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Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

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Bélanger, Mireille, Allaman, Igor, Magistretti, Pierre J.·2011·Cell Metabolism

DOI 10.1016/j.cmet.2011.08.016

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Abstract

The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes-a type of glial cell-have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.

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THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.
Ogawa, S., Tank, D. W., Menon, R., Ellermann, J. M., Kim, S. G., Merkle, H., & Ugurbil, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5951 · Cited by 3,681
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927 · cited 2×
“The stimulation of astrocytic glucose utilization by glutamate was subsequently confirmed by several independent groups (reviewed in Pellerin et al., 2007; Barros and Deitmer, 2010).”
BackgroundSelf-citation
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,837
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711
Self-citation
Metabolism and functions of glutathione in brain
Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702
BRAIN WORK AND BRAIN IMAGING
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630
Uniquely Hominid Features of Adult Human Astrocytes
Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K.-A., Pozzan, T., & Carmignoto, G. (2002) · Nature Neuroscience · doi:10.1038/nn980 · Cited by 1,446
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334 · cited 1×
“Nevertheless, under particular circumstances the brain has the capacity to use other blood-derived energy substrates, such as ketone bodies during development and starvation (Nehlig, 2004; Magistretti, 2008) or lactate during periods of intense physical activity (van Hall et al., 2009).”
Background
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153
Astrocyte-mediated control of cerebral blood flow
Takano, T., Tian, G.-F., Peng, W., Lou, N., Libionka, W., Han, X., & Nedergaard, M. (2005) · Nature Neuroscience · doi:10.1038/nn1623 · Cited by 1,137
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114
Basic Neurochemistry: Molecular, Cellular, and Medical Aspects
DAVISON, A. N. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.8.1021-a · Cited by 949
Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission
Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., & Giaume, C. (2008) · Science · doi:10.1126/science.1164022 · Cited by 912
Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
Mulligan, S. J., & MacVicar, B. A. (2004) · Nature · doi:10.1038/nature02827 · Cited by 872
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844
Cell–cell and intracellular lactate shuttles
Brooks, G. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178350 · Cited by 833
Supply and demand in cerebral energy metabolism: the role of nutrient transporters
Simpson, I. A., Carruthers, A., & Vannucci, S. J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600521 · Cited by 812
Activity-dependent regulation of energy metabolism by astrocytes: an update
Pellerin, L., Bouzier‐Sore, A., Aubert, A., Serres, S., Merle, M., Costalat, R., & Magistretti, P. J. (2007) · Glia · doi:10.1002/glia.20528 · Cited by 805
Self-citation
Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress
Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 792
Astroglial networks: a step further in neuroglial and gliovascular interactions
Giaume, C., Koulakoff, A., Roux, L., Holcman, D., & Rouach, N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2757 · Cited by 789
Brain metabolism dictates the polarity of astrocyte control over arterioles
Gordon, G. R., Choi, H. B., Rungta, R. L., Ellis‐Davies, G. C. R., & MacVicar, B. A. (2008) · Nature · doi:10.1038/nature07525 · Cited by 770
Synaptic Islands Defined by the Territory of a Single Astrocyte
Halassa, M. M., Fellin, T., Takano, H., Dong, J.-H., & Haydon, P. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1419-07.2007 · Cited by 767
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742
Astrocytic complexity distinguishes the human brain
Oberheim, N. A., Wang, X., Goldman, S., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.004 · Cited by 739
Circulation and Energy Metabolism of the Brain
Clarke, D. D., & Sokoloff, L. (1999) · Cited by 732
Astrocyte–neuron metabolic relationships: for better and for worse
Allaman, I., Bélanger, M., & Magistretti, P. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2010.12.001 · Cited by 639
Self-citation
Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling
Metea, M. R., & Newman, E. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4048-05.2006 · Cited by 637
Astrocyte glycogen and brain energy metabolism
Brown, A. M., & Ransom, B. R. (2007) · Glia · doi:10.1002/glia.20557 · Cited by 626
Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease
Mosconi, L., Pupi, A., & de Leon, M. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.007 · Cited by 616
Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.
