Daily intake of Lactobacillus gasseri CP2305 relieves fatigue and stress-related symptoms in male university Ekiden runners: A double-blind, randomized, and placebo-controlled clinical trial
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The heat-inactivated, enteric-colonizing Lactobacillus gasseri CP2305 (CP2305) ameliorates psychological stress-related symptoms. In this study, we examined effects of CP2305 on top athletes experiencing physical and mental stresses. Forty-nine male university Ekiden (long distance relay race) runners daily took the CP2305-containing beverage for 12 weeks during training for and competing in All-Japan university championships. The CP2305 intake significantly facilitated recovery from fatigue and relieved anxiety and depressive mood, compared with placebo intake. The CP2305 intake significantly prevented the training-induced reduction of hemoglobin and facilitated exercise-induced increase in serum growth hormone levels. The CP2305 intake significantly increased the alpha- and beta-diversities of fecal microbiota, and the compositions of Bifidobacterium and Faecalibacterium . Gene expression profiling of peripheral blood leukocytes indicated that CP2305 prevented the stress-induced changes in the expression of genes related to mitochondrial functions. Our results suggest that daily intake of paraprobiotic CP2305 may be beneficial to athletes facing stressful situations.
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CP2305 intake increased alpha- and beta-diversity and the compositions of Bifidobacterium and Faecalibacterium in the gut microbiota.
“In relation to the gut microbiota, CP2305 intake increased the alpha- and beta-diversity, and the compositions of Bifidobacterium and Faecalibacterium.”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [271]
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PARAPROBİYOTİKLER, POSTBİYOTİKLER VE SAĞLIK ÜZERİNE ETKİLERİ
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THE INFLUENCE OF GUT MICROBIOTA ON PERFORMANCE IN ATHLETES
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- Authors
- Sawada, D., Kuwano, Y., Tanaka, H., Hara, S., Uchiyama, Y., Sugawara, T., Fujiwara, S., Rokutan, K., & Nishida, K.
- Affiliations
- Asahi Breweries (Japan) (JP)
- Tokushima University (JP)
- Aoyama Gakuin University (JP)
- Corresponding author
- Nishida, Kensei
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 57
- Pages
- 465-476
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W2941603141
- Cited by
- 76
- References
- 53
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 10 · 2020: 9 · 2019: 4
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
- Funders
- Asahi Group Holdings, Ltd
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- paraprobiotics, fatigue recovery, psychological stress, anxiety, depressive mood, athletes, hemoglobin, growth hormone, fecal microbiota diversity, Bifidobacterium, Faecalibacterium, leukocyte gene expression, mitochondrial function
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