Cited by 76Probiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyGut microbiota and health

Daily intake of Lactobacillus gasseri CP2305 relieves fatigue and stress-related symptoms in male university Ekiden runners: A double-blind, randomized, and placebo-controlled clinical trial

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Sawada, Daisuke, Kuwano, Yuki, Tanaka, Hiroki, Hara, Susumu, Uchiyama, Yoshihide, Sugawara, Tomonori, Fujiwara, Shigeru, Rokutan, Kazuhito +1 more·2019·Journal of Functional Foods

Abstract

The heat-inactivated, enteric-colonizing Lactobacillus gasseri CP2305 (CP2305) ameliorates psychological stress-related symptoms. In this study, we examined effects of CP2305 on top athletes experiencing physical and mental stresses. Forty-nine male university Ekiden (long distance relay race) runners daily took the CP2305-containing beverage for 12 weeks during training for and competing in All-Japan university championships. The CP2305 intake significantly facilitated recovery from fatigue and relieved anxiety and depressive mood, compared with placebo intake. The CP2305 intake significantly prevented the training-induced reduction of hemoglobin and facilitated exercise-induced increase in serum growth hormone levels. The CP2305 intake significantly increased the alpha- and beta-diversities of fecal microbiota, and the compositions of Bifidobacterium and Faecalibacterium . Gene expression profiling of peripheral blood leukocytes indicated that CP2305 prevented the stress-induced changes in the expression of genes related to mitochondrial functions. Our results suggest that daily intake of paraprobiotic CP2305 may be beneficial to athletes facing stressful situations.

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  • CP2305 intake increased alpha- and beta-diversity and the compositions of Bifidobacterium and Faecalibacterium in the gut microbiota.

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Authors
Sawada, D., Kuwano, Y., Tanaka, H., Hara, S., Uchiyama, Y., Sugawara, T., Fujiwara, S., Rokutan, K., & Nishida, K.
Affiliations
  • Asahi Breweries (Japan) (JP)
  • Tokushima University (JP)
  • Aoyama Gakuin University (JP)
Corresponding author
Nishida, Kensei
Venue
Journal of Functional Foods
Publisher
Elsevier BV
Published
2019-06
Volume
57
Pages
465-476
ISSN
1756-4646 (ISSN-L)
OpenAlex
W2941603141
Cited by
76
References
53
Citations by year
2026: 9 · 2025: 11 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 10 · 2020: 9 · 2019: 4
FWCI
6.56
Type
journal article
Language
en
Open access
Locations
  • Journal of Functional Foods (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
Funders
Asahi Group Holdings, Ltd
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
paraprobiotics, fatigue recovery, psychological stress, anxiety, depressive mood, athletes, hemoglobin, growth hormone, fecal microbiota diversity, Bifidobacterium, Faecalibacterium, leukocyte gene expression, mitochondrial function

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