Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238

mouse brain in stereotaxic coordinates

Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 2,007

Role of β-hydroxybutyric acid in the central regulation of energy balance

Laeger, T., Metges, C. C., & Kuhla, B. (2010) · Appetite · doi:10.1016/j.appet.2010.04.005 · Cited by 123

The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis

Tsatsanis, C., Dermitzaki, E., Avgoustinaki, P. D., Malliaraki, N. E., Mytaras, V., & Margioris, A. N. (2015) · HORMONES · doi:10.14310/horm.2002.1649 · Cited by 122

Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions

Barbe, A., Bongrani, A., Mellouk, N., Estienne, A., Kurowska, P., Grandhaye, J., Elfassy, Y., Lévy, R., Rak, A., Froment, P., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071526 · Cited by 126

Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

Sanches, J. M., Zhao, L. N., Salehi, A. A., Wollheim, C. B., & Kaldis, P. (2021) · FEBS Journal · doi:10.1111/febs.16306 · Cited by 136

Adiponectin Inhibits Lipolysis in Mouse Adipocytes

Qiao, L., Kinney, B., Schaack, J. B., & Shao, J. (2011) · Diabetes · doi:10.2337/db10-1017 · Cited by 117

AMP activated protein kinase: a next generation target for total metabolic control

Misra, P. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.1.91 · Cited by 117

Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis

Goldsammler, M., Merhi, Z. O., & Büyük, E. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0366-6 · Cited by 124

Hypothalamic AMPK and energy balance

López, M. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12996 · Cited by 117

Central Resistin Regulates Hypothalamic and Peripheral Lipid Metabolism in a Nutritional-Dependent Fashion

Vazquez, M. J., González, C. R., Varela, L., Lage, R., Tovar, S. A., Sangiao‐Alvarellos, S., Williams, L. M., Vidal‐Puig, A., Nogueiras, R., López, M., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1708 · Cited by 118

Breast milk leptin and adiponectin in relation to infant body composition up to 2 years

Brunner, S., Schmid, D., Zang, K., Much, D., Knoeferl, B., Kratzsch, J., Amann‐Gassner, U., Bader, B., & Hauner, H. (2014) · Pediatric Obesity · doi:10.1111/j.2047-6310.2014.222.x · Cited by 115

Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors

Zhang, D., Wang, X., Wang, B., Garza, J., Fang, X., Wang, J., Scherer, P. E., Brenner, R., Zhang, W., & Lu, X.-Y. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.58 · Cited by 115

AMP‐ACTIVATED PROTEIN KINASE ACTIVATION AS A STRATEGY FOR PROTECTING VASCULAR ENDOTHELIAL FUNCTION

Zou, M., & Wu, Y. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04851.x · Cited by 116

Microbiota, metabolome, and immune alterations in obese mice fed a high‐fat diet containing type 2 resistant starch

Barouei, J., Bendiks, Z., Martinic, A., Mishchuk, D. O., Heeney, D. D., Hsieh, Y., Kieffer, D. A., Zaragoza, J., Martin, R. J., Slupsky, C. M., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700184 · Cited by 112

Peroxisome Proliferator-Activated Receptor-γ-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status

Festuccia, W. T., Öztezcan, S., Laplante, M., Berthiaume, M., Michel, C., Dohgu, S., Denis, R., Brito, M. N., Brito, N. A., Miller, D. S., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1553 · Cited by 111

Convergence between biological, behavioural and genetic determinants of obesity

Ghosh, S., & Bouchard, C. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.72 · Cited by 110

Role of AMP‐Activated Protein Kinase in the Control of Appetite

Kola, B. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01745.x · Cited by 117

Adiponectin protects against cerebral ischemia–reperfusion injury through anti-inflammatory action

Chen, B., Liao, W., Xu, N., Xu, H., Wen, J.-Y., Yu, C., Liu, X., Li, C., Zhao, S., & Campbell, W. D. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.002 · Cited by 111

When do we eat? Ingestive behavior, survival, and reproductive success

Schneider, J. E., Wise, J. D., Benton, N. A., Brozek, J. M., & Keen‐Rhinehart, E. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.07.005 · Cited by 109

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

Galić, S., Loh, K., Murray‐Segal, L., Steinberg, G. R., Andrews, Z. B., & Kemp, B. E. (2018) · eLife · doi:10.7554/elife.32656 · Cited by 112

Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner

Zhang, S., Wu, X., Wang, J., Shi, Y., Hu, Q., Cui, W., Bai, H., Zhou, J., Du, Y., Han, L., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102390 · Cited by 113

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen, X., Jia, X., Qiao, J., Guan, Y., & Kang, J. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0247 · Cited by 112

Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production

Teng, R., Gavrilova, O., Suzuki, N., Chanturiya, T., Schimel, D. M., Hugendubler, L., Mammen, S., Yver, D. R., Cushman, S. W., Mueller, E., et al. (2011) · Nature Communications · doi:10.1038/ncomms1526 · Cited by 106

Antidiabetic Potentials of Momordica charantia : Multiple Mechanisms Behind the Effects

Chaturvedi, P. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0258 · Cited by 106

Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose

Liu, Z., Gan, L., Wu, T., Feng, F., Luo, D., Gu, H., Liu, S., & Sun, C. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.388 · Cited by 106

Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond

Lu, J., Huang, K., Chang, L., Huang, Y.-S., Chi, Y., Su, T.-C., Chen, C., & Yang, W. (2008) · Journal of Biomedical Science · doi:10.1007/s11373-008-9261-z · Cited by 104

Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome

de Medeiros, S. F., Rodgers, R. J., & Norman, R. J. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab004 · Cited by 107

Effects of acute sleep loss on leptin, ghrelin, and adiponectin in adults with healthy weight and obesity: A laboratory study

van Egmond, L. T., Meth, E. M. S., Engström, J., Ilemosoglou, M., Keller, J. A., Vogel, H., & Benedict, C. (2023) · Obesity · doi:10.1002/oby.23616 · Cited by 106

Adipose Tissue Hormones and the Regulation of Food Intake

Henry, B. A., & Clarke, I. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.1730.x · Cited by 103

Hypothalamus and thermogenesis: Heating the BAT, browning the WAT

Contreras, C., Nogueiras, R., Diéguez, C., Medina‐Gómez, G., & López, M. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.002 · Cited by 104

AMPK and the Endocrine Control of Metabolism

Townsend, L. K., & Steinberg, G. R. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad012 · Cited by 114

Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

Contreras, C., Nogueiras, R., Diéguez, C., Rahmouni, K., & López, M. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.019 · Cited by 104

The Novel Perspectives of Adipokines on Brain Health

Lee, T. H.-Y., Cheng, K. K. Y., Hoo, R. L. C., Siu, P. M., & Yau, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225638 · Cited by 100

Interactions between adipose tissue and the immune system in health and malnutrition

Wensveen, F. M., Marinović, S., Šestan, M., Wensveen, T. T., & Polić, B. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.006 · Cited by 103

Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior

Chabry, J., Nicolas, S., Cazareth, J., Murris, E., Guyon, A., Glaichenhaus, N., Heurteaux, C., & Petit-Paitel, A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.018 · Cited by 101

Body Weight, Insulin Resistance, and Serum Adipokine Levels 2 Years after 2 Types of Bariatric Surgery

Trakhtenbroit, M. A., Leichman, J. G., Algahim, M. F., Miller, C. C., Moody, F. G., Lux, T. R., & Taegtmeyer, H. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.10.035 · Cited by 97

Role of hypothalamic AMP-kinase in food intake regulation

Minokoshi, Y., Shiuchi, T., Lee, S. P., Suzuki, A., & Okamoto, S. (2008) · Nutrition · doi:10.1016/j.nut.2008.06.002 · Cited by 98

Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice

Zhang, D., Wang, X., & Lu, X. (2016) · Endocrinology · doi:10.1210/en.2015-2078 · Cited by 98

Circadian blueprint of metabolic pathways in the brain

Greco, C. M., & Sassone‐Corsi, P. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0096-y · Cited by 94

Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance

de Morentin, P. B. M., González, C. R., Saha, A. K., Martins, L., Diéguez, C., Vidal‐Puig, A., Tena‐Sempere, M., & López, M. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9165-5 · Cited by 96

Ghrelin and lipid metabolism: key partners in energy balance

Varela, L., Vazquez, M. J., Cordido, F., Nogueiras, R., Vidal‐Puig, A., Diéguez, C., & López, M. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0068 · Cited by 95

Adiponectin receptor binding proteins – recent advances in elucidating adiponectin signalling pathways

Buechler, C., Wanninger, J., & Neumeier, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.09.035 · Cited by 96

Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients

Arano, T., Nakagawa, H., Tateishi, R., Ikeda, H., Uchino, K., Enooku, K., Goto, E., Masuzaki, R., Asaoka, Y., Kondo, Y., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25861 · Cited by 90

