Deep sleep maintains learning efficiency of the human brain
Open accessAbstract
It is hypothesized that deep sleep is essential for restoring the brain’s capacity to learn efficiently, especially in regions heavily activated during the day. However, causal evidence in humans has been lacking due to the inability to sleep deprive one target area while keeping the natural sleep pattern intact. Here we introduce a novel approach to focally perturb deep sleep in motor cortex, and investigate the consequences on behavioural and neurophysiological markers of neuroplasticity arising from dedicated motor practice. We show that the capacity to undergo neuroplastic changes is reduced by wakefulness but restored during unperturbed sleep. This restorative process is markedly attenuated when slow waves are selectively perturbed in motor cortex, demonstrating that deep sleep is a requirement for maintaining sustainable learning efficiency.
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Adopting healthy sleep habits is critical for fostering learning and memory consolidation in both animal and human models.
“it is well established that adopting healthy sleep habits is critical for fostering learning and memory consolidation in both animal and human models (9, 10).”
From Nightly sleep duration predicts grade point average in the first year of college (2023) · cites this paper as [10]
The Abstract reports that unperturbed deep sleep restores the capacity for motor learning in humans, while perturbing slow waves attenuates that effect. The paper does not establish the broader claim about adopting healthy sleep habits, memory consolidation, or animal models; its Results describe a human motor-learning experiment. (LLM, conf=0.86)
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- Authors
- Fattinger, S., de Beukelaar, T. T., Ruddy, K. L., Volk, C., Heyse, N. C., Herbst, J. A., Hahnloser, R. H. R., Wenderoth, N., & Huber, R.
- Affiliations
- University of Zurich (CH)
- ETH Zurich (CH)
- Corresponding author
- Wenderoth, Nicole
- Huber, Reto
- Venue
- Nature Communications
- Published
- 2017-05-22
- Volume
- 8
- Issue
- 1
- Pages
- 15405-15405
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5458149
- OpenAlex
- W2618704403
- Cited by
- 148
- References
- 51
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 20 · 2023: 15 · 2022: 28 · 2021: 12 · 2020: 17 · 2019: 17 · 2018: 5 · 2017: 3
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-05-25)
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Lirias (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion, cc-by)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- ETH Zürich Research Collection (cc-by)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (149561, 153387, 320030)
- Fonds Wetenschappelijk Onderzoek (G.0401.12)
- Universität Zürich
- Vlaamse regering
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- slow-wave sleep, motor learning, neuroplasticity, motor cortex, slow waves, sleep deprivation, motor training, learning efficiency, wakefulness
- MeSH terms
- Acoustic Stimulation, Adult, Behavior, Brain, Electrodes, Electroencephalography, Electromyography, Female, Humans, Learning, Male, Motor Cortex, Motor Skills, Neuronal Plasticity, Sleep, Wakefulness, Transcranial Magnetic Stimulation, Young Adult
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