The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Unraveling the Biological Roles of Reactive Oxygen Species
Open accessAbstract
Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.
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In the citing paper
“Antioxidants are heterogeneous [159] they work in distinct ways and importantly they do not solely regulate ROS.”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [159]
In the citing paper
“Multiple key signalling pathways contribute to microglial immune activation, including NFκB and MAPKs (Figure 3) and there is evidence ROS is an important modulator of the immune response by influencing these cell signalling pathways in microglia.”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [137]
In the citing paper
“At physiological concentrations, ROS are vital secondary messengers in multiple cellular processes, including inflammation, cellular growth and differentiation [136,137].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [137]
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Citations
Cites
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Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Self-citationReconciling the chemistry and biology of reactive oxygen species
Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504
Self-citationWang, H., & Joseph, J. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00107-0 · Cited by 2,355
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Self-citationMitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165
Molecular mechanisms of N-acetylcysteine actions
Zafarullah, M., Li, W. Q., Sylvester, J., & Ahmad, M. (2003) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180300001 · Cited by 1,343
Genetically encoded fluorescent indicator for intracellular hydrogen peroxide
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Research works printed but not linked: 2
- Bjelakovic, 2008, Cochrane Database Syst. Rev., 2, CD007176
- Cochemé, 2010, Curr. Opin. Investig. Drugs, 11, 426
Cited by
Sorted by citations
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335
Brigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations
Kalyanaraman, B., Darley-Usmar, V. M., Davies, K. J. A., Dennery, P. A., Forman, H. J., Grisham, M. B., Mann, G. E., Moore, K. P., Roberts, L. J., & Ischiropoulos, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.030 · Cited by 1,842
Self-citationDefining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Sies, H., Belousov, V. V., Chandel, N. S., Davies, M. J., Jones, D. P., Mann, G. E., Murphy, M. P., Yamamoto, M., & Winterbourn, C. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00456-z · Cited by 1,735
Self-citationNeutrophil Function: From Mechanisms to Disease
Amulic, B., Cazalet, C., Hayes, G. L., Metzler, K. D., & Zychlinsky, A. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074942 · Cited by 1,782
Metadata
- Authors
- Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., Nyström, T., Belousov, V., Schumacker, P. T., & Winterbourn, C. C.
- Affiliations
- MRC Mitochondrial Biology Unit (GB)
- Karolinska Institutet (SE)
- Max Planck Institute for Biology of Ageing (DE)
- National University of Singapore (SG)
- Howard Hughes Medical Institute (US)
- Medical College of Wisconsin (US)
- Ewha Womans University (KR)
- University Hospital Coventry (GB)
- University College London (GB)
- University of Gothenburg (SE)
- Institute of Bioorganic Chemistry (RU)
- Northwestern University (US)
- University of Otago (NZ)
- Corresponding author
- Murphy, Michael P.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 13
- Issue
- 4
- Pages
- 361-366
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4445605
- OpenAlex
- W1967236260
- Cited by
- 836
- References
- 49
- Citations by year
- 2026: 31 · 2025: 44 · 2024: 49 · 2023: 55 · 2022: 61 · 2021: 64 · 2020: 61 · 2019: 47 · 2018: 51 · 2017: 53 · 2016: 66 · 2015: 64 · 2014: 60 · 2013: 59 · 2012: 48
- FWCI
- 24.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- National University of Singapore (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust (081394)
- Medical Research Council (MC_G0901472)
- Biotechnology and Biological Sciences Research Council (BB/D020786/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- reactive oxygen species, oxidative damage, redox signaling, biological regulation, oxidative stress, redox biology
- MeSH terms
- Antioxidants, Signal Transduction, Reactive Oxygen Species, Oxidative Stress
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