Plasma leptin and adiponectin in COPD exacerbations: Associations with inflammatory biomarkers

Krommidas, G., Κostikas, Κ., Papatheodorou, G., Koutsokera, A., Gourgoulianis, K. I., Roussos, C., Koulouris, N. G., & Loukides, S. (2009) · Respiratory Medicine · doi:10.1016/j.rmed.2009.08.012 · Cited by 90

AMPK‐dependent hormonal regulation of whole‐body energy metabolism

Dzamko, N. L., & Steinberg, G. R. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01969.x · Cited by 90

Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

Yang, S.-H., Li, W., Sumien, N., Forster, M. J., Simpkins, J. W., & Liu, R. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.005 · Cited by 89

Glucocorticoids, stress and eating: The mediating role of appetite‐regulating hormones

Kuckuck, S., van der Valk, E. S., Scheurink, A. J. W., van der Voorn, B., Iyer, A. M., Visser, J. A., Delhanty, P. J. D., van den Berg, S. A. A., & van Rossum, E. F. C. (2022) · Obesity Reviews · doi:10.1111/obr.13539 · Cited by 99

Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications

Wang, Y., Zhou, M., Lam, K. S. L., & Xu, A. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000200012 · Cited by 90

Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance

Arias, M., Ranchal, I., Romero‐Gómez, M., & Crespo, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151223163 · Cited by 87

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

Yang, C. S., Lam, C. K. L., Chari, M., Cheung, G. W. C., Kokorovic, A., Gao, S., Leclerc, I., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes · doi:10.2337/db10-0221 · Cited by 86

Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways

Luna‐Vital, D. A., Luzardo‐Ocampo, I., Cuéllar-Núñez, M. L., Loarca-Piña, G. F., & de Mejía, E. G. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108343 · Cited by 90

Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons

Wen, J., Liu, C., Bi, W., Hu, Y., Chen, Q., Huang, H., Liang, J., Li, L., Lin, L., & Chen, G. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0054 · Cited by 91

Adiponectin and energy homeostasis: consensus and controversy

Dridi, S., & Taouis, M. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.06.003 · Cited by 85

AMPK and the neuroendocrine regulation of appetite and energy expenditure

Stark, R., Ashley, S. E., & Andrews, Z. B. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.012 · Cited by 94

Changes in the gene expression of adiponectin and adiponectin receptors (AdipoR1 and AdipoR2) in ovarian follicular cells of dairy cow at different stages of development

Tabandeh, M. R., Hosseini, A., Saeb, M., Kafi, M., & Saeb, S. (2010) · Theriogenology · doi:10.1016/j.theriogenology.2009.11.006 · Cited by 85

Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass

Swick, A. G., Orena, S., & O’Connor, A. (2013) · Metabolism · doi:10.1016/j.metabol.2013.02.012 · Cited by 84

Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons

Li, C., Meng, F., Garza, J. C., Liu, J., Lei, Y., Kirov, S. A., Guo, M., & Lu, X. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0649-0 · Cited by 83

Impaired Hypothalamic Regulation of Endocrine Function and Delayed Counterregulatory Response to Hypoglycemia in Magel2-Null Mice

Tennese, A. A., & Wevrick, R. (2011) · Endocrinology · doi:10.1210/en.2010-0709 · Cited by 87

Adenosine monophosphate–activated protein kinase in diabetic nephropathy

Kim, Y., & Park, C. W. (2016) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2016.02.004 · Cited by 85

Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease

Ng, R. C.-L., & Chan, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030592 · Cited by 84

Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance

Wang, B., & Cheng, K. K. Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113552 · Cited by 87

Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice

Qiao, L., Yoo, H. S., Bosco, C., Lee, B., Feng, G., Schaack, J. B., Chi, N., & Shao, J. (2014) · Diabetologia · doi:10.1007/s00125-014-3180-5 · Cited by 80

Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study

Schuur, M., Henneman, P., Swieten, J. C. V., Zillikens, M. C., de Koning, I., Janssens, A. C. J. W., Witteman, J. C. M., Aulchenko, Y. S., Frants, R. R., Oostra, B. A., et al. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9476-y · Cited by 83

Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16

Ding, H., Zheng, S., Garcia-Ruiz, D., Hou, D., Wei, Z., Liao, Z., Li, L., Zhang, Y., Han, X., Zen, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms11533 · Cited by 83

Advances on human milk hormones and protection against obesity.

