Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides

Sela, David A.; Mills, David A.

doi:10.1016/j.tim.2010.03.008

Cited by 468Infant Nutrition and HealthGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides

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Sela, David A., Mills, David A.·2010·Trends in Microbiology

DOI 10.1016/j.tim.2010.03.008PMC PMC2902656

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Abstract

As the sole nutrition provided to infants, bioactive molecules dissolved in milk influence the development of our gut microbiota. Accordingly, human milk oligosaccharides (HMOs) are minimally digested by the infant and persist to negatively and positively regulate gut microbiota. Infant-type bifidobacteria utilize these soluble carbohydrate oligomers by convergent mechanisms. Bifidobacterium longum subsp. infantis efficiently consumes several small mass HMOs and possesses a large gene cluster and other loci dedicated to HMO metabolism. In contrast, adult-associated bifidobacteria such as the closely related B. longum subsp. longum are deficient for HMO utilization, although they retain the capacity to ferment plant oligosaccharides and constituent pentose sugars. Thus, the ability to subsist on HMO could demark infant-associated ecotypes potentially adapted to colonize the nursing infant.

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B. infantis grows exceptionally well in the presence of complex milk oligosaccharides to the exclusion of other potentially harmful bacteria.
“This bacteria grows exceptionally well in the presence of complex milk oligosaccharides to the exclusion of other potentially harmful bacteria [27–29].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [28]

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Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life
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Oral supplementation of healthy adults with 2′- O -fucosyllactose and lacto- N -neotetraose is well tolerated and shifts the intestinal microbiota
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Cross-feeding by Bifidobacterium breve UCC2003 during co-cultivation with Bifidobacterium bifidum PRL2010 in a mucin-based medium
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Annual Research Review: Critical windows – the microbiota-gut-brain axis in neurocognitive development
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Human Milk Components Modulate Toll-Like Receptor–Mediated Inflammation
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The role of early life nutrition in the establishment of gastrointestinal microbial composition and function
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Bifidobacterium breve UCC2003 metabolises the human milk oligosaccharides lacto-N-tetraose and lacto-N-neo-tetraose through overlapping, yet distinct pathways
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Strain-level epidemiology of microbial communities and the human microbiome
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The genus Bifidobacterium : from genomics to functionality of an important component of the mammalian gut microbiota
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Self-citation
Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyond
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Authors: Sela, D. A., & Mills, D. A.
Affiliations: University of California, Davis (US)
Corresponding author: Mills, David A.
ORCID: Sela, David A.
Mills, David A.
Venue: Trends in Microbiology
Publisher: Elsevier BV
Published: 2010-07
Volume: 18
Issue: 7
Pages: 298-307
ISSN: 0966-842X (ISSN-L)
DOI: 10.1016/j.tim.2010.03.008
PMC: PMC2902656
OpenAlex: W1998628730
Cited by: 468
References: 82
Citations by year: 2026: 16 · 2025: 14 · 2024: 26 · 2023: 28 · 2022: 29 · 2021: 42 · 2020: 33 · 2019: 28 · 2018: 40 · 2017: 33 · 2016: 35 · 2015: 35 · 2014: 31 · 2013: 29 · 2012: 30
FWCI: 2.80
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Microbiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (T32GM008799, T32GM08799)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD061923, R01HD059127)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: human milk oligosaccharides, Bifidobacterium, Bifidobacterium longum subsp. infantis, Bifidobacterium longum subsp. longum, infant gut microbiota, infant nutrition, pentoses
MeSH terms: Bifidobacterium, Humans, Infant, Infant, Newborn, Milk, Human, Oligosaccharides, Gastrointestinal Tract, Metabolic Networks and Pathways

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Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides

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