Topography of sleep slow wave activity in children with attention-deficit/hyperactivity disorder
Abstract
Introduction Sleep slow wave activity (SWA, EEG power between 1 and 4.5 Hz) is a major characteristic of non-rapid eye movement (NREM) sleep, which seems to be critically involved in cortical plasticity. Studies using high-density electroencephalography (hd-EEG) showed that the topographical distribution of SWA mirrors cortical maturation, expressing a local maximum that is characteristic for a certain age range. We compared the sleep EEG of children with attention-deficit/hyperactivity disorder (ADHD) with healthy controls to explore differences in sleep SWA.Methods All-night hd-EEG recordings (128 electrodes) were performed in a group of nine children diagnosed with ADHD and nine age- and sex-matched healthy controls. SWA topography was calculated and contrasted between the groups.Results We found a local increase of SWA in a cluster of six electrodes over central regions in children with ADHD compared to control children (+17% ± 6% SE, p < .01). This group difference was specific for the SWA range and stable across the night.Conclusions Children with ADHD showed a less mature topographical SWA distribution in comparison to healthy children of the same age and sex. This neuromaturational delay in ADHD is in accordance with neuroimaging and behavioral studies. Thus, our study supports the use of sleep SWA topography as a reliable imaging tool for the study of cortical plasticity.
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Slow wave activity (SWA, 1-4.5 Hz) during SWS is altered in children with ADHD: enhanced over central positions and attenuated by trend over frontal positions.
“As recently shown, slow wave activity (SWA, 1e4.5 Hz) during SWS is altered in children suffering from ADHD: while over central positions the SWA was enhanced, it was attenuated by trend over frontal positions [35].”
Children with ADHD are suspected to display less frontal slow wave activity during sleep.
“Children suffering from ADHD are suspected to display less frontal slow wave activity during sleep [35].”
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- Authors
- Ringli, M., Souissi, S., Kurth, S., Brandeis, D., Jenni, O. G., & Huber, R.
- Affiliations
- University Children's Hospital Zurich (CH)
- University of Zurich (CH)
- Corresponding author
- Huber, Reto
- Venue
- Cortex
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 49
- Issue
- 1
- Pages
- 340-347
- ISSN
- 0010-9452 (ISSN-L)
- OpenAlex
- W1982297589
- Cited by
- 101
- References
- 56
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 11 · 2021: 10 · 2020: 8 · 2019: 10 · 2018: 5 · 2017: 7 · 2016: 14 · 2015: 12 · 2014: 4 · 2013: 5 · 2012: 1
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cortex (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- attention deficit hyperactivity disorder, cortical maturation, cortical plasticity, NREM sleep, children, high-density EEG
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Cerebral Cortex, Child, Electroencephalography, Female, Humans, Male, Sleep
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