The DOI matches its Crossref record; 134 of the 135 references it cites were found in a registry or an index.
Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation
Open accessAbstract
The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes-a type of glial cell-have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.
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In the citing paper
“As the major lipid carrier in the brain, secreted ApoE is generally presumed to be converted into HDL-like LNPs by astrocytes.”
From ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer’s Disease Pathogenesis (2025) · cites this paper as [47]
In the citing paper
“In turn, these LNPs undergo receptor-mediated endocytosis in neurons and glia cells where their lipid constituents are disassembled in lysosomes to supply these constituents to the recipient cells.22, 44–47”
From ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer’s Disease Pathogenesis (2025) · cites this paper as [47]
In the citing paper
“Astrocytes provide critical support to neurons for synapse formation/pruning, neurotransmitter modulation, and metabolic homeostasis (Bélanger et al., 2011; Jha and Morrison, 2018).”
From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Bélanger et al., 2011
In the citing paper
“Compared with neurons, astrocytes are relatively resistant to oxidative stress (Bélanger et al. 2011; Wilson 1997).”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Bélanger et al. 2011
In the citing paper
“Neuronal cells in the brain have a particularly high metabolism, using 20% and 25% of the total consumed oxygen and glucose,34 this makes neurons and their mitochondria particularly susceptible to ROS damage.”
From Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans (2020) · cites this paper as [34]
Citations
Cites
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An Energy Budget for Signaling in the Grey Matter of the Brain
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“The stimulation of astrocytic glucose utilization by glutamate was subsequently confirmed by several independent groups (reviewed in Pellerin et al., 2007; Barros and Deitmer, 2010).”
BackgroundSelf-citationGlial and neuronal control of brain blood flow
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1 of the 135 references couldn’t be matched to a known paper.
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Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
“…because the primary energy consumers in the brain, neurons and astrocytes, each exhibit diametric patterns of glucose consumption (for review, see Bélanger et al., 2011; Bouzier-Sore and Pellerin, 2013); neurons heavily rely on oxidative metabolism, whereas astrocytes exhibit high glycolytic…”
BackgroundVerkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576
The Science and Translation of Lactate Shuttle Theory
Brooks, G. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.008 · Cited by 1,486
Ferroptosis: Mechanisms and links with diseases
Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00428-9 · Cited by 1,471
Metadata
- Authors
- Bélanger, M., Allaman, I., & Magistretti, P. J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Magistretti, Pierre J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 14
- Issue
- 6
- Pages
- 724-738
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2016927879
- Cited by
- 2,313
- References
- 135
- Citations by year
- 2026: 169 · 2025: 194 · 2024: 206 · 2023: 207 · 2022: 197 · 2021: 218 · 2020: 203 · 2019: 175 · 2018: 159 · 2017: 152 · 2016: 137 · 2015: 111 · 2014: 76 · 2013: 73 · 2012: 31
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- brain energy metabolism, astrocytes, neurons, neuroenergetics, glial cells, energy storage, neuronal activity
- MeSH terms
- Astrocytes, Brain, Energy Metabolism, Glycogen, Models, Biological, Neurons, Regional Blood Flow, Oxidative Stress, Lactic Acid
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