cited by 16 · see citing works

Gender differences and age-specific associations between body mass index and other cardiovascular risk factors in CMV infected and uninfected people

Terrazzini, N., Bajwa, M., Thomas, D. W., Smith, H. E., & Kern, F. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.09.011 · Cited by 15 · see citing works

Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study

Zheng, S., Fan, J., Yu, F., Feng, B., Lou, B., Zou, Q., Xie, G., Lin, S., Wang, R., Yang, X., et al. (2020) · BMJ · doi:10.1136/bmj.m1443 · Cited by 1,439 · see citing works

Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake

Wallace, T. C., Bailey, R. L., Blumberg, J. B., Burton-Freeman, B., Chen, C.-Y. O., Crowe-White, K. M., Drewnowski, A., Hooshmand, S., Johnson, E., Lewis, R., et al. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1632258 · Cited by 638 · see citing works

Immunosenescence and human vaccine immune responses

Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0164-9 · Cited by 530 · see citing works

Nutrition, immunity and COVID-19

Calder, P. C. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 587 · see citing works

Age-dependent Immune Response to the Biontech/Pfizer BNT162b2 Coronavirus Disease 2019 Vaccination

Müller, L., Andrée, M., Moskorz, W., Drexler, I., Walotka, L., Grothmann, R., Ptok, J., Hillebrandt, J., Ritchie, A., Rabl, D., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab381 · Cited by 511 · see citing works

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 498 · see citing works

Immunology of aging: the birth of inflammaging

Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08899-6 · Cited by 464 · see citing works

Vaccination in the elderly: The challenge of immune changes with aging

Ciabattini, A., Nardini, C., Santoro, F., Garagnani, P., Franceschi, C., & Medaglini, D. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.10.010 · Cited by 411 · see citing works

The integration of inflammaging in age-related diseases

Fülöp, T., Witkowski, J. M., Olivieri, F., & Larbi, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.003 · Cited by 356 · see citing works

Molecular and biological hallmarks of ageing

Aunan, J. R., Watson, M. M., Hagland, H. R., & Søreide, K. (2016) · British journal of surgery · doi:10.1002/bjs.10053 · Cited by 322 · see citing works

Human T cell immunosenescence and inflammation in aging

Bektas, A., Schurman, S. H., Sen, R., & Ferrucci, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0716-335r · Cited by 270 · see citing works

Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation

Rasmussen, L. J. H., Petersen, J. E. V., & Eugen‐Olsen, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.780641 · Cited by 256 · see citing works

Skin Cancer Epidemics in the Elderly as An Emerging Issue in Geriatric Oncology

Garcovich, S., Colloca, G. A., Sollena, P., Bellieni, A., Balducci, L., Cho, W. C. S., Bernabei, R., & Peris, K. (2017) · Aging and Disease · doi:10.14336/ad.2017.0503 · Cited by 252 · see citing works

Microbiota Modulation of the Gut-Lung Axis in COVID-19

de Oliveira, G. L. V., Oliveira, C. N. S., Pinzan, C. F., de Salis, L. V. V., & Cardoso, C. R. D. B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635471 · Cited by 238 · see citing works

Immunosenescence Study of T Cells: A Systematic Review

Rodríguez, I. J., Lalinde-Ruiz, N., León, M. L., Martínez-Enriquez, L. C., Velásquez, M. D. P. M., Aguirre, J. P. O., Bohórquez, O. M. R., Vargas, E. A. V., Hernández-Álvarez, E. D., & Parra-López, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604591 · Cited by 224 · see citing works

Immune senescence, epigenetics and autoimmunity

Ray, D., & Yung, R. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.04.002 · Cited by 219 · see citing works

Vaccination of special populations: Protecting the vulnerable

Doherty, M., Schmidt-Ott, R., Santos, J. I., Stanberry, L. R., Hofstetter, A. M., Rosenthal, S. L., & Cunningham, A. L. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.11.015 · Cited by 208 · see citing works

Immune checkpoint inhibitors and elderly people: A review

Daste, A., Domblides, C., Gross‐Goupil, M., Chakiba, C., Quivy, A., Cochin, V., de Monès, E., Larmonier, N., Soubeyran, P., & Ravaud, A. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.05.044 · Cited by 189 · see citing works

Sepsis and Immunosenescence in the Elderly Patient: A Review

Martín, S., Pérez, A. I. B., & Aldecoa, C. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00020 · Cited by 182 · see citing works

