Social memory engram in the hippocampus

Okuyama, Teruhiro

doi:10.1016/j.neures.2017.05.007

Cited by 95Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

Social memory engram in the hippocampus

Okuyama, Teruhiro·2018·Neuroscience Research

DOI 10.1016/j.neures.2017.05.007

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Abstract

Social memory is one of the crucial components of episodic memories. Gregarious animals living in societies utilize social memory to exhibit the appropriate social behaviors such as aggression, avoidance, cooperative behavior, and even mating behavior. However, the neural mechanisms underlying social memory in the hippocampus remains mysterious. Here, I review some evidence from work done in rodents and primates on the brain region(s) and circuits encoding and/or retrieving social memory, as well as a storage for social memory (i.e. social memory engram neurons). Based on our recent findings that neural ensemble in ventral CA1 sub-region of the hippocampus possesses social memory engram, I would discuss the neural network for social information processing in order to encode social memory; and its evolutionary conservation between rodents and human.

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Scribble controls social behaviors through the regulation of the ERK/Mnk1 pathwayPreprint
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Additional file 1 of The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model
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Additional file 1 of A new AAV tool for highly preferentially targeting hippocampal CA2
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Watarai, A., Tao, K., Wang, M., & Okuyama, T. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.12.008 · Cited by 46 · see citing works
Self-citation
Ventral CA1 neurons store social memory
Okuyama, T., Kitamura, T., Roy, D. S., Itohara, S., & Tonegawa, S. (2016) · Science · doi:10.1126/science.aaf7003 · Cited by 657 · see citing works
Self-citation
The Processing of Social Information by Neurons in the Rat's Hippocampus.
Hanzlík, A.-F. (2021) · Digital Repository (National Repository of Grey Literature)
Social representation
Whalley, K. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00803-3 · Cited by 9 · see citing works

Authors: Okuyama, T.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Okuyama, Teruhiro
ORCID: Okuyama, Teruhiro
Venue: Neuroscience Research
Publisher: Elsevier BV
Published: 2018-04
Volume: 129
Pages: 17-23
ISSN: 0168-0102 (ISSN-L)
DOI: 10.1016/j.neures.2017.05.007
OpenAlex: W2620781914
Cited by: 95
References: 84
Citations by year: 2026: 5 · 2025: 21 · 2024: 9 · 2023: 16 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 6 · 2018: 4
FWCI: 0.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
Funders: Grant-in-Aid for a Japan Society for Promotion of Science (JSPS) postdoctoral SPD fellowship
Junior faculty developing program
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: social memory, hippocampus, ventral CA1, episodic memory, neuronal ensembles, social behavior, memory encoding and retrieval, neural circuits, evolutionary conservation, rodents, primates
MeSH terms: Animals, Brain, Hippocampus, Humans, Models, Neurological, Neural Pathways, Neurons, Social Behavior, Mice, Rats, Memory, Episodic

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Social memory engram in the hippocampus

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