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Unraveling the Biological Roles of Reactive Oxygen Species
Open accessAbstract
Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.
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“Antioxidants are heterogeneous [159] they work in distinct ways and importantly they do not solely regulate ROS.”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [159]
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“Multiple key signalling pathways contribute to microglial immune activation, including NFκB and MAPKs (Figure 3) and there is evidence ROS is an important modulator of the immune response by influencing these cell signalling pathways in microglia.”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [137]
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“At physiological concentrations, ROS are vital secondary messengers in multiple cellular processes, including inflammation, cellular growth and differentiation [136,137].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [137]
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Metadata
- Authors
- Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., Nyström, T., Belousov, V., Schumacker, P. T., & Winterbourn, C. C.
- Affiliations
- MRC Mitochondrial Biology Unit (GB)
- Karolinska Institutet (SE)
- Max Planck Institute for Biology of Ageing (DE)
- National University of Singapore (SG)
- Howard Hughes Medical Institute (US)
- Medical College of Wisconsin (US)
- Ewha Womans University (KR)
- University Hospital Coventry (GB)
- University College London (GB)
- University of Gothenburg (SE)
- Institute of Bioorganic Chemistry (RU)
- Northwestern University (US)
- University of Otago (NZ)
- Corresponding author
- Murphy, Michael P.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 13
- Issue
- 4
- Pages
- 361-366
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4445605
- OpenAlex
- W1967236260
- Cited by
- 836
- References
- 49
- Citations by year
- 2026: 31 · 2025: 44 · 2024: 49 · 2023: 55 · 2022: 61 · 2021: 64 · 2020: 61 · 2019: 47 · 2018: 51 · 2017: 53 · 2016: 66 · 2015: 64 · 2014: 60 · 2013: 59 · 2012: 48
- FWCI
- 24.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- National University of Singapore (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust (081394)
- Medical Research Council (MC_G0901472)
- Biotechnology and Biological Sciences Research Council (BB/D020786/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- reactive oxygen species, oxidative damage, redox signaling, biological regulation, oxidative stress, redox biology
- MeSH terms
- Antioxidants, Signal Transduction, Reactive Oxygen Species, Oxidative Stress
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