T cells, aging and senescence

Pangrazzi, L., & Weinberger, B. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110887 · Cited by 180 · see citing works

Viral Infections, the Microbiome, and Probiotics

Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists

Metcalf, T. U., Wilkinson, P. A., Cameron, M. J., Ghneim, K., Chiang, C., Wertheimer, A. M., Hiscott, J. B., Nikolich-Zugich, J., & Haddad, E. K. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700148 · Cited by 166 · see citing works

The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence

Bauer, M. E., & la Fuente, M. D. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.01.001 · Cited by 164 · see citing works

Understanding immunosenescence and its impact on vaccination of older adults

Allen, J. C., Toapanta, F. R., Chen, W. H., & Tennant, S. M. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.11.002 · Cited by 157 · see citing works

Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial

Gonçalves-Mendes, N., Talvas, J., Dualé, C., Guttmann, A., Corbin, V., Marceau, G., Sapin, V., Brachet, P., Evrard, B., Laurichesse, H., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00065 · Cited by 142 · see citing works

Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses

Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110632 · Cited by 143 · see citing works

Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients’ treatment

Lelarge, V., Capelle, R., Oger, F., Mathieu, T., & Calvé, B. L. (2024) · npj Aging · doi:10.1038/s41514-024-00138-4 · Cited by 147 · see citing works

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota

Calder, P. C., Ortega, E. F., Meydani, S. N., Adkins, Y. C., Stephensen, C. B., Thompson, B., & Zwickey, H. L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac052 · Cited by 136 · see citing works

Torque Teno Virus Load—Inverse Association With Antibody-Mediated Rejection After Kidney Transplantation

Schiemann, M., Puchhammer‐Stöckl, E., Eskandary, F. A., Kohlbeck, P., Rasoul‐Rockenschaub, S., Heilos, A., Kozakowski, N., Görzer, I., Kikić, Ž., Herkner, H., et al. (2016) · Transplantation · doi:10.1097/tp.0000000000001455 · Cited by 120 · see citing works

A respiratory syncytial virus (RSV) F protein nanoparticle vaccine focuses antibody responses to a conserved neutralization domain

Swanson, K. A., Rainho-Tomko, J. N., Williams, Z. P., Lanza, L., Peredelchuk, M., Kishko, M., Pavot, V., Alamares-Sapuay, J. G., Adhikarla, H., Gupta, S., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba6466 · Cited by 115 · see citing works

Nutrition and immunity: lessons for COVID-19

Calder, P. C. (2021) · Nutrition and Diabetes · doi:10.1038/s41387-021-00165-0 · Cited by 113 · see citing works

Age-associated alterations in immune function and inflammation

Lewis, E. D., Wu, D., & Meydani, S. N. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110576 · Cited by 111 · see citing works

Age-related differences in humoral and cellular immune responses after primary immunisation: indications for stratified vaccination schedules

Wagner, A., Garner‐Spitzer, E., Jasińska, J., Kollaritsch, H., Stiasny, K., Kundi, M., & Wiedermann, U. (2018) · Scientific Reports · doi:10.1038/s41598-018-28111-8 · Cited by 110 · see citing works

Immunosenescence is both functional/adaptive and dysfunctional/maladaptive

Fülöp, T., Larbi, A., Hirokawa, K., Cohen, A. A., & Witkowski, J. M. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00818-9 · Cited by 106 · see citing works

Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19

Virgiliis, F. D., & Giovanni, S. D. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0402-y · Cited by 104 · see citing works

Age and gender leucocytes variances and references values generated using the standardized ONE‐Study protocol

Kverneland, A. H., Streitz, M., Geissler, E., Hutchinson, J., Vogt, K., Boës, D., Niemann, N., Pedersen, A. E., Schlickeiser, S., & Sawitzki, B. (2016) · Cytometry Part A · doi:10.1002/cyto.a.22855 · Cited by 99 · see citing works

Immunosenescence in multiple sclerosis: the identification of new therapeutic targets

Dema, M. G., Eixarch, H., Villar, L. M., Montalbán, X., & Espejo, C. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102893 · Cited by 101 · see citing works

Hematopoietic stem cell transplantation and cellular therapies for autoimmune diseases: overview and future considerations from the Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Alexander, T., & Greco, R. (2022) · Bone Marrow Transplantation · doi:10.1038/s41409-022-01702-w · Cited by 97 · see citing works

Efficacy of BCG Vaccination Against Respiratory Tract Infections in Older Adults During the Coronavirus Disease 2019 Pandemic

