Effects of acute sleep loss on leptin, ghrelin, and adiponectin in adults with healthy weight and obesity: A laboratory study
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Objective: This study investigated whether blood concentrations of leptin, ghrelin, and adiponectin are affected by acute total sleep deprivation in a sex‐ and weight‐specific manner. Methods: A total of 44 participants (mean age 24.9 years; 20 women; 19 with obesity) participated in a crossover design, including one night of sleep deprivation and one night of sleep in the laboratory. After each night, fasting blood was collected. Results: After sleep deprivation, fasting levels of leptin were lower (mean [SE], vs. sleep: 17.3 [2.6] vs. 18.6 [2.8] ng/mL), whereas those of ghrelin and adiponectin were higher (839.4 [77.5] vs. 741.4 [63.2] pg/mL and 7.5 [0.6] vs. 6.8 [0.6] μg/mL, respectively; all p < 0.05). The changes in leptin and adiponectin following sleep loss were more pronounced among women. Furthermore, the ghrelin increase was stronger among those with obesity after sleep loss. Finally, the sleep loss‐induced increase in adiponectin was more marked among normal‐weight participants. Conclusions: Acute sleep deprivation reduces blood concentrations of the satiety hormone leptin. With increased blood concentrations of ghrelin and adiponectin, such endocrine changes may facilitate weight gain if persisting over extended periods of sleep loss. The observed sex‐ and weight‐specific differences in leptin, ghrelin, and adiponectin call for further investigation.
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Lifestyle behaviors like exercise, stress management, and sleep quality significantly affect insulin sensitivity and lipid metabolism, modifying fat gain tendencies during overfeeding.
“Lifestyle behaviors like exercise, stress management, and sleep quality significantly affect insulin sensitivity and lipid metabolism, modifying fat gain tendencies during overfeeding.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [54]
Poor sleep quality is linked to increased ghrelin and decreased leptin, enhancing hunger and potentially leading to higher caloric intake during overfeeding.
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From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [54]
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- Authors
- van Egmond, L. T., Meth, E. M. S., Engström, J., Ilemosoglou, M., Keller, J. A., Vogel, H., & Benedict, C.
- Affiliations
- Department of Surgical Sciences, Sleep Science Laboratory Uppsala University Uppsala Sweden
- Uppsala University (SE)
- University of Potsdam (DE)
- Corresponding author
- Benedict, Christian
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2022-11-20
- Volume
- 31
- Issue
- 3
- Pages
- 635-641
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W4309513381
- Cited by
- 106
- References
- 41
- Citations by year
- 2026: 43 · 2025: 39 · 2024: 15 · 2023: 9
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Obesity (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Leiden Repository (Leiden University) (submittedVersion, cc-by-nc)
- Funders
- Hjärnfonden (FO2022‐0254)
- Novo Nordisk Fonden (NNF19OC0056777)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- acute sleep deprivation, leptin, ghrelin, adiponectin, sex differences, body weight, appetite-regulating hormones, weight gain, satiety hormones
- MeSH terms
- Adult, Female, Humans, Obesity, Sleep, Sleep Deprivation, Cross-Over Studies, Leptin, Adiponectin, Ghrelin, Young Adult
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