Prefrontal β2 Subunit-Containing and α7 Nicotinic Acetylcholine Receptors Differentially Control Glutamatergic and Cholinergic Signaling

Parikh, Vinay; Ji, Jinzhao; Decker, Michael W.; Sarter, Martin

doi:10.1523/jneurosci.5712-09.2010

Cited by 133Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Prefrontal β2 Subunit-Containing and α7 Nicotinic Acetylcholine Receptors Differentially Control Glutamatergic and Cholinergic Signaling

Open access

Parikh, Vinay, Ji, Jinzhao, Decker, Michael W., Sarter, Martin·2010·The Journal of Neuroscience

DOI 10.1523/jneurosci.5712-09.2010PMC PMC2864641

Open this paper in CoChat — free account Open PDF

Abstract

One-second-long increases in prefrontal cholinergic activity ("transients") were demonstrated previously to be necessary for the incorporation of cues into ongoing cognitive processes ("cue detection"). Nicotine and, more robustly, selective agonists at alpha4beta2* nicotinic acetylcholine receptors (nAChRs) enhance cue detection and attentional performance by augmenting prefrontal cholinergic activity. The present experiments determined the role of beta2-containing and alpha7 nAChRs in the generation of prefrontal cholinergic and glutamatergic transients in vivo. Transients were evoked by nicotine, the alpha4beta2* nAChR agonist ABT-089 [2-methyl-3-(2-(S)-pyrrolindinylmethoxy) pyridine dihydrochloride], or the alpha7 nAChR agonist A-582941 [2-methyl-5-(6-phenyl-pyridazin-3-yl)-octahydro-pyrrolo[3,4-c]pyrrole]. Transients were recorded in mice lacking beta2 or alpha7 nAChRs and in rats after removal of thalamic glutamatergic or midbrain dopaminergic inputs to prefrontal cortex. The main results indicate that stimulation of alpha4beta2* nAChRs evokes glutamate release and that the presence of thalamic afferents is necessary for the generation of cholinergic transients. ABT-089-evoked transients were completely abolished in mice lacking beta2* nAChRs. The amplitude, but not the decay rate, of nicotine-evoked transients was reduced by beta2* knock-out. Conversely, in mice lacking the alpha7 nAChR, the decay rate, but not the amplitude, of nicotine-evoked cholinergic and glutamatergic transients was attenuated. Substantiating the role of alpha7 nAChR in controlling the duration of release events, stimulation of alpha7 nAChR produced cholinergic transients that lasted 10- to 15-fold longer than those evoked by nicotine. alpha7 nAChR-evoked cholinergic transients are mediated in part by dopaminergic activity. Prefrontal alpha4beta2* nAChRs play a key role in evoking and facilitating the transient glutamatergic-cholinergic interactions that are necessary for cue detection and attentional performance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.5712-09.2010

Cites

82 of 82 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nicotinic modulation of neurotransmitter release is often subtype-specific and this specificity can vary across brain areas.
“Nicotinic modulation of neurotransmitter release is often subtype-specific and this specificity can vary across brain areas, with distinct nAChRs coupling to release of glutamate (α7) vs. GABA (α4β2*) (Mansvelder et al., 2002) or DA (α4/α6β2*) vs. ACh (α3β4*) (Grady et al., 2001) in the VTA, while β2* nAChRs can modulate the release of glutamate from thalamo-cortical projections (Parikh et al., 20”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Parikh et al., 2010
Removal of thalamic inputs blocks the ability of α4β2* nAChR agonists to evoke glutamatergic and cholinergic transients.
“We demonstrated that removal of these thalamic inputs blocks the ability of α4β2* nAChR agonists to evoke glutamatergic and cholinergic transients (Parikh et al, 2010).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Parikh et al, 2010