Moorlag, S. J. C. F. M., Taks, E., ten Doesschate, T., van der Vaart, T. W., Janssen, A. B., Müller, L., Ostermann, P. N., Dijkstra, H., Lemmers, H., Simonetti, E. R., et al. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac182 · Cited by 95 · see citing works

Nutrition and immunity: lessons for COVID-19

Calder, P. C. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00949-8 · Cited by 93 · see citing works

Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine

Vega, C. A., Tawfik, D. M., Trouillet‐Assant, S., Vachot, L., Mallet, F., & Textoris, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02367 · Cited by 94 · see citing works

Fostering healthy aging: The interdependency of infections, immunity and frailty

Vetrano, D. L., Triolo, F., Maggi, S., Malley, R., Jackson, T., Poscia, A., Bernabei, R., Ferrucci, L., & Fratiglioni, L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101351 · Cited by 95 · see citing works

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Walters, H. E., & Cox, L. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082325 · Cited by 85 · see citing works

Respiratory Syncytial Virus Infection in Older Adults: An Update

Alfano, F., Bigoni, T., Caggiano, F. P., & Papi, A. A. (2024) · Drugs & Aging · doi:10.1007/s40266-024-01118-9 · Cited by 85 · see citing works

Diabetes, cardiac disorders and asthma as risk factors for severe organ involvement among adult dengue patients: A matched case-control study

Pang, J., Hsu, J. P., Yeo, T. W., Leo, Y., & Lye, D. C. (2017) · Scientific Reports · doi:10.1038/srep39872 · Cited by 85 · see citing works

Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains

Nuñez, I. A., Carlock, M. A., Allen, J. D., Owino, S. O., Geffel, K. M., Nowalk, M. P., Susick, M., Diagle, K., Sweeney, K., Mundle, S. T., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185666 · Cited by 85 · see citing works

Challenges in adult vaccination

de Gomensoro, E., Giudice, G. D., & Doherty, T. M. (2018) · Annals of Medicine · doi:10.1080/07853890.2017.1417632 · Cited by 85 · see citing works

Immunologic mechanisms of fingolimod and the role of immunosenescence in the risk of cryptococcal infection: A case report and review of literature

Grebenciucova, E., Reder, A. T., & Bernard, J. T. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2016.07.015 · Cited by 81 · see citing works

Development and deployment of COVID-19 vaccines for those most vulnerable

Koff, W. C., Schenkelberg, T., Williams, T. M., Baric, R. S., McDermott, A. B., Cameron, C., Cameron, M. J., Frieman, M. B., Neumann, G., Kawaoka, Y., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd1525 · Cited by 78 · see citing works

Immune responses to influenza virus and its correlation to age and inherited factors

Bahadoran, A., Lee, S. H., Wang, S. M., Manikam, R., Rajarajeswaran, J., Raju, C. S., & Sekaran, S. D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01841 · Cited by 79 · see citing works

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Müller, L., & Benedetto, S. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020753 · Cited by 82 · see citing works

Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging

Brosh, R. M., Bellani, M. A., Liu, Y., & Seidman, M. M. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.005 · Cited by 81 · see citing works

Human Cytomegalovirus (HCMV)-Specific CD4 + T Cells Are Polyfunctional and Can Respond to HCMV-Infected Dendritic Cells In Vitro

Jackson, S. E., Sedikides, G. X., Mason, G. M., Okecha, G., & Wills, M. R. (2017) · Journal of Virology · doi:10.1128/jvi.02128-16 · Cited by 77 · see citing works

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection

Merani, S., Pawelec, G., Kuchel, G. A., & McElhaney, J. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00784 · Cited by 74 · see citing works

The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey

Noale, M., Trevisan, C., Maggi, S., Incalzi, R. A., Pedone, C., Bari, M. D., Adorni, F., Jesuthasan, N., Šojić, A., Galli, M., et al. (2020) · Vaccines · doi:10.3390/vaccines8030471 · Cited by 73 · see citing works

Immunosenescence: the Role of Aging in the Predisposition to Neuro-Infectious Complications Arising from the Treatment of Multiple Sclerosis

Grebenciucova, E., & Berger, J. R. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0771-9 · Cited by 71 · see citing works

Aging Fits the Disease Criteria of the International Classification of Diseases

Khaltourina, D. A., Matveyev, Y., Alekseev, A., Cortese, F., & Ioviţă, A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111230 · Cited by 71 · see citing works

