Why do we sleep?11Published on the World Wide Web on 7 November 2000.

Sejnowski, Terrence J.; Destexhe, Alain

doi:10.1016/s0006-8993(00)03007-9

Cited by 489Sleep and Wakefulness ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Why do we sleep?11Published on the World Wide Web on 7 November 2000.

Sejnowski, Terrence J., Destexhe, Alain·2000·Brain Research

DOI 10.1016/s0006-8993(00)03007-9

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Abstract

Slow-wave sleep consists in slowly recurring waves that are associated with a large-scale spatio-temporal synchrony across neocortex. These slow-wave complexes alternate with brief episodes of fast oscillations, similar to the sustained fast oscillations that occur during the wake state. We propose that alternating fast and slow waves consolidate information acquired previously during wakefulness. Slow-wave sleep would thus begin with spindle oscillations that open molecular gates to plasticity, then proceed by iteratively 'recalling' and 'storing' information primed in neural assemblies. This scenario provides a biophysical mechanism consistent with the growing evidence that sleep serves to consolidate memories.

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Within neocortical networks, spindle activity is probably associated with a massive calcium influx into pyramidal cells.
“Within neocortical networks, spindle activity is probably associated with a massive calcium influx into pyramidal cells (1061).”
From About Sleep's Role in Memory (2013) · cites this paper as [1061]

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Authors: Sejnowski, T. J., & Destexhe, A.
Venue: Brain Research
Publisher: Elsevier BV
Published: 2000-12
Volume: 886
Issue: 1-2
Pages: 208-223
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(00)03007-9
OpenAlex: W1996714928
Cited by: 489
References: 134
Citations by year: 2026: 6 · 2025: 12 · 2024: 15 · 2023: 14 · 2022: 14 · 2021: 12 · 2020: 14 · 2019: 30 · 2018: 16 · 2017: 20 · 2016: 23 · 2015: 20 · 2014: 14 · 2013: 24 · 2012: 23
FWCI: 9.98
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Centre National de la Recherche Scientifique
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: sleep, slow-wave sleep, memory consolidation, spindle oscillations, synaptic plasticity, cell assemblies, information storage
MeSH terms: Animals, Arousal, Biological Clocks, Brain, Computer Simulation, Electroencephalography, Hippocampus, Humans, Memory, Models, Neurological, Nerve Net, Neuronal Plasticity, Sleep, Sleep, REM, Thalamus, Pyramidal Cells, Neocortex, Excitatory Postsynaptic Potentials

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Why do we sleep?11Published on the World Wide Web on 7 November 2000.

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