Prichard, J. W., Rothman, D. L., Novotny, E. J., Petroff, O. A. C., Kuwabara, T., Avison, M. J., Howseman, A., Hanstock, C. C., & Shulman, R. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5829 · Cited by 612
Energetic basis of brain activity: implications for neuroimaging
Shulman, R. G., Rothman, D. L., Behar, K. L., & Hyder, F. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.005 · Cited by 590
Glycogen in astrocytes: possible function as lactate supply for neighboring cells
Dringen, R., Gebhardt, R., & Hamprecht, B. (1993) · Brain Research · doi:10.1016/0006-8993(93)91429-v · Cited by 536
Blood lactate is an important energy source for the human brain.
van Hall, G., Stømstad, M., Rasmussen, P., Jans, Ø., Zaar, M., Gam, C., Quistorff, B., Secher, N. H., & Nielsen, H. B. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.35 · Cited by 522
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
Lovatt, D., Sonnewald, U., Waagepetersen, H. S., Schousboe, A., He, W., Lin, J. H.-C., Han, X., Takano, T., Wang, S., Sim, F. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3404-07.2007 · Cited by 505
Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System
Tsujino, N., & Sakurai, T. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001321 · Cited by 499
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
Almeida, Á., Moncada, S., & Bolaños, J. P. (2003) · Nature Cell Biology · doi:10.1038/ncb1080 · Cited by 481
Energy-Efficient Action Potentials in Hippocampal Mossy Fibers
Alle, H., Roth, A., & Geiger, J. R. P. (2009) · Science · doi:10.1126/science.1174331 · Cited by 429
Different Responses of Astrocytes and Neurons to Nitric Oxide: The Role of Glycolytically Generated ATP in Astrocyte Protection
Almeida, A., Almeida, J., Bolaños, J. P., & Moncada, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261560998 · Cited by 423
Fundamental neuroscience
McCandless, D. W. (1997) · Metabolic Brain Disease · doi:10.1007/bf02676357 · Cited by 423
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600263 · Cited by 408
The role of astroglia in neuroprotection
Bélanger, M., & Magistretti, P. J. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/mbelanger · Cited by 396
Self-citation
The glutamate‐glutamine cycle is not stoichiometric: Fates of glutamate in brain
McKenna, M. C. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21444 · Cited by 385
Glycolysis: a bioenergetic or a survival pathway?
Bolaños, J. P., Almeida, Á., & Moncada, S. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.006 · Cited by 374
Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
Vı́lchez, D., R�os, S., Cifuentes, D., Pujadas, L., Vallès, J., García-Fojeda, B., Criado‐García, O., Fernández-Sánchez, E., Medraño-Fernández, I., Domínguez, J. E., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1998 · Cited by 374
Astroglial Contribution to Brain Energy Metabolism in Humans Revealed by13C Nuclear Magnetic Resonance Spectroscopy: Elucidation of the Dominant Pathway for Neurotransmitter Glutamate Repletion and Measurement of Astrocytic Oxidative Metabolism
Lebon, V., Petersen, K. F., Cline, G. W., Shen, J., Mason, G. F., Dufour, S., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01523.2002 · Cited by 371
The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic13C Nuclear Magnetic Resonance Spectroscopy
Boumezbeur, F., Petersen, K. F., Cline, G. W., Mason, G. F., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2040-10.2010 · Cited by 362
Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.
Magistretti, P. J., Morrison, J. H., Shoemaker, W. J., Sapin, V., & Bloom, F. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6535 · Cited by 351
Self-citation
Antioxidant defense of the brain: a role for astrocytes
Wilson, J. X. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y97-146 · Cited by 349
Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism
Lam, T. K. T., Gutierrez-Juarez, R., Pocai, A., & Rossetti, L. (2005) · Science · doi:10.1126/science.1112085 · Cited by 341
A Temporary Local Energy Pool Coupled to Neuronal Activity: Fluctuations of Extracellular Lactate Levels in Rat Brain Monitored with Rapid‐Response Enzyme‐Based Sensor
Hu, Y., & Wilson, G. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041484.x · Cited by 337
Energy Substrates for Neurons during Neural Activity: A Critical Review of the Astrocyte-Neuron Lactate Shuttle Hypothesis
Chih, C.-P., & Roberts, E. L. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000081369.51727.6f · Cited by 325
Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex
Genoud, C., Quairiaux, C., Steiner, P., Hirling, H., Welker, E., & Knott, G. W. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040343 · Cited by 321
Brain glycogen re-awakened
Brown, A. M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02421.x · Cited by 308
Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus
Witcher, M. R., Kirov, S. A., & Harris, K. M. (2006) · Glia · doi:10.1002/glia.20415 · Cited by 306
Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo
Itoh, Y., Esaki, T., Shimoji, K., Cook, M., Law, M. J., Kaufman, E., & Sokoloff, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831078100 · Cited by 297
The Nrf2–ARE cytoprotective pathway in astrocytes
Vargas, M. R., & Johnson, J. A. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001094 · Cited by 295
An Increase in Lactate Output by Brain Tissue Serves to Meet the Energy Needs of Glutamate-Activated Neurons
Schurr, A., Miller, J. J., Payne, R. S., & Rigor, B. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00034.1999 · Cited by 295
Glial Glutamate Transporters Mediate a Functional Metabolic Crosstalk between Neurons and Astrocytes in the Mouse Developing Cortex
Voutsinos‐Porche, B., Bonvento, G., Tanaka, K., Steiner, P., Welker, E., Chatton, J., Magistretti, P. J., & Pellerin, L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01170-4 · Cited by 293
Self-citation
Amyloid-β Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability
Allaman, I., Gavillet, M., Bélanger, M., Laroche, T., Viertl, D., Lashuel, H. A., & Magistretti, P. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5098-09.2010 · Cited by 291
Self-citation
Lactate: A Preferred Fuel for Human Brain Metabolism in Vivo
Smith, D., Pernet, A., Hallett, W. A., Bingham, E., Marsden, P. K., & Amiel, S. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000063991.19746.11 · Cited by 282
Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study
Bouzier‐Sore, A., Voisin, P., Bouchaud, V., Bezancon, E., Franconi, J., & Pellerin, L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05056.x · Cited by 265
Brain Lactate Is an Obligatory Aerobic Energy Substrate for Functional Recovery After Hypoxia: Further In Vitro Validation
Schurr, A., Payne, R. S., Miller, J. J., & Rigor, B. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010423.x · Cited by 262
Astrocytes protect neurons from nitric oxide toxicity by a glutathione‐dependent mechanism
Chen, Y., Vartiainen, N. E., Ying, W., Chan, P. H., Koıstınaho, J., & Swanson, R. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00374.x · Cited by 260
Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens
Gibbs, M. E., Anderson, D. G., & Hertz, L. (2006) · Glia · doi:10.1002/glia.20377 · Cited by 251
The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals
Figley, C. R., & Stroman, P. W. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07584.x · Cited by 246
Cellular Bases of Brain Energy Metabolism and Their Relevance to Functional Brain Imaging: Evidence for a Prominent Role of Astrocytes
Magistretti, P. J., & Pellerin, L. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.1.50 · Cited by 243
Self-citation
Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy
Boumezbeur, F., Mason, G. F., de Graaf, R. A., Behar, K. L., Cline, G. W., Shulman, G. I., Rothman, D. L., & Petersen, K. F. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.197 · Cited by 238
Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography
Swanson, R. A., Morton, M. M., Sagar, S. M., & Sharp, F. R. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90329-z · Cited by 237
Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity
Tekkök, S. B., Brown, A. M., Westenbroek, R., Pellerin, L., & Ransom, B. R. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20573 · Cited by 224
Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex
Chuquet, J., Quilichini, P., Nimchinsky, E. A., & Buzsáki, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0762-10.2010 · Cited by 217
Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex.
Lin, A.-L., Fox, P. T., Hardies, J., Duong, T. Q., & Gao, J.-H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909711107 · Cited by 213
Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K+ channels
Ainscow, E., Mirshamsi, S., Tang, T., Ashford, M. L. J., & Rutter, G. A. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022434 · Cited by 203
The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study
Gallagher, C., Carpenter, K. L. H., Grice, P., Howe, D. J., Mason, A., Timofeev, I. S., Menon, D. K., Kirkpatrick, P. J., Pickard, J. D., Sutherland, G. R., et al. (2009) · Brain · doi:10.1093/brain/awp202 · Cited by 201
Glial Nax Channels Control Lactate Signaling to Neurons for Brain [Na+] Sensing
Shimizu, H., Watanabe, E., Hiyama, T. Y., Nagakura, A., Fujikawa, A., Okado, H., Yanagawa, Y., Obata, K., & Noda, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.014 · Cited by 200
Astrocytes : pharmacology and function
Murphy, S. P. (1993) · Cited by 198
Evidence for the Mitochondrial Lactate Oxidation Complex in Rat Neurons: Demonstration of an Essential Component of Brain Lactate Shuttles
Hashimoto, T., Hussien, R., Cho, H.-S., Kaufer, D., & Brooks, G. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002915 · Cited by 196
The in vivo neuron‐to‐astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation
Mangia, S., Simpson, I. A., Vannucci, S. J., & Carruthers, A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06003.x · Cited by 189