Cellular senescence in lymphoid organs and immunosenescence

Budamagunta, V., Foster, T. C., & Zhou, D. (2021) · Aging · doi:10.18632/aging.203405 · Cited by 68 · see citing works

Targeting aging and age-related diseases with vaccines

Wu, R., Sun, F., Zhang, W., Ren, J., & Liu, G.-H. (2024) · Nature Aging · doi:10.1038/s43587-024-00597-0 · Cited by 66 · see citing works

COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study

Jurado, A., Martín, M. C., Abad‐Molina, C., Orduña, A., Martínez, A., Ocaña, E., Yarce, O., Navas, A. M., Trujillo-Aguilera, A., Fernández, L., et al. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00194-w · Cited by 64 · see citing works

Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis

He, W., Xiao, K., Fang, M., & Xie, L. (2021) · Aging and Disease · doi:10.14336/ad.2020.0627 · Cited by 65 · see citing works

Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide‐positive nerve fibres

Pilkington, S. M., Barron, M. J., Watson, R. E. B., Griffiths, C. E. M., & Bulfone‐Paus, S. (2018) · British Journal of Dermatology · doi:10.1111/bjd.17268 · Cited by 61 · see citing works

Ingestion, Immunity, and Infection: Nutrition and Viral Respiratory Tract Infections

Govers, C., Calder, P. C., Savelkoul, H. F. J., Albers, R., & van Neerven, R. J. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.841532 · Cited by 66 · see citing works

Aspirin Use and Risk of Hepatocellular Carcinoma in a National Cohort Study of Korean Adults

Hwang, I. C., Chang, J., Kim, K., & Park, S. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-23343-0 · Cited by 60 · see citing works

Increased T cell immunosenescence and accelerated maturation phenotypes in older kidney transplant recipients

Schaenman, J. M. D., Rossetti, M. M., Sidwell, T., Groysberg, V. M., Sunga, G. M., Korin, Y. D., Liang, E. C., Zhou, X., Abdalla, B. A., Lum, E. L., et al. (2018) · Human Immunology · doi:10.1016/j.humimm.2018.06.006 · Cited by 60 · see citing works

‘RA and the microbiome: do host genetic factors provide the link?

Wells, P. M., Williams, F. M. K., Matey-Hernandez, M. L., Menni, C., & Steves, C. J. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.02.004 · Cited by 59 · see citing works

Oxidative-Inflammatory Stress in Immune Cells from Adult Mice with Premature Aging

Garrido, A., Cruces, J., Ceprián, N., Vara, E., & la Fuente, M. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030769 · Cited by 58 · see citing works

Clinical perspectives on the age-related increase of immunosuppressive activity

Salminen, A. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02193-4 · Cited by 57 · see citing works

CNS Ageing in Health and Neurodegenerative Disorders

Kesidou, E., Theotokis, P., Damianidou, O., Boziki, M. K., Konstantinidou, N., Taloumtzis, C., Sintila, S.-A., Grigoriadis, P., Evangelopoulos, M., Bakirtzis, C., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062255 · Cited by 57 · see citing works

Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

Rénia, L., Goh, Y. S., Rouers, A., Bert, N. L., Chia, W. N., Chavatte, J., Fong, S., Chang, Z. W., Zhuo, N. Z., Tay, M. Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32312-1 · Cited by 58 · see citing works

Spices, Condiments, Extra Virgin Olive Oil and Aromas as Not Only Flavorings, but Precious Allies for Our Wellbeing

Dini, I., & Laneri, S. (2021) · Antioxidants · doi:10.3390/antiox10060868 · Cited by 56 · see citing works

Innate Antiviral Immunity in the Skin

Handfield, C., Kwock, J. T., & MacLeod, A. S. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.02.003 · Cited by 53 · see citing works

Adverse events following mRNA SARS-CoV-2 vaccination among U.S. nursing home residents

Bardenheier, B. H., Gravenstein, S., Blackman, C., Gutman, R., Sarkar, I. N., Feifer, R. A., White, E. M., McConeghy, K. W., Nanda, A., & Mor, V. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.05.088 · Cited by 53 · see citing works

Intracellular signalling pathways: targets to reverse immunosenescence

Fülöp, T., Witkowski, J. M., Page, A. Y. L., Fortin, C. F., Pawelec, G., & Larbi, A. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12836 · Cited by 53 · see citing works

Lower levels of interleukin‐1β gene expression are associated with impaired Langerhans’ cell migration in aged human skin

