Cited by 314T-cell and B-cell ImmunologyCancer, Hypoxia, and MetabolismImmune cells in cancer

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Metabolism in T cell activation and differentiation

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Pearce, Erika L·2010·Current Opinion in Immunology

DOI 10.1016/j.coi.2010.01.018PMC PMC4486663

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Abstract

When naïve or memory T cells encounter foreign antigen along with proper co-stimulation they undergo rapid and extensive clonal expansion. In mammals, this type of proliferation is fairly unique to cells of the adaptive immune system and requires a considerable expenditure of energy and cellular resources. While research has often focused on the roles of cytokines, antigenic signals, and co-stimulation in guiding T cell responses, data indicate that, at a fundamental level, it is cellular metabolism that regulates T cell function and differentiation and therefore influences the final outcome of the adaptive immune response. This review will focus on some earlier fundamental observations regarding T cell bioenergetics and its role in regulating cellular function, as well as recent work that suggests that manipulating the immune response by targeting lymphocyte metabolism could prove useful in treatments against infection and cancer.

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“Given that metabolism and T-cell differentiation are tightly linked (O’Neill et al., 2016; Pearce, 2010), we next sought to determine whether any of the central carbon metabolites generated during exercise could be a determining factor in the action of CD8+ T cells in this process.”
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Authors: Pearce, E. L.
Affiliations: Trudeau Institute (US)
Corresponding author: Pearce, Erika L
ORCID: Pearce, Erika L
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2010-06
Volume: 22
Issue: 3
Pages: 314-320
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2010.01.018
PMC: PMC4486663
OpenAlex: W1970662865
Cited by: 314
References: 82
Citations by year: 2026: 27 · 2025: 25 · 2024: 20 · 2023: 18 · 2022: 17 · 2021: 17 · 2020: 23 · 2019: 20 · 2018: 12 · 2017: 24 · 2016: 15 · 2015: 19 · 2014: 21 · 2013: 24 · 2012: 22
FWCI: 1.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Emerald Foundation
National Cancer Institute (R01CA181125)
National Institute of Allergy and Infectious Diseases (R01AI091965)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: T cell metabolism, T cell activation, T cell differentiation, bioenergetics, clonal expansion, costimulation, memory T cells
MeSH terms: Animals, Cell Differentiation, Glucose, Humans, Lymphocyte Activation, T-Lymphocytes, Lipid Metabolism, Mice

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Metabolism in T cell activation and differentiation

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