Assessment of the Role of the Glutathione and Pentose Phosphate Pathways in the Protection of Primary Cerebrocortical Cultures from Oxidative Stress
Ben‐Yoseph, O., Boxer, P. A., & Ross, B. D. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062329.x · Cited by 189
Brain uptake and metabolism of ketone bodies in animal models
Nehlig, A. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.07.006 · Cited by 185
A mouse model for Glut-1 haploinsufficiency
Wang, D., Pascual, J. M., Yang, H., Engelstad, K., Mao, X., Cheng, J., Yoo, J. H., Noebels, J. L., & Vivo, D. C. D. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl032 · Cited by 185
Role of glutamate in neuron-glia metabolic coupling
Magistretti, P. J. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462cc · Cited by 185
Self-citation
Astrocytes generate Na + -mediated metabolic waves
Bernardinelli, Y., Magistretti, P. J., & Chatton, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405315101 · Cited by 178
Self-citation
Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons
Halim, N. D., Mcfate, T., Mohyeldin, A., Okagaki, P., Korotchkina, L. G., Patel, M. S., Jeoung, N. H., Harris, R. A., Schell, M. J., & Verma, A. (2010) · Glia · doi:10.1002/glia.20996 · Cited by 177
Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, T. M., Schousboe, A., Waagepetersen, H. S., & Ransom, B. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20335 · Cited by 169
The contribution of astrocyte signalling to neurovascular coupling
Carmignoto, G., & Gómez‐Gonzalo, M. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.007 · Cited by 168
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Garcı́a-Nogales, P., Almeida, Á., & Bolaños, J. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206835200 · Cited by 164
Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions
Kasischke, K. A., Lambert, E. M., Panepento, B., Sun, A., Gelbard, H. A., Burgess, R. W., Foster, T. H., & Nedergaard, M. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.158 · Cited by 160
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Magistretti, P. J., & Allaman, I. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1997-6_56 · Cited by 160
Self-citation
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Barros, L. F., & Deitmer, J. W. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.002 · Cited by 155
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Tarasov, A. I., Dusonchet, J., & Ashcroft, F. M. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s113 · Cited by 151
Developmental changes in the Ca2+-regulated mitochondrial aspartate–glutamate carrier aralar1 in brain and prominent expression in the spinal cord
Ramos, M., del Arco, A., Pardo, B., Martı́nez-Serrano, A., Martínez‐Morales, J. R., Kobayashi, K., Yasuda, T., Bogónez, E., Bovolenta, P., Saheki, T., et al. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(03)00097-x · Cited by 150
High resolution measurement of the glycolytic rate
Bittner, C. X. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00026 · Cited by 150
A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid
Castro, M. A., Beltrán, F. A., Brauchi, S. E., & Concha, I. I. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06151.x · Cited by 147
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Cerdán, S., Rodrigues, T. B., Sierra, A., Benito, M., Fonseca, L. L., Fonseca, C. P., & García-Martín, M. L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.036 · Cited by 146
Activity‐induced tissue oxygenation changes in rat cerebellar cortex: interplay of postsynaptic activation and blood flow
Offenhauser, N., Thomsen, K., Caesar, K., & Lauritzen, M. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.082776 · Cited by 145
Functional receptors for vasoactive intestinal polypeptide in cultured astroglia from neonatal rat brain
Magistretti, P. J., Manthorpe, M., Bloom, F. E., & Varon, S. S. (1983) · Regulatory Peptides · doi:10.1016/0167-0115(83)90136-2 · Cited by 140
Self-citation
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Porras, O. H., Loaiza, A., & Barros, L. F. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1882-04.2004 · Cited by 139
ATP-Sensitive Potassium Channel-Mediated Lactate Effect on Orexin Neurons: Implications for Brain Energetics during Arousal
Parsons, M. P., & Hirasawa, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5741-09.2010 · Cited by 138
Lactate, not pyruvate, is neuronal aerobic glycolysis end product: An in vitro electrophysiological study
Schurr, A., & Payne, R. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.002 · Cited by 138
Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents
Walls, A. B., Heimbürger, C. M., Bouman, S. D., Schousboe, A., & Waagepetersen, H. S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.058 · Cited by 133
Astrocytes: Pharmacology and Function
Kettenmann, H. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90080-9 · Cited by 133
13C MR Spectroscopy Study of Lactate as Substrate for Rat Brain
Qu, H., Haberg, A. K., Haraldseth, O., Unsgård, G., & Sonnewald, U. (2000) · Developmental Neuroscience · doi:10.1159/000017472 · Cited by 132