Pilkington, S. M., Ogden, S., Eaton, L. H., Dearman, R. J., Kimber, I., & Griffiths, C. E. M. (2017) · Immunology · doi:10.1111/imm.12810 · Cited by 53 · see citing works

Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions

Duggal, N. A. (2018) · Biogerontology · doi:10.1007/s10522-018-9771-7 · Cited by 53 · see citing works

Exploring salivary diagnostics in COVID-19: a scoping review and research suggestions

Kapoor, P., Chowdhry, A., Kharbanda, O. P., Popli, D. B., Gautam, K., & Saini, V. (2021) · BDJ Open · doi:10.1038/s41405-021-00064-7 · Cited by 52 · see citing works

Reduced Numbers and Impaired Function of Regulatory T Cells in Peripheral Blood of Ischemic Stroke Patients

Ruhnau, J., Schulze, J., von Sarnowski, B., Heinrich, M., Langner, S., Pötschke, C., Wilden, A., Kessler, C., Bröker, B. M., Vogelgesang, A., et al. (2016) · Mediators of Inflammation · doi:10.1155/2016/2974605 · Cited by 52 · see citing works

Spirituality and Religious Practices and Its Association with Geriatric Syndromes in Older Adults Attending to a Geriatric’s Clinic in a University Hospital

Avelar-González, A. K., Bureau-Chávez, M., Durón-Reyes, D. E., Mondragón-Cervantes, M. I., Jiménez-Acosta, Y. D. C., Leal-Mora, D., & Díaz-Ramos, J. A. (2020) · Journal of religion and health · doi:10.1007/s10943-020-00990-0 · Cited by 10 · see citing works

A Review of Nutritional Requirements of Adults Aged ≥65 Years in the UK

Dorrington, N., Fallaize, R., Hobbs, D. A., Weech, M., & Lovegrove, J. A. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa153 · Cited by 48 · see citing works

Measuring the immune system: a comprehensive approach for the analysis of immune functions in humans

Claus, M., Dychus, N., Ebel, M., Damaschke, J., Maydych, V., Wolf, O. T., Kleinsorge, T., & Watzl, C. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1809-5 · Cited by 46 · see citing works

Impact of influenza, herpes zoster, and pneumococcal vaccinations on the incidence of cardiovascular events in subjects aged over 65 years: a systematic review

Addario, A., Célarier, T., Bongué, B., Barth, N., Gavazzi, G., & Botelho-Nevers, É. (2023) · GeroScience · doi:10.1007/s11357-023-00807-4 · Cited by 48 · see citing works

Immunogenicity and Safety Following 1 Dose of AS01E-Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults: A Phase 3 Trial

Schwarz, T. F., Hwang, S.-J., Ylisastigui, P. P., Liu, C.-S., Takazawa, K., Yono, M., Ervin, J. E., Andrews, C. P., Fogarty, C. M., Eckermann, T., et al. (2023) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiad546 · Cited by 42 · see citing works

Effect of CMV and Aging on the Differential Expression of CD300a, CD161, T-bet, and Eomes on NK Cell Subsets

López-Sejas, N., Campos, C., Hassouneh, F., Sánchez-Correa, B., Tarazona, R., Pera, A., & Solana, R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00476 · Cited by 42 · see citing works

Divide, Conquer, and Sense: CD8+CD28− T Cells in Perspective

Arosa, F. A., Esgalhado, A. J., Padrão, C. A., & Cardoso, E. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00665 · Cited by 42 · see citing works

Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults

van den Berg, S. P. H., Wong, A., Hendriks, M., Jacobi, R. H. J., van Baarle, D., & van Beek, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00082 · Cited by 40 · see citing works

Influenza Vaccine-Induced Antibody Responses Are Not Impaired by Frailty in the Community-Dwelling Elderly With Natural Influenza Exposure

Narang, V., Lu, Y., Tan, C. T., Camous, X., Nyunt, M. S. Z., Carré, C., Mok, E. W. H., Wong, G. C. L., Maurer‐Stroh, S., Abel, B., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02465 · Cited by 39 · see citing works

Safety and immunogenicity of non-typeable Haemophilus influenzae-Moraxella catarrhalis vaccine

Damme, P. V., Leroux-Roels, G. G., Vandermeulen, C., Ryck, I. D., Tasciotti, A., Dozot, M., Moraschini, L., Testa, M., & Arora, A. K. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.04.041 · Cited by 39 · see citing works

Inosine pranobex is safe and effective for the treatment of subjects with confirmed acute respiratory viral infections: analysis and subgroup analysis from a Phase 4, randomised, placebo-controlled, double-blind study

on behalf of the Isoprinosine Study (EWO ISO-2014/1) Team, Beran, J., Šalapová, E., & Špajdel, M. (2016) · BMC Infectious Diseases · doi:10.1186/s12879-016-1965-5 · Cited by 38 · see citing works

Interventions to restore appropriate immune function in the elderly

Aspinall, R., & Lang, P. O. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0111-6 · Cited by 38 · see citing works

Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing: A comparison between elderly and young adult women

van Splunter, M. E., Perdijk, O., Fick-Brinkhof, H., Vollenbroek, E. G. M., Meijer, B., Brugman, S., Savelkoul, H. F. J., van Hoffen, E., & van Neerven, R. J. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225825 · Cited by 37 · see citing works

Cellular Senescence, Immunosenescence and HIV

Fülöp, T., Herbein, G., Cossarizza, A., Witkowski, J. M., Frost, E. H., Dupuis, G., Pawelec, G., & Larbi, A. (2016) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000448542 · Cited by 36 · see citing works

Stress and immunological aging

Reed, R. G. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.012 · Cited by 36 · see citing works

The Frailty Risk Score predicts length of stay and need for rehospitalization after kidney transplantation in a retrospective cohort: a pilot study

Schaenman, J. M. D., Castellon, L., Liang, E. C., Nanayakkara, D. D., Abdalla, B. A., Sarkisian, C. A., & Goldwater, D. S. (2019) · Pilot and Feasibility Studies · doi:10.1186/s40814-019-0534-2 · Cited by 36 · see citing works

Optimising COVID-19 vaccine efficacy by ensuring nutritional adequacy

Rayman, M. P., & Calder, P. C. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521000386 · Cited by 36 · see citing works

The interaction between intestinal microenvironment and stroke

Zhao, L., Xiao, J., Li, S., Guo, Y., Fu, R., Hua, S., Du, Y., & Xu, S. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14275 · Cited by 35 · see citing works

Contribution of viral and bacterial infections to senescence and immunosenescence

Reyes, A., Ortiz, G., Duarte, L. F., Fernández, C., Hernández‐Armengol, R., Palacios, P. A., Prado, Y., Andrade, C. A., Rodríguez‐Guilarte, L., Kalergis, A. M., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1229098 · Cited by 36 · see citing works

Effects of a 6 Week Low-Dose Combined Resistance and Endurance Training on T Cells and Systemic Inflammation in the Elderly

Despeghel, M., Reichel, T., Zander, J., Krüger, K., & Weyh, C. (2021) · Cells · doi:10.3390/cells10040843 · Cited by 35 · see citing works

How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells

Aiello, A., Ligotti, M. E., Garnica, M., Accardi, G., Calabrò, A., Pojero, F., Arasanz, H., Bocanegra, A., Blanco, E., Chocarro, L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179880 · Cited by 36 · see citing works

VPM1002 as Prophylaxis Against Severe Respiratory Tract Infections Including Coronavirus Disease 2019 in the Elderly: A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study

Blossey, A. M., Brückner, S., May, M., Parzmair, G. P., Sharma, H., Shaligram, U. S., Grode, L., Kaufmann, S. H. E., Netea, M. G., & Schindler, C. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac881 · Cited by 35 · see citing works

Immunosenescence and vaccine failure in the elderly

Grubeck-Loebenstein, B., Della Bella, S., Iorio, A. M., Michel, J.-P., Pawelec, G., & Solana, R. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03324904 · Cited by 269 · see citing works

Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity

Oh, S. J., Lee, J. K., & Shin, O. S. (2019) · Immune Network · doi:10.4110/in.2019.19.e37 · Cited by 261 · see citing works

Immunosenescence

Torres, K. C. D. L., Pereira, P. M., Lima, G. D. S. F., de Souza, B. H., de Miranda, D. M., Bauer, M. E., & Romano‐Silva, M. A. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Age-related decline in immunity: implications for vaccine responsiveness

Kumar, R., & Burns, E. A. (2008) · Expert Review of Vaccines · doi:10.1586/14760584.7.4.467 · Cited by 156 · see citing works

Immunosenescence and age-related viral diseases

Ma, Y. C., & Fang, M. (2013) · Science China Life Sciences · doi:10.1007/s11427-013-4478-0 · Cited by 31 · see citing works