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Function of the thalamic reticular complex: the searchlight hypothesis
Crick, F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.14.4586 · Cited by 1,651 · see citing works
The thalamic reticular nucleus: structure, function and concept
Pinault, D. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.008 · Cited by 683 · see citing works
Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection
Sarter, M., Hasselmo, M. E., Bruno, J. P., & Givens, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.006 · Cited by 667 · see citing works
Self-citation
Prefrontal Acetylcholine Release Controls Cue Detection on Multiple Timescales
Parikh, V., Kozak, R., Martinez, V., & Sarter, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.025 · Cited by 623 · see citing works
Self-citation
Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents
Orr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494 · see citing works
Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: Selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density.
McGaughy, J. A., Kaiser, T. E., & Sarter, M. F. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.2.247 · Cited by 435 · see citing works
Self-citation
Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density
McGaughy, J., Kaiser, T., & Sarter, M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.2.247 · Cited by 435 · cited 1× · see citing works
“Cholinergic drugs modulate attentional performance and the activity of brain regions mediating attention (McGaughy et al., 1996; Turchi and Sarter 1997; Arnold et al., 2002; Sarter et al., 2005; Kozak et al., 2006, 2007; Bentley et al., 2008; Furey et al., 2008; Deco and Thiele, 2009).”
BackgroundSelf-citation
Effects of nicotinic stimulation on cognitive performance
NEWHOUSE, P. A. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.11.001 · Cited by 401 · see citing works
Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function
Buisson, B., & Bertrand, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01819.2001 · Cited by 361 · see citing works
Phasic acetylcholine release and the volume transmission hypothesis: time to move on
Sarter, M. F., Parikh, V., & Howe, W. M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2635 · Cited by 340 · see citing works
Self-citation
Gain Modulation by Nicotine in Macaque V1
Disney, A. A., Aoki, C., & Hawken, M. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.034 · Cited by 331 · see citing works
Multiorgan Autonomic Dysfunction in Mice Lacking the β2 and the β4 Subunits of Neuronal Nicotinic Acetylcholine Receptors
Xu, W., Orr‐Urtreger, A., Nigro, F., Gelber, S. E., Sutcliffe, C. B., Armstrong, D. L., Patrick, J. W., Role, L. W., Beaudet, A. L., & Biasi, M. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09298.1999 · Cited by 283 · see citing works
Effect sizes and p values: What should be reported and what should be replicated?
Greenwald, A. G., Gonzalez, R., Harris, R., & Guthrie, D. (1996) · Psychophysiology · doi:10.1111/j.1469-8986.1996.tb02121.x · Cited by 273 · see citing works
Nicotinic Stimulation Produces Multiple Forms of Increased Glutamatergic Synaptic Transmission
Radcliffe, K. A., & Dani, J. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07075.1998 · Cited by 271 · see citing works
Nicotine Induces Glutamate Release from Thalamocortical Terminals in Prefrontal Cortex
Lambe, E. K., Picciotto, M. R., & Aghajanian, G. K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300032 · Cited by 261 · see citing works
Distributed Network Actions by Nicotine Increase the Threshold for Spike-Timing-Dependent Plasticity in Prefrontal Cortex
Couey, J. J., Meredith, R. M., Spijker, S., Poorthuis, R. B., Smit, A. B., Brussaard, A. B., & Mansvelder, H. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.006 · Cited by 253 · see citing works
Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task
Grottick, A. J., & Higgins, G. A. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00305-3 · Cited by 240 · see citing works
Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice
Young, J. W., Crawford, N., Kelly, J. S., Kerr, L. E., Marston, H. M., Spratt, C., Finlayson, K., & Sharkey, J. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.03.008 · Cited by 233 · see citing works
A Pilot Controlled Clinical Trial of ABT-418, a Cholinergic Agonist, in the Treatment of Adults With Attention Deficit Hyperactivity Disorder
Wilens, T. E., Biederman, J., Spencer, T. J., Bostic, J., Prince, J., Monuteaux, M. C., Soriano, J., Fine, C., Abrams, A., Rater, M., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.12.1931 · Cited by 230 · see citing works
Cortical input to the basal forebrain
Záborszky, L., Gaykema, R. P. A., Swanson, D. J., & Cullinan, W. E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00049-3 · Cited by 221 · see citing works
Modulators in concert for cognition: Modulator interactions in the prefrontal cortex
Briand, L. A., Gritton, H., Howe, W. M., Young, D. A., & Sarter, M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.007 · Cited by 216 · see citing works
Self-citation
Nicotine Enhances Visuospatial Attention by Deactivating Areas of the Resting Brain Default Network
Hahn, B., Ross, T. J., Yang, Y., Kim, I., Huestis, M. A., & Stein, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5129-06.2007 · Cited by 199 · see citing works
Differential cortical acetylcholine release in rats performing a sustained attention task versus behavioral control tasks that do not explicitly tax attention
Arnold, H. M., Burk, J. A., Hodgson, E. M., Sarter, M., & Bruno, J. P. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00292-0 · Cited by 195 · see citing works
Self-citation
Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo‐cortical transmission
Gioanni, Y., Rougeot, C., Clarke, P. B. S., Lepousé, C., Thierry, A. M., & Vidal, C. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00403.x · Cited by 191 · see citing works
Broad-Spectrum Efficacy across Cognitive Domains by α7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways
Bitner, R. S., Bunnelle, W. H., Anderson, D. J., Briggs, C. A., Buccafusco, J. J., Curzon, P., Decker, M. W., Frost, J. M., Grønlien, J. H., Gubbins, E. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2444-07.2007 · Cited by 184 · see citing works
Self-citation
Functional Characterization of Intrinsic Cholinergic Interneurons in the Cortex
von Engelhardt, J., Eliava, M., Meyer, A. H., Rozov, A., & Monyer, H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4647-06.2007 · Cited by 177 · see citing works
Microelectrode array studies of basal and potassium‐evoked release of l ‐glutamate in the anesthetized rat brain
Day, B. K., Pomerleau, F., Burmeister, J. J., Huettl, P. F., & Gerhardt, G. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03673.x · Cited by 174 · see citing works
Cholinergic Mediation of Attention
Parikh, V., & Sarter, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.021 · Cited by 171 · see citing works
Self-citation
Nicotinic control of axon excitability regulates thalamocortical transmission
Kawai, H., Lazar, R., & Metherate, R. (2007) · Nature Neuroscience · doi:10.1038/nn1956 · Cited by 171 · cited 2× · see citing works
“Such tonic increases in ACh release may facilitate the prefrontal glutamatergic–cholinergic interactions and thus optimize cue detection (Kawai et al., 2007).”
Background
Cortical acetylcholine and processing capacity: effects of cortical cholinergic deafferentation on crossmodal divided attention in rats
Turchi, J. N., & Sarter, M. F. (1997) · Cognitive Brain Research · doi:10.1016/s0926-6410(97)00027-x · Cited by 165 · see citing works
Self-citation
Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: Focus on cognition
Wilens, T. E., & Decker, M. W. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.002 · Cited by 164 · see citing works
Self-citation
Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease
Potter, A., Corwin, J., Lang, J., Piasecki, M., Lenox, R., & Newhouse, P. A. (1999) · Psychopharmacology · doi:10.1007/s002130050897 · Cited by 163 · see citing works
Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task
Hoyle, E., Genn, R. F., Fernandes, C., & Stolerman, I. P. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0549-2 · Cited by 161 · see citing works
