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Memory engram storage and retrieval
Open accessAbstract
A great deal of experimental investment is directed towards questions regarding the mechanisms of memory storage. Such studies have traditionally been restricted to investigation of the anatomical structures, physiological processes, and molecular pathways necessary for the capacity of memory storage, and have avoided the question of how individual memories are stored in the brain. Memory engram technology allows the labeling and subsequent manipulation of components of specific memory engrams in particular brain regions, and it has been established that cell ensembles labeled by this method are both sufficient and necessary for memory recall. Recent research has employed this technology to probe fundamental questions of memory consolidation, differentiating between mechanisms of memory retrieval from the true neurobiology of memory storage.
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Hebb, D. O. (2005) · doi:10.4324/9781410612403 · Cited by 9,825
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794
Structural and molecular interrogation of intact biological systems
Chung, K., Wallace, J., Kim, S.-Y., Kalyanasundaram, S., Andalman, A. S., Davidson, T. J., Mirzabekov, J. J., Zalocusky, K. A., Mattis, J., Denisin, A. K., et al. (2013) · Nature · doi:10.1038/nature12107 · Cited by 2,008
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365
Mechanisms of CaMKII action in long-term potentiation
Lisman, J., Yasuda, R., & Raghavachari, S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3192 · Cited by 1,134
Creating a False Memory in the Hippocampus
Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R. L., Ryan, T. J., & Tonegawa, S. (2013) · Science · doi:10.1126/science.1239073 · Cited by 968
Self-citationNMDA receptors, place cells and hippocampal spatial memory
Nakazawa, K., McHugh, T. J., Wilson, M. A., & Tonegawa, S. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1385 · Cited by 619
Self-citationBidirectional switch of the valence associated with a hippocampal contextual memory engram
Redondo, R. L., Kim, J., Arons, A. L., Ramirez, S., Liu, X., & Tonegawa, S. (2014) · Nature · doi:10.1038/nature13725 · Cited by 512 · cited 3×
“To this end, it has been shown that when the positive or negative emotional valence associated with a specific contextual memory was reversed in an optogenetic counter-conditioning schedule, the functional connectivity of DG and BLA engram cells was abolished [51].”
Self-citationIdentification of a Functional Connectome for Long-Term Fear Memory in Mice
Wheeler, A. L., Teixeira, C. M., Wang, A. H., Xiong, X., Kovacevic, N., Lerch, J. P., McIntosh, A. R., Parkinson, J., & Frankland, P. W. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002853 · Cited by 315
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Wang, C., Yue, H., Hu, Z., Shen, Y., Ma, J., Li, J., Wang, X.-D., Wang, L., Sun, B., Shi, P., et al. (2020) · Science · doi:10.1126/science.aaz2288 · Cited by 629
Detecting Activated Cell Populations Using Single-Cell RNA-Seq
Wu, Y. E., Pan, L., Zuo, Y., Li, X., & Hong, W. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.026 · Cited by 438
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Sekeres, M. J., Winocur, G., & Moscovitch, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.006 · Cited by 370
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Rule, M. E., O’Leary, T., & Harvey, C. D. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.08.005 · Cited by 227
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Ryan, T. J., & Frankland, P. W. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00548-3 · Cited by 182
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Rule, M. E., Loback, A. R., Raman, D. V., Driscoll, L. N., Harvey, C. D., & O'Leary, T. (2020) · eLife · doi:10.7554/elife.51121 · Cited by 106
Social memory engram in the hippocampus
Okuyama, T. (2018) · Neuroscience Research · doi:10.1016/j.neures.2017.05.007 · Cited by 95
Sharma, A., Kazim, S. F., Larson, C. S., Ramakrishnan, A., Gray, J. D., McEwen, B. S., Rosenberg, P. A., Shen, L., & Pereira, A. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903566116 · Cited by 92
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Metastable dynamics of neural circuits and networks
Brinkman, B. A. W., Yan, H., Maffei, A., Park, I. M., Fontanini, A., Wang, J., & La Camera, G. (2022) · Applied Physics Reviews · doi:10.1063/5.0062603 · Cited by 64
In vivo ephaptic coupling allows memory network formation
Pinotsis, D. A., & Miller, E. K. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad251 · Cited by 62
Suppression weakens unwanted memories via a sustained reduction of neural reactivation
Meyer, A.-K., & Benoit, R. G. (2022) · eLife · doi:10.7554/elife.71309 · Cited by 27
Shah, D., Verhoye, M., Van der Linden, A., & D’Hooge, R. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy329 · Cited by 25
Computing Education Research Today
Fincher, S. A., Tenenberg, J., Dorn, B., Hundhausen, C., McCartney, R., & Murphy, L. (2019) · The Cambridge Handbook of Computing Education Research · doi:10.1017/9781108654555.003 · Cited by 7
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Huang, W.-C., Zhang, W., Liang, Y., Bei, Y., Chen, Y., Feng, T., Pan, X., Tan, Z., Wang, Y., Wei, T., et al. (2026) · arXiv · doi:10.48550/arxiv.2602.06052 · Cited by 70
Metadata
- Authors
- Tonegawa, S., Pignatelli, M., Roy, D. S., & Ryan, T. J.
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 35
- Pages
- 101-109
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W1178553251
- Cited by
- 388
- References
- 10
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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