Cited by 613Reading and Literacy DevelopmentNeurobiology of Language and BilingualismFace Recognition and Perception

Cerebral organization of component processes in reading

Pugh, K. R., Shaywitz, B. A., Shaywitz, S. E., Constable, R. T., Skudlarski, P., Fulbright, R. K., Bronen, R. A., Shankweiler, D. P. +3 more·1996·Brain

Abstract

The cerebral organization of word identification processes in reading was examined using functional magnetic resonance imaging (fMRI). Changes in fMRI signal intensities were measured in 38 subjects (19 males and 19 females) during visual (line judgement), orthographic (letter case judgement), phonological (nonword rhyme judgement) and semantic (semantic category judgement) tasks. A strategy of multiple subtractions was employed in order to validate relationships between structure and function. Orthographic processing made maximum demands on extrastriate sites, phonological processing on a number of frontal and temporal sites, and lexical-semantic processing was most strongly associated with middle and superior temporal sites. Significant sex differences in the cerebral organization of reading-related processes were also observed.

Integrity signals

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Crossref · 10.1093/brain/119.4.1221

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36 of 36 references verified0 citation errors · 0 not checkable

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Authors
Pugh, K. R., Shaywitz, B. A., Shaywitz, S. E., Constable, R. T., Skudlarski, P., Fulbright, R. K., Bronen, R. A., Shankweiler, D. P., Katz, L., Fletcher, J. M., & Gore, J. C.
Affiliations
  • Haskins Laboratories (US)
  • Yale University (US)
  • The University of Texas Health Science Center at Houston (US)
Corresponding author
Pugh, K. R.
Venue
Brain
Published
1996-08-01
Volume
119
Issue
4
Pages
1221-1238
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2093162419
Cited by
613
References
36
Citations by year
2026: 5 · 2025: 3 · 2024: 4 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 11 · 2017: 10 · 2016: 6 · 2015: 17 · 2014: 12 · 2013: 21 · 2012: 18
FWCI
31.67
Type
journal article
Language
en
Open access
closed
Locations
  • Brain (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01hd021888-10)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-01994, P01HD21888, P50 HD2580, P01HD001994)
Topics
  • Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Keywords
reading, word recognition, orthographic processing, phonological processing, lexical-semantic processing, visual word recognition, sex differences, brain organization, extrastriate cortex, temporal cortex, frontal cortex
MeSH terms
Adult, Cerebral Cortex, Female, Humans, Male, Neural Pathways, Reading, Task Performance and Analysis

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