The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Nogo limits neural plasticity and recovery from injury
Open accessAbstract
The expression of Nogo-A and the receptor NgR1 limit the recovery of adult mammals from central nervous system injury. Multiple studies have demonstrated efficacy from targeting this pathway for functional recovery and neural repair after spinal cord trauma, ischemic stroke, optic nerve injury and models of multiple sclerosis. Recent molecular studies have added S1PR2 as a receptor for the amino terminal domain of Nogo-A, and have demonstrated shared components for Nogo-A and CSPG signalling as well as novel Nogo antagonists. It has been recognized that neural repair involves plasticity, sprouting and regeneration. A physiologic role for Nogo-A and NgR1 has been documented in the restriction of experience-dependent plasticity with maturity, and the stability of synaptic, dendritic and axonal anatomy.
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Cites
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Self-citationNeuronal Intrinsic Mechanisms of Axon Regeneration
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NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans
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Delayed anti-Nogo-A therapy improves function after chronic stroke in adult rats
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Self-citationTews, B., Schönig, K., Arzt, M. E., Clementi, S., Rioult-Pedotti, M.-S., Zemmar, A., Berger, S. M., Schneider, M., Enkel, T., Weinmann, O., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217665110 · Cited by 56
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Repair Mechanisms of the Neurovascular Unit after Ischemic Stroke with a Focus on VEGF
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Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury
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Metadata
- Authors
- Schwab, M. E., & Strittmatter, S. M.
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 27
- Pages
- 53-60
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2077387648
- Cited by
- 373
- References
- 8
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.