Presynaptic α7- and β2-Containing Nicotinic Acetylcholine Receptors Modulate Excitatory Amino Acid Release from Rat Prefrontal Cortex Nerve Terminals via Distinct Cellular Mechanisms
Dickinson, J. A., Kew, J. N. C., & Wonnacott, S. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046623 · Cited by 159 · see citing works
Enhancement of Attentional Performance by Selective Stimulation of α4β2* nAChRs: Underlying Cholinergic Mechanisms
Howe, W. M., Ji, J., Parikh, V., Williams, S., Mocaër, E., Trocmé-Thibierge, C., & Sarter, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.9 · Cited by 150 · cited 2× · see citing works
“The more robust attentional effects of 4 2* nAChR agonists when compared with nicotine appear to be attributable to a more potent positive modulation of the amplitude, but not the duration, of these transients (Howe et al., 2009, 2010).”
Background
Augmented Prefrontal Acetylcholine Release during Challenged Attentional Performance
Kozak, R., Bruno, J. P., & Sarter, M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi079 · Cited by 144 · see citing works
Self-citation
Cholinergic neurons in the rat central nervous system demonstrated by in situ hybridization of choline acetyltransferase mRNA
Oh, J. D., Woolf, N. J., Roghani, A., Edwards, R. H., & Butcher, L. L. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90031-v · Cited by 141 · see citing works
Attentional effects of nicotinic agonists in rats
Hahn, B., Sharples, C. G. V., Wonnacott, S., Shoaib, M., & Stolerman, I. P. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00099-6 · Cited by 135 · see citing works
α7 and non‐α7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex
Livingstone, P. D., Srinivasan, J., Kew, J. N. C., Dawson, L. A., Gotti, C., Moretti, M., Shoaib, M., & Wonnacott, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06613.x · Cited by 133 · see citing works
Attentional orienting is impaired by unilateral lesions of the thalamic reticular nucleus in the rat
Weese, G. D., Phillips, J. M., & Brown, V. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-22-10135.1999 · Cited by 132 · see citing works
Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats
McGaughy, J., Decker, M. W., & Sarter, M. (1999) · Psychopharmacology · doi:10.1007/s002130050991 · Cited by 128 · see citing works
Self-citation
Glutamatergic Contributions to Nicotinic Acetylcholine Receptor Agonist-Evoked Cholinergic Transients in the Prefrontal Cortex
Parikh, V., Man, K., Decker, M. W., & Sarter, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5251-07.2008 · Cited by 127 · see citing works
Self-citation
Competitive Neuronal Nicotinic Receptor Antagonists: A New Direction for Drug Discovery
Dwoskin, L. P., & Crooks, P. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29396-4 · Cited by 125 · see citing works
ABT-089, A Neuronal Nicotinic Receptor Partial Agonist, for the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: Results of a Pilot Study
Wilens, T. E., Verlinden, M. H., Adler, L. A., Wozniak, P. J., & West, S. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.029 · Cited by 123 · see citing works
nAChR agonist-induced cognition enhancement: Integration of cognitive and neuronal mechanisms
Sarter, M., Parikh, V., & Howe, W. M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.019 · Cited by 123 · see citing works
Self-citation
Facilitation of glutamatergic neurotransmission by presynaptic nicotinic acetylcholine receptors
Girod, R., Barazangi, N., McGehee, D., & Role, L. W. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00145-3 · Cited by 122 · see citing works
Collateral innervation of the medial and lateral prefrontal cortex by amygdaloid, thalamic, and brain‐stem neurons
Sarter, M. F., & Markowitsch, H. J. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902240312 · Cited by 121 · see citing works
Self-citation
Rapid assessment of in vivo cholinergic transmission by amperometric detection of changes in extracellular choline levels
Parikh, V., Pomerleau, F., Huettl, P., Gerhardt, G. A., Sarter, M., & Bruno, J. P. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03614.x · Cited by 117 · see citing works
Self-citation
Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health
Bentley, P., Driver, J., & Dolan, R. J. (2007) · Brain · doi:10.1093/brain/awm299 · Cited by 115 · see citing works
Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway
Xiao, C., Nashmi, R., McKinney, S. L., Cai, H., McIntosh, J. M., & Lester, H. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2939-09.2009 · Cited by 115 · see citing works
Second-by-Second Measures of l-Glutamate in the Prefrontal Cortex and Striatum of Freely Moving Mice
Hascup, K. N., Hascup, E. R., Pomerleau, F., Huettl, P. F., & Gerhardt, G. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.131698 · Cited by 110 · see citing works
Selective Effects of Cholinergic Modulation on Task Performance during Selective Attention
Furey, M. L., Pietrini, P., Haxby, J. V., & Drevets, W. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301461 · Cited by 107 · see citing works
Nicotinic actions on neuronal networks for cognition: General principles and long-term consequences
Poorthuis, R. B., Goriounova, N. A., Couey, J. J., & Mansvelder, H. D. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.031 · Cited by 102 · see citing works
Improvement in performance of a delayed matching-to-sample task by monkeys following ABT-418: a novel cholinergic channel activator for memory enhancement
Buccafusco, J. J., Jackson, W. J., Terry, A. V., Marsh, K. C., Decker, M. W., & Arnerić, S. P. (1995) · Psychopharmacology · doi:10.1007/bf02311172 · Cited by 100 · see citing works
Self-citation
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys
Decker, M. W., Bannon, A. W., Curzon, P., Gunther, K. L., Brioni, J. D., Holladay, M. W., Lin, N.-H., Li, Y., Daanen, J. F., Buccafusco, J. J., et al. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37015-6 · Cited by 88 · see citing works
Self-citation
Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype
Walsh, H., Govind, A. P., Mastro, R., Hoda, J. C., Bertrand, D., Vallejo, Y., & Green, W. N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m703432200 · Cited by 87 · see citing works
In vivo monitoring of extracellular glutamate in the brain with a microsensor
Oldenziel, W. H., Dijkstra, G. D. H., Cremers, T. I. F. H., & Westerink, B. H. C. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.015 · Cited by 87 · see citing works
Attention – oscillations and neuropharmacology
Deco, G., & Thiele, A. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06833.x · Cited by 85 · see citing works
Differential behavioral effects of partial bilateral lesions of ventral tegmental area or substantia nigra pars compacta in rats
Pioli, E. Y., Meissner, W. G., Sohr, R., Gross, C. E., Bézard, E., & Bioulac, B. H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.084 · Cited by 80 · see citing works
Three-dimensional chemoarchitecture of the basal forebrain: Spatially specific association of cholinergic and calcium binding protein-containing neurons
Záborszky, L., Buhl, D. L., Pobalashingham, S., Bjaalie, J. G., & Nádasdy, Z. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.019 · Cited by 80 · see citing works
ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A Potent and Selective Cholinergic Channel Modulator with Neuroprotective Properties
Sullivan, J. P., Donnelly‐Roberts, D. L., Briggs, C. A., Anderson, D. J., Gopalakrishnan, M., Xue, I. C., Piattoni-Kaplan, M., Molinari, E. J., Campbell, J. E., McKenna, D. G., et al. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37014-4 · Cited by 79 · see citing works
Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)
Dunbar, G. C., Inglis, F., Kuchibhatla, R., Sharma, T., Tomlinson, M., & Wamsley, J. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107066855 · Cited by 75 · see citing works
ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders
Rueter, L. E., Anderson, D. J., Briggs, C. A., Donnelly‐Roberts, D. L., Gintant, G. A., Gopalakrishnan, M., Lin, N., Osinski, M. A., Reinhart, G. A., Buckley, M. J., et al. (2004) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2004.tb00011.x · Cited by 70 · see citing works
Self-citation
Prefrontal Cortex of the Mouse Defined as Cortical Projection Area of the Thalamic Mediodorsal Nucleus
Guldin, W. O., Pritzel, M., & Markowitsch, H. J. (2008) · Brain Behavior and Evolution · doi:10.1159/000121636 · Cited by 68 · see citing works
