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Cited by 373

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Nogo limits neural plasticity and recovery from injury

Open access
Schwab, Martin E, Strittmatter, Stephen M·2014·Current Opinion in Neurobiology

Abstract

The expression of Nogo-A and the receptor NgR1 limit the recovery of adult mammals from central nervous system injury. Multiple studies have demonstrated efficacy from targeting this pathway for functional recovery and neural repair after spinal cord trauma, ischemic stroke, optic nerve injury and models of multiple sclerosis. Recent molecular studies have added S1PR2 as a receptor for the amino terminal domain of Nogo-A, and have demonstrated shared components for Nogo-A and CSPG signalling as well as novel Nogo antagonists. It has been recognized that neural repair involves plasticity, sprouting and regeneration. A physiologic role for Nogo-A and NgR1 has been documented in the restriction of experience-dependent plasticity with maturity, and the stability of synaptic, dendritic and axonal anatomy.

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Crossref · 10.1016/j.conb.2014.02.011

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Metadata

Authors
Schwab, M. E., & Strittmatter, S. M.
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2014-08
Volume
27
Pages
53-60
ISSN
0959-4388 (ISSN-L)
OpenAlex
W2077387648
Cited by
373
References
8
FWCI
3.26
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.