Savino, F., Benetti, S., Liguori, S. A., Sorrenti, M., & di Montezemolo, L. C. (2013) · PubMed · Cited by 83

Genomic and Epigenomic Responses to Chronic Stress Involve miRNA-Mediated Programming

Babenko, O., Golubov, A., Ilnytskyy, Y., Kovalchuk, I., & Metz, G. A. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029441 · Cited by 81

Central Resistin/TLR4 Impairs Adiponectin Signaling, Contributing to Insulin and FGF21 Resistance

Benomar, Y., Amine, H., Crépin, D., Al Rifai, S., Riffault, L., Gertler, A., & Taouis, M. (2016) · Diabetes · doi:10.2337/db15-1029 · Cited by 76

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Mellouk, N., Ramé, C., Barbe, A., Grandhaye, J., Froment, P., & Dupont, J. (2018) · International Journal of Endocrinology · doi:10.1155/2018/4579734 · Cited by 82

Circulating Inflammatory Cytokines and Adipokines Are Associated With Increased Risk of Barrett's Esophagus: A Case–Control Study

Garcia, J. M., Splenser, A. E., Kramer, J. R., Alsarraj, A., Fitzgerald, S. J., Ramsey, D. J., & El‐Serag, H. B. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.038 · Cited by 78

Adiponectin protects rat hippocampal neurons against excitotoxicity

Qiu, G., Wan, R., Hu, J., Mattson, M. P., Spangler, E. L., Liu, S., Yau, S., Lee, T. M. C., Gleichmann, M., Ingram, D. K., et al. (2010) · AGE · doi:10.1007/s11357-010-9173-5 · Cited by 80

Signaling and Communication in Plants

Mugnai, S. (2011) · Frontiers in artificial intelligence and applications · doi:10.3233/978-1-60750-972-1-205 · Cited by 81

Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space

Rosa, S. C. D. S., Liu, M., & Sweeney, G. (2021) · Physiology · doi:10.1152/physiol.00031.2020 · Cited by 80

Loss of Adiponectin Promotes Intestinal Carcinogenesis in Min and Wild-type Mice

Mutoh, M., Teraoka, N., Takasu, S., Takahashi, M., Onuma, K., Yamamoto, M., Kubota, N., Takamoto, I., Kadowaki, T., Sügimura, T., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.019 · Cited by 79

What is “Hyper” in the ALS Hypermetabolism?

Ferri, A., & Coccurello, R. (2017) · Mediators of Inflammation · doi:10.1155/2017/7821672 · Cited by 77

Cbln and C1q family proteins – New transneuronal cytokines

Yuzaki, M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7550-3 · Cited by 77

Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1

Sun, F., Lei, Y., You, J., Li, C., Sun, L., Garza, J. C., Zhang, D., Guo, M., Scherer, P. E., Lodge, D. J., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0102-9 · Cited by 77

Nutritional signals and reproduction

Dupont, J., Reverchon, M., Bertoldo, M. J., & Froment, P. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.028 · Cited by 79

Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance

Liu, M., Xiang, R., Wilk, S. A., Zhang, N., Sloane, L. B., Azarnoush, K., Zhou, L., Chen, H., Xiang, G., Walter, C. A., et al. (2012) · Diabetes · doi:10.2337/db12-0169 · Cited by 76

Organismal Carbohydrate and Lipid HomeostasisPreprint

Hardie, D. G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006031 · Cited by 82

EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?

López, M. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0927 · Cited by 78

Adipokines in Patients with Cancer Anorexia and Cachexia

Smiechowska, J., Utech, A. E., Taffet, G. E., Hayes, T. G., Marcelli, M., & Garcia, J. M. (2010) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3181cf91ca · Cited by 74

Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression

Nicolas, S., Debayle, D., Béchade, C., Maroteaux, L., Gay, A.-S., Bayer, P., Heurteaux, C., Guyon, A., & Chabry, J. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0210-y · Cited by 73

Adipokines in Breast Milk: An Update

Çatlı, G., Dündar, N. O., & Dündar, B. N. (2014) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.1531 · Cited by 73

Hypothalamic AMPK as a Regulator of Energy Homeostasis

Huynh, M. K. Q., Kinyua, A. W., Yang, D. J., & Kim, K. W. (2016) · Neural Plasticity · doi:10.1155/2016/2754078 · Cited by 78

Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?

Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72

Neurogenesis-independent antidepressant-like effects of enriched environment is dependent on adiponectin

Nicolas, S., Veyssière, J., Gandin, C., Zsürger, N., Piétri, M., Heurteaux, C., Glaichenhaus, N., Petit-Paitel, A., & Chabry, J. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.03.017 · Cited by 72

Metabolic hormones are integral regulators of female reproductive health and function

Athar, F., Karmani, M., & Templeman, N. M. (2023) · Bioscience Reports · doi:10.1042/bsr20231916 · Cited by 82

Involvement of Endothelial Apoptosis Underlying Chronic Obstructive Pulmonary Disease–like Phenotype in Adiponectin-null Mice: Implications for Therapy

Nakanishi, K., Takeda, Y., Tetsumoto, S., Iwasaki, T., Tsujino, K., Kuhara, H., Jin, Y., Nagatomo, I., Kida, H., Goya, S., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201007-1091oc · Cited by 73

GnRH secretion is inhibited by adiponectin through activation of AMP-activated protein kinase and extracellular signal-regulated kinase

Cheng, X., Wen, J., Yang, J., Yang, Y., Ning, G., & Li, X.-Y. (2010) · Endocrine · doi:10.1007/s12020-010-9375-8 · Cited by 71

CNS-targets in control of energy and glucose homeostasis

Kleinridders, A., Könner, A. C., & Brüning, J. C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.10.006 · Cited by 74

Ghrelin in obesity and endocrine diseases

Scerif, M., Goldstone, A. P., & Korbonits, M. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.02.011 · Cited by 73

AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin

Ruiz, M., Ståhlman, M., Borén, J., & Pilon, M. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m092494 · Cited by 69

An overview of obesity mechanisms in humans: Endocrine regulation of food intake, eating behaviour and common determinants of body weight

Theilade, S., Christensen, M., Vilsbøll, T., & Knop, F. K. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14270 · Cited by 74

Maternal Nutrient Restriction between Early and Midgestation and Its Impact Upon Appetite Regulation after Juvenile Obesity

Sebert, S. P., Hyatt, M. A., Chan, L. L. Y., Patel, N. N., Bell, R. C., Keisler, D. H., Stephenson, T. J., Budge, H., Symonds, M. E., & Gardner, D. S. (2008) · Endocrinology · doi:10.1210/en.2008-0542 · Cited by 70

Hypothalamic lipotoxicity and the metabolic syndrome

de Morentin, P. B. M., Varela, L., Fernø, J., Nogueiras, R., Diéguez, C., & López, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.016 · Cited by 73

Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation

Nakagomi, A., Okada, S., Yokoyama, M., Yoshida, Y., Shimizu, I., Miki, T., Kobayashi, Y., & Minamino, T. (2015) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2015.9 · Cited by 67

The ghrelin/GOAT/GHS-R system and energy metabolism

Lim, C. T., Kola, B., & Korbonits, M. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9169-1 · Cited by 70

Targeting Intermediary Metabolism in the Hypothalamus as a Mechanism to Regulate Appetite

Lopaschuk, G. D., Ussher, J. R., & Jaswal, J. S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002428 · Cited by 71

Appetite- and Weight-Regulating Neuroendocrine Circuitry in Hypothalamic Obesity

Gan, H., Cerbone, M., & Dattani, M. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad033 · Cited by 75

Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamus

Hoyda, T. D., Fry, M., Ahima, R. S., & Ferguson, A. V. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.144519 · Cited by 68

Abdominal Fat, Adipose-Derived Hormones and Mild Cognitive Impairment: The J-SHIPP Study

Kamogawa, K., Kohara, K., Tabara, Y., Uetani, E., Nagai, T., Yamamoto, M., Igase, M., & Miki, T. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000321985 · Cited by 68

Role of hypothalamic AMP-kinase in food intake regulation

Minokoshi, Y., Shiuchi, T., Lee, S. P., Suzuki, A., & Okamoto, S. (2008) · Nutrition · doi:10.1016/j.nut.2008.06.002 · Cited by 98

The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS

Kadowaki, T., Yamauchi, T., & Kubota, N. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.070 · Cited by 274

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637

Dorsal Hindbrain 5′-Adenosine Monophosphate-Activated Protein Kinase as an Intracellular Mediator of Energy Balance

Hayes, M. R., Skibicka, K. P., Bence, K. K., & Grill, H. J. (2008) · Endocrinology · doi:10.1210/en.2008-1319 · Cited by 87

AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 777