Up-regulation of nicotinic acetylcholine receptors following chronic exposure of rats to mainstream cigarette smoke or α4β2 receptors to nicotine
Yates, S. L., Bencheri, M., Fluhler, E. N., & Lippiello, P. M. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02100-0 · Cited by 65 · see citing works
Cortical choline transporter function measured in vivo using choline‐sensitive microelectrodes: clearance of endogenous and exogenous choline and effects of removal of cholinergic terminals
Parikh, V., & Sarter, M. F. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03766.x · Cited by 63 · see citing works
Self-citation
Effects of handling on extracellular levels of glutamate and other amino acids in various areas of the brain measured by microdialysis
Timmerman, W., Cisci, G., Nap, A., Vries, J. B. D., & Westerink, B. H. C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01538-3 · Cited by 60 · see citing works
Toward a Neuro-Cognitive Animal Model of the Cognitive Symptoms of Schizophrenia: Disruption of Cortical Cholinergic Neurotransmission Following Repeated Amphetamine Exposure in Attentional Task-Performing, but Not Non-Performing, Rats
Kozak, R., Martínez, V., Young, D. A., Brown, H. D., Bruno, J. P., & Sarter, M. F. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301352 · Cited by 53 · see citing works
Self-citation
NMDA and dopamine interactions in the nucleus accumbens modulate cortical acetylcholine release
Zmarowski, A., Sarter, M., & Bruno, J. P. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04333.x · Cited by 52 · see citing works
Self-citation
Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys.
Buccafusco, J., Terry, A., Decker, M. W., & Gopalakrishnan, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.010 · Cited by 47 · see citing works
Self-citation
Dendritic Ca2+ signalling due to activation of α7‐containing nicotinic acetylcholine receptors in rat hippocampal neurons
Fayuk, D. A., & Yakel, J. L. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135319 · Cited by 43 · see citing works
Evidence for a cortical projection to the magnocellular basal nucleus in the rat: an electron microscopic axonal transport study
Lemann, W., & Saper, C. B. (1985) · Brain Research · doi:10.1016/0006-8993(85)90228-8 · Cited by 41 · see citing works
Neuronal activity in the nucleus accumbens is necessary for performance-related increases in cortical acetylcholine release
Neigh, G. N., Arnold, H. M., Rabenstein, R. L., Sarter, M. F., & Bruno, J. P. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.006 · Cited by 39 · see citing works
Self-citation
Afferents to the ventral tegmental nucleus of gudden in the mouse, rat, and cat
Irle, E., Sarter, M. F., Guldin, W. O., et al. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902280406 · Cited by 36 · see citing works
Self-citation
Different effects of ionotropic and metabotropic glutamate receptor antagonists on attention and the attentional properties of nicotine
Quarta, D., Naylor, C. G., Morris, H. V., Patel, S., Genn, R. F., & Stolerman, I. P. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.023 · Cited by 33 · see citing works
Local and global calcium signals associated with the opening of neuronal α7 nicotinic acetylcholine receptors
Gilbert, D., Lecchi, M., Arnaudeau, S., Bertrand, D., & Demaurex, N. (2008) · Cell Calcium · doi:10.1016/j.ceca.2008.10.003 · Cited by 33 · see citing works
Selectivity of ABT-089 for α4β2* and α6β2* nicotinic acetylcholine receptors in brain
Marks, M. J., Wageman, C. R., Grady, S. R., Gopalakrishnan, M., & Briggs, C. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.022 · Cited by 30 · see citing works
Stimulation of cortical acetylcholine release following blockade of ionotropic glutamate receptors in nucleus accumbens
Neigh, G. N., Kravitz, B. A., Sarter, M. F., & Bruno, J. P. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02201.x · Cited by 26 · see citing works
Self-citation
Depolarization Initiates Phasic Acetylcholine Release by Relief of a Tonic Block Imposed by Presynaptic M2 Muscarinic Receptors
Parnas, H., Slutsky, I., Rashkovan, G., et al. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01131.2004 · Cited by 24 · see citing works