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Dienel, G. A., Ball, K. K., & Cruz, N. F. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04595.x · Cited by 127
Direct measurement of oxidative metabolism in the living brain by microdialysis: a review
Zielke, H. R., Zielke, C. L., & Baab, P. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05941.x · Cited by 124
Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats
Ances, B. M., Buerk, D. G., Greenberg, J. H., & Detre, J. A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01868-7 · Cited by 122
Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte–Neuron Lactate-Shuttle Hypothesis
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Sickmann, H. M., Walls, A. B., Schousboe, A., Bouman, S. D., & Waagepetersen, H. S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05915.x · Cited by 119
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Lam, C., Chari, M., & Lam, T. K. T. (2009) · Physiology · doi:10.1152/physiol.00003.2009 · Cited by 117
Mitochondrial transport proteins of the brain
Berkich, D. A., Ola, M. S., Cole, J., Sweatt, A. J., Hutson, S. M., & LaNoue, K. F. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21500 · Cited by 114
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The aerobic brain: lactate decrease at the onset of neural activity
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Sibson, N. R., Shen, J., Mason, G. F., Rothman, D. L., Behar, K. L., & Shulman, R. G. (1998) · Developmental Neuroscience · doi:10.1159/000017327 · Cited by 92
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Self-citation
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Self-citation
Regulation of Glycogen Metabolism in Astrocytes: Physiological, Pharmacological, and Pathological Aspects
Magistretti, P. J., Sorg, O., & Martin, J. (1993) · Elsevier eBooks · doi:10.1016/b978-0-12-511370-0.50015-1 · Cited by 84
Self-citation
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Self-citation
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Laughton, J. D., Bittar, P. G., Charnay, Y., Pellerin, L., Kövari, E., Magistretti, P. J., & Bouras, C. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-35 · Cited by 80
Self-citation
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Stuart, C. A., Ross, I. R., Howell, M. E. A., McCurry, M. P., Wood, T. G., Ceci, J. D., Kennel, S. J., & Wall, J. S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.014 · Cited by 49
Ex vivo NMR study of lactate metabolism in rat brain under various depressed states
Serres, S., Bezançon, E., Franconi, J., & Merle, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20277 · Cited by 43
Neuronal functions, feeding behavior, and energy balance inSlc2a3+/−mice
Schmidt, S., Richter, M., Montag, D., Sartorius, T., Gawlik, V., Hennige, A. M., Scherneck, S., Himmelbauer, H., Lutz, S. Z., Augustin, R., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90491.2008 · Cited by 35
The effect of glycogen phosphorolysis on basal glutaminergic transmission
Mozrzymas, J. W., Szczęsny, T. J., & Rakus, D. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.033 · Cited by 27
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Hérard, A.-S., Dubois, A., Escartin, C., Tanaka, K., Delzescaux, T., Hantraye, P., & Bonvento, G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04346.x · Cited by 25
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“…because the primary energy consumers in the brain, neurons and astrocytes, each exhibit diametric patterns of glucose consumption (for review, see Bélanger et al., 2011; Bouzier-Sore and Pellerin, 2013); neurons heavily rely on oxidative metabolism, whereas astrocytes exhibit high glycolytic…”
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Physiology of Astroglia
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Authors: Bélanger, M., Allaman, I., & Magistretti, P. J.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Centre Hospitalier Universitaire Vaudois (CH)
Corresponding author: Magistretti, Pierre J.
ORCID: Allaman, Igor
Magistretti, Pierre J.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2011-12
Volume: 14
Issue: 6
Pages: 724-738
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2011.08.016
OpenAlex: W2016927879
Cited by: 2,313
References: 135
Citations by year: 2026: 169 · 2025: 194 · 2024: 206 · 2023: 207 · 2022: 197 · 2021: 218 · 2020: 203 · 2019: 175 · 2018: 159 · 2017: 152 · 2016: 137 · 2015: 111 · 2014: 76 · 2013: 73 · 2012: 31
FWCI: 5.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 630 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: brain energy metabolism, astrocytes, neurons, neuroenergetics, glial cells, energy storage, neuronal activity
MeSH terms: Astrocytes, Brain, Energy Metabolism, Glycogen, Models, Biological, Neurons, Regional Blood Flow, Oxidative Stress, Lactic Acid

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Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

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