Cited by 64Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cholinergic double duty: cue detection and attentional control

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Sarter, Martin, Lustig, Cindy·2019·Current Opinion in Psychology

Abstract

Cholinergic signaling in the cortex involves fast or transient signaling as well as a relatively slower neuromodulatory component. These two components of cholinergic activity mediate separate yet interacting aspects of cue detection and attentional control. The transient component appears to support the activation of cue-associated task or response sets, whereas the slower modulatory component stabilizes task-set and context representations, therefore potentially facilitating top-down control. Evidence from humans expressing genetic variants of the choline transporter as well as from patients with degenerating cholinergic systems supports the hypothesis that attentional control capacities depend on levels of cholinergic neuromodulation. Deficits in cholinergic-attentional control impact diverse cognitive functions, including timing, working memory, and complex movement control.

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  • Given the importance of cholinergic neurotransmission in attentional orientation, disruptions to the cholinergic system may have adverse impacts on cognitive functioning.

    “Furthermore, given the importance of cholinergic neurotransmission in attentional orientation, it can be expected that disruptions to the cholinergic system may have adverse impacts on cognitive functioning83.”

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  1. [27]St Peters M, Demeter E, Lustig C, Bruno JP, Sarter M: Enhanced control of attention by stimulating mesolimbic-corticopetal cholinergic circuitry. J Neurosci (2011) 31(26): 9760– 9771. 21715641 PMC3137238

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Authors
Sarter, M., & Lustig, C.
Affiliations
University of Michigan (US)
Corresponding author
Sarter, Martin
Venue
Current Opinion in Psychology
Publisher
Elsevier BV
Published
2019-10
Volume
29
Pages
102-107
ISSN
2352-250X (ISSN-L)
OpenAlex
W2927777221
Cited by
64
References
62
Citations by year
2026: 5 · 2025: 7 · 2024: 14 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 5 · 2019: 4
FWCI
0.95
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Psychology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • University of Michigan
  • Presbyterian Historical Society (RO1 DA045063, P50 NS091856)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
cholinergic neurotransmission, neuromodulation, cue detection, attentional control, top-down control, cholinergic degeneration, working memory, timing
MeSH terms
Acetylcholine, Animals, Attention, Brain, Cerebral Cortex, Cognition, Cues, Humans, Mice, Rats

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