Flagged first, then by citations

Sorted by citations

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404 · see citing works
Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733 · see citing works
Self-citation
Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention
Guillem, K., Bloem, B., Poorthuis, R. B., Loos, M., Smit, A. B., Maskos, U., Spijker, S., & Mansvelder, H. D. (2011) · Science · doi:10.1126/science.1207079 · Cited by 191 · see citing works
Neuromodulation by acetylcholine: examples from schizophrenia and depression
Higley, M. J., & Picciotto, M. R. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.06.004 · Cited by 184 · see citing works
Enhancement of Attentional Performance by Selective Stimulation of α4β2* nAChRs: Underlying Cholinergic Mechanisms
Howe, W. M., Ji, J., Parikh, V., Williams, S., Mocaër, E., Trocmé-Thibierge, C., & Sarter, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.9 · Cited by 150 · see citing works
Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex
Wallace, T. L., & Bertrand, D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.04.001 · Cited by 133 · see citing works
Leveraging the cortical cholinergic system to enhance attention
Demeter, E., & Sarter, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.060 · Cited by 75 · see citing works
Self-citation
Mechanistic insights into nicotine withdrawal
Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works
Cholinergic double duty: cue detection and attentional control
Sarter, M., & Lustig, C. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.12.026 · Cited by 64 · see citing works
Self-citation
Cholinergic and Adenosinergic Modulation of Synaptic Release
Yang, D., Ding, C., Qi, G., & Feldmeyer, D. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.006 · Cited by 24 · see citing works

Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption
del Pino, J., Moyano, P. M., Díaz, G. G., Anadón, M. J., Díaz, M. J. V., García, J. M., Lobo, M., Pelayo, A., Solà, E., & Frejo, M. T. (2017) · Toxicology · doi:10.1016/j.tox.2017.09.008 · Cited by 25 · see citing works
Characterization of central nicotinic receptors by studies on the nicotine cue and conditioned taste aversion in rats
Stolerman, I. P. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90451-0 · Cited by 33 · see citing works
Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H]acetylcholine to nicotinic receptors
Ksir, C., Hakan, R., Hall, D. P., & Kellar, K. J. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90058-9 · Cited by 204 · see citing works
The Effects of Chronic Nicotine Administration on Brain Nicotinic Receptor Numbers
Collins, A. C., & Marks, M. J. (1987) · Advances in behavioral biology · doi:10.1007/978-1-4613-1911-5_28 · Cited by 8 · see citing works
Widespread post-transcriptional regulation of co-transmissionPreprint
Chen, N., Zhang, Y., Rivera-Rodriguez, E. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.01.530653 · Cited by 4 · see citing works

Authors: Parikh, V., Ji, J., Decker, M. W., & Sarter, M.
Affiliations: University of Michigan (US)
Abbott (United States) (US)
ORCID: Parikh, Vinay
Ji, Jinzhao
Decker, Michael W.
Sarter, Martin
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-03-03
Volume: 30
Issue: 9
Pages: 3518-3530
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5712-09.2010
PMC: PMC2864641
OpenAlex: W1977500396
Cited by: 133
References: 82
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 2 · 2017: 8 · 2016: 13 · 2015: 11 · 2014: 16 · 2013: 20 · 2012: 12
FWCI: 5.87
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Abbott Laboratories
National Institute of Mental Health (R01MH080332, R21MH080426, MH080426)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: prefrontal cortex, nicotinic acetylcholine receptors, alpha4beta2 nAChR, alpha7 nAChR, glutamate release, thalamic afferents, dopaminergic input, cue detection, nicotine
MeSH terms: Acetylcholine, Afferent Pathways, Animals, Denervation, Female, Male, Mice, Inbred C57BL, Synaptic Transmission, Receptors, Nicotinic, Synapses, Thalamus, Time Factors, Signal Transduction, Prefrontal Cortex, Ventral Tegmental Area, Presynaptic Terminals, Mice, Knockout, Glutamic Acid, Nicotinic Agonists, Excitatory Postsynaptic Potentials, Mice, alpha7 Nicotinic Acetylcholine Receptor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prefrontal β2 Subunit-Containing and α7 Nicotinic Acetylcholine Receptors Differentially Control Glutamatergic and Cholinergic Signaling

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks